SUBJECT
ENTRIES
g.13.1. Internal
Diseases
g.13.2. Surgery
g.13.3. Pediatry. Obstetrics and Gynecology
g.13.4. Stomatology
g.13.5. Roentgenology and Radiology
g.13.6. Public
Healthcare
8.g.13.1.1. Difficulties in the treatment of patients
with chronic hepatitis C and ulcerative colitis. /T. Gegeshidze,
According to the WHO data, 3-4 million people
worldwide are being affected annually with HCV infection. Official registration
of HCV infection in
Auth.
8.g.13.1.2. The etiological structure and antibiotic
sensitivity of bacterial prostates. /K. Aphridonidze, M.
Dzagnidze, N. Cholokashvili, E.Mirvelashvili,
In the study, the chronic prostatitis microbe and the
prostate secretion of 84 patients were tested bacteriologically. From the
prostate secretion of all the patients the microorganisms of different genera
were grown up: TRV-38%, Staphylococcus
aureus – 35.7%, Enterococcus fecallis
– 14.2%, Staphylococcus epidermidis –
11.9%. Gram-positive microbes have high sensitivity to penicillin, makropan and
tarivid and resistance to kanamycin, gentamicin and ampicillin.
Auth.
8.g.13.1.3. Risk assessment and management in case of
asymptomatic high-degree AV blocks. /I. Venkata Kiran Kumar
Raju, K. Jalabadze, K. Etsadashvili,
Permanent pacemaker implantation is a well-established
indication for the patients with high degree AV block and syncope, but there
are the controversial data about the device implantation for the patients with
asymptomatic high degree AV block. We report the case of 56-old patient with
accidentally diagnosed asymptomatic high degree AV block, (proximal location)
according to surface ECG. During the EP study 6 second- long asystole was
developed. This case stresses on misleading interpretation of ECG to assess the
risk and further prognosis in such cases.
Auth.
8.g.13.1.4. Clinical and laboratory peculiarities of
the anthrax infection in
The aim of the study was to evaluate clinical and
laboratory peculiarities of the anthrax (infection based on the infectious
diseases, AIDS and Clinical Immunology Scientific Centre data. 17 patients
underwent follow-up during 2007-2008 years. 14 (82.3%) out of 17 were males and
3 (17,7%) out of 17 were females. In the majority of the patients rout of
infection was the contact with the infected animal and/or their products. In
one case, the rout of infection was the contact with the contaminated soil
(during rural activities In 3 (17.6%) patients the disease progression was
mild, in 8 (47.1%) - moderate, and in 6 (35.3%) - severe. The diagnosis was
confirmed on the basis of clinical and epidemiological data. Bacteriological
and/or PCR analyses of the carbuncle contents were done for the identification
of B. anthracis. Patients with mild and moderate severity were treated with
oral antibiotics of the ftorquinolone group, namely – ciprofloxacin 1000 mg/day
for 10-14 days. In-patients with severe disease combination of two
antibiotics-ciprofloxacin and benzyl penicillin were administered. At the
parallel I/V transfusion of glucose and electrolytes were managed.
Auth.
8.g.13.1.5. Comparative results of treatment of
patients with cerebral stroke in neurology department and hospital with a
stroke unit. /I. Verulashvili/.
A comparative analysis of treatment results in
patients with an acute stage of cerebral stroke treated in 2007-2008 both in
the N. Khipshidze Central University Hospital by a stroke unit, equipped with
high-tech equipment and staffed with specialists of a multidiscipline team (158
patients; mean age 56.3±7.5) and in a neurology department of Municipal
Hospital #1 (169 patients; mean age 53.83±6.1) was conducted. The obtained data
prove the fact that a medical aid to cerebral stroke patients rendered in the
hospital with a stroke unit, has apparent advantages: therapy is accompanied by
a good regress of a neuralgic deficit (correspondingly 76% to 28%) and somatic
complications (correspondingly 7% to 2.5%). Lethality (correspondingly 3.2 to
5.8 lethal events per 100 patients), invalidation and domestic incapability of
a patient to the end of the third month of a disease onset are greatly
decreased in-patients treated in stroke unit. An advantage of stroke units is
that this specialized care can be given to a broad spectrum of patients
regardless of the interval after stroke or severity of neurological
impairments.
Auth.
8.g.13.1.6. Acute toxic damage of liver: pathogenesis
and new ways of treatment. /D. Tophuria, R.
Khetsuriani, A. Shukakidze., N. Mzareulishvili, Z. Tophuria, G. Didava/.
Pathomorphological changes of the liver due to the
action of numerous toxic agents (CCL4, various medications) are generally
manifested by two types of damages, the so called hepatocellular or cytotoxic
and cholestasis. In serious toxic damage cases may develop massive necrosis and
fulminant liver insufficiency, the most frequent causative toxic substances
being halothane, isoniazid, phenytoin and organic solvents. Mammalian mature
cells do not have affinity to division and reparative regeneration, but
hepatocytes in this case serve as unique objects; oval progenitor cells can
proliferate and differentiate both in hapatocyte and bile secreting epithelial
cells. These cells are highly resistant to hypoxic conditions and easily
cultivate in vitro conditions. By an
electron microscopy study of progenitor cells, a high number of oval
mitochondrias and endoplasmic reticulum microtubules can be observed. According
to these findings, we can postulate that such ultrastructural changes are
leading to high functional activity of cells and reparative regeneration
process intensity.
Auth.
8.g.13.1.7.
In regard to CNS, there are some discrepancies in
published data concerning irreversible damages induced by local hyperthermia.
We studied sensitivity of cerebral tissue to hyperthermia, its immediate effect,
manifested by histological changes and the role of local blood flow, blood
rheological properties, and the possible role of free radicals in development
of mentioned damages. Through the cranial window local area of cerebral surface
was irrigated by artificial CSF heated up to 41, 43 or 450C. Serial
brain coronal sections 50 mm thick were analyzed under light microscope. lCBF
was measured by the hydrogen clearance method. Blood rheological properties
were changed by injection of Dextran T-500 and free radicals existence was
controlled by DMSO injection. High sensitivity of cerebral tissue to
hyperthermic exposure even at a temperature of 410C has been
confirmed. We consider cerebrovascular thrombosis as one of the most
significant complication of brain hyperthermia. Deteriorated blood rheological
properties aggravates hyperthermia-induced cerebral lesion. Administration of
free radicals scavengers can partially lessen hyperthermia induced cerebral
lesion.
Auth.
8.g.13.1.8. Prevalence of depression and anxiety in
postmenopausal women. /T. Gegenava, M.
Gegenava, G. Kavtaradze/.
Depression affects twice as many women as men. Midlife
is often considered a period of increased risk for depression in women.
Menopause is often believed to be a time when women are more likely to become
depressed. This period is associated with gradual declines in estrogen levels.
Some studies suggest that changes in estrogen levels are associated with onset
of depression. The symptoms of depression in menopause or perimenopause are:
two or more weeks of depressed mood, decreased interest or pleasure in
activities, change in appetite, change in sleep patterns, fatigue or loss of
energy, difficulty concentrating, excessive feeling of guilt or worthlessness,
thoughts of suicide, extreme restlessness and irritability. Many symptoms of
menopause overlap with symptoms of depression, including problems with sleep,
physical symptoms such as hot flashes, fatigue, irritability, anxiety and
difficulty concentrating. Research was performed in 88 postmenopausal women.
Depression was assessed by the Beck Depression Inventory, which includes 21
questions and assesses the state of patients during the last two weeks. Anxiety
was assessed by Spilberger’s State and Trait Anxiety Inventory. Our study
demonstrated that depression was revealed at high and moderate degree in
postmenopausal women c2 = 11.92 (p=0.008), as well as anxiety was
revealed at high degree in this group c2 = 5.73 (p = 0.058). Sleep
disorder was found in 75% postmenopausal women. Our study demonstrated that
there is a high prevalence of depression and anxiety in postmenopausal women.
Auth.
8.g.13.1.9. Assessment of heart rate variability in
chronic heart failure. /N. Mamamtavrishvili, P.
Matchavariani, N. Nakashidze, R. Abashidze, L. Burduli, A. Kvirkvelia/.
The making of prognosis of patients with chronic heart
failure and the establishment of independent predicators of mortality are among
the most urgent clinical objectives. To date it has been established that,
together with many factors, the analysis of the state of the neurovegetative
control of the heart, in particular, the spectral analysis of heart rate
variability (HRV) with long-term (24-hour) ECG recordings, makes it possible to
assess the risk of unfavorable outcome in CHF patients. A depression of the heart
rate variability indices in patients with chronic heart failure against the
norm has been found to be in correlation with the disease severity and may be
considered as an independent prognostic marker of the unfavorable outcome.
Auth.
8.g.13.1.10. Clinical characters and treatment of
varicella-zoster virus infection at the modern stage. /T. Megrelishvili, E. Vashakidze, E. Pachkoria,
Tendency of varicella-zoster virus infection among
children and adults has increased in
Auth.
8.g.13.1.11. The effect of calcium antagonists to the
amount of monoamines in different structures of the brain of albino rats under
extreme conditions. /A. Mirzayeva, A.
Baghirov, G. Ganiyeva, V. Asmatov, M. Ganiyev/.
Taking into consideration the necessary role of
monoamines in the realization of brain functions, the effect of one-time and
prolonged administration of calcium antagonists in albino rats under extreme
conditions on the amount of monoamines in different structures of brain
(norepinefrin, serotonin, dopamine) was studied. Based on the neurochemical
study results, it was detected that under extreme conditions, the acute and
chronic experiments, the amount of norepinefrin and dopamine decreased and the
amount of serotonin increased. Under extreme conditions, upon administration of
25mg/kg verapamil, 10mg/kg amlodipin, 10 mg-kg flunarizin in different
structures of the brain (hypothalamus, striate body, frontal cortex) the amount
of norepinefrin and dopamine decreased and serotonin increased in acute and chronic
experiments.
Auth.
8.g.13.1.12. Use of cytopathologic methods in modern
pulmonology. /T. Mamaladze, L.
Vashakidze,
In the 20th century, laboratory diagnosis
has undergone revolutionary changes. In cytology one of the most successful
automated complex AutocytoPrep, CytoScreen, ThinPrep was implemented. This
system is successfully used in pulmonology. A combined cytological analysis of
sputum and chest X-ray provides the most accurate diagnosis of lung tumors. It
was confirmed by our study that to improve the accuracy of lung tumor diagnosis
the chest X-ray and sputum cytology should be applied jointly.
Auth.
8.g.13.1.13. The etiological structure of viral
hepatitis in
The etiological structure of viral hepatitis has been
studied based on the data received in 2001-2008. In the 21st
century, the disease tends to increase. The rate of incidence in 2007-2008, as
compared with 2003-2004, had a 2-fold increase. The incidence of viral
hepatitis type B and C prevails, especially their chronic forms. According the
2007-2008 data, hepatitis type C is considered to be the most common disease.
Its exact Percentage equals to 27.4%. We should point out that mostly an
increase of specific volume for hepatitis type B and C is detected in the
capital of
Auth.
8.g.13.1.14. QT-interval prolongation after
ventricular premature contractions (VPCs). /Mohammed
Haroon Rashid, K. Etsadashvilli, A. Melia, K. Jalabadze,
Long QT syndrome (LQTS) is an inherited ion
channelopathy resulting in abnormal ventricular repolarization and abnormal
prolongation of QT interval on the ECG. Syncope, fainting, cardiac arrest and
sudden death are common manifestations of LQTS; this case report describes a
patient with prolonged QT interval after extrasystole and a family history of
sudden cardiac deaths.
Auth.
8.g.13.1.15. Treatment of patients with atypical
chronic cholecystitis by natural factors in Lashichala balneotherapeutic health
resort. /N. Saakashvili,
Chronic cholecystitis is frequently complicated due to
changes of secondary development of the cardiovascular system. As the mentioned
disease is not subordinated by medical treatment assigned to the cardiovascular
system, with the curative purposes we applied "Lashichala" – a
mineral water with carbon dioxide of low mineralization, hydrocarbonate and
potassium-sodium. 120 patients with chronic non-petrosal cholecystitis were
evaluated. After crenotherapy (spa treatment), the majority of the patients
(with cardiac syndrome) showed clinic improvement signs: decrease of angina pains,
normalization of heart rate, blood pressure, etc.; all the mentioned are
correlatively connected with the improvement of subjective and objective
indices of the gallbladder. The treatment with "Lashichala" mineral
water resulted in a decrease of inflammatory process in the gallbladder,
improvement of quality of bile, which consequently decreased the influence of
pathological reflexes from the gallbladder to the heart. The
"Lashichala" mineral water is ecologically safe and effective means
for persons with biliary system disease.
Auth.
8.g.13.1.16. Prevention and treatment of
gastroduodenitis with new mineral water “Vardzia”. /N. Saakashvili,
For normal functioning of body, the conservation of
microelements balance is very important and is possible by means of mineral
waters. For the first time, we have studied the effect of carbonic acid
hydrocarbonate, sodium chloride mineral water of high mineralization (17.9 g/dm3)
"Vardzia" in 20 patients with chronic gastroduodenitis. From its
optimal composition by microelements, monotherapy with mineral water
"Vardzia" gave rise to the positive dynamics of sickness’ clinical
symptoms among the patients and improved mucous membrane structure of duodenum.
The physico-chemical, organoleptic features, as well as high curative
properties of the mineral water "Vardzia" make it possible to apply
this water not only for bowel treatment, but also for preventing asiderotic
(iron-deficiency) anemia and atherosclerosis.
Auth.
8.g.13.1.17. Family case of
Auth.
8.g.13.1.18. Long-term effect of subchronic manganese
intoxication on the rat’s memory. /A. Shukakidze, R.
Khetsuriani, D. Tophuria, T. Bikashvili, N. Mitagvaria,
The one of the most important aspects of
neurotoxicity, induced by manganese excess is the revealing of long-term
effects of manganese subchronic intoxication. The effect of a 30-day peroral
administration of manganese chloride – MnCl2. 4H2O (10,
20 and 50 mg/kg per day) on adult male albino rats’ memory has been
investigated. Before exposure to manganese, the rats were tested in a
multi-branch maze (learning of optimal way to get from the start platform to
the nest-box). The repeated session of the maze testing was provided both 1 and
90 days after completion of manganese administration. It has been established
that everyday manganese administration during 30 days after completion of maze
learning and acquisition of automatic behavior skill causes temporal
disturbances (increased quantity of mistakes), but more important is
statistically significant prolongation of time necessary for maze-test
solution. Thus, the mentioned doses of MnCl2. 4H2O do not
essentially affect the memory – the animals are able to slowly but completely
accomplish the earlier acquired stereotype of behavior.
Auth.
8.g.13.1.19. The attributive value of risk factors in
forming digestive disorders in adolescents. /M.
Chikava,
The aim of the research was to assess the attributive
value of risk factors of digestive disorders in 14-21 year-aged adolescents.
One-stage epidemiological research was conducted among the medium and late
period adolescent population of
Auth.
8.g.13.1.20. The
morphological index for cervical carcinoma prediction. /Ts. Gatenadze, J. Ungiadze, O.
Chakhoian, M. Nakashidze,
The aim of the research
is a complex clinical and morphological evaluation of the factors influencing
the development and prediction of cervical carcinoma. The case histories of 505
patients (from 20 to 70 year- old) with I-III clinical stages of primary
cervical carcinoma having undergone a surgical and combined treatment in an
oncology center in
Auth.
8.g.13.1.21. The effect
of TORCH infections on spermatogenesis in men. /T. Bukia, L. Shanidze, K. Maisuradze/. Georgian Medical News. – 2010. – # 1(178). –
pp. 27-31. – rus.; abs.: geo., eng., rus.
The purpose of the study
was to reveal causal relations between infection of the urinogenital tracts by
intracellular parasites, the so-called TORCH infections, and the decrease of
spermatogenesis. For observation 182 men of the reproductive age (from 22 to 38
years) with oligozoospermia and aspermia, without any complaints or clinical
symptoms indicating the existence of the urinogenital tract infections, were
selected. Out of those, 131 revealed oligozoospermia, i.e. the quantity of
spermatozoons was no higher than 20 mln/ml of the ejaculate, and 51 revealed –
aspermia. For examination of some TORCH infections, medical doctors in charge
directed 44 oligozoospermia patients and 15 aspermia patients, who respectively
constituted the group I and the group II. Examinations were carried out for
Chlamydia trachomatis – (Ch.t), Herpes simplex virus – (HSV), Ureaplasma
urealiticum - (U.u.), Cytomegalovirus - (CMV), and Mikoplasma hominis – (M.h.).
In the group with oligozoospermia, cases of infection by Chlamydias (41.5%) and
Herpes virus (51.3%) were frequent, but Ureaplasma (56.5%) was more frequent
than any infections. Cytomegalovirus occurred in the least number of cases. The
making of any conclusions on the frequency of infections by M.h. is difficult
due to the low number of examinations. A similar picture was observed in Group
II as well. Following the successful treatment of infections in Group I, 8 patients with Ch.t. and 8 patients with U.u.
showed an improved spermogram after several months. Treatment of other infections
did not yield tangible results. In Group II spermatogenesis remained without
any changes.
Auth.
8.g.13.1.22. Patients with allergic
rhinitis. /Sh. Tsiklauri/. Georgian Medical News. –
2010. – # 1(178). – pp. 34-40. – rus.; abs.: geo., eng., rus.
High prevalence of
allergic rhinitis makes more topical the problem of searching for new, more
effective means of treatment of this pathology. 67 patients with allergic
rhinitis were examined. 35 of them had a persistent form of pathology and 32 of
them – an intermittent form of allergic rhinitis. It has been established that
the treatment by vanadium intranasal electrophoresis caused attenuation up to
disappearance of the complaint, had a normalizing action on the olfactory nasal
function, motor activity of scintillation epithelium of nasal mucosa, and other
objective indices of clinical status. The mentioned positive shifts were more
pronounced in the patients with an intermittent form of allergic rhinitis.
Auth.
8.g.13.1.23. The risk of myocardial infarction
in out-patients with type II diabetes. /E. Kerimova, V. Azizov, V.
Mirzazade/. Georgian Medical News.
– 2010. – # 1(178). – pp. 41-45. – rus.; abs.: geo., eng., rus.
The
aim of this study was the identification of a risk of myocardial infarction in
out-patients with type 2 diabetes. The study was carried out on 340 patients
with type 2 diabetes. The risk of ischemic disease was determined during 10
years by PROCAM program. It was found that 178 (52.4%) patients with type 2
diabetes had low risk of development of myocardial infarction, 89 (26.2%)
patients with moderate and 73 patients (21.4%) with high risk of myocardial
infarction. The following interconnection was determined: the age of the
patients(r=+0,46; P<0,001); the family history of diabetes (r=+0,22;
P<0,01); smoking (r=+0,23; P<0,01); systolic arterial pressure (r=+0,18;
P<0,05); cholesterol (r=+0,20; P<0,01); high-density lipoprotein
(r=-0,24; P<0,001); low-density lipoprotein (r=+0,21; P<0,001).
Auth.
8.g.13.1.24. A
correlation of rheological properties of blood, Il-1β and lipid profile in patients with chronic
cor pulmonale. /L. Nanijanyan, M.
Sargsyan, G. Khachatryan/. Georgian Medical News. –
2010. – # 1(178). – pp. 46-48. – rus.; abs.: geo., eng., rus.
Cor pulmonale is a
frequent complication of chronic pulmonary diseases. Despite its long-term
study, a number of issues of this problem still remains unsolved and
disputable; the diagnosis of the disease at the early stage of development is
complicated; its treatment is of little effect, while the death rate is high. This
study aims at working-out an algorithm of diagnosis of cor pulmonale on the
basis of mathematical modeling and analysis of laboratory data. The worked-out
dimensionless coefficients of the most informative indices of the level of
blood corpuscles, blood lipids spectrum, and the human interleukin-1β will
permit, independently, within the acceptable ranges, diagnosing the early
stages of the disease, estimating its dynamics and predicting its further
development.
Auth.
8.g.13.1.25.
Dimensionless coefficients counted on the basis of instrumental indices in
patients with chronic cor pulmonale. /L. Nanijanyan, M.
Sargsyan, G. Khachatryan/. Georgian Medical News. –
2010. – # 1(178). – pp. 48-51. – rus.; abs.: geo., eng., rus.
Cor pulmonary remains
one of the actual tasks of modern pulmonogy, cardiology. The aim of the
investigation is working-out algorithm diagnoses of cor pulmonary on the
grounds of mathematical modeling and analyses of the results of several
instrumental indices. The results of the investigation indices showed that
worked-out by means of mathematical analyses the dimensionless coefficients
permit find out the necessary instrumental indices for CP diagnose.
Dimensionless coefficients promote control over the efficiency of treatment and
also enable the development of new optimal scheme CP therapy.
Auth.
8.g.13.1.26. Effects of
neurotoxic lesions of the CA1 region of the hippocampus on place and cue
learning in Morris water maze trial. /G. Maghlakelidze, G.
Beselia,
The aim of the present
study was to investigate the effects of neurotoxic lesions of the dorsal CA1
region of the hippocampus on place-cue learning in a Morris water maze task.
The injections of ibotenic acid injections to the hippocampal CA1 caused a loss
of pyramidal cells in CA1, while saving most of the pyramidal cells in CA3 and
granule cells in DG intact. Under conditions of a visible platform training
trials, differences in the platform reaching latency between the animals of
different groups were not found. When testing was performed under conditions of
a submerged platform, the platform finding latency significantly increased
(P<0.05). This fact evidences of a deficit of the place learning strategy in
the CA1-lesioned rats. The decreased place-bias in the CA1-lesioned rats in the
hidden platform training trials compared to the sham-operated rats was
significant, but in trials when the animals had to choose between the earlier
learned place and the visible platform’s new location, most of them swam first
to the old spatial location. The place learning deficit in the CA1-lesioned
rats compared to the sham-operated rats was not significant. We suggest that
spatial learning deficit caused by the dorsal hippocampus lesions
cannot be accounted solely to the loss of dorsal hippocampal CA1 region cells.
Auth.
8.g.13.1.27. Study of
object learning and reactions to spatial and non-spatial changes in rats with
dentate gyrus lesions. /G. Beselia, G.
Maghlakelidze,
In order to investigate
the possible involvement of DG in spatial and object recognition memory, we
have opted for a non-associative task where no explicit reward was present.
Colchicine was used for bilateral DG lesions for its well-known specificity for
DG lesion. The colchicine-induced lesions produce severe damage in the granule
cells of DG, while minimally affecting pyramidal cells in CA1 and CA3. The main
results are as follows: The overall habituation to the familiar environment in
the rats with DG lesions was decreased against the sham operated rats. There was
no significant impairment in detecting spatial novelty. THE DG lesions did not
affect the detection of a novel object placed in a familiar location.
Considering both the impaired habituation and the generally intact detection of
spatial changes, we suggest that the exploratory activity in relation to the
entire environment and to the particular objects is thought to be preserved by
diverse nervous substrate, and testing under the given conditions allows for
their differential estimation.
Auth.
8.g.13.1.28. Study of
potential cytoprotective activity of different antioxidants. /L. Ratiani, T. Ratiani, G.
Sharashenidze, G. Janigashvili, T. Sanikidze/. Georgian Medical News. – 2010. – # 1(178). –
pp. 72-77. – rus.; abs.: geo., eng., rus.
It
is known that infiltration of atherosclerotic plaques by activated T
lymphocytes occurs at the early stage and cytokines produced by those
lymphocytes become actively involved in an inflammatory process. Consequently,
the preparations capable of stabilization of immune cells will probably be
effective for treatment and prevention of atherosclerosis. Intensively
proliferated Jurkat leukemia T cell line (human leukemia cell culture) is
widely used in scientific and therapeutic research as human T lymphocyte
pattern. The aim of the study was to establish the cytoprotective action of
different antioxidant preparations on Jurkat cells incubated under oxidative
stress conditions. The dose- (100 μl, 50 μl) and time-related
decrease of viability of Jurkat cells incubated under high oxidative stress
conditions was determined. Low doses of hydrogen peroxide (H2O2)
(25 μlm 11 μl) reveal cytotoxicity only during a short-term
incubation (8 hours). Vitamins C and E have
cytotoxic effects on intact Jurkat cells separately, while Megavite and
Phenovin are not characterized by cytotoxicity. Upon simultaneous incubation of
Jurkat cells with antioxidants under conditions of a moderate oxidative stress
(H2O2 25 μl, 50 μl) all antioxidative
preparations (except vitamin C) reveal static activity on viability of Jurkat
cells. Upon incubation of Jurkat cells with antioxidants under conditions of an
intensive oxidative stress (H2O2 100 μl), the
cytoprotective activity of antioxidant preparations is rather low.
Auth.
8.g.13.1.29. Impact of treatment with intranasal
electrophoresis of vanadium on the allergic reactivity and immunological
indices in patients with allergic rhinitis. /Sh.
Tsiklauri/. Georgian Medical News. –
2010. – #2(179). – pp. 19-26. – rus.; abs.:
geo., eng., rus.
67 patients with allergic rhinitis were investigated. Out of these
patients, 35 had a persistent form of allergic rhinitis and 32 – an
intermittent form of pathology. It has been established that in patients with
allergic rhinitis the treatment with intranasal electrophoresis of vanadium
strengthens T-cellular immunity, has a desensitization action, increases
non-specific resistance of the organism and has a normalizing effect on the
indices of humoral immunity. The above positive shifts were more pronounced in
the patients with an intermittent form of allergic rhinitis.
Auth.
8.g.13.1.30. The spirometry findings of
bronco-obstructive syndrome during concomitant intestinal parasitosis. /K. Aliyev, G. Aliyeva,
The aim of research is
to study spirometry findings of the broncho-obstructive syndrome (BOS) during a
concomitant intestinal parasitosis. 81 patients aged from 5 to 61 years (male
43, female 38) were examined. The patients were divided into 2 groups: group I
– 40 patients treated only with a bronchodilator therapy (14 patients with
protozoa, 14 – with helminthes, 12 – diseased with a combination of parasites);
group II – 41 patient treated with a bronchodilator therapy together with an
anti-parasitic therapy (14 patients with protozoa, 17 - with helminthes, 10 -
diseased with a combination of parasites).
22 patients with BOS without parasites made a control group. Functional
disorders at the initial examination did not significantly differ among the
patients with protozoa, helminthes, a combination of parasites and the patients
without parasites. A considerable difference was observed in the post-treatment
dynamics: the bronchodilator therapy of patients infected with parasites only
cannot attain a significant improvement of the external respiratory function
indices, whereas in the patients with helminthes many parameters can be found
to decrease. The lowest growth of indices was observed in the patients of group
I – 2.17/ 5.09% (-6,81min; 10,54max). The highest growth was observed in the
patients of group II – 20.26/12.45% (2,77min; 43,85max). An increase in
indicators in the post-treatment spirometry of the control group was more
moderate against those of the groups I and II – 5.96/ 2.97% (0,39min; 9,59max).
Thus, the use of the anti-parasitic therapy in combination with the
bronchodilator therapy to treat patients with intestinal parasitosis (group II
leads to reliably significant positive dynamics of spirometry findings not only
in group I (ð<0.05 by many parameters) but also in the control group
(ð<0.01 by many parameters).
Auth.
8.g.13.1.31. The effect of dorsal hippocampal lesion
upon development of a fixed set in albino rats. /S. Tsagareli, A. Stamateli,
The experiments have
been carried out on intact and hippocampectomized white (albino) rats. At the
first stage of these experiments, in a two-entrance communicating chamber,
behind which a feeding trough was placed, the animals were to develop a
food-procuring conditioned reflex for visual stimulus differentiation. The two
doors of this chamber were illuminated at different intensity. After the
animals had achieved the learning criterion, the development of a fixed set was
initiated. At the given stage of the trial, the rats used to be let go in the
same direction several times, in particular toward the brightly lit door, after
which the doors in the control test were again illuminated at equal intensity.
If the animal went up to the cued door, the response was considered to be
assimilated, or to be contrasted where it chose the opposite direction. The
frequency of the assimilated and contrasted responses was quantitatively
established. The experiments confirmed the possibility of development of a
fixed set in the rats. It has been established that the gradual character of a
fixed set depends upon the stimulus frequency. The intensity of the set is
increased in parallel with the stimulus frequency growth. The active role of
the dorsal hippocampus in the development of a fixed set has been revealed.
Auth.
8.g.13.1.32. Postsynaptic responses of the cerebral
hemisphere cortex neurons being activated by nociception during stimulation of
locus coeruleus. /T. Labakhua, T.
Janashia, G. Gedevanishvili/. Georgian Medical News. –
2010. – #2(179). – pp. 46-51. – rus.; abs.:
geo., eng., rus.
In acute experiments on
curare-administered cats, the effects of stimulation of the locus coeruleus on
postsynaptic processes evoked in neurons of the somatosensory cortex by
stimulation of nociceptive (intensive stimulation of the tooth pulp) and
non-nociceptive (moderate stimulation of the infraorbital nerve and
ventro-posteromedial (VPM) nucleus of the thalamus) afferent inputs. Seven
cells activated exclusively by nociceptors and ten cells activated by both
nociceptive and non-nociceptive effects (hereafter, nociceptive and convergent
neurons, respectively) were recorded intracellular. In the neurons of both
groups, responses to nociceptive stimulation (of sufficient intensity) looked
like in EPSP-spike-IPSP (the latter of significant duration, up to 200-300
msec) complex. Conditioning stimulation of the LC which preceded test stimulus applied
to the tooth pulp or VPM nucleus by 100 to 800 msec, induced a 40-60% decrease
of the IPSP amplitude only, while maximal effect of the effect, in both cases,
was noted within intervals of 300-700 msec between conditioning and
test-stimulus. During stimulation of the LC, noradrenaline released via
receptor and second messengers, provides postsynaptic modulation of GABA-ergic
system, decreasing the IPSP amplitude, which occurs after stimulation of both
the tooth pulp and VPM thalamic nucleus. This process may be realized through
either pre- or postsynaptic mechanisms.
Auth.
8.g.13.1.33.
C-KIT-positive multipolar cells in human penile erectile tissue: expression of
connexin 43 and relation to trabecular smooth muscle Cells. /S. Ückert, G. Kedia, I. Satzger, U. Gaismar,
M. Sohn, M. Kuczyk, P. Hedlund,
The aim of this study
was to evaluate the hypothesis that interstitial cells might play a role in
controlling and synchronizing via gap junctions the electrical activity of
smooth muscle cells. The expression and distribution of interstitial cells in
human penile erectile tissue was evaluated to determine whether or not
cavernous interstitial cells express the gap junction protein connexin 43.
Specimens of human corpus cavernosum were excised from full preparations of
human penises. Cryostat sections (10 µm to 15 µm) of formaldehyde-fixated
tissue segments were incubated using a double-labelling technique with antibodies
directed against smooth muscle α-actin, C-KIT, and connexin 43. Then,
sections were exposed to secondary antibodies. Visualization was commenced by
means of laser fluorescence microscopy. Double-staining techniques revealed
immunosignals specific for C-KIT (transmembrane receptor protein) and connexin
43 (gap junction protein) in multipolar cells located adjacent to smooth muscle
cells. The number of C-KIT-positive cells was significantly lower within the
smooth musculature than within bundles of connective tissue surrounding smooth
muscle cells of corpus cavernosum or cavernous arteries. Our findings demonstrate the distribution of c-kit-
and connexin 43-positive interstitial cells in the connective tissue and smooth
musculature of the corpus cavernosum. Additional studies are needed in order to
evaluate further the ultrastructure of human penile erectile tissue and enable
the identification of gap junctions mediating direct cell-to-cell
communication.
Auth.
8.g.13.1.34. The
efficacy of atorvastatin in the case of paroxysmal atrial fibrillation in
patients with ischemic heart disease. /G.
Dundua, G. Abuladze,
The purpose of the study
was to estimate the efficacy of atorvastatin in complex treatment with
antiarrhythmic drugs against the background of an ischemic heart disease in
patients with paroxysmal atrial fibrillation (AF). The investigation was
conducted on 65 patients (37-72 years old) during 2 years. Two groups were
composed. Group I included 28 patients who underwent an anti arrhythmic
treatment on the background of standard therapy. Group II was composed of 37
patients who underwent a combined treatment with therapy by atorvastatin (at a
10-20mg daily dose). During period of investigation AF was observed in 32% of
patients in Group I and in 14% of patients in Group II. It was revealed that
the complex therapy with atorvastatin minimizes the episodes of AF.
Auth.
8.g.13.1.35. Tolerance
induced by non-opioid analgesic microinjections into rat’s periaqueductal gray
and nucleus raphe. /N.
Tsiklauri, I.Nozadze, G.
Ghurtskaia, V. Berishvili, E. Abzianidze, M. Tsagareli/. Georgian Medical News. – 2010. – #3(180). –
pp. 47-55. - eng.; abs.: geo., eng., rus.
Several lines of
investigations have shown that the microinjection of non-opioid analgesics,
non-steroidal anti-inflammatory drugs (NSAIDs) in the midbrain periaqueductal
gray matter (PAG) induces antinociception with some effects of tolerance. Our
recent findings also have shown the same effects of tolerance in
intraperitoneal (i.p.) injections of analgin (metamizol), ketorolac, and
xefocam. Moreover, just recently, we have shown that microinjection of three
NSAIDs analgin, ketorolac and xefocam into the central nucleus of amygdala
produces tolerance to these drugs and cross-tolerance to morphine. The present
study was designed to examine whether together with analgin, microinjection of
another type of NSAIDs clodifen, ketorolac and xefocam into the PAG and the
nucleus raphe magnus (NRM) leads to the development of tolerance in male rats.
The experiments were carried out on experimental and control (with saline)
white male rats by the models of tail-flick (TF, to the stimulation of focusing
light beam) and hot plate (HP, paw withdrawal) tests. For microinjections of
NSAIDs stainless steel guide cannula was implanted into the PAG and NRM by the
stereotaxic atlas. Latency increase of these reflexes indicated the degree of
antinociception. Analysis of variance with post-hoc Dunnet Multiple Comparison
Test was used for statistical evaluations. Our study showed that microinjection
of NSAIDs into the PAG produced antinociception as revealed by a latency
increase in TF and HP compared to the baseline control with saline
microinjected into the same nucleus. However, when these drugs microinjection
subsequent testing also took place in the following days the antinociceptive
effects progressively diminished so that on the 4th and especially the 5th
experimental days the TF and HP latencies were similar to the averaged control
baseline for rats that received repeated (5 days) injections of only saline. On
the 5th day, one hour after of NSAIDs testing, experimental groups of rats
received i.p. Injections of μ-opioid
antagonist naloxone and we did not reveal significant alterations in TP and HP
latencies in non-opioid tolerant rats as well as in control animals.
Microinjections of NSAIDs into the NRM also produced antinociception as
revealed by a latency increase in TF and HP compared to the baseline control of
as in intact rats so with saline microinjected ones into the same nucleus.
Subsequent NSAIDs microinjections caused progressively less antinociception, so
by day 4 there was no effect, similar to saline microinjections (baseline
control) for both the TF and the HP tests, except analgin. The later did not
show complete tolerance even on the 5th experimental day. Special control
experiments showed that post-treatment with naloxone in RVM diminished NSAID-induced
antinociception on the first and second experimental days and impeded the
development of tolerance to the antinociceptive effect of NSAIDs. Obtained results underscore the strong
convergence of antinociceptive mechanisms of opioids and non-opioids,
particularly NSAIDs in the PAG-RVM downstream circuit in the acute effect of
and the development of tolerance to both types of analgesics. On the other
hand, our data confirm the results of other authors that NSAIDs are in close
relation with endogenous opioids and the tolerance to these non-opioid drugs
probably depends on opioid tolerance.
Auth.
8.g.13.1.36. Correction
of oxidative stress in the rat brain cortical cellular culture with vitamins E
and C. /D. Davitashvili, D.
Museridze, I. Svanidze, N. Pavliashvili, T. Sanikidze/. Georgian Medical News. – 2010. – #3(180). –
pp. 56-60. - rus.; abs.: geo., eng., rus.
The oxidative
stress-induced alteration in concentration of oxygen, lipid and nitrogen free
radicals in the cultured brain cortex of newborn albino rats and its correction
with vitamins E and C were investigated. Modeling the oxidative stress was
achieved with addition of Í2Î2 into the nutrient medium.
In order to prevent an oxidative stress-induced cytotoxic effect, concomitantly
with Í2Î2, vitamins E and C were added into the nutrient
medium. Oxygen, lipid and nitrogen free radicals were registered by the
Electron Paramagnetic Resonance (EPR) method and spin-traps. The data obtained
in our study revealed decreasing of intensity of NO content and increasing of
spin trapped superoxide - (O2-) and lipoperoxide-radicals
(LOO.) in explants of brain cortex of the newborn albino rats
cultured under oxidative stress conditions. These changes were attenuated
following the action of vitamins E and C (decreasing of intensity of EPR
signals of O2- and LOO, increasing of free NO content).
Auth.
8.g.13.1.37.
Interrelation of the lipid status with staging of breast cancer. /N. Kebadze, U. Gabunia,
The
lipid status of 30 women (38-64 years) with breast cancer (stages I-II A, B)
was investigated. Selection and distribution of patients in groups occurred on
the basis of the accepted classification by the size, invasiveness and presence
of metastases. The main changes in the lipid formula of blood included
increased levels of total cholesterol and low-density lipoproteins’
cholesterol. The relationship between dislipoproteinemia and invasiveness was
revealed. Thus, these changes can be considered as a predictor of growth,
distribution, and correction of lipid homeostasis (dietary and drug) as a
primary factor of secondary preventive maintenance of breast cancer.
Auth.
8.g.13.1.38. Influence
of some simple phenols on biochemical and morphological indices of rat blood. /B. Arziani, Ts. Chikhladze, N.Gumbaridze, G.
Lekishvili/. Georgian Medical News.
– 2010. – #3(180). – pp. 69-76. - rus.; abs.: geo., eng., rus.
Influence
of various doses of xenobiotics on several biological and morphological indices
of rat blood has been studied. It was established that intraperitoneal
injections of the investigated phenols influenced biochemical indices of rat
blood, specific to the particular phenolic compound. The strongest effect was
observed in the case of 4-nitrophenol and the weakest one in the case of
hydroquinone; it evidences strong toxicity of 4-nitrophenol and the antioxidant
properties of hydroquinone. Influence of various doses of phenol, 4-nitrophenol
and hydroquinone on the change of structural indices of the constituents of
blood has been studied. Importance of the immune system for selection of
adaptation pathways of the organism has been demonstrated. A correlation
between the administered concentration of the investigated phenols and several
biochemical and morphological indices of blood has been established.
Auth.
8.g.13.1.39.
Peculiarities of atherosclerosis developed after Chlamydia infection and
behaviour of some hematological and biochemical parameters. /M. Emukhvari, M. Akhvlediani, T. Bukia, N.
Sharashidze,
The aim of our study was
to establish diagnostically informative criteria of hematological and biochemical
analyses and their combinations as well as to establish a relationship between Chlamydia pneumoniae and
atherosclerosis. This is to be done for the purpose of establishing the entire
pathogenesis of carotid and coronary atherosclerosis and inflammation. The
investigation of Chlamydia pneumoniae infection
is proved to be a possible risk factor for the carotid atherosclerosis
developed in adults that makes the course of atherosclerosis heavier. As a
result of the atherosclerotic process, changes in the blood laboratory
parameters were more expressed in the group of patients having repeated cases
of pneumonia in childhood.
Auth.
8.g.13.1.40. Pro- and
antioxidant activity of bilirubin. EPR Study. /M. Shengelia,
The aim of the study was
to establish mechanisms of bilirubin oxidation and their involvement in the
physiological and pathological processes in the living body (EPR study of
photoradiated bilirubin). The photosensitized formation of free radical of
bilirubin with g=2.003 and max H=1.0mTl, under action of blue light with max =450 nm by means of electronic spin resonance (ESR)
was shown. Irradiation of sample in vacuum by visible light does not cause
formation of free radicals. Irradiation of powder of bilirubin and also its
solution in chloroform leads to formation of the radical of bilirubin. An
analysis of a spectrum (ESR) as powder, also its solution in chloroform, that
induces free-radical signal shows that it belongs to bilirubin rather than to
the solvent. Irradiation of the bilirubin chloroform solution causes max=650 nm lines in the absorption spectrum that is
characteristic of the absorption spectrum of solutions in the biliverdin
chloroform.
Auth.
8.g.13.1.41. Therapeutic bronchoscopy in
critical patients with ventilator-associated pneumonia. /Z. Kheladze, S. Jaiani, B. Tsutskiridze, Zv.
Kheladze, G. Chakhunashvili, D. Chakhunashvili/. Georgian Medical News. – 2010. – #4(181). – pp. 17-23. – rus.; abs.: geo., eng., rus.
The
study material is based on the experimental treatment of broncho-pulmonary
derangements, including ventilator-associated pneumonias (VAP). 105 critically
ill patients were studied. The authors recommend methods of prevention and
treatment of these types of pathologies, which are based on the therapeutic
fiber-optic bronchoscopy with the use of different curative mixtures. The more satisfying course of pathological processes,
a decrease of clinical presentations and manifestations of intoxication, an
indisputable improvement in the course of disease, and a reduction in average
length of treatment prove the advantages of this method. An important
economical effect is also achieved due to the reduction of the length of stay
and the use of costly drugs and diagnosticums. The achieved results allow us to
recommend the widespread use of the therapeutic fiber-optical bronchoscopy in
patients with acute diseases of lungs, particularly with VAP. The expressed
efficiency, reliability and the important economical effect are the basic
advantages of this method.
Auth.
8.g.13.1.42. Clinical and demographic
analysis of a prehospital diagnosis of myocardial infarction in Adjara in
2006-2008. /N. Tsintsadze/. Georgian Medical News. – 2010. – #4(181). –
pp. 33-42. – rus.; abs.: geo., eng., rus.
The goal of the
investigation is to study the results of a prehospital diagnosis of myocardial
infarction in 519 patients of different gender and age. Myocardial infarction
was atypical in 27.8.0% and typical in 72.0% of patients. Late diagnosis of
typical and atypical MI made 13.4% and 21.2% respectively. No statistically
significant differences were found in the frequency of diagnostic errors in
different demographic groups of the patients. For the three years of the study,
a tendency for an MI overdiagnosis was observed, especially in young patients
and males. The cases of late diagnosis were equal in both males and females. A
reduction of hypo and rise in overdiagnosis during the three years was,
generally, conditioned by an atypical course iof the disease.
Auth.
8.g.13.1.43. Atrial myxomas: histopathologic
variants. /Z. Tsagareli, Z.
Bakhutashvili, F. Phrangishvili, L. Gogiashvili, M. Dgebuadze/. Georgian Medical News. – 2010. – #4(181). –
pp. 63-66. – rus.; abs.: geo., eng., rus.
Atrial myxomas are rare,
usually benign, intracardiac tumors composed of mucopolysaccharides. Almost all
myxomas are found attached to the endocardium in the atria with vast majority
being on the left side and can be removed by surgical resection. Two rare cases
of myxomas ablated from the left atrial cavity are presented. Surgical correction is curative with a low
operative mortality and an excellent long-term prognosis. Tumor morphology and
histological appearance are presented. The effect of age on the left atria
morphology was observed.
Auth.
8.g.13.1.44. On a hypothetic model of the
involvement of the immune system in the proliferation of cells and
dissemination of tumors. /D. Sephiashvili/. Georgian Medical News. – 2010. – #4(181). –
pp. 67-71. – rus.; abs.: geo., eng., rus.
Tumor cells lose their
ability of apoptosis. It makes one think that phagocytes which absorb malignant
cells are themselves transformable into cancer cells. It is not excluded that
the cloning–transposition of the cells absorbed by phagocytes is carried out
within a norm and participates in the cell renovation (reparation-regeneration)
and differentiation process. The role of transposition in the metastasis of
tumor cells and in the etiopathogenesis is to be determined. An experimental
proof of transposition will assist in development of new approaches to the
treatment of various diseases, including tumor pathologies.
Auth.
8.g.13.1.45. Criteria development for making
a working program of a Critical Care Medicine clinic. /D. Tabaghua, Z. Kheladze, Zv. Kheladze,
The Critical Care
Medicine clinic’s 20-year long experience has been studied and summarized for
elaborating a long-term development program to enable each critical care
medicine clinic better plan its operations and make them more cost-effective.
The study data included: the admission rate and distribution of patients
according to seasons, months, weeks and days, as well as according to the
critical state. The study results show that maximum admission by seasons was
fixed in spring (27%; by months - in May (10%); by weeks – in the first week of
the month (27%); and by hours - during 18-24 hrs (35%). The maximum mortality
rate by seasons was observed in spring (28%); by months - in April and December
(12%). The nervous system pathologies prevailed (24%); the percentage of
cardiovascular, respiratory and digestive system pathologies was almost equal -
9, 8 and 8% respectively. The maximum mortality (36%) was observed in the case
of the nervous system pathologies; also high mortality (20%) was observed
during traumas
Auth.
8.g.13.1.46. An experimental research in the
efficacy of using saffron extract in treating ocular pathologies. /P. Shukurova, R. Babaev/. Georgian Medical News. – 2010. – #5(182). – pp.
38-42. – eng.; abs.: geo., eng., rus.
The aim of the present
research was to study the mechanism of efficacy and therapeutic action of a
saffron extract (Crocus sativus L.)
during retinal degeneration and a light corneal injury. Experiments on
Chinchilla rabbits were conducted to evaluate the state of free radical-based
oxidation of the retina and its electric activity. The experimental retinal
degeneration was found to be accompanied with the deterioration of all the
electroretinogram parameters and the free radical-based retinal oxidation
stirring up. The conducted experimental study allows concluding that the
saffron extract’s antioxidation function plays a crucial role in its
therapeutic action and serves as a pathogenic basis for its application in visual
impairments of various origins.
Auth.
8.g.13.1.47. Primary chlamydial infection
correlates with high level of serum interleukin 12 (IL-12). /N. Shavlakadze, B. Gorgoshidze/. Georgian Medical
News. – 2010. –
#5(182). – pp. 46-50. – eng.; abs.: geo., eng.,
rus.
According to the
existing data, cytokines actively participate in the pathogenesis of chlamydial
infection. However, the role of IL-12 in chlamydiosis development has not been
studied yet. The aim of our research is to define the role of IL-12 in the
pathogenesis of the disease. The levels of IL-12, IL-4 and IFN-γ were determined in 27 healthy and 56
Chlamydia-infected individuals by using sandwich ELISA in vitro. An enzyme-linked immunosorbent assay, direct and
indirect immunoflourescence were used for laboratory testing of Chlamydia. A
statistical analysis of the results showed that the level of IL-12 was raised
in the serum of some patients compared to the control group. The patients
demonstrating high levels of IL-12 also had high levels of IFN-γ and low to normal levels of IL-4. The high levels of
IL-12 were mainly in the patients with primary chlamydial infection. Thus,
IL-12 may participate in the development of the primary immune response to
Chlamydia, in particular in the Th1 direction.
Auth.
8.g.13.1.48. Valuation of diagnostic
methods of pneumonia alveolitis. /S.
Mahmudova/. Georgian Medical News. – 2010. – #5(182). – pp.
55-67. – rus.; abs.: geo., eng., rus.
The aim of this study
was to identify the effectiveness of a modern complex of roentgenological,
endoscopic, functional, citomorphologic and immunological methods in diagnosis
of alveolitis. Between May-June 2002 and July-August 2003, a single-stage
diagnosis was conducted among 1192 workers (400 in Siasan broiler factory, 391
in
Auth.
8.g.13.1.49. Influence of
carbamazepine on kindling grades in depressive and non-Depressive rats. /M. Barbakadze, I. Bilanishvili, M.
Chkhetiani,
It
has been clinically established that epilepsy and depression frequently
represent a comorbid pair. Most investigators consider epilepsy as a cause of
such emotional disorders as anxiety and depression. On the other hand, some
anti-epileptic drugs were found to aggravate the depressive state, even to a
suicidal outcome. Bearing in mind these findings, we endeavoured an
experimental study on laboratory rats, 25% of which display an inborn
depressive behaviour. An anti-epileptic drug to be tested was carbamazepine,
while the epileptic state was elicited by means of the kindling method.
Selection of animals was made with the Porsolt’s forced swimming test. Seven
rats had clear depression-like traits; the same number of the non-depressive
animals served as controls. Along with the inherently depressive rats, the
third group of animals was used, in which depression was elicited with the
immobilisation stress procedure (exogenous depression). Epileptization of the rats
was performed with sub-threshold electrical stimulation of the ventral
hippocampus. The rapid kindling paradigm has been implemented in these
experiments (40 stimulations in one day). Following development of epileptic
state up to the grades 4-5 according to the
Auth.
8.g.13.1.50. The efficacy
of propafenone treatment of supraventricular tachycardia. /T. Chachua, G. Abuladze, M. Nebieridze/. Georgian Medical News. – 2010. – #6(183). – pp.
18-21. – rus.; abs.: geo., eng., rus.
Drug therapy remains one
of the main methods of treatment of patients with supraventricular paroxysmal
tachycardia, which involves the prevention attacks of cardiac arrhythmias.
Drugs of choice for termination and prevention of paroxysmal supraventricular
tachycardia in the absence of pronounced signs of structural myocardial damage
are antiarrhythmic IC class drugs (Propafenone–Propanorm, Promed CS,
Auth.
8.g.13.1.51.
Microbiological investigation of diabetic foot infections. /D. Chikviladze, Kh. Gachechiladze, M. Mikeladze, D.
Metreveli, D. Avazashvili/. Georgian Medical News.–
2010.– #6(183). – pp. 22-26. – rus.; abs.: geo., eng., rus.
The aim of the article
was to determine the structure of infections agents in diabetic foot infections
and their sensibility to antibiotics. The total of 295 microbial isolates was
obtained from 115 patients with confirmed diabetic foot infection, treated in
2005-2009. Of these, aerobes were found in 92.88%, anaerobes - in 7.12%.
Microbial associations, various aerobic bacteria were found in 58.49% of cases,
associations of aerobes with anaerobes - in 17.92% of cases; microbial
monocultures were isolated from 21.70% of patients. The most common
gram-positive infectious organism of diabetic foot infection was S. aureus,
while the gram-negative - P. aeroginosa. A share of methicillin-resistant S.
aureus strains was 57.52%. In 95.57% of cases S. aureus strains were sensitive
to vancomicin. The strains of P. aeruginosa were highly resistant to all the
investigated antibiotics. The Enterobactericeae family pathogens have shown
high sensitivity to carbapenemes (95.96%). It is concluded that the success of
antimicrobial therapy depends on a correct choice of an antibiotic, which is
based on timely detection of the infection’s etiology and determination of the
separated microbial agent‘s sensitivity to antimicrobial drugs, considering the
pharmacokinetic features of the chosen drug.
Auth.
8.g.13.1.52. Effects of
the uncompetitive NMDA receptor antagonist memantine on recognition memory in
rats. /M. Dashniani, M. Burjanadze, G. Beselia,
Memantine is an NMDA
receptor antagonist that has been recently approved in EU for the treatment of
moderate to severe Alzheimer’s disease. The previous studies have not allowed
for the evaluation of the possible effects of this drug at
therapeutic doses on different forms of memory. To address this question, we
administered memantine to adult rats, using 2.5 or 5 mg/kg doses to
evaluate their effects on open field activity and recognition
memory. Memantine or saline was administered daily by
intraperitoneal injection during 5 days. The memantine treatment was
found to produce a dose-related suppression of total ambulation. There was no
significant memory impairment in the rats treated with the 2.5 mg/kg memantine.
However, the 5 mg/kg intraperitoneal dose of memantine disrupted
both the recognition memory and locomotor behaviors. It can be
supposed that the therapeutic effects of memantine in patients with Alzheimer
disease are attributable to its interaction with other neurotransmitter
systems.
Auth.
8.g.13.1.53.
Noradrenergic modulation of convulsive activity. /T. Chachua, I. Bilanishvili,
The mechanisms
underlying pathogenesis of epileptic responses have been insufficiently
studied. Therefore, determination of the structures, transmitters and receptors
of the brain, which putatively produce the development and intensity modulation
of convulsions, is of much importance. The locus coeruleus is a noradrenergic
structure and an endogenous modulator of epilepsy, which role determination in
the course of seizure activities is an important problem of epileptology. The
goal of the study was to assess the importance of the noradrenergic synapses in
the development of the local hippocampal convulsive activity. Studies were
carried out on adult rats, under conditions of an acute experiment. The effects
of microinjections of agonist (clonidine) and antagonist (yohimbine) of the -2
adrenergic receptors on the course of local hippocampal convulsive responses
(without behavioral manifestation) have been evaluated. It was found that
microinjection of -2 adrenergic receptors' agonist conditioned blockage
of the local hippocampal convulsions, while the -2 adrenergic receptors'
antagonist increased the convulsive activity. It is suggested that the effects
of locus coeruleus are conditioned by activation of the -2
adrenergic receptors.
Auth.
8.g.13.1.54. The nitric
oxide production in monocytes and macrophages in patients infected with
Chlamydia trachomatis depends on the amount of cytokines. /N. Shavlakadze, B. Gorgoshidze/. Georgian Medical News. – 2010. – #6(183). –
pp. 40-45. – rus.; abs.: geo., eng., rus.
We studied the NO production
in the peripheral blood monocytes in patient infected with Chlamydia
trachomatis and in the macrophages located in the Chlamydia-caused inflammation
centers. With this aim we have investigated 132 patients with chlamydiosis and
85 probands for control group. The infections were identified by IFA, IFU and
PCR. The 20-ml venal blood of the patients was examined and the Versant’s
solution was used to excrete monocytes, microphages being excreted from the
urethra and cervix areas. The monocyte and macrophage cultures were distributed
according to different schemes. The statistic elaboration of the results showed
that the monocytes in the peripheral blood and the macrophages in the infected
area actually secreted NO. Its induction depends on IFN gamma and TNF alpha
amounts (correlation coefficients: 0.98, p<0.05). The process increases
especially under the joint influence of these cytokine (correlation
coefficients: 0.91, p<0,001). The process seems to be considerably subdued
in the Chlamydia-infected patients (correlation coefficients: - 0.97,
p<0.05). The patients seem to be affected significantly by the additional
factors.
Auth
8.g.13.1.55.
Interleukin-17/23 and Chlamydia trachomatis. /N. Shavlakadze, B. Gorgoshidze/. Georgian Medical News. – 2010. – #6(183). –
pp. 45-51. – rus.; abs.: geo., eng., rus.
C. trachomatis is a
gram-negative bacteria infecting most organs of the urogenital tract and
harming greatly the female or male reproductive field. Moreover, as this is not
the limit of its destructive nature, it can form a favorable ground for
developing ulcer and tumor processes. As observed, it is characterized of a
special chronization ability, which is developed irrespective of the mighty
immune humoral and cell-mediated immune response of the host. T(CD4)
lymphocytes and their products – cytokines are also known to be directly
involved into these processes. IL-17 and its regulator IL-23 are among them.
Our study aimed at investigating the above two cytokines in the patients
chlamydiosis. We have investigated 56 Chlamydia- infected patients; 31
non-infected patients who were the carriers of a different pathology flora and
21 healthy donors. The investigation covered some impaired localities as well
as the whole organism. To attaint the objective, we analyzed the
clinical-anamnesis data and carried out the appropriate instrumental,
laboratorial and immunological researches. Stating the chlamydia infection was
carried on with the serological and immunofluorescence and PCR methods. The
study of IL-17 and IL-23 is carried out by the ELISA and RT-PCR methods. Based
on a statistical analysis of the obtained results, it may be concluded that
IL-17 occurs in almost all the patients infected with chlamydia – their organs
or systemic environment compared with the patients of non-chlamydia infection
(97% against 21%, P<0,05). At the same time, IL-17 has been measured by
higher parameters, than IL-23. The highest parameters of IL-17 were recorded in
the patients having acute chlamydiosis in the impaired localities, also in the
patients having arthritis and antiovary antibodies, IL-23 in a reliably
increased amount was recorded in the metaplasia-prone patients. The obtained
data are a direct indication of the real participation of IL-17 and IL-23 in
the immune pathogenesis of chlamydiosis.
Auth.
8.g.13.1.56. The
features of complete blood count in the geriatric population in the
north-western part of
The present work is
devoted to the study of complete blood count in the geriatric population in the
north–western part of
Auth.
8.g.13.1.57. Metabolic syndrome and risk
factors for developing arterial hypertension. /N. Dadasheva/. Georgian Medical News. – 2010. – #7-8(184-185). – pp. 27-33 – rus.; abs.: geo., eng., rus.
Insulin resistance and
the resulting hyperinsulinemia is a set of heart disease risk factors that
increase the chance of developing arterial hypertension – a key symptom of
metabolic syndrome (MS). The basic role in pathogenesis of ÀH at ÌS belongs to insulin
resistance (IR) and is caused by its compensative hyperinsulinemia (HI) in a
combination with accompanying metabolic infringements. In addition, during ÌS evident dislipidemia develops, in particular an
increase in the ÒH level, the general XS,
LPLD and a decrease in LPHD. Recently, one more theory of AH pathogenesis with
adiposity has been discussed, according to which the AP growth is caused by an
increase in the leptin level in these patients. Thus, the AH pathogenesis in
patients with metabolic variations and risk factors is very combined, varied
and requires differentiated and multilateral methods of treatment.
Auth.
8.g.13.1.58. The impact of thyroid diseases
on bone metabolism and fracture risk. /M. Amashukeli, E.
Giorgadze, M. Tsagareli, N. Nozadze,
Osteoporosis is a
systemic skeletal disease characterized by low bone mass and
micro-architectural deterioration of bone tissue, leading to enhanced bone
fragility and a consequent increase in fracture risk. One of the leading causes
of secondary osteoporosis is thyroid diseases; this fact is of special
importance for
Auth.
8.g.13.1.59. Epidemiological assessment of
the hepatitis B and C infectious disease markers in
The article deals with
an estimation of spreading of the subclinical form of hepatitis B and C viruses
in the healthy adult inhabitants of Baku and Nakhchivan cities by detection of
frequency of revealing serological markers of HBV (HBsAg) and HCV (anti-HCV)
infections. By means of a meta-analysis the results previously received in
several seroepidemiological studies among healthy inhabitants of these cities
are generalized. Average HBsAg and anti-HCV detection rate has made - 3.0% and
4.0%, respectively. Based on the above results, the
Auth.
8.g.13.1.60. Unexpected increase in the cases
of bacterial meningitis in the 2009 summer in
In the 2009 summer,
during a period from 20 June to 31 August, 32 patients with the clinical
diagnosis of bacterial meningitis were hospitalized in two hospitals of
Auth.
8.g.13.1.61. Immunohistochemical expression
of BRCA1 protein in invasive ductal carcinoma of the breast. /G. Burkadze, O. Khardzeishvili, M. Gudadze, G.
Tsikhiseli, G. Turashvili/. Georgian Medical News. – 2010. – #7-8(184-185). – pp. 51-60 – eng.; abs.: geo., eng., rus.
Immunohistochemically
detected BRCA1 positivity has been reported to indicate the presence of
full-length functional protein, while immunohistochemical negativity may be a
result of sporadic BRCA1 mutation. We set out to study the immunohistochemical
expression of BRCA1 protein in breast cancer and assess associations with lymph
node status, histologic grade and expression of other biomarkers. We examined
100 patients aged from 21 to 71 years diagnosed with invasive ductal carcinoma.
Immunohistochemistry was performed using anti-BRCA1, ER, PR, HER2/neu, and Ki-67 (MIB-1) antibodies.
Cytoplasmic or nuclear-cytoplasmic BRCA1 expression was identified in a total
of 64 breast cancer patients. None of the breast cancer tissue samples showed
solely nuclear BRCA1 immunoreactivity. BRCA1 expression was associated with
higher histologic grade, and majority of BRCA1-positive patients were below 50
years of age. Most BRCA1-negative patients had intermediate grade tumors. BRCA1
expression was positively associated with ER and PR positivity, and negatively
associated with HER2/neu
overexpression. Although immunohistochemistry can be an inexpensive and
valuable preliminary method for detecting the BRCA1 status, BRCA1 protein
localization is a complex issue. Well designed studies are needed to further
investigate the performance of various anti-BRCA1 antibodies in formalin- fixed
paraffin-embedded tissue samples, assess their association with BRCA1 gene
mutations and determine clinical usefulness of BRCA1 immunohistochemistry.
Auth.
8.g.13.1.62. The macro-microscopic
peculiarities of the human urinary bladder glands. /G. Huseynova/. Georgian Medical News. – 2010. – #7-8(184-185). – pp. 77-81– eng.; abs.: geo., eng., rus.
We studied the glands of
the 130 persons, victims from the casual reasons (a trauma, an asphyxia, etc.)
from newborn to senile age; we investigated different variants of bladder gland
forms, the changes in different parts of the organ’s wall (proximal, average,
distal one-third) from the newborn period to senile age by the method of
macro-microscopy and morphometry of the total specimens of the urinary bladder.
The glands were preliminarily stained with the 0.05% methylene dark blue
solution by the Sinelnikov’s method and by hematoxilin and eozin. The glands
were investigated with the application of stereo binocular microscope MBS-9.
The statistical data processing included the calculation of arithmetic-mean
values, their errors, confidential intervals (excel). The view of the human
urinary bladder glands in the macro-microscopy investigation is different. The
glands have roundish, oval, ribbon forms. The form of the glands in the different
parts of human urinary bladder (proximal, middle and distal) is different. In
the micro-topography the glands have proximal-distal changes; the number of
glands increases in the proximal- distal direction together with the content of
complex glands (the glands with 3, 4 and more initial parts).
Auth.
8.g.13.1.63. Prevention
of errors and complications in the formation of esophageal layer-by-layer
apparatus anastomosis. /O. Ghibradze, M.
Gurgenidze, G. Bakuradze, D. Tevdoradze, M. Samsonia/. Georgian Medical News. – 2010. – #9(186). – pp.
7-13 rus.; abs.: geo., eng., rus.
The aim of the research
is to analyze the outcome of treatment of patients with cardioesophageal
cancer. Subtotal resection of esophagus with gastrectomy was performed on 3
patients. On 9 patients the resection of esophagus with gastrectomy from left
thoracophrenolaparotomy was performed. Gastrectomy with resection of abdominal
part of esophagus was performed on 10 patients. Transhiatal mediastinal
lymphadenectomy S2D2 was carried out in all cases. The esophageal anastomosis
has been formed by circular apparatus EEA and SPTU. The functional condition of
anastomosis was investigated by X-ray, endoscopical and endo-sonographical
methods in the postoperative period. The complications caused by technical errors of esophageal anastomosis were
reviewed. The regeneration of circular anastomosis depends of adequate blood
supply of anastomosis, observance of safety rules of imposing circular
anastomosis. Reasonable application of circular apparatus, the refined
techniques of imposing anastomosis, X-ray, endoscopical and endo-sonographical
research methods decrease complications and promote recovery.
Auth.
8.g.13.1.64. Dominated EEG patterns and their
prognostic value in coma caused by traumatic brain injury. /M. Beridze, M. Khaburzania, R. Shakarishvili, D.
Kazaishvili/. Georgian Medical News.
– 2010. – #9(186). – pp. 28-33. – eng.; abs.: geo., eng., rus.
The study aimed at
investigating dominated EEG patterns in traumatic coma of different severity
and elucidating their prognostic value for outcome of disease within a month. A
total of 53 coma patients with severe traumatic brain injury have been
investigated. Exclusion criteria comprised the patients needing the
neurosurgical intervention due to hemorrhage. Brain injury was visualized by
conventional CT at admission. The level of consciousness was evaluated by
Glasgow Coma Scale (GCS). Patients were divided in 5 groups according to GCS.
Electrophysiological investigations were performed on 5th day from
development of coma by application of 16-channel computer encephalography.
Outcome of coma (death, vegetative state, recovery) was evaluated within month
from disease onset. According to dominated EEG background activity patterns the
1st group (GCS=4) showed the delta EEG pattern in 50 % of patients,
the beta EEG pattern- in 33.4% and the alpha EEG pattern – in 16.6%. The 2nd
group (GCS=5) revealed the delta EEG in 40%, the beta EEG- in 6.7% and the
theta EEG - in 53.3%. The 3rd group (GCS=6) showed the delta EEG
pattern in 27.8% and the theta EEG pattern- in 72.2%. In 4th group
(GCS=7) the theta EEG pattern found in 77.7% and the beta EEG pattern in 22.3%.
The 5th group (GCS=8) revealed the theta EEG activity in 80% and
beta EEG activity –in 20%. Positive correlation was found between the GCS and
the frequency of theta EEG pattern (r=+0.62; p<0.05). Positive correlation
was established between the frequency of delta EEG pattern, death and
persistent vegetative state (r=+0.57 and r=+0.16 respectively, p<0.05)
within month. Positive correlation was established between the frequency of
delta EEG pattern and the size of brain injury (r=+0.3; p=0.04). Multinomial
logistic regression revealed the significance of brain lesion size, GCS and EEG
pattern for functional outcome of coma. In severe traumatic coma patients, the
delta EEG pattern is associated with the deep coma state and predicts the poor
functional outcome within a month.
Auth.
8.g.13.1.65. Pulmonary hypertension in female patients
with cardiovascular and respiratory tract disease. /M. Gegenava, T. Gegenava, G. Kavtaradze/. Georgian
Medical News. – 2010. – #9(186). –
pp. 34-37. – eng.; abs.: geo., eng., rus.
Pulmonary arterial
hypertension (PAH) is defined as a group of disease characterized of a progressive
increase of pulmonary vascular resistance (PVR) leading to right ventricular
failure. The aim of our study was to determine the frequency of PAH in female
patients with cardiovascular and pulmonary tract disease. The research was
performed on 80 postmenopausal women (mean age, 54±3 yr). They were divided
into groups according to the main disease: 1. Chronic obstructive pulmonary
disease COPD n=16. 2. Acute pneumonia n=23. 3. Cardiovascular disease n=25.
This group was compared with the control group (nonpostmenopausal women). In
postmenopausal women high level of PAH by echocardiographic trial was
manifested in patients with cardiovascular disease n=17 (68%); In cases of
pneumonia n=13; 56,5% (P<0.001) and in COPD n=12; 75% (P=0.001). There wasn’t
revealed significant level of pulmonary hypertension in nonpostmenopausal women
(P=0.001). By transthoracic echocardiography tricuspidal regurgitation (TR),
right atrial (RA) and right ventricular (RV) dilatation was showed in every
patient with important degree of PH. By electrocardiography (ECG) signs of RV
and RA hypertrophy were expressed in great majority of patients with high
degree of PH. Furthermore, RV hypertrophy revealed in n=64 (80%) of patients
and right deviation of axis in n=60 (75%). The results have indicated that PAH
is widely extended in postmenopausal period, when the protective effects of
oestrogens on the endothelium decrease. The problem is urgent and needs
particular attention. Early diagnosis and treatment of pulmonary hypertension
make it possible to control cardiovascular and pulmonary disease and avoid
complications.
Auth.
8.g.13.1.66. Enterohemorrhagic E. coli and
hemolytic-uremic syndrome in
It is important to
consider that between July-October 2009 in the Pathology Center of Infectious
Diseases (
Auth.
8.g.13.1.67. Epidemiologic peculiarities of infections
caused by the hepatitis B and C viruses among lung tuberculosis patients. /M. Mamedov,
The article presents the
results of serological investigation for presence of specific markers of hepatitis
B (HBV) and hepatitis C (HCV) infections in serum samples obtained from 600
patients with acute and chronic forms of lung tuberculosis (LT) and in control
group I – 600 healthy adults and in control group II - 796 patients with
somatic pathology from a multiprofile hospital. It has been established that
among LT patients the frequency of revealing HBsAg and anti-HCV is
statistically steady; similar indicators are among persons from both control
groups. The frequency of revealing of these markers in patients with chronic
forms of LT is considerably higher than the in patients with acute forms of LT.
At the same time, both infections in patients with LT were often presented in
the form of subclinical hepatitis identified by increase in the aminotransferase
activity in blood.
Auth.
8.g.13.1.68. The efficacy of topical drugs in the
treatment of non-inflammatory acne vulgaris. /N.
Merkviladze, T. Gaidamashvili, P. Tushurashvili, E. Ekaladze,
Treatment of acne
vulgaris still remains a pressing problem. The purpose of the research was to
study the treatment and side effects of topical drugs – Diacneal and Skinoren
in patients with non-inflammatory acne vulgaris. The results of the research
have confirmed the swift and stable treatment effect of both preparations being
expressed in a decrease in the number and size of comedonal and
papulo-comedonal formations, actually without side effects. Thus, in spite of
divergence of either chemical composition or mechanism of action, both,
Diacneal and Skinoren, may be recommended as a very good choice for monotherapy
of non-inflammatory acne vulgaris.
Auth.
8.g.13.1.69. Parameters of innate immunity manifested
in clinical and subclinical forms of infections caused by hepatitis B and C
viruses. /A. Guliyeva, M.
Mamedov, A. Dadasheva,
The authors determined
parameters of innate immunity (IIM) in patients with acute and chronic forms of
viral hepatitis B and C and in persons with subclinical infections caused by
hepatitis B and C viruses. The results obtained demonstrated that the
clinically manifested (acute and chronic) and subclinical forms of infections
caused by hepatitis B and C viruses were accompanied by the development of IIM
depression. At the same time, the signs of IIM depression in the patients with
clinically manifested forms of infections were expressed in higher degree than
in the persons with subclinical forms of infections.
Auth.
8.g.13.1.70. The evaluation of nitrogen metabolism and
the reactivity of the organism in patients with dry skin. /N. Tsiskarishvili, A. Katsitadze,
It is known that in norm
horny layer of the epidermis is able to retain water due to the presence of
hygroscopic substances inside corneocytes in the form of so-called natural
moisturizing factors (NMF), consisting of free amino acids and their
derivatives, which are formed during the decay of filaggrin as well as lactic
acid, urea, sugars, and intercellular lipid membranes, creating a barrier that
prevents transepidermal water loss. At the same time, the results of recent
studies have shown that urea - a kind of natural antioxidant that protects
tissues from the accumulation of aggressive forms of oxygen. It is able to
stabilize the lysosomal membranes, thus preventing autolysis of cells. The
ability of urea at low concentrations to modify the reactivity of functional
groups of proteins leads to conformational changes of immunoglobulin, which has
an inhibitory effect on the immune system, including the diminishing impact on
the development of reaginic type reactions. Urea has anti-inflammatory,
hyposensitizing, and antioxidant effect. Based on the above the aim of this
study was to determine the content of urea and some indicators of cellular and
humoral immunity in case of chronic dermatoses, accompanied by dryness of the
skin. Indicators of nitrogen metabolism of blood serum (urea. ammonia), some
parameters of cellular and humoral immunity were studied in 27 patients, who
according to nosological units were distributed as follows: atopic dermatitis
(12), psoriasis (7), xerosis (8). In the study of the concentration of urea in
the blood, and some indicators of cellular immunity, as well as the content of
immunoglobulin E in the blood of our patients a decrease in the number of
T-lymphocytes, mainly due to T – suppressor and raising the level of
immunoglobulin E have been revealed. Specific patterns of changes in these
parameters, depending on nosological unit, severity of disease and degree of
dryness of the skin have also been observed.
Auth.
8.g.13.1.71. Traditional Chinese medicine in diagnosis
and treatment of fibromyalgia syndrome. /R.
Aliyev, T. Vieth, G. Gaiger/. Georgian Medical News.
– 2010. – #11(188). – pp. 38-45. – rus.; abs.: geo.,
eng., rus.
Fibromyalgia syndrome
(FS) is known for the difficulties arising from classification. The
accompanying pain in skeletal muscles, myofascial peri-articular structures and
a number of polymorphic symptoms cannot be separated into complexes of
symptoms. The application of principles of traditional Chinese medicine (TCM)
helps in analyzing the symptoms of FS to detect a leading syndrome and thereby
establish an individual therapy. Medical histories and objective examinations
of 25 patients with FS and 22 patients with vertebrogenic pain syndromes were
analyzed according to TCM. A questionnaire was used to determine the leading
constitutional type according to the 5-elements-theory. Analyses of the results
showed that 83% of patients with FS were of constitutional type of the element
earth. The following syndromes were found to be important in FS: 1)
liver-Qi-stagnation, 2) Yin and blood deficiency of the liver, 3) Yang-weakness
of the spleen and kidney, 4) Yin-weakness of the kidney. Applying TCM for FS
allows for separating a group of symptoms and thus individual therapy. The
determination of the constitutional type according to the 5-elements-theory may
be used for a better understanding of the disharmony pattern.
Auth.
8.g.13.1.72. Heterogeneity and gene-geography of b-thalassemia in
Auth.
8.g.13.1.73. Orexinergic system and pathophysiology of
epilepsy. /N. Doreuli, M. Alania,
G. Vashalomidze,
Neuropeptids orexins,
also known as the hypocretins, are expressed in the lateral hypothalamus.
Orexin-containing cells project widely throughout the brains, are crucial for
the regulation of wakefulness and dysfunction of this system is associated with
pathophysiology of narcolepsy-cataplexy. Orexin neurons play an important role
in motivation, feeding and adaptive behaviors. Distribution of orexinergic
receptors in the hippocampus tended to the ideas that orexins might be involved
in the functions relating to the hippocampus. Effects of neuropeptide orexin-A
on epileptiform activity in hippocampal slices were investigated. 500µm thick
hippocampal slices from 8-10 week-old rodents were used. Field excitatory
postsynaptic potential (pop-FEPSP) and population spike in CA1 of hippocamopus
were registered using standard protocol of in
vitro electrophysiological experiments. Initial slope of the FEPSP and
amplitude of II pop-spike were measured. Bursting neurons in CA3 were recorded
in modified saline. We have found that orexin-A decrease duration/amplitude of
multiple discharges of pop-spikes and inhibits spontaneous epileptiform after discharges
induced by bicuculline methiodide in CA1. Orexin-A also modulates the frequency
of discharges of bursting neurons in CA3. Our results suggest possible
involvement of orexinergic system in antiepileptic action.
Auth.
8.g.13.1.74. The Level of fluoxetine in blood plasma
and washed from erythrocyte supernatant. /D.
Zurabashvili, I. Giorgobiani, M. Arveladze, I. Gamkhrelidze,
Antidepressant
fluoxetine and their major therapeutically active metabolite Norfluoxetine was
monitored in albumen and glicoprotein of blood plasma and washed from
erythrocyte supernatant. In the paper we describe rapid and reliable method
using high-performance liquid chromatography for simultaneous measurement of
plasma and supernatant concentration of fluoxetine and norfluoxetine. The
described method has been successfully used in clinical and laboratory cases.
Large inter-individual variations in plasma and supernatant concentrations of
fluoxetine and its major metabolites have been shown. In albumen fractions of
blood plasma the level of fluoxetine is higher then in supernatant. A
successful development of the clinico-pharmacokinetic direction at the present
stage is due to improvement and standardization of methods of clinical and
pharmacokinetic examination, which help to ensure a reliable pretreatment
identification of the patients potentially sensitive to pharmacotherapy with
antidepressants.
Auth.
8.g.13.1.75. Quantitative Changes of Schwann and mast
cells in the process of peripheral nerve regeneration. /T. Giorgadze, R. Rukhadze, S. Giorgadze, N.
Gujabidze, N. Tevzadze/. Georgian Medical News. –
2010. – #11(188). – pp. 84-88. – rus.; abs.: geo., eng., rus.
One of the most common
problems in the fields of orthopedic surgery and neurology is that of the
injured peripheral nerve. Injured nerve fibers in the adult mammalian
peripheral nervous system can and often do regenerate, thereby restoring at
least some lost functions. During the past decade enormous progress has been
made in the understanding of the cellular events and molecular changes during
degeneration and regeneration of peripheral nerves. However, our knowledge of
the regulatory mechanisms and signaling cascades underlying the complex
molecular regeneration program is still very limited despite an enormous amount
of new experimental data. Injure to peripheral nerve initiates a complex
cascade of signals involving neurons, glia and cells of the immune system. The question
of what cells are responsible for nerve survival and tissue repair mechanisms
after injury remains controversial. Although it has largely been demonstrated
that macrophages and Schwann cells play important roles in degrading and
removing myelin few data have been reported regarding mast cells in Wallerian
degeneration. The present study has been designed to evaluate the correlation
between Schwann and mast cells during regeneration of the injured peripheral
nerve. Animals were divided into two groups: experimental and intact rats. The
left sciatic nerve was separated from the surrounding tissue, was transected in
its mid-thigh portion and sewed up. Sewed sciatic nerves were obtained and used
for morphological and Immunocytochemical observation 2 and 12 day, and 1 month
after transection. Our experimental data reveals that the mast cells, as well
as Schwann cells, play a pivotal role in regeneration process after injury. The
correlation between the changes of quantity of Schwann cells and mast cells during
the regeneration of injured peripheral nerve was not revealed.
Auth.
8.g.13.1.76. Comparative evaluation of
indicators of local, humoral immunity and nonspecific resistance in patients
with different pathology of the cervix. /A.
Harutyunyan/. Georgian Medical News.
– 2011. - #1(190). - pp. 7-15. – rus.; abs.: geo., eng., rus.
A comparative evaluation
of some indicators of immune system and analysis of the dependence of these
parameters (correlation) are carried out to identify interrelated mechanisms. The
observed changes in the concentrations of indicators of immune system and the
correlation between cytokines, humoral immunity and nonspecific resistance in
cervical mucus in patients with cervical pathology demonstrate the complex,
interrelated and changing interactions of the local immune system at various
stages of development of the pathological process of the cervix.
Auth.
8.g.13.1.77. Novelties in treatment approach of
poly-neoplasias developed during thyroid pathologies. /T. Makaridze, K. Mardaleishvili/. Georgian Medical News. – 2010. – #11(188). –
pp. 15-20. – rus.; abs.: geo., eng., rus.
The publication
discusses the pathogenic mechanisms developed during concordance of malignant
tumors of the thyroid gland and reproductive systems and dishormonal
hyperplasias, also functional disturbances which accompany the thyroid gland
diseases and the principles of treatment during synchronic and metachronic
manifestations. The treatment of polyneoplasias by "neurotransmitive
control” is proposed. Importance of thyroid suppressive therapy is assessed.
The efficacy of thyrotrophic hormone suppression by neurotransmitters in
prevention of malignant tumors of reproductive system is reported.
Auth.
8.g.13.1.78. The prognostic significance of
heart rate variability in patients with diabetes mellitus type 2 against the
background of ischemic heart disease and arterial hypertension. /G. Tabidze, O. Leonidze, L. Basiladze, A.
Tsibadze/. Georgian Medical
News. - 2011. - #1(190). pp. 33-36.
– rus.; abs.: geo., eng., rus.
In
recent decades the special attention has been given to the heart rate
variability (HRV) to assess the prognosis of the patients with cardiovascular
diseases. There were studied 47 male with arterial hypertension and heart
failure, by which the HRV was researched. In the group of patients
with diabetes mellitus (DM) type 2, ischemic heart disease (IHD), arterial
hypertension (AH) and heart failure (HF), the heart rate variability (HRV) has
been considerably lower in comparison with the group of patients iwithout DM.
The initial activation of the sympathetic
nervous system in the group of patients with DM, IHD, AH and HF, we can speak
about the expected progression of heart failure even before occurrence of any
significant changes of central hemodynamics. It has been established that the
higher is the functional class of heart failure the more revealed are
sympathetic influences and worse is the heart rate variability.
Auth.
8.g.13.1.79. Two clinical cases of the
antiphospholipid syndrome. /E. Kartvelishvili, T.
Astvatsaturova/. Georgian Medical News.
- 2011. - #1(190). - 37-41. – rus.; abs.: geo., eng., rus.
Because of importance of
early diagnosis of the antiphospholypid syndrome (APS) we present two case
histories from clinical practice of the Scientific-Practical Center of
Rheumatology. The first clinical case (male, born in 1961, diagnosed with
systemic lupus erythematosus and secondary APS) shows that verification of
diagnosis in men is much harder than in women. The patient was diagnosed with
secondary APS only 8 years after the onset of the disease. The second clinical case (female, born 1959,
diagnosed with primary APS) is interesting because during many years the
patient was diagnosed with SLE and secondary APS. We performed careful analysis
of the case and made the diagnosis of primary antiphospholipid syndrome.
Nowadays the patient is given an adequate treatment and his health is stable,
but the risk of recurrent thrombosis still remains. Presented case
histories show the variety of clinical symptoms and the complexity of diagnosis
of APS.
Auth.
8.g.13.1.80. Opioid sensitivity of nucleus
raphe magnus after analgesia by non-steroidal anti-inflammatory drugs. /I. Nozadze,
N. Tsiklauri, G. Ghurtskaia,
Our recent
investigations have shown that microinjection of three non-steroidal
anti-inflammatory drugs (NSAIDs), analgin, ketorolac and xefocam, into the
central nucleus of amygdala produces tolerance to these drugs and
cross-tolerance to morphine. We have observed the same phenomenon in midbrain
periaqueductal grey matter and nucleus raphe magnus. The medullar nucleus raphe
magnus (NRM) is one of important parts of CNS circuit that controls nociceptive
transmission at the level of spinal cord. It is functionally involved in
descending pain modulation, and mainly consists of serotoninergic neurons. The
aim of this study was to examine opioid sensitivity of NSAIDs action in NRM of
male rats. For this purpose 30 minutes later of NSAIDs administrations we
microinjected μ-opioid antagonist
naloxone and tested rats for tail flick and hot plate latencies. Our
investigation showed that microinjection of naloxone in NRM significantly
decreased antinociceptive effects of NSAIDs at the first day in the TF and HP
latencies. At the second day, naloxone generally had trend effects in both TF
and HP tests. These results strongly support the suggestion on endogenous
opioid involvement in NSAIDs antinociception and tolerance. On the other hand,
our evidence confirms once more that NRM is involved in the descending pain
control circuit inhibiting spinal nocifensive reflexes.
Auth.
8.g.13.1.81. Changes of redox processes in
liver under PV-88 during an experimental hemorrhagic shock. /Gr. Sulaberidze, M. Ghvaladze, G. Didava, B. Kotchlamazashvili, M. Chkhaidze, T.
Gegeshidze/. Georgian Medical News. – 2011. - #1(190). – pp. 65-69. – rus.;
abs.: geo., eng., rus.
PV-88 is the Ca2+ L
channel blocker from pyrrole compounds that was used on the 60th
minute of a hemorrhagic shock (HS) modeled by the Wiggers-Feine method
(intravenous administration, 3 mg/kg). The mean arterial pressure was 40 mmHg.
The effects were studied on the 80th minute after blood letting. Blood was
exfused 40 ml/kg. Effect of PV-88 on redox processes in liver was studied.
Experiments were carried out on male cats. Right lobe of the liver and the
metabolic indices: ATP, CO, NAD, NADP, ALP, SDH, LDH were studied with the use
of histochemistry (Pearse). Investigations have shown that on 80th minute after
PV-88 administration CO (p<0.05), NADP (p<0.05), ALP (p<0.001), SDH
(p<0.05), and LDH (p>0.05) were increased, while ATP (p<0.001) and NAD
(p<0.001) were decreased. Increase in LDH was not statistically significant.
According to the results of investigations, after administration of PV-88 at HS
60 on the 80th minute the oxygen concentration in the liver and the aerobic
process increased respectively.
Auth.
8.g.13.1.82. Cytokine regulation in patients
with brain tumors. /L. Haroutunian, Z. Ter-Pogossian,
The aim of the study was
to investigate serum levels, as well as the ability to produce in vitro, some
pro-inflammatory and anti-inflammatory cytokines in patients with brain tumors
(BT). Serum concentrations of IFN-gamma, IFN-alpha, TNF-alpha, IL-4, IL-6,
IL-8, and RA IL-1 were determined in 17 patients with brain tumors, and in 21
healthy donors. The results showed that baseline levels of cytokines studied
was above normal in most patients (78%) had the highest rates of IFN-gamma.
During the whole observation period, slightly higher in patients compared with
healthy individuals (t=1,8) was the content of IFN-alpha. Serum concentrations
of IL-4 in patients before treatment were significantly higher than in control
group (p<0,01), remaining at about the same level, and after treatment.
Levels of Rail-1, IL-6 and IL-8 in patients before treatment were within normal
limits, while remaining unchanged at the end of the survey. Indicators induced
in vitro production of cytokines studied to some extent correlated with their
serum levels. Hyperproduction in vitro IFN-gamma was observed in 61% of patients,
low production - 28% of patients, and only in 11% of cases, these figures were
within normal limits. In patients with malignant brain tumors were identified
violations of serum levels and production of cytokines studied. The most
significant was the increase of PHA-induced production of IFN-gamma, which was
not reduced by the end of treatment. High serum and, in particular, PHA-induced
levels of IFN-gamma at the end of treatment may be recommended as an additional
criterion for immunodiagnosis in a dynamic laboratory monitoring.
Auth.
8.g.13.1.83. Epidemiological aspects of
breast cancer in women in major cities of the
Breast
cancer is the most frequent type of cancer among women and is a leading cause
of cancer death among women in the
Auth.
8.g.13.1.84. Treatment of Non-accommodated
concomitant strabismus. /M. Kikolashvili, D.
Shengelia, L. Tsomaia/. Georgian Medical News. – 2011. - #2(191). - pp. 22-26.
– rus.; abs.: geo., eng., rus.
The aim of the study was
a comparative evaluation of surgical treatment and complex pre- and
postoperative pleoptic, orthoptic, diploptic treatment of non-accommodated
concomitant strabismus and identification of the optimum age for surgical
treatment of strabismus. The 75 patients (from 2 to 10 years old) with
manifested concomitant convergent strabismus were divided into two groups:
patients operated at the age from 2 to 4 years old; patients operated at the
age of 4-10 years). The 75 of patients operated at the age from 2 to 4 years
old, which underwent orthoptic-diploptic treatment pre- and postoperatively got
binocular vision showed the full recovery in only 40% of the cases of the same
age-group undergone the surgical treatment in combination with the direct
occlusion. Binocular vision was achieved in 68% of the patients operated at the
age of 4-10 years with complex treatment, and in 25% in the patients of the
same age group with surgical treatment plus occlusion. The findings showed the
efficacy of complex treatment as well as pre and postoperative
pleoptic-orthoptic-diploptic treatment of strabismus and direct occlusion.
Thus, the results of this study suggest that the delay of surgical treatment
limits the ability to obtain optimal results.
Auth.
8.g.13.1.85. Sporadic pancreatic head
sarcoidosis: a rare clinical case analysis. /M. Tsintsadze, T.
Beridze, U. Volker, G. Loppel, R. Schauer/. Georgian
Medical News. – 2011. - #2(191). - pp. 26-32. – rus.; abs.: geo., eng., rus.
Systemic
sarcoidosis is an autoimmune disease with a prevalence of 40 per 100.000 people
which mostly affects young adults. It is characterized of non-caseous
granulomatous changes of interstitial tissue, predominantly in the lungs.
Extrapulmonal sarcoidosis has been described in every organ but is present only
in 1-5% with pancreatic involvement. Furthermore, sarcoidosis leading to a
symptomatic mass in the pancreas is extremely rare and must be differentiated
from cancer and pancreatitis. For therapy, it is crucial to find the right
diagnosis before planning an operation. Otherwise a radical surgery may lead to
an unwanted outcome.
Auth.
8.g.13.1.86. Prevention of insult with nondirective
anticoagulant therapy by warfarin (warfarex) in patients with atrial
fibrillation. /G. Abuladze,
The aim of the study was
to estimate efficiency and safety of treatment by non-direct anticoagulant -
warfarex in the patients with persistent and paroxysmal forms of AF for the
prevention of thromboembolic complications. 55 patients between 37 and 75 years
old with atrial fibrillation (AF) were investigated. Follow-up was 2 years.
Primary diseases were post myocardic cardiosclerosis, cardiomyopathy, IHD,
arterial hypertension. The patients with persistent form of AF underwent
treatment by warfarex. In the case of paroxysmal form of AF patients were
prescribed warfarex during the first 48 hours from the beginning of paroxysm
and for 3-4 weeks after cardioversion. The dose of warfarex was chosen
according to the International Normalized Ratio (2.0-3.0). The results of the
study show that warfarex is effective and safe for the prevention of
thromboembolic complications in the case of persistent and paroxysmal forms of
AF.
Auth.
8.g.13.1.87. Study of self-regulating
behavior at different stages of psychogenic stress before the formation of
depressive-like state in rats. /T. Matitaishvili, T.
Domianidze, K. Tchitchinadze,
During last decades
abnormalities of the neuro-psychic sphere have become a topic of great
interest. Among them an important place takes depression. Psychogenic factors
are commonly the most frequent cause of a depressive condition and until now
the study of the so-called transitional period (from the beginning of stressor
action till the formation of depressive state) continues to be an actual task
of scientific research. This in mind, we studied the self-regulating behavior
in rats in different stages of psychogenic stress until the formation of a
depression-like condition. To access the behavioral changes, the "open
field” test, FST (forced swimming test, "Porsolt” test) and TST (tail
suspension test) were used. We also registered behavioral indices while
applying stressors. Stress was applied in a modified shuttle chamber. At the very beginning of the study (the first stage of
stress - alarm) an animal was forced to develop a reaction of active avoidance
on metronome beats (100 beats per second), later, after its fixation, the same
reaction was developed on tone (500 Hz). Then simultaneous testing of two
developed reactions of active avoidance was performed (the second stage of
stress). After the long-term application of stressors (48 days) the second
stage of stress proceeds into the deep (the third) one. On this stage animals
showed decreased motor activity in the "open field” test, decreased
mobility in FST and TST, changes being statistically valid. All behavioral
changes indicating depression-like condition in the animals were normalized
after per os administration of antidepressant Fluoxetine at doses of 40 mg/kg. The
results obtained in the study confirm that on different stages of psychogenic
stress changes in behavioral indices are natural and self-regulating. They
appear to be compensatory as only on their exhaustion the depression-like
condition is formed.
Auth.
8.g.13.1.88. Anti-diabetic activity of
berberin and extract obtained from the bark of Phållodendron Lavalei, introduced in the subtropical
regions of
The goal of the study
was to identify anti-diabetic impact of berberin and extract obtained from the
bark of Ðhållodendron Lavalei introduced in the subtropical
regions of
Auth.
8.g.13.1.89. Changes of metabolic indices
caused by berberin and extract obtained from the bark of Ðhållodendron Lavalei
introduced in the subtropical regions of
The goal of the study
was to identify changes in lipid metabolism, functional condition of liver and
kidney influenced by berberin and extract, obtained from the bark of Ðhållodendron Lavalei,
introduced in sub tropic regions of
Auth.
8.g.13.1.90. In vivo investigation of the
effect of extracellular ubiquitin effect on liver histoarchitectonics. /R. Sujashvili, E. Bakuradze,
Ubiquitin is a small
regulatory protein of living cells. It affects almost all cellular processes.
Investigation of ubiquitin is very important for discovering the new
therapeutics for different heavy human diseases. The main goal of the work was
to reveal the effect of extracellular ubiquitin on liver histoarchitectonics of
mature and immature white rats. The obtained data indicate the inefficiency of
used doses - 200μg/ml and 500 μg/ml - of extracellular ubiquitin single and multiple
in vivo injections to evident changes of histoarchitectonics of immature and
mature white rat liver. Further
investigation of the in vivo injection effects on the histoarchitectonics of intact
and damaged liver and hepatocyte cell cycle regulation by immunological assays
seems to be actual and interesting.
Auth.
8.g.13.1.91. Optimization of venous
return during the anhepatic phase of experimental liver transplantation. /E. Azmaipharashvili, M. Geldiashvili, Z.
Chkhaidze, N. Khodeli, O. Philishvili, G. Tomadze, M. Jangavadze, J.
Phartsakhashvili, D. Kordzaia/.
Experimental and Clinical Medicine. – 2010. - #1(56). - pp. 9-14. – geo.; abs.:
eng.
To assess the
effectiveness of different schemes of veno-venous bypass during the anhepatic
phase (AP) of experimental liver transplantation, experiments have been
performed on 8 male dogs weighing 15–20 kg. After hepatectomy, a pump-driven
venous bypass from the infrahepatic segment of the caudal vena cava and portal
vein was conducted into the brachiocephalic vein (I group; n=4) or the
suprahepatic segment of the caudal vena cava (II group; n=4). Hemodynamics was
monitored for 3 hours. During the entire AP in the I group the pressure in the
cranial venous system was increasing (p>0.05), while the blood flow index
was decreasing (p<0.05); the same parameters in the II group were maintained
unchanged. The obtained results confirm that veno-venous bypass into the
suprahepatic segment of the caudal vena cava can be considered as more
physiologic and can prolong a safe AP up to 3 hours.
Auth.
ჰ8.g.13.1.92. Comparative influence of
β-blockers on the liver
under conditions of acute toxic hepatitis induced by acetaminophen. /L. Gabunia, I. Khabeishvili, N. Kvernadze,
The effects of
non-selective β-blocker
propranolol, selective β-blocker
bisoprolol and non-selective β-blocker
with additional vasodilatatory properties - carvedilol on the functional
parameters and morphology of the liver during the paracetamol-induced acute
toxic hepatitis have been studied. The experimental results have shown that
hapatotoxicity is not a characteristic side effect for all types of β-blockers. Propranolol worsens, bisoprolol
has no effect and carvedilol slightly but still improves the functional
parameters of the liver in case of acute toxic hepatitis. The positive
treatment effect of carvedilol on hepatocytes could be explained by its
antioxidant or Ca-antagonist properties. Investigation of functional parameters
of the liver before treatment course with propranolol is strongly recommended,
especially in patients suffering with liver insufficiency.
Auth.
8.g.13.1.93. Phage therapy of
surgical infections. /G. Gvasalia,
The study represents an
analysis of thirty years’ experience in phage therapy of surgical infections,
which proves that the phage therapy does not represent an alternative for
antibiotic therapy but has a summary or synergistic effect. Unlike antibiotics,
the acquired resistance of bacteria to phages is rare and the primary
resistance is usually to commercial preparations. This kind of resistance is
surmountable by using selected or adapted bacteriophages against isolated
bacterial strains. Antibiotic resistance is not related to the resistance to
bacteriophages. Possibility of using bacteriophages locally is advantageous due
to their reproductive ability in the wound and stability to enzymatic
inactivation and dilution. Therefore, local bacteriophage therapy can cause the
inhibition of infection in ischemic-neuropathic, granulation, sclerotic tissues
and extensive wounds, where systemic antibiotics cannot achieve therapeutic
concentration. Phage therapy and prophylactics of soft tissue gunshot wounds on
battlefield (Abkhazia 1992-1993) prolongs the "golden” period for wound
care, decreases the chances for tissue infection by 14-4% and treatment of
purulent wounds by 6-8 days. Bacteriophages were successfully used for
environmental and personnel sanitation in surgical and critical care wards due
to its high efficacy and low price. The reason why bacteriophages are not still
used as a potent antibacterial means is subjective as well as there is lack of
information in clinical bacteriophage therapy. Further research in this field
should be planned according to the evidence based medicine standards, to answer
the questions about phage dynamics and phage kinetics during therapy of
surgical infections, as well as the mathematic modelling of correlative
relationship between quantitative bacteriology and bacteriophages.
Auth.
8.g.13.1.94. Changes in liver during
alloxan diabetes. /N. Janashia/.
Experimental and Clinical Medicine. – 2010. - # 2(57). - pp. 29-32. – geo.;
abs.: eng.
This study has been
conducted to detect the histological changes that could be inducted in the
liver of Wistar rats. Animals were killed one month after injection. The
results showed several morphological alterations in liver tissues (granular and
vacuole dystrophy), changes in micro-circular channel, inflammatory the injury
of liver histology over a short time in alloxan diabetic rat.
Auth.
8.g.13.1.95. Cytokines and their role
in the development of cardiovascular system diseases. /N. Mamamtavrishvili,
N. Silagava, M. Dzamukashvili, N. Gelashvili, N. Zarnadze/. Experimental and
Clinical Medicine. – 2010. - #2(57). - pp. 32-35. – geo.; abs.: eng.
The role of cytokines in
the development of cardiovascular organic pathologies is shown in the reviewed
article. One of the main factors which affect the progress of ischemic heart
diseases along with hemodynamic abolition is the activation of inflammatory
reactions with participation of preinflammatory cytokines. Changes in the
levels of cytokines are associated with the disease progression, as well as
with its outcome. There is also shown the need for new preparations along with
the presence of "traditional preparations”.
Auth.
8.g.13.1.96. Alterations of gonadal
axis and concentration of sexual steroids in the phenol-intoxicated male
organism. /E. Melikadze, T. Kvatchadze,
It is known that the
male reproduction system is too sensitive to the impact of environmental
conditions. One of such endocrine deregulators is phenol. An experiment was
conducted on 60 adult male albino rats (body mass 200-250g). Each animal
experienced phenol intoxication daily during 15 days in a special closed cabin.
On the 60th day the animals were decapitated, and afterward in the blood serum
was defined the alternation of the concentration of the gonadotropic hormones
LH, FSH and sexual steroids - testosterone, estrone, estradiol - by means of
the immunoenzymatic method. Significant alternations in the hormones
concentration were revealed during the experiment: it was revealed that LH did
not stimulate testosterone secretion; conversely, it decreased, while the
estrogen concentration increased. The mentioned data enable us to conclude that
the impact of phenol vapor caused disorders in the male reproduction function.
Auth.
8.g.13.1.97. Age-related changes of
cholesterol index in erythrocyte membrane and their Influence on deformability
of erythrocytes. /M. Arabuli, R.
Khetsuriani, A. Shukakidze, D. Tophuria, N. Tchlikadze, I. Kirvalidze/.
Experimental and Clinical Medicine. – 2010. - #3(58). - pp. 40-43. – geo.;
abs.: rus., eng.
The research objective
was to study age-related changes of the index of erythrocyte membrane
cholesterol and their influence on the deformability of erythrocytes. Studies
have been performed in 3 age groups: new-borns (umbilical cord blood), adults
(22-30 years old) and elderly people (75-89 years old). Based on the results,
we can assume that erythrocyte deformability depends on the cholesterol index
of the erythrocyte membrane, and with less cholesterol the deformability of
erythrocytes increases. Erythrocyte deformability in new-borns is high, which
is due to the low content of cholesterol in their membranes. Deformability is
higher also in the elderly, because in their membranes cholesterol is less then
in the membranes of adults.
Auth.
8.g.13.1.98. Treatment of chronic
prostatitis in light of concomitant cardiovascular disease. /A. Bakuridze,
B. Iakobadze, N. Shavdia,
Given the favourable
impact of á-adrenoblockers
on the prostate function in order to improve blood circulation in the organ,
the preparation "Kardura” (2 mg once per day) was prescribed to 20
patients with chronic elderly prostatitis-associated cardiovascular problems
and disuretic disorders. In the complex treatment of uretroprostatitis, the activity
of the immune system increased, indicators of the pituitary-gonadal system
became settled, which makes it possible to recommend Kardura for the treatment
of prostatitis in the elderly.
Auth.
8.g.13.1.99. The action of biflazim
on the hypophyseal-gonadal and hypophyseal-adrenal systems during
non-gonorrheal urethritis. /A. Bakuridze, B. Iakobadze, N. Shavdia,
To investigate the
efficacy of thrombin-biflazim, the preparation was given per os after meals to
34 patients with non-specific urethritis complicated with scrotal inflammation.
Biflazim was effective to resolve gonadal inflammation and pathospermia.
Biflazim did not affect prolactemia, reduced follitropin and luteotropin to the
normal level, increased the level of testosterone and estradiol in the blood,
and regulated the function of gluco- and mineral cortical hormones.
Auth.
8.g.13.1.100. Morphological changes
developed in rat pancreatic islets during alloxan diabetes and after the effect
of plaferon. /I. Latsabidze/.
Experimental and Clinical Medicine. - 2010. - #3(58). - pp. 12-15. – geo.;
abs.: eng.
We have studied
sclerotic changes developed in rat pancreatic islets at different stages of
alloxan diabetes and after treatment with Plaferon. At the later term of
alloxan diabetes, the infiltration of islets with fibroblasts, lymphocytes,
plasmocytes, and collagen fibers takes place. In animals treated with plaferon
the activation of macrophages occurs and at the same time collagen lysis is
marked. It facilitates the movement of insular granules towards the capillary,
which is revealing of the compensatory-adaptation process.
Auth.
8.g.13.1.101. Immunotropic effects of the
preparation eskus-gel in the complex
treatment of arthritis. /T. Ghlonti, B.
Korsantia, K. Ghlonti/. Experimental and
Clinical Medicine. – 2010. - #5(60). - pp. 18-22. rus.; res.:eng.
The ointment eskus-gel possessing anti-inflammatory,
analgesic and local antiseptic properties is widely used to treat arthritis
caused by various diseases or injuries. For the first time the immunotropic
effect of the drug for pain in the knee joint was tested. The results showed a
more rapid normalization of the immune status of patients, especially – of the
interferon system against the control group. The immune response dynamics
depended on the treatment efficacy.
Auth.
8.g.13.1.102. Some clinical-cardiologic
indices in patients with chronic tonsillitis and rheumatic carditis. /I. Kekelidze, T. Khechinashvili, N. Jashi,
A diagnosis of chronic
tonsillitis is frequently associated with certain difficulties. At the same
time, the solution of diagnostic problems of tonsilogenic cardiac lesions is of
major importance in both theoretical and practical medicine. Therefore, the
authors of the conducted study have tried to work out efficient methods of
diagnosing, prevention and treatment of chronic tonsillitis and rheumatic
carditis. For this reason, based on the methods of clinical and
echodopplerography, 86 subjects, aged 11-45 years, have been studied. As a
result: a) close interrelation between the above-mentioned pathological
conditions was determined, b) accurate subsidiary methods of differential
diagnosis were developed; c) rational therapeutic tactics, including surgical
and conservative means of treatment, and timely preventive measures against the
disease and its complications were worked out.
Auth.
8.g.13.1.103. Modern literary data concerning
pancreatic cancer treatment. /L. Basiladze, A.
Tsalughelashvili, Z. Chomakhashvili/.
Experimental and Clinical Medicine. – 2010. - #6(61). - pp. 41-48. – geo.;
abs.: eng.
The authors have studies
103 literary sources, the bulk of which was published after 2000. The object of
the study is the data concerning the epidemiology, etiology, clinic, diagnosis
of cancer pancreatic and all kinds of cancer treatment. On the basis of their
study and analysis, the authors has concluded that the study of pancreatic
cancer is to start from the very beginning, that is the results existing at the
current stage should be analyzed and the ways of their improvement via
available methods should be implemented.
Auth.
8.g.13.1.104. Morphological characteristic of
fibroblasts in different histological types of colon and breast cancer. /T. Ghvamichava, I. Gachechiladze, T. Matchavariani,
K. Kavtiashvili,
The Investigation showed
an active process in the stromal elements of malignant tumors. The growth and
proliferation in the fibroblasts of malignant tumors were determined. The
changes in the stromal elements are supposed to be one of the reasons for
malignant tumor spread and growth.
Auth.
8.g.13.1.105. Symmetry of nervous plexuses of
human spinal cord and sympathetic trunk. /N.
Javakhishvili/. Experimental and
Clinical Medicine. – 2010. - #6(61). - pp. 8-13. – geo.; abs.: eng.
A study of the symmetry
and order of the spinal cord nervous trunks allows to suggest that the
connection of the thoracal nerves with the branchial, lumbar and sacral
plexuses displays a tendency of the human nervous system to develop the torso
size reduction and upper extremity lengthening. The same appears less
characteristic of the sympathetic nervous system. However, such tendency is
observed in its separate component – stellate ganglions of the branchial
plexus, i.e. the system has some connection with the human extremities
innervation.
Auth.
8.g.13.1.106. Functional anatomy of
intercostal muscles given biomechanical principles. /Z. Katsitadze, M. Abesadze/. Experimental and Clinical Medicine. – 2010. - #6(61).
- pp. 13-17.- geo.; abs.: eng.
A century long dispute
on the role of the external and internal intercostal muscles in the process of
respiration is still topical. Some of the authors consider them synergists, the
others – antagonists. As the authors of this article note, the dispute was caused
by the fact that all the above-mentioned researches were based on the data of
electromyography, according to which both types of muscles during inspiration
and expiration showed equally positive impulsation which must be considered a
display of reciprocal interaction. The authors of the article, using a method
of the biomechanical analysis, have proved the antagonism of the external and
internal intercostal muscles during respiration.
Auth.
8.g.13.1.107. Exfoliative cytology in
diagnostics of basal cell carcinoma. /N. Kiladze,
Basal cell carcinoma is
the most common type of malignant non-melanoma skin cancer. It is locally
invasive, aggressive and destructive, but has limited capacity to metastasize.
Since the proportions of these tumors are heavily pigmented, clinically they
may resemble invasive melanoma. The aim of this study was to evaluate the
reliability of the cytological method of examination, and comparison of results
with pathomorphologic data and dermatoscopic picture. 98 cases of pigmental
basal cell carcinoma were analyzed, and it was proved that exfoliative cytology
may become the method of choice as it has high sensitivity and specificity and
as well numerous advantages to offer the patient and dermatologist working in
an outpatient clinic.
Auth.
8.g.13.1.108. Detection of maspin and
mammaglobin transcripts as circulating tumor cell markers in peripheral blood
samples from patients with invasive ductal carcinoma of different malignancy
potential and molecular phenotype. /G.Burkadze, Z. Avaliani,
The presence of lymph
nodes and distant metastases is the most powerful prognostic factor for
patients with invasive ductal carcinoma (IDC) of the breast. Nowadays, there is
growing evidence that the detection of circulating tumor cells (CTC) in
peripheral blood samples might serve as one of the important markers of
metastatic potential, prognosis and relapse of IDC. Maspin and mammaglobin
transcripts in blood are frequently used as reliable markers for CTC. The aim
of our study was to evaluate CTC in peripheral blood samples from patients with
IDC of different malignancy potential and molecular phenotype, using maspin and
mammaglobin transcripts as CTC markers. Neither maspin nor mammaglobin
transcripts were detected in the I and IV group patients. Both maspin and
mammaglobin transcripts were detected in one patient from group II and 7
patients from group III. Only mammaglobin transcript was detected in one
patient from group II and also one patient from group III. The only CTC -
positive patient in group II was Her2-/ER/PR- as well as 6 CTC, positive
patients from group III. One CTC positive patient from group III was
Her2+/ER/PR-. Both mammaglobin positive patients from II and group III were
Her2+/ER/PR-. In conclusion, CTC is more likely to be detected in patients with
Her2-/ER/PR- IDC. This might be useful for evaluation of prognostic and
predictive factors in patients with IDC. This study was supported by the
research grant from the Georgia National Science Foundation #GNSF/ST08/6-461.
Auth.
8.g.13.1.109. Primary intracranial
gliomas: biological "behaviour”. /T. Mermanishvili, T. Jorbenadze,
The studies have clearly
shown that the degree of malignancy of glial tumours depends on their origin
(astrocytic, oligodendroglial and ependymal), as well as on the age and sex of
patients. Along with clinical parameters, these morphological data can
contribute to the selection of optimal prognosis and treatment for disease.
Auth.
8.g.13.1.110. Variants of division of
the hepatic artery in the liver portal. /N. Zosidze, G. Tsetskhladze, Z. Chomakhashvili, R.
Bolkvadze/. Experimental and
Clinical Medicine. – 2011. - #1. - pp. 34-38. – geo.; abs.: eng.
According to the results
of the conducted anatomic research the authors have come to the conclusion that
in cases when the left branch of the hepatic artery did not divide in the
portal area (3.7%) and the additional left artery of liver was revealed as the
only source for supplying the left part with arterial blood (2,5%), the only
one artery existed in the distal part of the left portal complex. In the distal
part of the left portal complex, in 81.2% of cases two arteries were revealed
(arteries of II and III segments), in 11.3% - three arteries (trifurcation type
division of either the left branch of the hepatic artery or of the left
additional artery), whereas in 1.3% - four arteries were found (trifurcation
type division of the hepatic artery’s left branch and the left additional
artery). In this part of the right portal complex, in 87.5% of cases the lobe
vein is accompanied by the right branch of the hepatic artery, in 2.5% by the -
right paramedial and lateral arteries, in 1.3% - by the right sector and
bladder arteries. In the rest 8.75% there were right additional and IV segment
arteries, out of which in 7.5% the IV segment artery was coming from the right
branch of the hepatic artery. The middle part of the right portal complex in
37.5% contained only the right lobe branch of the portal vein, while in 62.5%
there were two sector veins in this area.
Auth.
8.g.13.1.111. The effect of electromagnetic field
and vegetable preparation "Seratonus” on the active avoidance reaction. /G. Iordanishvili, M. Nikolaishvili, T. Museliani,
G. Jiqia, M. Tchitchakhua, K. Archvadze,
The electromagnetic
field of communication frequency evolves in rats a strong emotional reaction of
fear in response to the electric irritation. Chaotic movements and
emotional activity of the experimental rats caused by fear prevent them from
forming a stable response to the light-induced irritation in the nerve
structures and between the complexes of nerve structures responsible for the
avoidance reaction to a painful irritation, conditioning the reaction
deliverance from ailing irritation. Feeding the animals with the amino-acidic
preparation "Seratonus” removes the reaction of fear, decreases pain,
intensifies attention, and positively influences the animals’ behaviour in the
reflex avoidance reaction acquisition process.
Auth.
8.g.13.1.112. The effect of marigold
extract on experimental diabetes mellitus. /M. Esaiashvili, N. Gogia, T. Meladze,
Diabetes is a chronic
metabolic disorder that continues to be a major health problem worldwide. Many
studies suggest a central role for oxidative stress in the pathogenesis of this
multi-faceted metabolic disorder. This has prompted to investigate antioxidants
as a complementary therapeutic approach. Tagetes
patula L. is one of the French marigold groups of the Asteraceae family. It
is recognised in folklore for its medicinal and pesticide properties. Marigold
flowers produce lutein ester and patuletin, which have antioxidant activity. We
performed a diabetes study in mice exposed to streptozotocin and antioxidant,
marigold extract. Summarizing the experimental results obtained in mice treated
with STZ, we can conclude that an antioxidant, marigold extract reduces blood
glucose level, increases lifetime, and can, therefore, be used as a
complementary therapeutic agent.
Auth.
8.g.13.1.113. Determination of
hereditary characteristics of thyroid gland disease based on research of family
forms. /N. Zosidze, T. Lezhava, G. Tsetskhladze, Z.
Chomakhashvili, R. Bolkvadze/. Experimental and
Clinical Medicine. – 2011. - #1. - pp. 47-48. – geo.; abs.: eng.
The article aims at
determining the hereditary characteristics of the thyroid gland disease based
on family forms. The patients with a high index of composition of variable
metaphases were subjected to a treatment course that resulted in a reduction in
the rate of abnormalities and their approximation to the norm (3.3%). In the
mentioned groups, indices were corrected after the therapy course had been
over.
Auth.
8.g.13.1.114. Orexin-A to inhibit
bicuculline-induced multiple discharges in CA-1 field and modulate the activity
of bursting neurons in CA-3 field of hippocampal slices. /N. Doreuli, M. Alania, G. Vashalomidze,
The effects of
neuropeptide orexin-A on the epileptiform activity in hippocampal slices were
investigated. Orexin-A was found to decrease the duration/amplitude of multiple
discharges of population spikes and to inhibit the spontaneous epileptiform
after-discharges induced by bicuculline methiodide. Analyses of the effects of
orexin-A on the spontaneous activity of bursting neurons in CA-3 of hippocampus
has revealed that orexin-A modulates the bursting frequency of these neurons by
inhibiting neurons with high-frequency bursting discharges and by increasing
activity in silent or slow active neurons. Our results suggest a possible
involvement of orexinergic system in antiepileptic action.
Auth.
8.g.13.1.115. Age-related alterations of some
physical characteristics of red blood cells. /T. Sanikidze, M. Arabuli, G.
Lomsadze/. Materials of
Aim of the study – establishment
of some age related physical characteristics of red blood cells. Eritrocytes’
deformability, intracellular concentration of Na+, K+ ions,
and cells diameter in different groups (I group – 22-30 year, II group – 75 –
89 group) of men-volunteers were studied. As a result, it was established that
in the red blood cells of young volunteers the intracellular content of K+,
Na+ ions was lower than in the aged volunteers, due to s decrease in
cellular energotores with age. Age-related alterations of the ions content
induces the disorders of the cellular osmotic balance, swelling and increasing
diameter of the erythrocytes. As a result, in the aged volunteers their
deformability decreases.
Auth.
8.g.13.1.116. Reasons of pro-inflammatory
cytokines elevation in chronic heart failure. /N. Bregadze-Tabagari, L. Tvildiani, T. Talakvadze,
The aim of this study
was the investigation of TNF-α and IL-6 levels in blood serum and
clinical-laboratory parameters of the "protein-energy” status in patients
with chronic heart failure (CHF) of different functional classes (FC) and
etiology. A group of 95 patients with CHF was divided into 2 subgroups: (by
etiology – ischemic/non-ischemic: 50/45 and functional classes – II/III/IV:
32/40/23 respectively). We studied TNF-α, IL-6, albumin, total protein,
iron, creatinine, ferritin, BMI, lymphocyte differential count, also T3;
T4, T3/T4. Our data indicate statistically
significant elevation of TNF-α and IL-6 with increasing the FC and
decreasing "protein-energetically” status. It may be concluded that one of
the possible reasons of cytokines expression is protein insufficiency in
cellular nutrition.
Auth.
8.g.13.1.117. The pathomorphological,
pathophysiological and psycho-physiological equivalents of psychosomatic
pathology. /L. Ninoshvili/.
Psychosomatic diseases are unique and
distinctive: they invade human organism, disband the unity of body cover. This
time, the agent of disease provoker is not a substrate or a physico-chemical
agent. The frequency of psychic stresses and resultant psychosomatic deviation
in very great today: the pathologies clearly associated with mental stressed
have increased. The frequency of suicides has risen by 60% during the last 50
years. The affective-cognitive structure is always corporeally reflected, or
has a material impress- the somatic substratum equivalent, which, in this
case, means the brain problems caused by the nerve-cell dysfunction. This is
expressed by an acute excitation and increased activity of nerve cells in a
definite section and/or interconnected sections of the brain. Such activation
of the cells is always followed by a rise in
arterial blood pressure. The brain tissue
responds to it by swelling of the local microscopic level, which is expressed
by the formation around blood vessels of some "clouds", or the
so-called "muffs". Finally, after some time, this results in the
formation of demyelination loci, slowing down and deteriorating the
excitation processes of the nervous fibers in the damaged places. As a result,
disintegration of the excessive mediator or its recapture is impeded and
cathecholamines flow out through perivuscular liquor ducts. The brain cortex
inhibitor GABAergic interneurons fall victim to the cathecholamines’
aggression. Thus, it can be rightly to speak of the involvement of all the
sections of CNS in the psychosomatic pathology development process.
Auth.
8.g.13.1.118. Mechanisms of
preventions
of
a sudden
cardial
death
in patients
with
old myocardial infarction. /A. Isakadze,
G. Eliava/. Gaenati Herald. – 2010. – vol. 3, #4. – pp. 22-33. – geo.; abs.: geo.;
eng., rus.
A high risk of a
sudden cardial death in patients with old myocardial infarction urges to
look for new alternative ways of treatment. The pathologic
mechanisms of development of a sudden cardial death promote to the development
of electrical non-stability both in the zone of myocardial infarction and outside
it, leading finally, to the provoking of a ''malignant'' arrhytmia. According to literary data, in addition to the use of
a cardioverter-defibrillator, the utilization of ethyl esters of omega-3 fatty
acids is recommended for reducing the risk of a sudden cardial death. As clinical observations show, they have physiological cardioprotective effects. A study
of the current state of the aforesaid question has shown the necessity of further research in the problems of a sudden cardial death in order to
ascertain the limits of the reversible pathophysiological upheavals
during 6 hours after detection of acute symptoms, when the patient’s can be still saved.
Auth.
8.g.13.1.119. Peculiarities of
metabolic
processes
upon
action of noxious agents in lungs. /A. Isakadze, G.
Eliava/. Gaenati Herald. – 2010. – vol. 3, #4. – pp. 33-41. – geo.; abs.: geo.;
eng., rus.
During pathologic condition of the organism and the lung proper, the adaptation-compensation transformation
of tissue metabolism and gaseous exchange take place,
requiring additional energy spending. The effects of the
expired air, hypoxia and
bronchial asthma condition provoke transformanion of the redox process, the restoraion of generation of macroergic admixtures that are necessary for the
formation of
surface-active components of the surfactant and bronchial secretion
of the lungs.
Auth.
8.g.13.1.120. Clinical presentation
development peculiarities. /R. Mzhavanadze,
The progress achieved
in the cell structure study has conditioned a substantial rapprochement of morphology and biochemistry. The weaker are the compensatory-adaptive reactions on noxious agents, the more expressed is
the correlation between
the morphological changes and dysfunctions and the clinical presentation.
Auth.
8.g.13.1.121. The Morgan-Adams-Stokes syndrome
and difference
of its signs from signs of an epilepsy
attack. /D. Gugeshashvili, G. Eliava/. Gaenati Herald. – 2010. – vol. 3, #4. – pp. 48-54. – geo.; abs.: geo.;
eng., rus.
The number of disorders
requiring the assistance of a pacemaker has widened. Lately it is being also
used in the cases when chronotropic and dromotropic preparations are used for
various occasions. The Morgan-Adams-Stokes syndrome is
the most frequent expression of a circulatory collapse. In contrast to an epilepsy seizure,
it is not characterized by aura, salivation,
foaming at the mouth, but by a change of complexion. Prognosis depend on a timely beginning of
electrocardiac stimulation in the case of the Morgan-Adams-Stoke syndrome
recurrent attacks.
Auth.
8.g.13.1.122. Mechanisms of dysfunction of
vital
organs in case of various anemias. /A. Isakadze, G.
Eliava/. Gaenati Herald. – 2010. – vol. 3, #4. – pp.
55-61. – geo.; abs.: geo.; eng., rus.
In most cases, the type of anemia in the structure of disease
should be identified. Identification of the pathogenic mechanisms promotes to the conduct of an adequate therapy.
The chronic hypoxia and circulatory dysfunction can provoke a heart failure.
Identification of the dysfunctions dependent
on the localization of hemodynamic disorders will be identified in various body
organs and parts.
Auth.
8.g.13.1.123. Dynamics
of arterial
hypertension
in population
surveys.
/D. Gugeshashvili, G. Eliava/. Gaenati Herald. – 2010. – vol. 3, #4. – pp. 69-75. – geo.; abs.: geo.;
eng., rus.
A significant variability in the spread of arterial hypertension in individual populations is conditioned by a whole series of factors: ethnic, socio-economic, etc.
Upon conduct of treatment and preventive activities and forming patient
groups, both systolic and
diastolic arterial pressure should be taken into
account. Given high myocardial ischemia mortality, isolated systolic arterial hypertension should be prioritized as the main cause of the above.
Auth.
8.g.13.1.124. Evolutionary changes in the structure
and secretion of salivary glands. /G. Eliava,
The evolutionary principles have been detected in
salivary glands, the essence of which consists in assuming a reinforcing
function in the creation of a material substratum and additional functions in
duplication of other organs.
Auth.
8.g.13.1.125. Structural and functional changes of
lungs in an antenatal and postnatal ontogenesis. /D. Kobeshavidze,
In addition to breathing, lungs have other functions
as well, such, for example, as the taking part in heat regulation, secretary
function, and protective function. The maximum quantity of bronchial rows is
achievable by the sixteen-week development upon embryonic development of lungs.
Intensive “alveolization” is characteristic of newborns till the age of five.
In a postnatal ontogenesis, the development of lungs is characterized of both
the growing of acinuses and the continuous transformation of all their
structures.
Auth.
8.g.13.1.126. Perspectives of use of balloon coronary
angioplasty and coronary artery bypass grafting during different manifestations
of ischemic heart disease. /D. Gugeshashvili, G. Eliava/. Gaenati Herald. – 2010. – vol. 3, #3. – pp. 85-90. – geo.; abs.:
geo.; eng., rus.
In addition to drug treatment, coronary angiography is
recommended for patients with a severe angina, in order that balloon coronary
angioplasty or coronary artery bypass are conducted according to the degree and
character of the damage of coronary arteries. The use of early revasculization
technologies improves both the short-term and long-term prognosis.
Auth.
8.g.13.1.127. Characteristics of a change in the
cardiovascular system state during patent Botallo’s duct lumen of different
size. /D. Gugeshashvili, G.
Eliava/. Gaenati Herald. – 2010. –
vol. 3, #3. – pp. 91-96. – geo.; abs.: geo.; eng., rus.
Congenital malformations are anomalies of the
embryonic development of heart. One of the frequent anomalies is the patent
Botallo’s duct functioning in the embryonic period. When the Botallo’s duct has
a small lumen, the decompensation effects are not manifested for a long time.
When the duct is large, the prognosis is unreliable, this being associated with
the development of a septic process in the duct and its further transfer to
both the valves and the development of decompensation.
Auth.
8.g.13.1.128. Novel approaches to the prevention of
chronic kidney disease in patients with the metabolic syndrome. /N. Khipshidze, T. Gamezardashvili/. Bulletin of the
The metabolic syndrome
(MS) is a major public health threat. Individuals with MS are at increased risk
for development of chronic kidney disease (CKD). Despite effective medical
interventions that have targeted vascular renin-angiotensin system (RAS)
blockade, the prevalence of CKD remains considerably high. Few studies have
directly compared the
Auth.
8.g.13.1.129. Effects of DASH and sodium-restricted
diets on blood pressure in the normotensive elderly. /I. Andronikashvili, G. Simonia,
During the past century,
the evidence for the risks imposed on human health by excess salt consumption
was compelling. The causal relation between habitual dietary salt intake and
blood pressure has been established through experimental, epidemiological,
migration, and intervention studies. The aim of the work was to select from
persons having normal arterial pressure the salt sensitive ones and using DASH
and sodium-restricted diets to set the perspective for the development of
preventive measures. Salt sensitivity was assessed in normotensive 54 young and
68 elderly males. Accordingly salt sensitive subjects were divided into two
groups in accordance with age. Salt sensitivity was assessed by the difference
of mean arterial pressure (MAP) on high (200 mmol/day) vs. low (40 mmol/day)
salt diet. Compliance with the diet was confirmed by measurement of 24-hour
urinary sodium excretion during the last 2 days of both weeks. As was
mentioned, both the DASH diet and DASH diet with lower sodium intake caused
mean arterial pressure decrease, but the combination of the DASH diet plus
lower sodium intake consistently produced the greatest mean reductions in blood
pressure with peak levels in the elderly. Based on our results, we can suggest
that in spite of the fact that diet modifications cannot influence the genetic
nature of salt sensitivity, it can lower the mean arterial pressure in
normotensive salt sensitive individuals, thus creating the possibility of its
use for hypertension prevention.
Auth.
8.g.13.1.130. A new method of conservative residual
OME treatment. /S. Khechinashvili, M.
Gedevanishvili, N. Sharashenidze,
Nonsurgical conservative
therapy was used for residual OME (otitis media with effusion) treatment. In
this article OME is considered as chronic secretory salpingootitis. Secretory
salpingootitis in all patients studied developed in consequence of acute otitis
media (AOM). Patients were distributed in 4 groups and were treated by
instillation of Sinuforte/Nasodren spray (standardized Cyclamen tuber sap, S/N)
in both nostrils once daily for 10 days. The results of S/N monotherapy were
compared with outcomes of combined S/N/antibiotic, and standard
antibiotic/decongestant therapy. Results indicate that treatment based on
administration of S/N as a constituent of the therapy is associated with a
significant clinical benefit. Outcomes in S/N monotherapy group and combined
S/N/antibiotic group were obviously more favorable than in the group to which
the standard method of conservative OME treatment was applied. Clinically
proved curative outcomes of salpingootitis in humans treated with S/N could be
explained by prompt reflex discharge from hyperplastic/hypertrophic glands,
resulting reduction in edematous state of the mucosal lining in the auditory
tube, opening of the pharyngeal orifice of the tube and consequent facilitated
propulsion of exudates out of tubar, and respectively, middle ear cavities. In
other words, beneficial outcome is achieved due to effective draining of middle
ear cavity by inherent, natural way. These results permit to consider topically
applied S/N as an adequate stimulus for physiologic reflex discharge of
inflammatory secretions out of the auditory tube and for its frequent opening.
Auth.
8.g.13.1.131. Assessment of functional relationship
between the arterial pressure and heart rate variability in patients with
arterial hypertension. /M. Janiashvili, T.
Matcharashvili/. Bulletin of the
The report presents the
results of an analysis of functional relationship between arterial pressure and
heart rate variations in patients with arterial hypertension. We used the
method of mutual information calculation, which enables to assess both linear
and nonlinear correlations in analyzed data. It was found that functional
relationship between systolic and diastolic pressure increases at the first and
second stages of arterial hypertension, while at the third stage of disease it
decreases to the initial value. On the other hand, changes in the extent of
functional relationship between arterial pressure and heart rate variability
were not detected at increased severity of arterial hypertension.
Auth.
8.g.13.1.132. Diabetes mellitus and impaired
glucose tolerance among patients with coronary heart disease. /G. Chapidze, S. Kapanadze, N. Dolidze, N. Latsabidze,
N. Meshveliani/. Critical Care & Catastrophe Medicine. – 2009. - #5. –
eng.; abs.: eng., geo.
Diabetes mellitus (DM)
and impaired glucose tolerance (IGT) are associated with increased
cardiovascular disease (CVD) morbidity and mortality. DM and IGT prevalence and
their relation to other risk factors were investigated among coronary heart
disease (CHD) patients. 250 In- and outpatients with CHD visited or/and
admitted to the
Auth.
8.g.13.1.133. Progenitor precursors'
commitment during an acute stroke. /Z. Kheladze,
According to the
Critical Care Medicine Institute, 659 patients with stroke, 49.1% of which were
with ischemic heart and 50.9% - hemorrhagic stroke were treated. The coma
degree in all the patients was GCS-8 and less; general mortality constituted
49.3%, stroke mortality - 26.5%, and that of hemorrhagic stroke - 71.3%. The
stroke treatment standard included respiratory therapy (SIMV, PS & PC
modes), accompanied with a moderate hyperventilation and control of acid-base
balance markers, magnesium and polyelectrolyte therapy, enteral/tube feeding
(400 kcal/kg/24 hrs), etc. In addition to traditional therapy, the progenitor
precursor commitment was managed by nitroglycerine, electric current and plasma
beams (Zv.Kheladze, et al "New usage of electro impulses generator”,
patent, 2008.07.01 #4857; Zv.Khelade at all. "New usage of plasma flow
producer”, patent 2008.06.26 #4825, Z.Kheladze, Zv.Kheladze “New usage of
nitroglycerin”, patent of 2008.07.11 # P4858). In the course of the therapy, it
was established that the management of commitment of progenitor precursors
improves the critical state treatment results, especially in patients with
ischemic heart disease. In particular, the treatment reduces lethality and
disability, shortens the length and cost of the treatment.
Auth.
8.g.13.1.134. Cardiohemodynamics at
bi-directional A-V & V-A blockade. /R. Shonia/. Critical
Care & Catastrophe Medicine. – 2009. - #5. – eng.; abs.: eng., geo.
At the bi-directional
A-V and V-A blockade of fourth degree accompanied with various frequencies of
atrial and ventricular rhythm several kinds of transient cohesion of atrial and
ventricular cycles that determined quantitative characteristics of hemodynamic
loading on myocardium, its contractility and systolic output were detected. The
sizeable change (decrease or increase) of ventricular rate in comparison with
atrial rhythm leads to a reduction in the absolute number of hemodynamically
effective atrial systoles and prodigal pattern of the heart functioning. During
this pathology, the maximum number of hemodynamically effective atrial systoles
is formed only if the length of the atriums and ventricles cycle is equal. Many
compensatory mechanisms in the pathological regime of myocardium have been
studied. They elucidate the formation of the pathological clinical symptoms,
which develop in patients with the mentioned abnormalities.
Auth.
8.g.13.1.135. Peculiarities of treatment of
the elderly in critical medicine. /Z. Kheladze, L.
Lobzhanidze, Zv. Kheladze/. Critical Care & Catastrophe Medicine. – 2009. -
#5. – eng.; abs.: eng., geo.
In the Critical Care
Medicine Institute the number of old-aged critical patients during last three
years has markedly increased. Only in 2000-2009 hospitalized were 152 critical
patients from 81 to 101 years of age (average age – 89.6). The treatment of one
patient on average costs USD 1678.5. The most frequent diagnosis was stroke,
the ischemic stroke being prevailed. Patients were subjected to artificial
pulmonary ventilation and other therapeutic measures, including the progenitor
precursors’ commitment therapy. General mortality rate made 48%; the highest
death rate was registered in the cases of various shocks and acute stroke,
making 49.4% and 30-80% respectively. The mortality was the lowest during the
hypovolemic shock. In old-aged critical patients’ group the "ventilator
adaptation syndrome” was typical. Also of importance were the question of
selection of the optimum dosage of drugs, plurality of concomitant diseases and
other peculiarities. The analysis shows the efficiency of the intensive care in
old-aged critical patients.
Auth.
8.g.13.1.136. Breast cancer in critical and
non-critical patients. /N. Gordadze, M.
Kakabadze, U. Gabunia,
The breast cancer of the
IV stage is morphologically and clinically heterogeneous disease. However, it
is less clear how clinical features relate to tumor characteristics and
histological specificity in critical and non-critical female patients. In
accordance with these goals, it was necessary to accomplish a
morpho-epidemiological research in
Auth.
8.g.13.1.137. Two cases of the neuroleptic
malignant syndrome. /Z. Kheladze, Ts.
Kharaishvili,
The neuroleptic malignant
syndrome was first described by Dr. Delei in 1960. It is caused by negative
side-effect of the neuroleptic and anti-psychotic drugs. The frequency of the
neuroleptic malignant syndrome makes about 3-27%, the mortality rate being 40%.
The neuroleptic malignant syndrome’s pathogenesis is dysfunction of the
central, dopamine and sympathetic nervous system and skeleton muscle membrane,
etc. It diagnosed based on antecedent anamnesis, past drug, life and family
history and clinical presentation. The treatment program includes muscle
relaxants and dopaminergic drugs, psychotropic activity decreasing medications,
plasmapheresis, hormonotherapy, brain anti-edema, nosotropic, routine infusion
therapy, etc.
Auth.
8.g.13.1.138. Ventricular tachycardia in
critical patients. /R. Shonia/. Critical
Care & Catastrophe Medicine. – 2010. - #6. – eng.; abs.: eng., geo.
The effect of various
electrical versions of ventricular tachycardia on cardiohemodynamics has been
studied.
Auth.
8.g.13.1.139. New data on the pathogenesis of
intracerebral hematomas. /T. Kerdzevadze, G.
Gegia, Zv. Kheladze/. Critical Care & Catastrophe Medicine. – 2010. - #6. –
eng.; abs.: eng., geo.
The present work is
another attempt to study the pathogenesis of hemorrhagic stroke; the analysis
is based on the several well-known facts in medical practice and the
experimental data. Sudden, uncontrolled changes of arterial blood pressure
results in recurrent hemorrhage, ICP growth and perfusion blood pressure
reduction. For arterial blood pressure correction ganglioblockers and
peripheral venodilatatores should be used. Sudden decrease of intracranial
pressure leads to sharp expansion of vascular diameter prior to hydrodynamic
attacks (for example due to lumbar puncture). It may be one of the reasons of
sudden deterioration of neurological status. Also likely to be assumed, that a
strong headache due to aneurysm rupture is caused by blood intrusion into the
ventricular system.
Auth.
8.g.13.1.140. Subconscious management
problems in the critical care medicine.
/Z. Kheladze, G. Bakaia, T. Kurtsikidze, M. Dvalidze/. Critical Care &
Catastrophe Medicine. – 2010. - #6. – eng.; abs.: eng., geo.
The aim of the first
part of the research was to find out the Midazolam’s effect on rats movement
activity and behavior. The research was performed on white, male 250- 300 g
rats. In the clinical part of the research, 12 adult patients were observed
with an attempt to manage their subconscious. The results obtained found
Midazolam to be an effective and desired sedative agent for managing the
subconscious. This does not exclude usage of other agents for the purpose.
Auth.
8.g.13.1.141. Hepatic encephalopathy –
damage of neurolinguistic code.
/M. Meparidze, T. Kodua, Zv. Kheladze, K. Lashkhi/. Critical Care &
Catastrophe Medicine. – 2010. - #6. - eng.; abs.: eng., geo.
A variable spectrum of
psycho-mental symptoms developed due to hepatic insufficiency, disruption of
communication between the body and the environment, the digestive and the
nervous systems is given. 106 patients with different gastrointestinal
pathologies, divided into 4 groups and 19 patients of the control group were
observed. The study results are given and the following conclusions made: The
damage of neuromatrix and linguistic matrix under the impact of external
(environmental, verbal, nonverbal) and internal (dismetabolic) factors and
deformation of those matrixes are formed at different levels (interpersonal,
mind-body, etc.). Hepatic encephalopathy is not a pathology caused by the liver
failure. The full-blown picture of HE may be produced by verbal or nonverbal
influence on the patient’s brain – through deformation of the linguistic code.
Auth.
8.g.13.1.142. The hepatoprotective effect of verapamil
during a hemorrhagic shock in an experiment. /M.
Gvaladze, T. Gegeshidze, Gr. Sulaberidze, G. Didava, M. Chkhaidze,
During hypoxic state, especially for the period of
hemorrhagic shock, lyses of liver parenchymal cell membranes occur due to
calcium ion excess. Membrane protection from such a pathologic process is
theoretically possible through blockage of the calcium L channels, namely – by
verapamil. The later was utilized to study its hepatoprotective effect.
Modeling of the hemorrhagic shock was performed by Wiggers-Feine method. Blood
was exfused from sedated male cats (nembutal 40mg/kg, intravenous blood
exfusion 40ml/kg) till arterial blood flow dropped to 40 mm/Hg (HS60). During
artificial ventilation - 130-150 ml/min/kg in the period of 1 hour, pH in the
arterial blood was 7.35-7.45, PO2 – 90mm/Hg; the airflow measurement
was controlled by the “
Auth.
8.g.13.1.143. Influence of arterial pulse on blood
flow. /M. Beraia/. Georgian Journal of Radiology.
- 2010. - #1-2 (34-35) – pp. 8-11. - eng.;
abs.: ge.
Description of blood flow only by means of
Navier-Stoke equation is impossible currently, since hemodynamics in large
arteries is unsteady, with the flow separation and waveform propagation of the
viscoclastic mass. The purpose of the present paper is to study the influence
of arterial pulse on blood flow. Pulse pressure is increasing stain rate at the
contiguous flow layers. At the circular sites in protodiastola flow separation
and wave superposition promote to high net flow. At the circular sites flow
wave interference and reflection constrain the endothelial boundary layer to
shift.
Auth.
8.g.13.1.144. Non-epileptic paroxysmal disorders. /D. Gigineishvili, R. Shakarishvili/. Georgian
Journal of Radiology. - 2010. - #1-2 (34-35) – pp. 12-15. - rus.; abs.: eng.
We retrospectively analyzed diagnoses of all
inpatients (34), of whom non-epileptic seizures (NES) have been identified in
the Epilepsy Centre during a period of 12 months. NES of psychogenic origin
(82.4%) prevailed over physiologic NES (17.6%) and conversion-somatoform
disorders (ICD-10) were the most frequent diagnostic in the first group
(71.4%), whereas neurally mediated syncope – in the latter (50%). There was a
female predominance (20/14) in the whole group. Evidence of coexisting epilepsy
was found in 3 cases, all of them in the group with conversion-somatoform
disorders. Our data indicate that psychiatric as well as cardiologic evaluation
of patients with treatment-refractory or undiagnosed seizures can clarify the
final diagnosis.
Auth.
8.g.13.1.145. The quantitative estimation of cerebral blood
flow in patients with severe traumatic brain injury. /R. Fanarjian/. Georgian Journal of Radiology. - 2010.
- #1-2 (34-35) – pp. 16-19. - eng.; abs.: rus.
Our study of cerebral blood flow in severe
traumatic brain injury is an example of the effective use of TCD in the daily
practice of neurological and neurosurgical hospitals. High
self-descriptiveness, relative simplicity and non-invasive usage allow
monitoring of cerebral hemodynamics and identifying efficiency of the conducted
pharmacotherapy. The obtained quantitative data can serve as criteria for
prediction of outcomes. Many aspects of pathophysiological mechanisms of blood
flow alterations in severe head injury require further research. A combination
of clinical data and highly informative methods of study is required to identify
effective methods for their correction.
Auth.
8.g.13.1.146. Manganese
encephatolopathy induced by synthetic psychostimulants. /M. Okujava, M. Janelidze, I.Khatiashvili,
In the last two decades
the use of a "designer drug” - methcathinone (otherwise known as Jeff or
Ephedrine) has increased in Eastern European countries. This psychoactive
substance is synthesized from widely available and relatively cheap ingredients
– over-the-counter drugs, which contain ephedrine and potassium permanganate.
The increasing number of patients with chronic use of methacthinone having
addressed our department indicates on the threatening scale of the problem.
During the last 4 years we have investigated 32 patients with chronic
intravenous use of methcathinone. The duration of the substance abuse ranged
from 1.5 month to 3 years. The frequency of indication ranged from 1 injection
per week to 4 injections per day. The most common symptoms were: bradykinesia,
postural disturbance, ataxia, dysarthria, dysphonia, hypometric vertical
saccades, dystonia (mostly of the face and lower extremities), apathy and
cognitive decline. Disability of the patients was evaluated using Schwab and
England Scale. Twelve cases showed deep disability (Scwab and England Scale
<50%). Patients from this group needed assistance during their daily
activities due to the evident ataxia and postural disturbances. Substance abuse
with the duration of more than 6 months was associated with stable strong
disability which was not regressing despite the cessation of the drug abuse and
the treatment with the L-dopa medications. All patients underwent MRI of the
brain.
Auth.
8.g.13.1.147. Primary intracranial astrocytic
neoplasms: some epidemiologic considerations.
/T. Mermanishvili, Ò. Jorbenadze,
The aim of our study was
to perform à hospital-based
epidemiological analysis of primary intracranial astrocytomas in
Auth.
8.g.13.1.148. Òhå role of mammography in
the diagnosis of breast pathologies in males. /T. Daraselia, Ê. Gigauri, Ò. Chagnelia/. Georgian Journal of Radiology. - 2010. -
#1-2 (34-35) – pp. 62-66. - geo.; abs.: eng.
Gynecomasty in males
gives a vivid clinical picture of steroid hormone imbalance caused with
absolute and relative hyperestrogenemia. In males the tumor of mammary gland is
ïît frequent ïàd it needs differentiated diagnostics other than the
nodular form of gynecomasty. Early diagnostics of the tumor has the decisive
meaning from the viewpoint of the treatment and prognosis of the disease, but
the screening program is ïît provided for the early
stage of revealing of the pathology of mammary glands in males and the
mammography is usually made àt later period after
revealing of the clinical sings.
Auth.
8.g.13.1.149. Analysis of data of dysbacteriosis
syndromes in patients with diarrhea, constipation and mixed symptomatology. /I. Giorgadze, N. Tophuria, M. Giorgadze, N.
Balarjishvili, N. Cholokashvili, L. Tkemaladze/. Proceedings of the
In the classification of WHO, dysbacteriosis or
disbios is considered to be not a separate nosologic unit but a syndrome and,
therefore, secondary. It is supposed that there is a direct connection between
the symptoms of dysbacteriosis and gastrointestinal diseases - diarrhea,
constipation and their combinations. The goal of this study was to establish
which of the symptoms was leading in patients with dysbacteriosis syndrome -
diarrhea, constipation or their alteration and average clinical manifestation.
Total of 1040 patients were investigated. Only dysbacteriosis or decay from
normal flora was revealed in 814 cases. In cases of dysbacteriosis the quantity
of the patients with diarrhea symptoms significantly exceeds the quantity of
the patients with constipation and combined symptoms in the whole contingent of
the patients as well as in the patients with dysbacteriosis during the changes
in one, two, three or all the four representatives (bifidumbacter,
lactobacteria, enterococci and intestinal bacillus). In age groups - children’s
contingent - cases of symptoms of diarrhea were revealed twice more than in
adults. So, in patients with dysbacteriosis syndrome, the symptoms of diarrhea
were more as compared to constipation and mixed symptomatology.
Auth.
8.g.13.1.150. Microbiological diagnosis of mixed
anaerobic-aerobic infections during complicated Infections. /M. Giorgadze/. Proceedings of the
Treatment of wounds is one of the pressing problems
that are hard to solve. Totally, we have investigated 35 cases in dogs of
random breed. In the first group, the animals with symptoms of mixed
anaerobic-aerobic infections were included, 11 of them had infection of
abdominal cavity, 13 - inflammation of soft tissue. In the second group, the
operated animals with symptoms of peritonitis and generalized infection were
included. Using bacteriological analysis, in 22 animals of the first group
obligate anaerobic bacteria were found, 20 of them from peritoneum, and 14
animals had them in the mediastinum area and pleural cavity; 10 of bacterial
isolation was in case of soft tissue infection. Gram-positive bacteria and
cocci were sensitive to most antibiotics, but aminoglycosides. Staphylococci
are sensitive to monomycin, streptomycin, tetracycline, macrolides. E. coli was still sensitive to
aminoglycosides, but penicillin group antibiotics are losing their efficacy.
Auth.
8.g.13.1.151. Alteration of blood redox-status during
cholelithic disease in postmenopausal women. /M.
Shengelia, N. Gogebashvili,
Cholelithic disease is one of the most widespread
diseases of the digestive tract. Taking into attention that the cholelithic
production often is associated with the inflammatory and other processes
connected with oxidative stress, we have proposed that the alterations of
oxidative metabolism and formation of signal molecules - reactive oxygen and
nitrogen species are very important pathogenetic links in the pathogenesis of
the cholelithic disease. The aim of our study was the establishment of alterations
of blood’s redox-status during the cholelithic disease in postmenopausal women.
As a result of our studies, we have shown that during the cholelithic disease
in postmenopausal women an oxidative degree of blood ceruloplasmin increases,
and Fe3+- transferrin content decreases which points to the
disorders of the one of the links of blood antioxidant system, which is
favorable for alteration of redox-homeostasis and injury of membrane structures
in patients’ body. This is revealed by increasing the content of products of
lipoperoxidation (Mn2+ions, lipoperoxides, superoxides). Under
oxidative stress conditions it is possible to excess oxidation of natural
antioxidants (bilirubin), which is accomplishing for the development of
inflammatory processes and cholelithic formation.
Auth.
8.g.13.1.152. The effect treatment with
intranasal electrophoresis of vanadium on the function of external breathing in
patients with allergic rhinitis. /Sh. Tsiklauri/.
Proceedings of the
Total of 67 patients have been examined, out of which
35 patients had a persistent form of allergic rhinitis. 32 patients had an
intermittent form of allergic rhinitis. It has been established that treatment
with intranasal electrophoresis of vanadium induced expressed improvement of
bronchial permeability in these patients, as well as increase of reserve
possibilities of lungs and decrease, up to complete elimination, of arterial
and venous hypoxemia. The above-mentioned positive shifts were significant in
patients with intermittent form of allergic rhinitis.
Auth.
8.g.13.1.153. Effectiveness and safety of early
treatment by ezetimibe and statins in patients with acute coronary syndrome. /N. Khipshidze, Th.
Gegenava, K. Nadaraia/. Cardiology and Internal Medicine. - 2010 - ¹ 3-4(31-32). . – pp. 9-12. – geo.; abs.: eng.
According to our study, for patients with
NSTE-ACS, a ezetimibe/atorvastatin combination provided superior lipid-lowering
efficacy vs doubling the statin doze. After 16 weeks of study, superior
clinical benefit was revealed on nonfatal MI and unstable angina that requires
hospitalization, although without a statistically reliable difference on the
frequency of coronary death, coronary revascularization and nonfatal stroke.
Auth.
8.g.13.1.154.
The acute coronary syndrome (ACS) is a topical and
significant problem nowadays. Development of ACS predicts transfer of chronic
ischemic disease into the acute phase and is the most frequent reason of
hospitalization. Evaluation of risks of patients with acute coronary syndrome
has shown that the main factors associated with in-hospital mortality and
development of cardiovascular diseases are: age (70-80 year); ST-segment
elevation, myocardial infarction and heart failure. Diabetes and age - 60-69
years are associated with the average risk, and 40-59 years – with the low one.
Auth.
8.g.13.1.155. Surgical treatment of heart failure caused by
coronary heart disease and severe valvular pathology (case report).
/E.Pirvelashvili, L. Janelidze,
Severe mitral and tricuspid regurgitation associated
with myocardial ischemia is a Class I indication for cardiac surgery. Mitral and tricuspid
annuloplasty or mitral valve replacements are
performed during coronary bypass surgery with
the aim of improving the patient´s ventricular function and clinical symptoms.
The purpose of this case is to review the role of cardiac surgery in the
management of such combined
pathological conditions.
Auth.
8.g.13.1.156. Resistant arterial hypertension. /N. Katamadze, S. Beridze/. Cardiology and Internal Medicine. - 2010 - ¹ 3-4(31-32). . - pp. 23-29. - geo.; abs.: eng.
Resistant arterial hypertension is diagnosed when the
target tension according to the optimal treatment
with a three-component scheme (including
thiazid diuretics) is not achieved or the treatment with a four- component (or more) scheme is
effective. Arterial hypertension
with corrected reasons and/or forms which need motivated additional research
also belong to resistant
hypertension. Distribution of resistant arterial hypertension is high - 10-30%
of patients with arterial hypertension have this form. Elimination
of the reasons of pseudo-persistency, correction of secondary reasons of
arterial hypertension and effective treatment improve the prognosis of arterial hypertension.
Auth.
8.g.13.1.157. Crohn’s disease and Melkersson-Rosenthal
syndrome. /Kh. Pachkoria, M. Abesadze, S. Kemoklidze, M. Kikvidze,
The Melkersson-Rosenthal syndrome (MRS) is a rare
condition characterized of a triad of recurrent oral-facial swelling, commonly
affecting lips, intermittent facial nerve palsy and tongue changes (lingua
plicate). Oligosymptomatic forms are more common. The authors observed 2 women
with a classic triad of MRS. In the first case, treatment with corticosteriod
was successful, but after 5 months swelling relapsed. In the second case,
diagnosis of jejunal Crohn’s disease (CD) and Melkersson-Rosenthal syndrome
were established. Treatment with corsticosteroid (Medrol) was successful, but
lip and facial swelling relapsed and hirsutism and obesity were detected.
Auth.
8.g.13.1.158. Liver function and outcome in patients with
chronic heart failure: abnormal elevation of serum hepatic enzyme and
therapeutic efficacy of NAD-containing drugs. /M.Rogava, T.
Bochorishvili, K. Kapanadze, E.Berberashvili/. Cardiology and Internal Medicine. - 2010 - ¹ 3-4(31-32). - pp. 33-37. - eng.; abs.: geo.
Therapy of Nadcin in patients with heart failure and
preserved left ventricle function and Adenocin in patients with pronounced
contractile dysfunction leads to a pronounced improvement of NYHA FC of CHF and
exercise capacity. Cardiac deremodeling and
Auth.
8.g.13.1.159. Dysmetabolic arterial hypertension. /J. Lezhava/. Cardiology and Internal Medicine. - 2010 - ¹ 3-4(31-32). . - pp. 38-48. - geo.; abs.: eng.
Since the first publications about the metabolic
syndrome, a large amount of data about its clinical significance has appeared.
A series of investigations have demonstrated the important role of this syndrome in the
development of diabetes mellitus, coronary heart disease, atherosclerosis and
arterial hypertension, often
accompanied by dangerous complications. Nevertheless, controversial points
still exist regarding diagnostic criteria, which allow us to identify metabolic
syndrome in scientific studies and routine practice. In this review we made an attempt to
analyze different approaches to this problem in light of results of
contemporary investigations.
Auth.
8.g.13.1.160. The urgency of cystic fibrosis problem.
/N.Badriashvili, N.Sharikadze, M.Giorgobiani/. Cardiology and Internal Medicine. - 2010 - ¹ 3-4(31-32). . - pp. 49-51. - geo.; abs.: eng.
CF is a chronic multi-system disorder characterized by
recurrent endobronchial infections, progressive
obstructive pulmonary disease and pancreatic
insufficiency with intestinal malabsorbtion.
We investigated 38 children with CF aged from
1 month to 14 years who were hospitalized in pediatric clinic of TSMU. The
sweat chloride test (chloride concentration 60) was used to diagnose CF. The investigation showed
that in 38 patients 25 were with combined and 13 with pulmonary form of CF. The study revealed a
marked depression of immunity characterized by reduction of quantity: of CD3, CD4,
CD19-lymphocytes and the concentration of IgG, IgA, IgM. Parameters of
interferon-producing leukocyte function were studied in vitro using the
Soloviev-Bektenirov technique. Patients with CF received complex treatment, which
included: Creon, Bronchodilatators, Mucolitic
agents, and Antibiotics, Imudon, URS-19,
vitamine for correction of immune system. There were also used nutrition and
kinesis therapy.
Auth.
8.g.13.1.161. Allergic rhinitis and
its impact on asthma - ARIA. /N. Khaltaev, J.
Bousquert/. Georgian Pediatrician. - 2010.
- # 1-2. – pp. 27-35. –
geo. eng.
Allergic rhinitis is a
global health problem. It influences social life, sleep, study, and work
process. In 1999 as a result of activities of WHO, a document ARIA was adopted,
which was a recommendation with special significance for specialists and
professionals, also general profile doctors. The ARIA update started in 2004,
although the 1999 ARIA work group recommendations are still in force.
N. Chkaidze
8.g.13.1.162. Damage of the
cardiovascular system during juvenile rheumatoid arthritis. /G. Chakhunashvili,
Juvenile rheumatoid
arthritis is urgent nowadays and it is extremely interesting to forecast
further disorders of organ systems. The article deals with modern literary
discussions about the damage of the cardiovascular system during juvenile
rheumatoid arthritis. Our literary discussion proves once more that the
cardiovascular system’s damage plays a great part in the development of
juvenile rheumatoid arthritis. It needs proper attention and treatment in the
early stages. Often the cardiovascular system’s damage develops without any
symptoms; therefore, routine cardiologic examination should serve as a basis
for prognostication and monitoring of these patients.
Auth.
8.g.13.1.163. Myopericarditis
(case study). /G. Chakhunashvili, T. Kutubidze, M.
Shvangiradze/. Pediatric Cardiology. - 2011 - ¹ 5. - pp. 33-34. - geo.; abs.: geo., eng.
The article describes
the treatment of a 14-year aged patient having addressed the clinic with severe
sternal and back pain and diagnosed with an acute myoppericarditis.
Auth.
8.g.13.1.164. Cost effectiveness of an antimicrobial
therapy. /R. Jashi/.
Social, Ecological and Clinical Pediatrics. – 2011. - #13-8-7. - pp. 55-60. –
geo.; abs.: geo., eng.
Switching early from IV
to
Auth.
8.g.13.1.165. Blood groups, food and parasitic diseases. /D. Tskhomelidze/. Social, Ecological and Clinical Pediatrics. – 2011. -
#13-8-7. - pp. 74-75. – geo.; abs.: geo., eng.
It is known that taenia
solium, taenia saginata, trichinella spiralis, diphyllobothrium latum and some
other parasites are correlated with eating undercooked or raw meat (pork, beef,
fish). We studied the relationship between different blood groups of humans
with eating meat and meaty food. As a result of our research, it was revealed
that humans with the blood group (A) or (O) are less predisposed to eating meat
and meaty food than people with the other groups of blood. Given this, we think
that the above-mentioned category of humans are less liable to such infections
as taeniasis, trichinosis, etc.
Auth.
8.g.13.1.166. Endothelium-dependent regulation of the tone of brain
blood vessels. /N. Mitagvaria, E. Bibiluri, M. Nebieridze, M. Darbaidze, E. Sukhishvili,
N. Sakhvarelidze, M. Devdariani, L. Gobechia/. Scientific Works of
The role of endothelium
in the local regulation of vascular tone is considered.
Auth.
8.g.13.1.167. Pathomorphological, pathophysiological and
psychophysiological equivalents of psychosomatic pathologies. /L. Ninoshvili/.
Scientific Works of
The article deals with
the involvement of all sections of the central neural system into pathological
psychosomatic and morphological processes during maldevelopment of
psychosomatic pathologies.
Auth.
8.g.13.1.168. Halogen-containing preparations in medicine. /E.
Tskrialashvili/. Scientific Works of
The halogenated
preparations used in medical practice - sodium and potassium chlorides,
bromides, iodides, iodine - are discussed and characterized.
Auth.
8.g.13.1.169.
The Mesenteric neoplasm (case report). /L.
Akhmeteli, L. Saghinashvili, L. Dzneladze/. Collection of Scientific Works of
The mesenteric neoplasm is one of the rarest
abdominal tumors. Since the first report of a mesenteric neoplasm by the
Italian anatomist Benevieni in 1907, only about 820 cases have been reported.
Schwannomas (malignant neurilemomas) are benign neurogenic tumors that arise
from Schwann cells, which are the cells forming nerve sheaths (neurolemma).
They may involve all peripheral, cranial or autonomic nerves. Schwannomas are
very homogeneous tumors and they typically appear as a solitary, well
encapsulated and smooth surfaced round mass. They are usually benign,
relatively slow-growing. Abdominal schwannoma may cause diagnostic problems
because clinical symptoms are misleading or uncharacteristic even if the tumor
is large. Our case-report involves a 62 years old woman who was admitted to the
emergency service in a heavy condition with acute cerebral dishaemia, ischemic
stroke, fibrillation arrhythmia, diabetes mellitus (II). On the 3-rd day
generalised abdominal tenderness and muscle spasm was noted.
Auth.
8.g.13.1.170.
Two cases of complicated gastric MALT lymphoma. /L. Gophodze, G. Tomadze,
G. Asatiani, Z. Demetrashvili, G.Chikobava, A. Megreladze/. Collection of Scientific Works of
Helicobacter pylori infection plays a central
role in the development of gastric MALT-type (mucosa-associated lymphoid
tissue) lymphoma. Invasion and destruction of the gastric epithelium with the
development of so-called lympho-epithelial lesions is the most important
diagnostic criterion. We reported 2 cases of complicated gastric MALT lymphoma.
In the first case it was the destruction and perforation of stomach body, with
diffuse purulent peritonitis, in the second one – ulceration of small curvature
and profuse gastro-duodenal bleeding. In both cases gastrectomy was performed.
The phenotype of MALT-type lymphoma was identical to non-neoplastic
B-lymphocytes of the marginal zone (CD20+). Individual therapy is strongly
dependent from histological type and lymphoma stadium. Postoperative therapy
includes H. pylori eradication as a rule.
Auth.
8.g.13.1.171.
Intrastromal corneal ring segments in keratoconus treatment. /M. Dvali,
To describe the visual, refractive, and
corneal aberrometric outcomes, topography maps and OCT images in the eyes of
keratoconic patients that underwent implantation of KeraRing Intrastromal
corneal ring segments (ISCRS) and modified ISCRS – KeraBow. Setting/Venue:
Tbilisi State Medical University, eye clinic "Akhali Mzera” Tbilisi,
Georgia This prospective analysis comprised eyes with grade I, II or grade III
corneal ectasia (keratoconus, ectasia after Lasik), as well as patients with
mild to moderated myopia with abnormal corneal topography maps that had ISCRS
implantation using standard technology. Visual, refractive, and corneal
aberrometric outcomes were analysed over follow up period of one to seven
years. ICL (Staar Surg.) implantation was combined with ISCRS in presence of
High Myopia and Keratoconus. Statistical analysis included preoperative and
postoperative UCVA, BCVA and keratometry (K) values. The mean UCVA improved
from 0.04-0.2 preoperatively to 0.2-1.0 postoperatively and the mean BCVA, from
0.4 to 0.6 respectively; One month postoperatively, there was a statistically
significant reduction in sphere. At 6 months, there was a statistically
significant reduction in manifest cylinder. That was consistent with the
significant reduction in corneal astigmatic aberration. Corneal topography
showed corneal flattening in all eyes. The maximum K value changed from 45.5 –
58.4 D preoperatively to 43.5 to 52.1 D postoperatively, the changes were
statistically significant. After implantation of the both models, the UCVA and
BCVA were improved in eyes with keratoconus. There was significant postoperative
corneal flattening that remained stable over the follow-up period. Implantation
of ISCRS is a measure of vision correction in patients with mild or moderate
myopia and abnormal corneal topography, which makes the laser correction
inexpedient. Important results were received in keratoconic patient with myopia
using combination of ICL and ISCRS implantation as well.
Auth.
8.g.13.1.172. Influence of
halothane on emotion, behaviour and adaptation ability of a rat against the
background of the midazolam premedication. /Z. Vadachkoria, L. Dzidziguri, E. Mitaishvili, G.
Mosidze, E. Bakuradze, I. Modebadze, D. Dzidziguri/. Collection of Scientific Works of
Influence of halothane on behavioral
parametrs and adaptation ability of experimental animals has been studied. The
high level research activity has been determined in all three groups in the
first three days of experiment. The adaptation to environment has been revealed
in control group after 2 days from sham operation and halothane anaesthesia
while the high level of research activity has been maintained in the test
group. The adaptation and decreasing of fear has been detected in the control
group on the 5th day of experiment. The high level research activity in the
test group indicates to the difficulties in adaptation and space orientation.
It is established that decreasing of adaptation ability and difficulties in
space orientation in rat are stipulated by suppression of inhibitory
neurotransmission in hippocampal CA3 filed. The Modulating influence of
midazolam on secretion of GABA from these cells has also been shown.
Auth.
8.g.13.1.173. Malignant
hypertension. /N. Katamadze/ Collection of Scientific Works of
Malignant hypertension is considered as an
emergency hypertensive (in comparison with hypertonic crisis) case, which had
already caused such injuries of target organs as retinopathy of
III-IV degree. Malignant hypertension is characterised by arterial hypertension
with neuroretinal symptoms and progressive loss of renal function. It can
develop de novo in so far
normotensive persons as well as on the basis of already preexisting hypertension.
A control of the blood pressure is an indispensable need in the other treatment
of the malignant hypertension. Only through the consistent and long-term
antihypertensive treatment can be reached partial feedback or even only a
little relief. A Screening concerning a secondary cause of the hypertension is
absolutely necessary above all with younger patients.
Auth.
8.g.13.1.174. Etiological
structure of urethritis in men detected by modern technologies of
microbiological research. /E. Kikacheishvili, M.
Dzagnidze, I. Dgebuadze,
Microbiocenosis of urethritis is a
permanently changing ecosystem. It depends on various factors, so in clinical
microbiology is very important to control both quorum of
causative agents and their sensitivity to new and old antimicrobial
preparations. Along with theoretical purposes, that has a wide practical application.
The aim of this research was to study the etiology of urethritis in men, using
high quality standard bacteriological technology-‘bio-merieux”. (Api and ATB
test). The study of materials taken from 80 patients with chronic recurrent
disease showed that the dominant causative agents (in 32,5% of cases) in S.
epidermidis, the second place occupies S. aureus (17.5%), then follow:
E.faecalis, Corynebacterium spp, C. freundii. Monoinfections were determined in
78.5% of cases, and mixed infections - in 22,5%. S. epidermidis+P.mirabilis was
most frequently detected. The study of sensitivity spectrum showed that main
causative agent - staphylococcus - revealed a high sensitivity to Gentamicine,
Monocycline, Teicoplanine, Rifampicine, Nitrofurantoine and resistance against
Norfloxacine, Levofloxacine, Oxacilline, Tetracycline and Penicillin.
Auth.
8.g.13.1.175. Comparison of
concomitant non-accommodated convergent strabismus treatment methods. /M. Kikolashvili, D. Shengelia, L. Tsomaia/. Collection of Scientific
Works of
A retrospective cohorative research carried
out on children (n=70), aged 1 to 10 years. The children have manifested
concomitant convergent strabismus. This cohort of patients, according to their
age, was divided into 2 clinical groups and subgroups. The first group included
the patients who underwent surgical treatment and occlusion. In the second
group, there were patients who underwent pre- and post operative pleopto-orthopto-diploptic
treatment. The analysis of research showed the complete repairing of binocular
vision and development of fusial reserves occurred in children who had
undergone complex treatment (pre- and post operative pleopto-orthopto-dipliptic).
It is important to note that late surgical treatment decreases the ability to
reach perfect results.
Auth.
8.g.13.1.176. The
pancreatoduodenal zone cancer. /N. Lomidze, I. Tsereteli, O. Urushadze, G. Nemsadze, V. Kaloiani, Z. Manijashvili, I. Latsabidze/. Collection of Scientific
Works of
Pancreatic cancer is the third leading
neoplasm of the gastrointestinal system and has a dismal prognosis. Primary
carcinoma of the duodenum is rare and uncommon neoplasm that represents less
than 0.5% of all gastrointestinal malignancies. The aim of this study is to
access patients with pancreatic, duodenal and periampullary cancers. 61
patients from N. Khipshidze Central Clinic (1995-2010) were investigated. 5 of
them with a duodenal cancer, 12 – with a periampullary cancer, 14 – with a
cancer of distal part of choledocus and 30 - with a pancreas head cancer. Mean
age of patients was 42-72. From studied population pancreatoduodenal resection
were performed on 16 (57%) patients (2004-2010) and 12 (43%) received
palliative treatment. From 28 patient 3 of them had duodenal cancer and whipple
procedure was done. Pathomorfological study proved adenocarcinoma in 2 of cases
and neiroendocrinal carcinoma – in 1 case. From 5 patients with distal
cholangiocarcinoma 3 of them received Whipple procedure. Pancreatoduodenal
resection and limphodisection D2 were done in 4 patients with periampullary
carcinoma. From 16 patients with pancreas head cancer 5 of them received
Whipple procedure with D2 limphodisection. The majority of patients with
pancreatic head cancer are poor candidates for resection at the time of
diagnosis due to early development of distant metastases and/or major
infiltrations of adjacent structures; patients with cholangiocarcinomas and
duodenal cancers appear to be better candidates for Whipple procedure.
Duodenopancreatectomy gave a longer survival time than duodenal resection in
patients with duodenal cancer.
Auth.
8.g.13.1.177. Sexual
dysfunctions in patients with ageing male syndrome: modern view of the
pProblem. /Z. Marshania, G.
Bochorishvili, T. Ivanishvili/. Collection of Scientific
Works of
The objective of this article was to study
the problem of sexual dysfunctions in patients with the ageing male syndrome
based on modern medical scientific sources. This syndrome is very frequently
accompanied with erectile dysfunction, which originates from functional and not
organic reversible damage of cavernous arteries. Along with complex treatment
of sexual dysfunctions (FDES-5 inhibitors, testosterone-therapy, psychotherapy,
surgical interference, intracavernouse injections, adaptogens, biostimulators,
local decompression, physiotherapy), it is necessary to take into consideration
accompanying diseases (insufficiency of penile cavernous corps‘ blood vessels,
diabetes, heart diseases, mental disorders) and diversification of forms of
sexual pleasure of ageing couples through widening acceptance range, increase
of activeness of a sexual partner and prolongation of sexual foreplay for the
purpose of ensuring mutual adaptation of couples in regards to changed sexual
requirements.
Auth.
8.g.13.1.178. The effect of an
extract obtained from cortex of Phellodendron lavalei introduced in the
subtropical zone of Georgia on the blood glucose level and glucose tolerance
test in mice. /M. Meskheli,
We studied
the effect of an extract obtained
from the cortex of Phellodendron lavalei introduced in the subtropical zone of
Georgia – Kobuleti on the blood glucose level and glucose tolerance test in
mice. Measurements of glucose level in blood were provided by the glucometer
Gluco Lab-auto-coding. According to the study results, the extract is
characterized of hypoglycemic activity, in particular it improves glucose
tolerance and reduces the blood glucose level in mice. Further investigation of
the efficacy and of the mechanisms of action of different parts of
Phellodendron lavalei in experimental models of diabetes is essential for
solving the problem of using Phellodendron lavalei as a plant raw material for
hypoglycemic drugs.
Auth.
8.g.13.1.179. Biologically
active substances of the Allium genus onion and their pharmacological action. /L. Mskhiladze, M.
Maisashvili, D. Tchintcharadze , J.
Kuchukhidze/. Collection of Scientific
Works of
Intensive chemical and pharmacological
investigation of Allium species has been conducted by Italian, French, English,
American, Indian, Chinese and Japanese scientists lately. They are
characterized of anticancer, antimicrobial and anti-atherosclerosis activity.
Taking into account the above, further study of the Allium species grown in
Auth.
8.g.13.1.180. Intestinal and
extra-intestinal manifestations of Crohn’s disease. /S. Kemoklidze, B.
Ratchvelishvili, Kh. Pachkoria, L.
Dzneladze, E. Adamia, I. Tavzarashvili/. Collection of Scientific Works of
The authors report the intestinal and
extra-intestinal manifestations of Crohn’s disease. The Intestinal
manifestations, including aphthous mouth ulcers, entero-enteral,
entero-vesical, entero-cutaneus and perianal fistulas, bleeding, obstruction
and malignant transformation. The extraintestinal manifestations include:
pyoderma gangrenosum, the Syogren’s syndrome polyarthritis, spondylarthritis,
lupus eruthematose and the Melkersson-Rosenthal syndrome.
Auth.
8.g.13.1.181. The
hepatoprotective effect of PV-88 during hemorrhagic shock in experiment. /M. Gvaladze, Gr.
Sulaberidze, G. Didava, M. Chkhaidze,
During hypoxic state, especially for the
period of hemorrhagic shock, lyses of liver parenchymal cell membranes occur
due to calcium ion excess. Membrane protection from such a pathologic process
is theoretically possible through blockage of the calcium L channels, namely –
by Verapamil and PV-88. The latter was utilized to study its hepatoprotective
effect. Modelling of the hemorrhagic shock was performed by Wiggers-Feine
method. Blood was exfused from sedated male cats (nembutal 40mg/kg, intravenous
blood exfusion 40ml/kg) till arterial blood flow drops to 40mm/Hg (HS60).
During artificial ventilation - 130-150 ml/min/kg in the period of 1 hour, Ph
in the arterial blood was 7.35-7.45, P02 – 90mm/Hg, airflow measurement was
controlled by the
Auth.
8.g.13.1.182. The role of
scleral weakness and thinness in progressive myopia. /D. Shengelia, A. Bakuridze, V. Beliashvili/.
Collection of Scientific Works of
Scleral biomechanical weakness and thinness
are known to be one of the main factors in the pathogenesis of progressive
myopia. We tested changes in axial length of the eyes, in far and near
distance, in patients with low, middle and high grades myopia. Statistically significant
differences were considered when p < 0.05. The study shows the widest
variation in the axial length in the middle grade of myopic patients. The
analysis of biomechanical considerations in the axial length presented here is
a very helpful to choose the adequate method for treatment of myopia.
Auth.
8.g.13.1.183. Using the active
points of the feet, pulse current, as well as phonophoresis of the lumbar
region in non-drug treatment regimen for itching. /N. Tsiskarishvili, A.
Katsitadze,
It is known that in number of pathogenic
factors that cause itchy skin, psycho-emotional, stressful situations play an
important role; they can provoke the development of neurosis, asthenia, and
chronic fatigue syndrome. That is why the proposed method of drug-free
deliverance from itching using individual the mind-body workout exercises to
affect the active points of the feet, therapeutic electronarcosis,
phonophoresis of lumbar region, appears exclusively relevant. The study
followed 27 patients aged from 18 to 65 years with the following nosology:
prurigo (10), diffuse neurodermatitis (7); limited neurodermatitis (5);
pregnant itching (5). Disease duration ranged from several months to 5 years.
The comparison group was homogeneous in the number of patients, nosological
units and duration of the disease. The degree of pruritus was assessed on
4-point scale. Patients’ control group received a sedative therapy,
desensitization means, corticosteroids. Patients were observed during treatment
(21-28 days) and for 1 month after therapy. In the test group compared with
control group skin itching subsided considerably faster (on average 4 days)
and, accordingly, at an earlier date could renounce the use of antihistamines,
sedatives. 87% of patients from the study group pointed to the improvement of
the general emotional state, reducing severity of depression related to the
skin condition, which unconditionally indicates an improvement in quality of
their life. The findings generally indicate a high clinical efficacy of the
proposed psychophysical exercises, therapeutic electronarcosis and
phonophoresis in the treatment of itchy skin dermatoses.
Auth.
8.g.13.1.184. Contemporary
methods of exudative otitis media treatment. /Sh. Japaridze, L. Lomidze,
The research was conducted in
Otorinolaringology Department of TSMU during 2009-2010 years. Altogether 132
patients (age – 3-59 years) with exudative otitis media were investigated.
Diagnosis was estimated with help of otoscopy, tympanometry and audiometry. The
patients were divided into 4 groups: In I group were 23 patients; in II group –
59 patients; in III group – 20 and in IV group – 30 patients. Duration of the
disease was from 1 month to 7 years. Treatment of exudative otitis in tested
patients was conducted in three stages. Surgical intervention, shunting of
tympani, has been done only in 30 patients from investigated 132 patients.
Auth.
8.g.13.1.185. Some Issues of
diagnostics and treatment of chronic maxillary sinusitis. /Sh. Japaridze, T. Khechinashvili,
Chronic paranasal sinusitis, including
maxillary sinusitis, nowadays is marked with the tendency of high incidence
rate and severe complications. 52 from 14 to 75-year old subjects with
different duration periods (from 1 to 10 years) of the disease have been
studied for the development of rational methods of treatment and of
differential diagnostic strategy. The patients under observation underwent
routine and modern (CT) roentgenographic investigation, cytological,
bacteriological, both local and general immunity tests. On the basis of the
performed studies in case of chronic presence of allergic component, close
interrelation between those parametres and imbalance of immune status was
revealed. The obtained results suggest the necessity to develop more rational
and effective curative methods, namely the complex use of immunomodulatory
preparations along with other medicinal remedies both before and after
conservative and radical treatment.
Auth.
8.g.13.1.186. Investigation of cardiac
autoantibodies for detection of cardiovascular system damage in children with
recurrent respiratory tract diseases. /K. Barabadze, A.
Tsabutashvili, N. Adamia/, Second International
Congress of Respiratory Association of
According to statistical
data, the frequency of cardiac diseases increases in the world, including
N. Chkhaidze
8.g.13.1.187. Clinical forms
and treatment of intrathoracic sarcoidosis. /T. Lobzhanidze/. Second International Congress of
Respiratory Association of
Sarcoidosis
is a multisystem disorder of unknown aetiology characterized histologically by
non-caseating granulomatous
inflammation in the affected organs. In
90% of cases damage of lungs was revealed. In approximately 1/3 of cases, the
disease starts gradually (chronic form), in other cases – acutely or without
symptoms. Two clinical forms of acute sarcoidosis are singled out. Chronic from
of the disease shows itself gradually, with episodic relapses and remissions.
As a result of progress of the disease gradually develop expressed, sometimes
dangerous for life, changes of lung function. The paper provides data on the
classification, clinical manifestations, course, treatment, and follow-up of intrathoracic sarcoidosis.
N. Chkhaidze
8.g.13.1.188. Anti-leukotrienes in
treatment of patients with seasonal allergic rhinitis. /M. Kherkheulidze, N. Khavlashvili, E. Kandelaki,
The aim of the study was
to assess the effectiveness of anti-leukotrienes preventive treatment on the
course of seasonal allergic rhinitis. Observational study included 48 patients
aged 6-12 years, who were divided into 2 groups. I (main group) comprised 28
patients with the already diagnosed seasonal allergic rhinitis, who received
the montelukast once per day starting 10-14 days earlier before onset of
allergic season and II group - 20 patients with clinical picture of seasonal
rhinitis without any previous treatment. Quality of life (PRQLQ, published by
E. Juniper) nasal symptom severity scores and total nasal symptom score and
correlation of symptom severity scores to quality of life questioner in both
groups was evaluated. The study shows that the most frequent symptom in both
groups was nasal secretion, but most serious or disturbing symptom that affects
quality of life was nasal obstruction. The result showed correlation between
severity of rhinitis, nasal symptom scoring and quality of life. The study
highlights effectiveness of using anti-leukotrienes in treatment for
improvement of nasal symptom scores as well as quality of life of patients with
seasonal rhinitis.
N. Chkhaidze
8.g.13.1.189. Analysis of a dynamic cardiac
rate system on the basis of computer imaging methods. /I. Chkheidze, M. Berishvili, L. Tokhadze/.
Transactions of
Graphic methods of research of a dynamic cardiac rate
system, which demonstrate a difference in change of indicators for healthy and
sick patients are considered. A research of cardiac rate dynamics has shown
that application of the presented methods allows to carry out an analysis of
properties of the medical and biologic system and the imaging character of the
algorithms realized in the MathCad program package, considerably simplifies
understanding of features of dynamic behavior of the system, its perception and
assists doctors in the establishment of the objective diagnosis.
Auth.
8.g.13.1.190. The effect of calcium
antagonists on the products obtained through lipid peroxidation in different
brain structures of white rats under emergency conditions. /A. Baghirov, A. Mirzayeva, G. Ganiyeva, V. Asmatov,
M.Ganiyev/.
For formation of free radical processes in the body,
emergency conditions and different widely applied medicines are given a more
important role. Stress factors and permanent drug therapy cause an increase in
MSS through lipid peroxidation. Based on the above, the authors investigated
pro- or antioxidant features of frequently applied drugs. Neurochemical tests
have found that under emergency conditions, both in acute and chronic
experiments, an increase in the amount of lipid peroxidation products in the
brain structures is observed. According to the conducted study, the calcium
channel antagonists, such as verapamil, amlodipin, flunarizin, have a slight
effect on the formation of the lipid peroxidation products in different
structures of brain and display an antioxidant effect.
Auth.
8.g.13.1.191. Depression in
hemodialysis-dependent patients. /T. Gegenava, M.
Gegenava, G. Kavtaradze, M. Sutidze/.
Depression plays a crucial role in the progression of
chronic medical illnesses. Amongst all psychiatric disorders, depression is the
most important and common in patients with ESRD. Depression in
dialysis–dependent patients effects mortality and rate of hospitalizations. It
has been suggested that approximately 20- 30% of the ESRD population suffer
from depression. The somatic characteristic of depression is similar to
symptoms of uremia like anorexia, sleep disturbance, fatigue, gastrointestinal
disorders and pain. Due to this overlap of symptoms of uremia with depression
it is usually neglected, under diagnosed and remain untreated. This study was
conducted in hemodialysis units of N. Khipshidze Central Clinic in a period
between March 1 and May 1, 2009. The number of patients made 40 (14 women and
26 men). The average age was 35, the duration of hemodialysis - 2-8 years. The
diagnosis of the patients and the cause of hospitalization was ESRD. The Beck
Depression Inventory, (BDI-II) comprising 21 items, which is considered to be
the most valid test for assessment of depression, was filled out by the
patients. Depression was revealed in the majority of patients n=30 (75%).
Moderate and severe depression was revealed in 22.5% of the patients, while the
majority had mild depression n=21 (52.5%). Anemia, hyponatremia, hypopospatemia
were also revealed in our study. It is known that these symptoms have
statistically significant relationship with depression. Findings offer that
depression is the most spread psychosomatic disorder among renal dialysis
patients. Treatment options should entail psychological treatment.
Auth.
8.g.13.1.192. The importance of
rectoscopy and colonoscopy during ulcerative colitis. /G. Tatishvili, B. Chakvetadze/.
All scientific data and own experience in specialized
hospital is indicative of too late and insufficient diagnostics of ulcerative
colitis in its ambulatory stage. That is why endoscopy at different stages of
disease has very important practical meaning. The diagnostic importance of
rectoscopy grows without preliminary preparation of the intestine, together
with biopsy. Colonoscopy makes it possible to speak about the process
localization and spread, its activity and the intestine wall involvement in the
process.
Auth.
8.g.13.1.193. The tactics of treating
stress ulcers in the pulmonary ventilation-dependent patients. /Z. Kheladze,
851 patients’ histories that were in a critical
condition and on mechanical ventilation have been analyzed. The bleeding from
stress ulcers was detected in 48 patients (5.6%). The urgent endoscopical service
was created in our clinic, which gives us the opportunity to make
treating-diagnostic endoscopy 24 hours a day. Together with standard methods,
plasma ray therapy was also used in the treatment course. As a result, the
treatment efficiency has significantly increased.
Auth.
8.g.13.1.194. Clinical-hemodynamic and anti-ischemic
effects Ivabradine and Nebivolol Ischemic Heart Disease with Left Ventricular
Disfunction. /G. Abuladze, A.
Kvirkvelia, M. Nebieridze, T. Chachua, G.Dundua/. Georgian Medical News. - 2010. - #10 (187). – pp. 24-27. – rus.; abs.: geo., eng., rus.
The aim of this study
was to examine the effectiveness of Ivabradine (available under the brandnames
of Procoralan, Coralan, Corlentor, Coraxan, "Servier”,
Auth.
8.g.13.1.195. "Comet tail” artefact in
diagnosis of pulmonary congestion in patients with diastolic heart failure. /M. Tsverava, D.Tsverava/. Georgian Medical News. - 2010.
- #10 (187). – pp. 28-35.
– eng.; abs.: geo., eng., rus.
The aim of this study
was to evaluate the importance of thoracic ultrasound examination in diagnosis
of DHF. Total of 380 patients with HF were evaluated. 86 patients had diastolic
HF (group 1) and 294 patients had systolic HF (group 2). The control, group 3,
consisted of 155 patients with left ventricular diastolic dysfunction but
without HF. HF patients did not take any medication before ultrasound
examination. All patients underwent thoracic X-ray and ultrasound examination.
Sonographic examination of the lung was done with 3,0-4,0 MgHz convex or sector
probe, from 10 points on thoracic wall (cross points of mid-clavicular line II,
IV and V intercostal spaces and anterior axilar line with IV and V spaces),
which corresponded to the projection of lower, middle and upper lobes of the
right lung and upper and lower lobes of the left lung. During pulmonary
ultrasound examination, 95.5% of patients with HF had the "comet tail phenomenon”,
which was registered only in 35.5% patients without HF (p>0,001). In DHF
group, the "comet tail phenomenon” was registered in 91.9% and in systolic
HF group in 96.6% patients. In 81.4% of patients with DHF the "comet tail
phenomenon” was registered from 3 and more registration points. In the control
group, the "comet tail” was registered from more than 3 points only in 2
(1.3%) patients. The best results in diagnosis of DHF can be achieved if we
take "3 and more registration points” as a reference point for diagnosis
of pulmonary congestion (sensitivity - 0,911, specificity - 0,942, positive
predictive value 0,975). In patients with diastolic HF during pulmonary
ultrasound examination significantly often was registered the "comet tail
phenomenon”. The count of registration points from the thoracic wall of the
"comet tail phenomenon” 3 and > is sensitive and specific sign of HF.
We think that lung sonography offers a new method for the diagnosis of
decompensated diastolic HF at bedside and may provide important information.
Auth.
8.g.13.1.196. Results of conservative
treatment of achillodynia with application of micro-current therapy. /R. Aliyev, G. Muslimov, G. Gaiger/. Georgian Medical News. - 2010. - #10 (187). – pp. 35-42.
– eng.; abs.: geo., eng., rus.
Achillodynia is
described as expression of chronic pain in the Achilles tendon. Pain in the
Achilles tendon can be the cause of wear and tear in the tendon tissue or as a
result of inflammation of the peritendineum, the underlying bursa and/or the
tendon insertion at the heel bone. It often occurs after sporting unusual
stress and is healed after a complex conservative treatment by rest, (partial)
relief and physical exercise within several weeks to months. The aim was to
turn knowledge on the effectiveness of complex conservative treatment measures,
in particular to gain by additional stimulation in the treatment of Achilles
tendon. 20 patients with a diagnosis of achillodynia were treated 05-2009 to
12-2009 in the orthopedic outpatient therapy center with the help of the extra,
micro-current therapy (CellVAS® device) and a complex conservative treatment
measures. The analysis was conducted using a questionnaire, clinical
examinations, magnetic resonance imaging (MRI) and a radiological examination
of the Achilles tendon with the ankle joint. At the beginning and end of the
intervention to the Board of subjective symptoms scores (NRS scale) and
assessment of treatment results by the doctor for 4-step rating scale were
collected. The study compares the treatment response in Achillodynia from a
control group. The average age of patients was 46.3 years at the time of
treatment. Of these patients: 14 (70%) were females and 6 (30%) male. Of 20
patients were 8 (40%) patients with very good, 7 (35%) patients with good, two
(10%) patients with satisfactory and three (15%) patients with poor results. In
addition, 17 of 20 patients (85%) with conservative treatment measures were
satisfied, 3 patients (15%) were dissatisfied. The subjective assessment of the
complaints numerical rating scale (NRS scale) improved significantly (p
<0.001) from 8.9 to 2.3 points after treatment. An objective evaluation by
the attending physician based on various clinical parameters was assessed in
75% of the cases as good or very good. The study shows that the described
complex conservative therapy is the integration of a micro-current treatment is
a very good method for the treatment of Achillodynia/Achilles tendon disorders
in athletes. The primary goal of treatment is to achieve freedom from pain and
was achieved consistently, as the subjective assessment of the complaints was
proved using the NRS scale. The high patient satisfaction with the treatment
suggests in addition, any therapy must keep in action the long-term development
of athletes in mind. In individual must be questioned what treatment method for
long-term sports development but also the health history (this is not
inevitably always the same) is an advantage. The conservative treatment seems
to be advantageous because it leaves open for therapy-resistant complaints, the
option of surgical treatment, and has generally very good chance of recovery.
Auth.
8.g.13.1.197. Effects of Oxytocin on
behaviour and memory in rats subjected to chronic restrained stress. /M. Kunchulia, T. Bolkvadze, M. Zhvania,
We studied whether 21
days of restraint chronic stress would affect the contextual fear conditioning,
a memory task with hippocampal-dependent components and anxiety-like behavior
in the open field, and to determine whether oxytocin treatment could prevent
the chronic stress induced memory and emotional disturbances.
Restraint-stressed rats were injected daily (21 days) with oxytocin (1 mg/kg)
or saline then tested in open field (day 22) and contextual fear conditioning
task (days 23-24). Our data demonstrate that chronic restraint stress induces
some behavioral changes in both saline-treated and oxytocin-treated animals. Particularly,
in the open field the animals both groups were characterized by
hyper-locomotion. However, oxytocin-treated animals spent more time in the
inner area of the open field, which indicates to decreased anxiety- related
behaviour in oxytocin-treated animals versus the saline-treated ones. In
additional restraint stress decreased freezing reaction to context,
irrespective of whether oxytocin was given or not. Our findings indicate that
during stress OT may be involved in the regulation of emotional behavior and
memory via different ways. The elucidation of corresponding mechanisms is of
great importance.
Auth.
8.g.13.1.198. The influence of
Fluoxetine on noradrenergetic neurotransmitters of brain cortex. /D. Zurabashvili, I. Giorgobiani, M. Arveladze, I.
Gamkhrelidze,
The aim of this work was
to evaluate the hypothesis that the second-generation antidepressant might play
a role in controlling the activity of noradrenalergic neurotransmitters. The
paper details the pharmacological profile of antidepressant drug Fluoxetine
with high affinity for 5-HT receptor, and explains how the antidepressant
activity chances noradrenalin reuptake inhibitor-medications. Brain cortexes of
20 rabbits were analyzed by high-performance liquid chromatography. The
conducted quantitative and qualitative analyzes show that antidepressant
activity of Fluoxetine could be mediated by the synergistic effects on the
serotoninergic and noradrenergic receptor pathways. Major depressive disorders
are heterogeneous monoamine condition. Our studies have demonstrated fluoxetine
efficacy and safety for treatment of major depressive disorders.
Auth.
8.g.13.1.199. Increased lipid
peroxidation inhibits regulation of erythropoiesis in patients with pancreatic
diabetes. /M.Feyzullayev/.
Experimental and Clinical Medicine. – 2010. - #1(56). - pp. 27-29. – rus.;
abs.: eng.
23 insulin-dependent
patients with pancreatic diabetes and 20 healthy donors (13 men and 10 women
aged 16 to 60) were observed. The illness duration varied from 1 month to 20
years. The investigation results showed that during hyperglycemia (20.5mmol/l)
an increase of the quantity of lipid peroxidation (POL) was marked in the
patients with ID PD in comparison with the control (0.19/0.49st.unit). The
results of the analysis showed some increase in the POL concentration which
caused damage to the structure of the erythrocytes, and the decrease in the
haemoglobin quantity from 140g/l to 128g/l (p<0.05). Blood diffluence
resulted in the impairment of erythrocyte differentiation and in the further
maturation of the peripheral blood elements. Due to this unusual method of
therapy, the compensation of carbohydrate metabolism and normalization of
erythropoiesis have been achieved in the patients with ID PD.
Auth.
8.g.13.1.200. The efficacy of
treatment for chronic nonspecific lung diseases by the methods of non-drug
therapy according to follow-up studies. /N. Faradjeva/.
Experimental and Clinical Medicine. – 2010. - #1(56). - pp. 38-40. - rus.;
abs.: eng.
131 patients have been
examined: 69 patients with infection-dependent bronchial asthma (IDBA); 37 –
with moderately severe, 32 - with severe and persistent illness; 63 patients –
with chronic bronchitis (CB); 31 patients with chronic purulent non-obstructive
bronchitis (CPNOB), and 32 - with chronic purulent obstructive bronchitis
(CPOB). 67 patients of the basic group (35 with IDBA and 32 with CB) received
the combination of drug therapy (DT), halotherapy (HT) and endobronchial
exposure (EBE) with sessions of various durations, and a general course of
treatment depending on the form and severity of the clinical course of the
disease. The control consisted of 65 patients receiving only MT. The analysis
of follow-up studies has shown a considerable clinical effect in both
nosological groups under the combination of MT and HT/EBE.
Auth.
8.g.13.1.201. A comparative
analysis of the main risk factors of coronary heart disease in the
Data concerning the
prevalence of the main factors of coronary heart disease (CHD) among the
Auth.
8.g.13.1.202. Prevalence of CHD
risk factors separately and in various combinations among the
A representative
sampling of unorganized male and female inhabitants of
Auth.
8.g.13.1.203. Spread of the
risk factors of coronary heart disease among the patients with rheumatoid
arthritis. /N. Zamanov/. Experimental and Clinical Medicine. – 2010. - #1(56). -
pp. 49-53. – rus.; res.:eng.
125 patients with
rheumatoid arthritis (RA) were involved in the investigation. Among the
classical risk factors of coronary heart disease (CHD) smoking was not marked
among the woman, and among the men has made 90%. Arterial hypertension was
found in 44.4% of the patients with RA. Serious changes were determined in the
lipid-protein blood spectrum. The risk factors of CHD are marked basically in
patients with seropositive form of RA. A positive correlative communication was
detected between such CHD risk factors as anemia, arterial hypertension,
C-reactive protein level. CHD risk factors in a greater degree were increased
in the patients whose RA continued more than 5 years. The level of fibrinogen
depends more on the duration of the disease, and the level of C-reactive
protein – on the degree of RA activity.
Auth.
8.g.13.1.204. Correction of
psycho-emotional frustration in patients with bronchial asthma during
halotherapy. /N. Farajeva/.
Experimental and Clinical Medicine. – 2010. - #2(57). - pp. 50-53. – rus.;
abs.: eng.
The research objective
was to define the antidepressant effect of halotherapy (HT) in the complex
treatment of bronchial asthma. 73 patients with heavy persisting
infectious-dependent bronchial asthma (IDBA) have been examined and treated.
The basic group patients received also HÒ in combination with drug therapy (DT). The
patients receiving only DT comprised the control group. The results of the
research carried out showed that only 42.2 % of the patients receiving only DT
recovered from psychoemotional frustration by the end of a 25-day course of
treatment, whereas a complex treatment including HÒ completely corrected the condition of 90.9 %
of the patients in 12 days of treatment.
Auth.
8.g.13.1.205. Structural
characteristics of endotheliocytes in practically healthy people. /N.
Khvitia,
The endothelium of
healthy people has been studied by light and electron microscopy. The
endothelial structure can be described as endocrine tissue.
Auth.
8.g.13.1.206. Pilot study of
primary prevention and screening on environmental factors in pathogenesis of
Sjogren’s syndrome associated salivary and lacrimal gland lesions. /T. Chachibaia, E. Aptsiauri, I. Bulia, A.
Aleksidze,
Sjogren’s syndrome is
chronic autoimmune inflammatory rheumatic disease that attacks exocrine, i.e.
salivary and lachrymal glands, causing such complication such as dryness of
mouth and eye in affected individuals. Mainly is diagnosed among women
population in 90% of cases. Sjogren’s syndrome affects mainly women in their
40-50s, though younger age onset is also characteristic. Later disease is
progressed and other organs are involved as well. There is substantial risk of
development of malignant lymphomas and characterised by 44-fold increased risk
compared to general population. Environmental factors are thought to trigger
inflammation in individuals with a genetic redisposition for the disease.
Primary prevention of Sjogren’s syndrome is directed to increase awareness of
harmful environmental conditions, which may be avoidable, also to educate
recognition of early warning symptoms of this condition. Timely diagnosed
lesion is better treatable and late onset complications are also preventable.
The aim of "Georgian Sjogren Association” is to perform screening and
provide prevention of Sjogren’s syndrome in
Auth.
8.g.13.1.207. The dynamics of
incidence of salmonellosis in
We have studied the
dynamics of incidence of salmonellosis in
Auth.
8.g.13.1.208. Suitable usage of camelyn in treatment of
osteoarthritis and osteochondrosis by means of ultraphonophoresis and
electrophoresis. /N. Saakashvili, T. Chilingarishvili, N. Jakobia, K.
Maghlakelidze, G. Chikovani, I. Malazonia, M. Lomidze, M. Natsvlishvili, I.
Kvinikadze, N. Kvinikadze/. Experimental and
Clinical Medicine. – 2010. - #4(59). - pp. 59-61. –geo.; abs.: eng., rus.
Camelyn is a
biologically active preparatipn produced by the Georgian famous surgeon
Benedikte Maghlakelidze in the mid-20th century from special, ecologically safe
Kolkhis honey. After a lot of clinical and experimental trials, it was
determined that Camelyn had immunomodulate, antioxidant and antiinflamatory
action. Osteoarthritis and osteochondrosis are the most common medical problems
in the world. It’s the number one cause of disability in
Auth.
8.g.13.1.209. ”Dualler-G” - new
approach to the treatment of allergy. /T. Tchumburidze, Z. Bendeliani,
Epidemiological data
reflect a significantly increased percentage of population suffering from
allergic diseases. Especially it concerns allergic reactions influenced by
industrial and biological factors. Allergic reaction plays the leading role in
pathogenesis of dermatitis, and mechanisms of such reactions are based on
release of histamine and serotonin. The development of a drug with both
antihistaminic and antiserotoninic activity was the goal of this study. Drugs
with close chemical structure and pharmacological activity were selected from
derivates of quinuclidin carbinols. This differences in pharmacological
activity of different compounds make Dualler-G a new antiallergic drug with
antihistamine and antiserotonine activity. The goal of the study was clinical
trail of Dualler-G in patients with dermatitis. The obtained data suggest that
Dualler-G shows high effectiveness in the treatment of different types of
dermatosis. The effect of Dualler-G, an original antiallergic drug, was
evaluated in patients displaying different kinds of dermatosis (urticarea, neirodermatitis,
lichen rubber planus, eczema). A total of 22 patients diagnosed with dermatitis
were randomized to receive in an open fashion 60 mg of Dualler-G per day, for 2
weeks. Efficacy was assessed according to the global improvement rating of
elements on skin or itching as symptoms or signs. Patients treatment with
Dualler-G (cases of urticarea, neirodermitis and lichen rubber planus) had
superior improvements in thei symptoms (elements on skin and itching) compared
to controls along the 2-week trial, but not in the cases of eczema. However,
cases of eczema level of eosinophils were reduced as well as the severity of
symptoms. The clinical course of the patients treated with Dualler-G tended to
be significantly better then that of the patients treated with other
antiallergic preparations, and the symptoms were significantly correlated in
the Dualler-G treated group. These data suggest that Dualler-G positively
effects the symptoms (skin elements and itching) in patients with different
kinds of dermatosis, and its efficacy is much higher against other drugs.
Auth.
8.g.13.1.210. Metabolic effects of
Nebivolol in patients with type II diabetes. /G.
Tabidze, T. Tsibadze, N. Kobaladze,
A novel super selective -blocker with NO-modulating activity Nebivolol used as
an antihypertensive drug in patients with non-insulin-dependent diabetes
exerted good hypotensive effect which was not associated with negative changes
of the lipid spectrum.
Auth.
8.g.13.1.211. Specifications of
community acquired pneumonia based on the findings of the Therapy Clinic of
Georgian Patriarchate. /R. Tabukashvili, V.
Kapetivadze, N. Gegeshidze, Kh.
Tsaava/. Experimental and Clinical
Medicine. - 2010. - #4(59). - pp. 68-70. – geo.; abs.: eng., rus.
The purpose of the
research was to reveal peculiarities of the course of community acquired
pneumonia. During 2007-2010, 427 patients were studied. The main group of the
patients was dated from III class of PORT-scale. We found that the number of
community acquired pneumonia cases tended to increase by years. In 2008, 15.98%
from all admitted patients was diagnosed; the number of patients with bilateral
pneumonia made 17.36%. In 2009, the figure amounted to 25.82% and 40.76%; in
2010, during three months – to 40.34% and 55.20%. An increase in complications
of the community acquired pneumonia was also detected, especially in the form
of pleurisy. Bacteriological investigations showed that the spectrum of
pathogenic organisms had not changed in the last ten years. These findings are
corroborated by statistically trustworthy studies as well.
Auth.
8.g.13.1.212. Arterial hypertension in women. /N. Katamadze, S. Beridze/. Experimental and Clinical Medicine. - 2010. -
#4(59). - pp. 73-76. – geo.; abs.: eng., rus.
Arterial hypertension,
as one of the important cardiovascular risk-factors, still remains one of the
most important medical subjects, including women. Only a small percentage of
patients know that they have hypertension, and even less number of people are
treated appropriately. The healthy lifestyle is the most important for primary
and secondary prevention of cardiovascular diseases. The desired effect is
often reached with a complex medical treatment. Despite of women’s systematic
involvement in clinical trials, it still remains difficult to formulate
specialized recommendations, because the percentage of woman is still not
representational. A better knowledge of the pathological mechanisms leading the
postmenopausal women to hypertension will assist in elaborating more proper and
rational treatment.
Auth.
8.g.13.1.213. Dislipoidemia in a
family physician practice. /A. Isakadze, Sh.
Shurghaia,
Dislipoidemia is one of
the most important risk factors of cardiovascular diseases. The priority of
prevention of cardiovascular diseases is to reduce the number of patients with
high cholesterol levels. A way of solving this task is to enhance the patients’
awareness of the target levels of lipid metabolic parameters and the necessity
of their regular monitoring. The awareness of the level of cholesterol and
its atherogenic fractions was assessed in a group of 222 patients who
considered themselves apparently healthy. In these patients, the parameters of
lipid and carbohydrate metabolism were determined and blood pressures and
anthropometric indices were measured. The study group demonstrated high
prevalence of dyslipoidemia and metabolic syndrome and low awareness of the
values of the lipid spectrum, which generates the necessity of performing
further studies to develop goal-oriented preventive programs, including
educational ones.
Auth.
8.g.13.1.214. Fe-askangel and its
application for treatment of iron-deficiency anemia. /T. Gabelia, L. Japaridze, N.Beridze
E. Salukvadze, T. Kvernadze,
A physico-chemical
method of adsorption modification of superfine askangel (Askana, Ozurgeti,
Georgia) with the coordination compound Fe (II)-fructose has been developed.
The results of the investigation show that the adsorption of Fe (II)-fructose
on the superfine askangel has a physical character. On the basis of the
clinical tests, the possibility of application of Fe-askangel as an effective
blood restorative agent for treatment of iron-deficiency anemia has been shown.
Auth.
8.g.13.1.215. The effects of Berberin
obtained from Ðhållodendron Lavalei introduced in sub-tropical areas of
The effects of Berberin
were studied on blood glucose level and on glucose tolerance in an experiment
with mice. Berberin is obtained from Ðhållodendron Lavalei,
the plant introduced in the subtropical areas of
Auth.
8.g.13.1.216. Microbiological
investigation of suppurative skin infections. /D. Chikviladze, Kh. Gachechiladze, D. Metreveli, M.
Mikeladze/. Experimental and
Clinical Medicine. - 2010. - #4(59). - pp. 101-103. – rus.; abs.: eng., geo.
The article represents
the results of investigations of feasible agents of suppurative skin infections
(furunculosis, carbunculosis) and their sensibleness/resistance to various
groups of antibiotics. During investigation were studied 95 strains of S. aureus, obtained from patients (age
ranged from 25 to 60 years) which suffered from furunculosis and carbunculosis
and were treated in 2005-2008. Sensibleness and resistance of obtained strains
to antibiotics of different groups were studied using the method of serial
dilutions in agar. High frequency of sensibleness of the obtained S. aureus strains was found to
vancomycin (98.8%), linezolid (96.4%), netilmicin (94.4%),
trimetroprime/sulphametocxazol (93.8%) and also to antibiotics for local use -
fusidic acid (97.9%) and mupirocin (98.5%). High frequency of resistance of the
obtained strains was found to ciprofloxacin (42.1%), tetracycline (51.8%),
chloramphenicole (38.5%), clindamicine (28.2%), erythromycin (53.8%), gentamicin
(60.3%), oxacilline (46.3%), levofloxacine (43.6%), lincomycine (53.8%),
rifampicine (40.1%). 55.5% were methicillin-resistance staphylococcus (MRSA).
Polyresistant were only 47.3% of the obtained S. aureus strains. The effectiveness of empiric antibiotic therapy
of skin infections depends on local data about antibiotic resistance.
Auth.
8.g.13.1.217. Ethiology role of some viruses in prevalence
of bronchial asthma. /N. Barnabishvili, P.
Gamtsemlidze, M. Mirtskhulava, Z. Barbakadze, Z. Phkhaladze, N. Mirtskhulava,
K. Zaridze/. Experimental and
Clinical Medicine. - 2010. - #4(59). - pp. 143-145. – geo.; abs.: eng., rus.
160 children aged 2-16
diseased with bronchial asthma were observed in
Auth.
8.g.13.1.218. Balneo-extension therapy
in rehabilitation of patients with osteoartrosis. /G. Shavianidze, M. Shavianidze, G. Lomidze,
Osteoarthrosis is a
degenerate-dystrophic disease of the joints, one of major factors of its
generation are loadings. The researches carried out by us have allowed
developing a new method - extension of joints, with inclusion in a complex
balneotherapy, including resort balneotherapy in Tskhaltubo. The extension of
joints has demanded the working out of treatment techniques and the adaptation
to the patented atmospheric and underwater applications. The obtained direct
and remote results have revealed that a rehabilitation course of bottom
finiteness sick of underwater horizontal extension in the conditions of a
resort, authentically exceeded results of other complexes; at "dry”
extension of the expressed anti-inflammatory effect at patients with sinovite
is noted. The received results have allowed to prove scientifically expediency
of application extension at is degenerate-dystrophic diseases of joints and to
create the new rehabilitation complexes including extension of joints,
balneotherapy and resort treatment.
Auth.
8.g.13.1.219. The automated control
system of laboratory research for transmissible diseases. /Sh. Tsanava, M. Chokheli, G. Mgeladze, A. Egoyan, M.
Mirtskhulava, P. Imnadze/. Experimental and
Clinical Medicine. - 2010. - #4(59). - pp. 149-151. – geo.; abs.: eng., rus.
The work discusses the
structure and basic principles of an automated control system for laboratory
research (ACSLR) developed in the
Auth.
8.g.13.1.220. Study of antimicrobial properties of iron
polyphosphate and perspective of its usage. /I.
Karalashvili, N. Klarjeishvili, N. Jabishvili, S. Urotadze, I. Javashvili/. Experimental and Clinical Medicine. – 2010. - #4(59).
- pp. 44-46. – geo.; abs.: eng., rus.
Antimicrobial and viral
properties of inorganic polymer compounds of iron polyphosphate have been
studied. In order to detect bactericidal and viral properties, the effect of
different concentration of iron polyphosphate solution on viruses and
microorganisms was studied. According to the results, it was determined that a
solution of iron polyphosphate is characterized of antimicrobial property and
deodorization ability. Iron polyphosphate is ecologically harmless, contains
iron and phosphate ions and represents a pink solution with no smell.
Auth.
8.g.13.1.221. Parafunction of
masseters, diagnosis and treatment. /S. Mhgebrishvili,
Under observation were
87 4-year students aged 21-25 of the stomatology faculty. All the students were
examined and their case histories were obtained. In the specially made cards,
complaints of the students regarding the rising of tonus of masseters,
toothache, gum scratching, headache and aches in the area of temple-lower jaw
joint were entered. As a result of the research, it was revealed that 7 (8%)
out of 87 students complained of scraping teeth, especially at night, followed
with toothache and headache, bleeding gums, stretching of muscles in the
morning. Objectively, the myotonic research revealed the rising of tonus of
chewing and temple muscles. Roentgen logically the symptoms of teeth
overloading were observed. Based on model studies of the mentioned 7 students
4(6%), it was revealed that on the upper and lower jaw the grinding teeth were
mentioned as cone wearing. They were provided with physiotherapeutic,
psychological, drug and orthopedic therapy. In 3-4 months after the treatment,
as a result of repeated researches, it was revealed that the chewing and temple
muscle tonus was in norm. Roentgen logically, the symptoms of functional
overload were not mentioned. The students no longer complained of headaches and
toothaches, scraping teeth, overload of muscles. Thus, parafunction of
masseters – bruxism – treatment has to be complex. Particularly, it has to
include the psychotherapeutic, physiotherapeutic and orthopedic methods.
Auth.
8.g.13.1.222. Depression and diabetes. /Sh. Vashadze, M. Kekenadze/. Experimental and Clinical Medicine. – 2010. - #5(60).
- pp. 22-24. – geo.; abs.: eng.
Depression is not
generally listed as a complication of diabetes. However, it can be one of the
most common and dangerous complications. The rate of depression in diabetics is
much higher than in general population. Diabetics with major depression have a
high rate of recurrent depressive episodes within the following five years. A
depressed person may not have the energy or motivation to maintain good
diabetic management. Depression is frequently associated with unhealthy
appetite changes. Suicidal diabetic adolescents have constant access to
potentially lethal doses of insulin. Symptoms of Depression: These are based on
the Diagnostic and Statistical Manual of the American Psychiatric Association,
4th Edition (DSM-4): a) Depressed mood for most of the day; b) Decreased
pleasure in normal activities; c) Sleeping difficulties or significantly increased
demand of sleep; d) Gaining or losing weight; e) Feelings of guilt or
worthlessness; f) Low energy level; g) Difficulties in concentrating and making
decisions; h) Suicidal thoughts. We have observed 100 people aged 13-70 (50
women and 50 men). The rate of depression and reactive anxiety are registered
with the help of psychometric tests according to the scale of depression (BDi).
The average period of the illness is 6-5 years. The age of the illness debut is
15 years. The presented diagnosis has been determined according to MKGB (2003)
criteria. We have asserted that 52% of the patients observed are depressed,
among them 45.2% has light form, 26.8% - medium form, and 21% - severe form. We
should note here that this indicator among unmarried people is very low,
especially among women. 10% expose the suicide ideas, among them 7% is
categorical, which, we think, is very dangerous. The majority of the depressed
people do not work. There have been major advances in the treatment of
depression. There are specific medications and specific psychotherapy
techniques that have been shown to help depression. Often individuals do well
with a combination of antidepressant treatment and psychotherapy. Be sure that
your clinician is willing to take the time to communicate with your diabetes
team. Ideally, the mental health clinician should be familiar with your type of
diabetes.
Auth.
8.g.13.1.223. Distribution of Rh-Hr blood group
antigens, alleles and haplotypes in the mountain district of Adjara (
Rh-Hr blood group
antigens represent a genetically stably determined trait being of many-sided
biological and clinical significance. Blood group antigens are either sugars or
proteins, and they are attached to various components in the red blood cell
membrane. The indigenous Adjarian population (105 subjects) was investigated
for Rh-Hr red blood group markers. Five erythrocytic group antigens (C, c, D,
E, e) were studied by immunoserological methods. The obtained results were
statistically processed. Maximum frequency distribution of the e antigen was found (100%), being followed
in frequency by the c antigen (89%).
The frequency of the D antigen made
up 82%, and that of the d antigen -
18%. The frequency of the c antigen
made up 61%, that of the E antigen -
23%. Six Rh-phenotypic groups of various frequencies were fixed. The CcDee
phenotype is the most characteristic of the said district population. Its
distribution frequency amounts to 38%.
Auth.
8.g.13.1.224. Depression and
dorsalgia. /Sh. Vashadze, M.
Kekenadze/. Experimental and
Clinical Medicine. – 2010. - #5(60). - pp. 30-33. – rus.; abs.: eng.
Depression is a state of
low mood and aversion to activity. A depressed person experiences or displays
these symptoms. In the course of supervision and antidepressant treatment, 30
patients with chronic dorsalgia estimated the contribution of depression to the
overall picture of the disease. Along with the complaints about lasting back
pains, a high level of depression and alarm was marked in the patients. Sleep
disturbances, vegetative dysfunction and the expressed decrease in quality of
life came to light as well. Psychometric tests allowed revealing the symptoms
of depression in 90 % of the patients. All patients received a course of
antidepressant treatment two times a day for 6 weeks. Along with a considerable
reduction of depression symptoms and alarm, therapy reduced the expression of
muscular dysfunction and pain syndrome authentically. At the initial stages of
treatment, positive dynamics concerning vegetative dysfunctions, sleep
disorders and low quality of life was marked. The research results confirmed
the fact of depression prevalence among the patients with chronic dorsalgia and
its negative influence on the course of pain syndrome. Antidepressants of high
efficiency and safety are shown during treatment associated with chronic back
pains along with depression, for they positively influence the basic syndrome.
Auth.
8.g.13.1.225. Prognostic and developed
scenarios of H1N1 flu pandemic. /R. Khakhnelidze, T.
Iakobadze, Kh. Katamadze,
A realistic picture of
the H1N1 flu 2009 pandemic was developed according to a moderate scenario. The
highest intensity of the flu pandemic cases was reported in places with
population diversity. The epidemic wave provoked by the flu pandemic lasted 6
weeks. The peak of the epidemic wave lasted about 2 weeks. The incidence rate
was higher in adolescents under 15 years of age than in other age groups. In
the age groups under 1 year and 1-4 years, the numbers of cases were
accordingly 8789 and 7167. Compared with seasonal influenza, the highest
incidence rate was in age group 20-29 (the number of cases was 1954). The
incidence rate was lower in the people of and over 60 years old, as it was predicted,
taking into consideration the circulation period of A (H1N1) virus subgroups.
Early influenza-associated hospitalizations and good management reduced the
complications and death rate. Intensive therapy and artificial lung ventilation
were used for hospitalized patients - accordingly 5% and 1.1%. Mortality rate
was high among 20-59 years old patients. Other somatic diseases or chronic
infections accompanied the flu.
Auth.
8.g.13.1.226. Correlation of Kell and
Mn erythrocyte blood group antigens and alleles with uterine and breast cancer.
/I. Nakashidze, L. Akhvlediani, M.
Nagervadze/. Experimental and
Clinical Medicine. – 2010. - #5(60). - pp. 36-40. – geo.; abs.: eng.
Our investigation shows
a certain correlation between concentrations of M and K alleles of blood minor
group antigens and uterine and breast cancer. As is well known, blood group
antigens have peculiarities in genitography, which need to be considered along
with the other risk factors. The given quantity of investigated samples is not
enough; therefore, the investigation is to be continued.
Auth.
8.g.13.1.227. Structural and
quantitative disorders of chromosomes during endemic, sporadic and multinodular
goitre. /N. Zosidze, K.
Jibladze, Sh. Photskhishvili/. Experimental and
Clinical Medicine. – 2010. - #5(60). – pp. 40-43. – geo.; res.:eng.
In the development of
thyroid gland diseases, a certain role is performed by genetic factors. We have
studied the spectrum of structural and quantitative disorders during endemic, sporadic, and multinodular
goitre. During the above-stated forms of the thyroid gland disease, the
instability of chromosomes is revealed through the structural disorders
expressed by high frequency chromosomes.
Auth.
8.g.13.1.228. Features of female
contracted pelvis. /I. Sikharulidze, M.
Kordzaia,
We have investigated
features of the pelvis of Georgian females. In our study we used the pelvis
classification of W.Caldwell and H.Moloy (1933) (they selected four types of
the pelvis: gynecoid, android, platipeloid and anthropoid). The characteristics
of women’s physical development were estimated by the indices of body length
(by R.Martin, 1928) and weight, and women’s constitutional type was determined
by the classification of I.Galant (1927). Characteristics of the physical
development of newborn children were also investigated. 450 practically healthy
women at the age of 17-44 were investigated according to the method known as external
pelviometry, adopted in obstetric practice. 218 women had the gynecoid type
pelvis, 232 women’s pelvis were contracted to different extents. According to
the constitutional type: gynecoid pelves were mostly typical of the mesosomic
women, and contracted pelves were typical of the women having leptosomic
constitution.
Auth.
8.g.13.1.229. Primary oligodendroglial intracranial
tumors: some epidemiologic considerations. /T.
Mermanishvili, T. Jorbenadze,
The aim of our study was
to perform a hospital-based epidemiological analysis of primary
oligodendroglial intracranial tumors in
Auth.
8.g.13.2.1. Differential
characteristics of open and laparoscopic adrenalectomy. /S. Hovhannisyan/. Georgian Medical News. – 2010. – #2(179). – pp. 11-14. – rus.; abs.: geo., eng., rus.
Clinical studies are
based on an analysis of the results of a survey and surgical treatment of 147
patients with adrenal tumors who were treated from 1994 to 2009 in the RMC
"
Auth.
8.g.13.2.2. Rectal foreign bodies. /T. Abuladze, T.
Ivanishvili, K. Shapatava/.
An algorithm of trans-anal extraction of rectal
foreign bodies and proctologic aid characteristics are analyzed. The algorithm
and its related in-hospital manipulations are discussed in detail. The
application of the algorithm in 17 cases has yielded positive results.
Auth.
8.g.13.2.3. Therapeutic approach
during upper gastrointestinal tract bleeding. /L. Akhmeteli, L. Saghinashvili,
305 cases of upper gastrointestinal bleeding from 2005
till 2008 in Surgery department of Khipshidze University Clinic of Tbilisi
State Medical University are discussed. The number of endoscopies made 09.36%,
electrocoagulation – 56.7%, repeated endoscopy - 3.66%, re-coagulation - 4.04%.
The number of surgical interventions made 5.25%, lethality – 1.31%. Thus,
despite of significantly increased cases of upper gastro-intestinal bleeding,
the number of surgical interventions was low. This can be explained by a wide
application of the therapeutic endoscopy technique and modern effective drugs.
Auth.
8.g.13.2.4. Hernioplasty by
Ramirez technique. /I. Gelashvili, N. Lomidze,
I. Tsereteli/.
Postoperative ventral hernia has always been one of
the most complex options in herniology. In the
Auth.
8.g.13.2.5. The role of endogenic toxemia
in the pathogenesis of a traumatic disease. /G.
Gvasalia, L. Saghinashvili, Z. Dzneladze/.
In the current study, 271 cases of trauma fixed at
Acad. N. Khipshidze University Central Clinic in 2004 – 2008 were considered
and main markers of endogenic toxemia syndrome were studied. The obtained
results show endogenic intoxication to be the main cause of pathogenesis and
thanatogenesis of a traumatic disease. The article deals with different
manifestations of intoxication during the first hours of the injury, at the
early shock stage and in the post-shock stage. From the aspect of clinical
practice, it should be emphasized that formal compensation of hemodynamic data
not only stop disturbances of homeostasis caused at shock but deepens them at a
definite stage of the post-aggressive period. The severity index of operational
intervention is more increased after performing a simultaneous surgery on two
or more zones than in the case of a stage-by-stage delay of these surgeries.
Auth.
8.g.13.2.6. Traumatic disease. /G. Gvasalia, L. Saghinashvili, Z.
Dzneladze/.
The aim of the study was to determine specifics of a
trauma structure under a big city conditions. For this purpose, 271 cases of
traumatic diseases were analyzed given the posttraumatic shock and hypotension
duration. The obtained results prove the shock and surgical infection problems
to be the priority ones during bodily injuries, which determine in general the
early or late lethality during an injury.
Auth.
8.g.13.2.7. Acute injury of
testicular appendages in children. /G. Davitaia, R.
Kutubidze,
The aim of the study was early identification of acute
injury of testicular appendages and elaboration of its effective surgical and
main pathogenic therapeutic principles. 63 boys aged 0-15 with nonspecific
orchiepididymitis were investigated during 2005-2008 years in the surgical
department of TSSU. An acute injury of testicular appendages was confirmed in
82.5% of patients (52 cases) on the basis of clinical investigation and
surgical intervention. An analysis of performed clinical-laboratory, radiological
and morphological investigations revealed that the nature of the injury
depended on the stage of the disease and a degree of the organ’s involvement in
the pathological process. Timely diagnostics of acute injury of testicular
appendages is the basis for differential, complex treatment, which consists of
urgent surgical intervention and postoperative pathogenic therapy (prevention
of inflammation and ischemia), prophylaxis of hormonal and spermatogenesis
dysfunction. A conservative treatment of the acute injury of testicular
appendages is ineffective. The indications of surgical intervention are: (1)
acute clinical symptomatology with ultrasound confirmation or without it; (2)
minimal clinical manifestation, when ultrasound reveals the signs of inflammation
and fluid accumulation in testicles; (3) the bigger is the size of testicular
appendages, the more urgent is surgical intervention; (4) minimum clinical
signs cannot serve as contraindication of a surgical intervention.
Auth.
8.g.13.2.8. Pancreatoduodenectomy. /N. Lomidze,
Pancreatic cancer is the third leading neoplasm of the
gastrointestinal system and has a dismal prognosis. Primary carcinoma of the
duodenum is the rare and uncommon neoplasm that represents less than 0.5% of
all gastrointestinal malignancies. The aim of this study is to access patients
with pancreatic, duodenal and periampullary cancers. The majority of patients
with pancreatic head cancer are poor candidates for resection at the time of
diagnosis due to early development of distant metastases and/or major
infiltrations of adjacent structures; patients with cholangiocarcinomas and
duodenal cancers appear to be better candidates for Whipple procedure. Duodenopancreatectomy
gave a longer survival time than duodenal resection in patients with duodenal
cancer.
Auth.
8.g.13.2.9. Intra-abdominal
hernioplasty using Proceed mesh. /N. Lomidze,
Ventral hernia is most prevalent among surgical
pathologies. Its surgical management is still very topical. In recent years,
the Proceed composite mesh has been created for intra-abdominal ventral hernia
recovery. It is biologically tolerable, inert, is resistant to infections,
characterized with elasticity, molecular penetration and mechanical resistance.
Compared to Prolene mesh, it has minimal risk of seroma development, infection
and abortion of the mesh.
Auth.
8.g.13.2.10. Long-term
catheterization of lung abscess under conditions of fiber-optic bronchoscopy
and contrast study. /N. Lomidze, D.
Maghalashvili,
The successful treatment of a lung abscess requires a
technique that should be atraumatic, exclude the bond of the abscess cavity
with the pleural cavity and soft tissues, ensure a reusable approach to the
abscess cavity with the frequency necessary for effective influence of the
microflora and adequate debridement and drainage of the purulent cavity contents.
The closest to the said requirements is bronchoscopy performed under local
anesthesia. The technique was used to treat 20 patients with acute (18) and
chronic (2) lung abscess. The authors conclude that the prolonged transnasal
drainage of the lung abscess saves patients from the repeated and frequent
bronchoscopy examinations, reduces the period of recovery and treatment
expenses.
Auth.
8.g.13.2.11. Main
development stages in inguinal hernia treatment. /N. Mzareulishvili, T. Akhmeteli., R. Khetsuriani,
First steps in radical treatment of inguinal hernias
were taken by Risel in 1877, who started the treatment of inguinal hernias by
opening the inguinal canal. The pioneer of radical herniology is
Lucas-Championniere 1885; his method consists in the following: after
herniotomy and forming inguinal canal walls by muscle-aponeurotical linings, a
radical treatment of inguinal hernias begins. Inguinal hernias pathogenetical
treatment was presented by Baxter in (1893) and
Auth.
8.g.13.2.12. Percutaneal
transhepatic biliary stenting – topical technical aspects. /M. Mizandari, G. Spanderashvili, A. Mtvaradze, L.
Baindurashvili, G. Nemsadze/.
Our purpose was to present the percutaneal
transhepatic biliary stenting (PTBS) technique. PTBS procedure was successfully
performed in 14 (73.7%) cases; in the rest 5 (26.3%) cases we failed conducting
the guidewire through the obstruction and so procedure was not fulfilled. In 3
(75.0%) of 4 self-expandable stents the complete expansion needed balloon
inflation; In 4 to 8 weeks period after the PTBS in 4 (28.6%) cases of
successfully fulfilled 14 PTBS stent potency loss was documented and PTBD was
performed to those patients. PTBS after preliminarily performed PTBD is safe
and effective technique and should be widely used in patients with inoperable
malignant biliary obstruction. PTBS might be performed using cholecystostomy
fistula also; in the cases of benign biliary obstruction, indications for PTBS
are limited.
Auth.
8.g.13.2.13. Percutaneal
imaging-guided mediastinal lymph node core biopsy – technique, advantages and
complications. /M. Mizandari, D.
Maghalashvili, A. Mtvaradze, G. Nemsadze, G. Spanderashvili, L.
Baindurashvili/.
Our purpose was guidance techniques, approaches,
possible complications of percutaneal imaging guided mediastinal lymph node
core biopsy (PIGMLNCB) are outlined PIGMLNCB is effective and minimally
invasive; other techniques for mediastinal lymph node core biopsy should be
used only in PIGMLNCB failure cases. The advantages of ultrasound guidance are
possibility of real-time imaging, non-invasiveness and cost-effectiveness; this
technique cannot be used in posterior mediastinum. The advantage of CT guidance
is the possibility of visualization of all thoracic structures. When the
adequate guidance technique is used, PIGMLNCB is a safe procedure and should be
recommended for wide use if appropriate indications are determined. Ultrasound
should be used for procedure guidance if the ‘target” can be adequately imaged
by this technique.
Auth.
8.g.13.2.14. New trend in endoscopic
surgery: transvaginal appendectomy. /T. Tabutsadze,
Natural Orifice Transluminal Endoscopic Surgery
(NOTES) is a new method of mini-invasive surgery, which involves passing
surgical instruments and a tiny camera through a natural orifice, such as the
mouth, vagina, urethra or rectum, which provides an access to the desired
organ. The method is approved due to its benefits – less pain, quicker
recoveries, fewer complications, and no scar. Here are discussed 3 operations
of transvaginal appendectomy. The operations were made without any technical
difficulties or complications. No gynecological or surgical problems or any
complications were detected during the observation period. NOTES – non-scar
surgery is a new trend and takes endoscopic surgery one step further. The
procedure is safe, physiological and precise. We think that in case of suitable
technical support in the near future NOTES will replace not only conventional
medicine but laparoscopic surgery technology as well.
Auth.
8.g.13.2.15. ‘‘Chess’’
mini-laparotomy in the surgical treatment of purulent peritonitis and
retroperitoneal space pyo-necrotic damage. /G.
Tatishvili, B. Chakvetadze/.
The problem of standardization of acute peritonitis
and pancreonecrosis is the oldest and widespread problem of contaminated
surgery. Post-operational lethality is up to 5 to 50%. In the past years, to
resolve this problem a lot of methods were used. We used "chess"
mini-laparotomy and lumbotomy for treating purulent peritonitis and
retroperitoneal space pyo-necrotic damage on our 5 patients. These methods,
despite on few observations, are seemed to be promising and need additional
observations and study.
Auth.
8.g.13.2.16. Modern methods of
chronic rhinitis treatment. /Sh. Japaridze, L.
Lomidze, M. Jashi, T. Khetchinashvili,
180 patients with chronic rhinitis were treated at the
ENT department of TSMU during 2006-2007; out of them 100 were treated with
ultrasound disintegration, 70 patients – with radiofrequency disintegration and
10 patients - with sub-mucosul resection of the lower conch. According to the
research results, the disintegration methods of ultrasound as radiofrequency
types are less traumatic, less bloody and most effective. Furthermore,
radiofrequency influence is more preferential between the two types of
disintegration methods.
Auth.
8.g.13.2.17. Incidence and risk
factors of nosocomial infections in the post-operative period in Georgian
population with congenital heart diseases. /M. Lomtadze, M. Chkhaidze, E. Mgeladze,
Nosocomial infections
still remain a serious problem in patients undergoing open heart surgery.
The aim of the study was to determine the incidence, etiology and main risk
factors of nosocomial infections (NI) following cardiac surgery in the
population with congenital heart diseases. A retrospective case study was
conducted. 387 patients with congenital heart disease (CHD), who underwent
cardiac surgery from January 2007 to December 2008, were studied. The age of
the most patients was up to 15 years; 73 patients (18.8%) were older than 15.
All 387 patients underwent a cardiac surgery. The rate of NI was 16%. The most
common infections were bloodstream infections (BSI) (7.75%) and respiratory
tract infections (7%), respectively. The rate of NI was higher in patients
under 1 year of age, after urgent surgery and urgent re-operation, long cardiopulmonary
bypass (CPB) and aortic cross-clamp time, also in patients with prolonged
mechanical ventilation, massive haemotransfusion, with open heart bone after
surgery, reintubation, hospitalization in another hospital during last three
month. It was concluded that the most
common nosocomial infection after cardiac surgery congenital heart diseases in
Georgian population was blood stream infection. The main risk factors of NI in
the same setting were age under 1 year, urgent surgery, urgent re-operation, long
CPB and aortic cross-clamp time, long duration of mechanical ventilation,
massive haemotransfusion, open heart bone after surgery, reintubation,
hospitalization in another hospital during last three month.
Auth.
8.g.13.2.18. Treatment of
postoperative esophageal leak by active drainage procedure (case report). /M. Kiladze, H. Vasadze, N. Chkhetia, E. Nadiradze, E.
Phkhakadze/. Georgian Medical News.
– 2010. – # 1(178). – pp. 11-14. – rus.; abs.: geo., eng., rus.
Postoperative esophageal leak is still a very serious and
complex problem associated with poor results because of considerable morbidity
and mortality rate. We described the case of successful treatment of suture
line leak of a 53-year-old patient after resection of a big size epiphrenic
diverticulum. Traditional right-sided transthoracic approach in 7th
intercostal space with dissection, exposure and resection of diverticulum by
stapler with 40F bougie within the esophagus was performed with reinforcement
of suture line. On 6th postoperative day the control water-soluble
contrast X-ray examination was done and pleural effusion and suture line
disruption was found. Immediately under X-ray control the large diameter chest
tube (Ch24) was inserted and periesophageal mediastinum as well as pleural cavity
was drained and active aspiration with simultaneously irrigation/lavage
procedures was started. Parallel fasting, systemic antibiotic therapy was
started and feeding balloon catheter gastrostomy by Stamm was created. The
healing process of the leak was controlled every week by water-soluble contrast
swallow and the chest drain tubes were twice changed (Ch20 and Ch14) during the
treatment. The complete healing and closure of the leak was achieved after 2,5
month of starting the treatment by using this method. Our case have
demonstrated, that aggressive conservative treatment approach with combination
of: active and adequate drainage of the leak site, systemic antibiotic therapy,
nutritional support by feeding gastrostomy with frequent radiologic examinations
for monitoring of healing process is the effective and safe treatment of
esophageal leaks.
Auth.
8.g.13.2.19. Cases of strangulated
obturator hernia. /B. Chakhvadze, D.
Nakashidze, K. Kashibadze, A. Beridze/. Georgian Medical News. – 2010. – #2(179). – pp. 7-11. – rus.; abs.: geo., eng., rus.
Obturator hernias are
extremely rare in surgical practice. Only about 600 cases are described in the
world medical literature. To diagnose obturator hernia is very complicated.
Hernial protrusion is not often observed. The strangulation of obturator hernia
is accompanied by rapidly developing symptoms of intestinal obstruction, which
is usually an indication for emergency surgery. The article analyzes two
clinical cases of strangulated obturator hernia and one traumatic eventration
and strangulation of small intestine in the obturator ring ruined by trauma. In
all cases the indication of surgery was clinical picture of a growing
intestinal obstruction or acute abdomen. Only in one case, despite the
prevailing clinical picture of acute intestinal obstruction in the light of
anamnesis and the accompanying neurological symptoms before the operation could
be suspected strangulated obturator hernia, which was confirmed during surgery.
As it was mentioned above, in doubtful cases to clarify the diagnosis should be
applied other methods of examination of patients, including computed
tomography.
Auth.
8.g.13.2.20. Endoscopic treatment in
critical patients with upper gastrointestinal bleeding. /Z. Kheladze, S. Jaiani, B. Tsutskiridze,
Zv. Kheladze,
G. Chakhunashvili, D. Chakhunashvili/. Georgian Medical News. – 2010. – #3(180). – pp. 7-13.
– rus.; abs.: geo., eng., rus.
The goal of the current
research was to ascertain the optimal methods of an endoscopic haemostasis in
critical care patients with GDB. The research was conducted on critically ill
patients. The different endoscopic methods of treatment: injectional
hemostasis, irrigation with local hemostatics, thermo coagulation, and combined
method were used. Treatment with injectional hemostasis resulted in hemostasis
in 75% of patients. Irrigation with local hemostatics was conducted using the
local hemostatic agent caprofer and
(or) 10% solution of epsylonaminocapronal acid. The final hemostasis was
achieved in the 90% of the cases; bleeding was stopped in 85% of the cases when
the hemorrhages occurred from chronic ulcers. The effect of thermo coagulation
method was 80-85%. Combined method of treatment (combination of the irrigation
with caprofer and thermo coagulation) helped to achieve 95% of the final
hemostasis in critically ill patients. The achieved results certify that the
combined use of caprofer and method of electro coagulation in critical care
patients with GDB is very perspective. Simultaneously with this, it is also
recommended to use anti-segregation therapy with blockers of proton pomp and
boosting the defense of the mucous tissue with high doses of mucogen.
Auth.
8.g.13.2.21. Determining factors of
effectiveness of extracorporeal shock wave lithotripsy in ureteral stones:
Results of own Investigation. /M. Manukyan/. Georgian Medical News. – 2010. – #4(181). –
pp. 7-13.
– rus.; abs.: geo., eng., rus.
The
purpose of the present study is to investigate main determining factors of
effectiveness of extracorporeal shock wave lithotripsy (ESWL) in urethral
stones and the influence of these factors on the number of necessary sessions
of ESWL procedure. The problem presents a special interest for insurance
medicine, as the number of sessions has a direct impact on the cost and length
of treatment. The present investigation included 162 patients with urolithiasis
having stones in urethra. To find out determining factors of effectiveness of
ESWL in urethral stones the following factors were considered: size,
localization, radio-opacity of stone, its duration of stay in urethra, the
degree of dilation of upper urinary tract. The influence of mentioned factors
on the number of necessary ESWL sessions was investigated. On the basis of the present study a conclusion can be
made that the principal factors determining the clinical efficacy of ESWL in
urethral stones are the stone size, condition of upper urinary tract and stone
radio-opacity. The level of localization of the stone in urethra has no
influence on ESWL efficacy. Therefore in case of large size stones, their long
stay in urethra and significant disorders of urodynamics in upper urinary
tract, in marked radioopacity of stones more than one session of ESWL is
required. In such cases, we recommend to consider other less invasive methods
of treatment of urethral stones (ureterorenoscopy or percutaneous urethra
lithotripsy).
Auth.
8.g.13.2.22. Probability
of development of "Steinstrasse” (stone street) depending on the number of
extracorporeal shock-wave lithotripsy in ureteral stones. /M. Manukyan/. Georgian Medical News. – 2010. – #4(181). – pp. 13-17. – rus.; abs.: geo., eng., rus.
One
of the complications of extracorporeal shock wave lithotripsy (ESWL) is the
urethral obstruction by large stone fragments and formation of "Steinstrasse”.
The present study aims at the investigation of the probability of development
of "Steinstrasse” depending on the number of ESWL sessions in urethral
stone treatment. 162 patients with urinary tract stone disease having urethral stones
were included in the present study. Based on the results of
the present study it is stated, that the probability of formation of
"Steinstrasse” increases along with the number of ESWL sessions.
Therefore, in such cases more intensive follow-up is necessary after ESWL for
prompt detection of "Steinstrasse” formation and prevention of possible
complications.
Auth.
8.g.13.2.23. Influence of stone size,
location and impaction on the success of ureteroscopic pneumolithotripsy. /H. Ciftci, M. Savas, A. Altunkol, E. Yeni, A. Verit,
B. Chelepkolu/. Georgian Medical News. – 2010. – #6(183). –
pp. 7-12. – rus.; abs.: geo., eng., rus.
This study was conducted
on 336 patients that had undergone ureteroscopic pneumolithotripsy for ureteric
stones between August 2005 and June 2008. Patient data were analyzed with
respect to stone localization, size and impaction. All ureterorenoscopic
procedures were performed under general anesthesia using a 9.5F rigid
ureteroscope. A plain film of the kidney ureteral bladder was performed on the
first postoperative day and week 4 to evaluate treatment efficacy. Patient age
was 42, 63±15 (14-77) yr. Mean stone size for all groups was 9.77±4mm (5-20
mm). A total of 336 patients were treated with ureteroscopic pneumolithotripsy,
129 female and 207 male. The overall initial success rate was 85.71%. The
success rate of ureteroscopic pneumolithotripsy, proximal, middle and distal
urethra, for stone location, 76.54%, 85.48%, 90.74%, for Stone size (>10 mm)
54%, 77%, 88 % and for Stone impaction; 50%, 75,6%, 85,4% respectively. There
was a statistically significant difference between stone free rates with
respect to the proximal ureter stone, increasing stone size (>10 mm) and
stone impaction (p<0.05) and a positive correlation with the operative complication
rate. It is concluded that it is possible to achieve high success and low
complication rates in pneumolithotripsy for distal ureteral stones.
Nevertheless, the success rate decreases and complication rate increases with
stone locations close to the proximal urethra. Complication rate increases with
increasing stone size and/or impacted ureteral stones.
Auth.
8.g.13.2.24. Familial adenomatous
polyposis of colon. /N. Grigolia, G. Giorgobiani, G. Chkhaidze, Sh.
Bolatashvili, G. Grigolia/. Georgian Medical News. – 2010. – #7-8(184-185). – pp. 21-26 – rus.; abs.: geo., eng., rus.
At present the only
treatment of familial diffuse polyposis is total colectomy and ileorectal
anastomosis. Two cases of familial diffuse polyposis are analyzed. The first
case: 18 year old man with diffuse polyposis of colon. The second case: 41 year
old man with diffuse familial polyposis of colon, liver abscess in segment V,
and fistula between the abscess and the colon. In the both cases a radical
proctocolectomy with the good, newest results was performed. The patient
underwent proctocolectomy with the ileoanal anastomosis with S-shaped ileal reservoir with ileostoma.
Auth.
8.g.13.2.25. Characteristic of
cytopathological changes in urine after extracorporeal shock-wave lithotripsy. /A. Grabsky, A. Muradyan, M. Aghayan,
The aim of the study is
to assess the damage to the urothelium caused by shock waves through
cytological examination of the urinary sediment in patients who had ESWL. Study
included 100 otherwise healthy first-time stone-formers aged 20 to 50, who
underwent ESWL on Modulit SLK machine. Urinary samples were taken before and
immediately after ESWL, in two days and on the fourth day after ESWL. Control
group included 20 healthy individuals. The urine was centrifuged, smears fixed
by conventional MGG method and stained by azure-eosine using Pappenheim’s
method. Cytogram data analysis was performed using morphometric methods,
allowing for qualitative and quantitative cell characteristics be translated
into digital form. Student t-criterion was used for statistical evaluation of
the difference of derived figure parameters. The authors put the stress on
destructives processes. In order to rule out biased assessment of the
cytograms, morphometric examination of urinary sediment was performed. Averaged
value of the total cell index was calculated with one of the forms of
cytopathology and deduced heterogeneity of cytological indices within a
particular group /Σep (where is the average value of the total cell index
with one of the forms of cytopathology within the whole sampling, Σep is
the total number epithelial cells). The sum of absolute indices of cytological
changes is considered as "destruction index” (DI), which reflects
accumulated pathological changes in epithelial cells: DI=/Σep + /Σep.
Immediately after ESWL a statistically valid (p±0.01) significant increase in
DI is registered. In two hours after the session DI is decreased, but remains
rather high, and almost normalizes by the fourth day. We also explored the
specificity particular for each term of examination, expressed by cytological
changes. Examination of indices of heterogeneity within a group with moderately
expressed destructive changes (/Σep) revealed that these digital values
even in healthy men are slightly above zero (0.15±0.03). Just after ESWL values
rise to 0.6±0.1, then slowly decrease to 0.4±0.1 (2 hours after) and 0.25±0.07
(four days after). As to parameters specific to deep cellular changes
(/Σep), it is equal to zero healthy men, rises after ESWL, then decreases
in two hours and almost normalizes by fourth day. Digital values for this
parameter are several orders lower than for parameters of cells with moderate
changes. Study results indicate that epithelial lining of the upper urinary
tract undergoes cytopathological changes of different degrees, still they are
of transitory and reversible nature, which is proven by urinary sediment
cytogram performed on the fourth post-procedure day.
Auth.
8.g.13.2.26. Roentgenoendosñopic surgery of the complicated forms of urolithiasis
with accompanying diabetes mellitus. /M. Aghayan,
Contact lithotripsy and
nephrolithoextraction allows saving the patients from staghorn stones without
having recourse to traumatic open surgical modalities. Percutaneous removal of
staghorn stones with the use of rigid-lens nephroscopes presents as an
effective and less-invasive treatment option with minimal amount of intra- and
postoperative complications, which is particularly important in case of
presence of accompanying diabetes mellitus.
Auth.
8.g.13.2.27. GF-6 - novel protective
agent for skin wounds. /Ê. Mulkijanyan, J. Novikova, M. Sulakvelidze/. Georgian
Medical News. – 2010.
– #9(186). – pp. 67-72. – eng.; abs.: geo., eng., rus.
The aim of present
investigation was the determination of specific pharmacological (wound healing)
properties and the evaluation of possible irritant, allergenic and toxic
effects of GF-6 – a novel protective agent for skin mechanical and burn wounds.
In mouse excisional wound model GF-6 (topically 0.1 ml per wound) exhibited the
ability to accelerate scab rejection and full re-epithelization in test wounds
with no signs of bacterial contamination. GF-6 caused no irritation responses
such as erythema, oedema, dotted hemorrhage, hyperkeratosis, hyperplasia,
alopecia and scaling in 14-day acute dermal irritation test. As well no signs
of skin hypersensitivity (itch, erythema, oedema), and histological alteration
(ulceration, dotted hemorrhage, changed capillary lumen, damaged hair follicle)
were observed in skin application test at all time points during the 14-day
observation period, evidencing that GF-6 is non-allergenic. In subchronic
dermal toxicity 90-day study of five-fold concentrated GF-6 no statistically
significant changes in respiratory, circulatory, autonomic and central nervous
system, somatomotor activity and behavior patterns were detected. The results
of hematological study testified to no influence of the GF-6 90-day application
on blood formed elements. Thus, GF-6 should be considered non-toxic,
non-irritant, non-allergenic wound healing and wound protecting agent.
Auth.
8.g.13.2.28. Surgical management of
patients with complicated peptic ulcer disease. /A.Ghirdaladze, B.Mosidze, G.Elisabedashvili,
T.Jorbenadze/. Georgian Medical News.
– 2010. – #11(188).. – pp. 7-15. – rus.; abs.: geo., eng., rus.
The article presents the
results of medical treatment after peptic ulcer surgery. I group - 59 patients
with late complications after peptic ulcer surgery and II group - 16 patients
with complications of peptic ulcer disease, operated in presence of absolute
indications. 13C-UBT and RUT of biopsy material were used to diagnose Hp
infection. HP positive patients received antibacterial treatment. After 1 month
from the end of therapy and 1 year after HP eradication control investigations
by 13C-UBT and endoscopy were performed. 77.3% of all and 84,4% of early non
treated patients were Hp positive. All patients (of I and II gr.), who followed
control testing after antibacterial treatment were finally detected as Hp
negative. In I group, control endoscopy revealed epitelization or scarring of
ulcer and reduction of inflammatory changes in gastric and duodenal mucosa in
all 44 cases of eradication of HP infection (in 2 patients with peptic ulcer of
GEA ulcer relapsed in later). In II group, in 8 patients, who received antibacterial
treatment additionally to surgical method, any late complications after surgery
were not revealed. In other 6 HP positive patients: 2 – ulcer recurrence and 2
– development of chronic gastritis of operated stomach were noted, which
required the treatment of HP infection in future. It is concluded that 1)
surgery does not change HP-status of patients and HP infection retains in more
than 80% of cases; 2) ulcer recurrence, chronic gastritis of operated stomach
or its stump are associated with Hp and regress after Hp eradication; 3)
progression of gastritis into atrophic remain after surgery, which increases
risk of cancer development and there is possibility of its regression after
antibacterial treatment of Hp infection. The recommendations were worked out:
1) perforated, bleeding or stenosing ulcer must be treated only by ulceroraphy,
suturing or pyloroplasty respectively, added with subsequent Hp eradication
therapy for the prevention of late complications after peptic ulcer surgery; 2)
vagotomy or partial gastrectomy must be a forced intervention in cases of
decompensate pylorostenosis, resistant to treatment ulcers, as ulcers
non-healing or recurring after adequate conservative treatment. Subsequent
verification and eradication of HP infection are necessary.
Auth.
8.g.13.2.29. Original method of
Cesarean section operation and its role in the prevention of obstetric
complications. /Sh. Koridze, N. Kintraia, D. Jintcharadze , A.
Koridze,
The authors made an
analysis of archival material of 1577 case histories of the patients who were
subjected to Cesarean section operation at
Auth.
8.g.13.2.30. Some aspects of
classification and treatment strategy of iatrogenic bile duct injury. /B. Agayev, Q. Muslimov, G. Aliyeva, T. Ibrahimov, V.
Alizade/. Georgian Medical News. –
2010. – #11(188). – pp. 65-74. – rus.; abs.: geo., eng., rus.
Iatrogenic bile duct
injury continues to be an important clinical problem, resulting in serious
morbidity and occasional mortality. None of the classification system is
universally accepted and worldwide used, as each has its own limitation. The
article reviews various classification systems of bile duct injury.
Traditionally, biliary injuries have been classified using the Bismuth's
classification. This classification does not encompass the whole spectrum of
injuries during laparoscopic cholecystectomy. Strasberg’s classification made
Bismuth’s classification much more comprehensive by including various other types
of extrahepatic bile duct injuries. Our own classification is simple enough,
embraces the majority possible variants of bile duct injuries and is convenient
in clinical use.
Auth.
8.g.13.2.31. Articaine – the best
choice among local dental anesthetics. /N.Nizharadze,
M. Mamaladze, N.Tchipashvili,
D.Vadachkoria/. Georgian Medical
News. – 2011. - #1(190). – pp. 15-23. – eng.; abs.: geo., eng., rus.
Local anesthesia enjoys
priority among pain control techniques in clinical dentistry. Among a wide
choice of local anesthetic drugs available in dentistry for the prevention and
management of pain 4% articaine solutions achieve highest level of the
anesthetic potency and lowest systemic toxicity in all clinical situations,
conditioned by its superlative physicochemical characteristics and the
pharmacological profile. These are - low lipid solubility, high plasma protein
binding rate, fast metabolization, fast elimination half time; low blood level.
Articaine inactivates in both ways: in the liver and the blood serum. It has
good spreading through tissues. Thus, articaine seems to be the local
anesthetic of first choice in tissues with suppurative inflammation, for
adults, children (over 4), elderly, pregnant women, breastfeeding women,
patients suffering from hepatic disorders and renal function impairment. In
Articaine solutions (1:200 000) epinephrine is in low concentration, thus
in patients at high risk adverse responses are maximally decreased. In these
patients articaine should be used with careful consideration of risk/benefit
ratio. Articaine solutions must not be used in persons who are allergic or
hypersensitive to sulphite, due to content of sodium metabisulfite as
vasoconstrictor’s antioxidant in it. Incidence of serious adverse effects
related to dental anesthesia with articaine is very low. Toxic reactions are
usually due to an inadvertent intravascular injection or use of excessive dose.
To avoid overdoses maximum recommendation dose (MRD) must not be exceeded and
aspiration test always performed prior all LA injections. In these article we
introduce new graphs providing a quick and effect way to determine maximum LA
dose. Where side-effects are developed, an adherence to adequate medical aid
will ensure complete rehabilitation of the patient in all cases.
Auth.
8.g.13.2.32. The characteristics of
various forms of complicated surgery infections of the diabetic foot syndrome
and their antibacterial treatment. /A. Kistauri, G.
Devidze, M. Jibladze/. Georgian
Medical News. – 2011. - #1(190). – pp. 28-32. – rus.; abs.: geo., eng., rus.
In case of neuropathic
forms, infection is the cause of tissue necrosis, while in the case of
neuroischemic forms it is critical ischemia. Antibacterial therapy is desirable
in all cases of the neuroischemic form, independently of the signs of
infection. However, in the case of neuropathic forms, a course of antibiotics
is prescribed only in case of the associated infection. The infected
neuroischemic ulcer is characterized of acute development (infection+ischemia),
unlike the infected neuropathic, ulcer. The researches showed that 42 patients
(40%) suffered from neuropathic form and 63(60%) – from neuroischemic form. In
purulent zones, anaerobic flora was revealed in 77.3%, aerobic flora – 17.7%;
the rise of microflora was not indicated in 5% of cases. Most often, with 43.6%
St. aureus was found out, and from the association of microbes – St. aureus +
Str. pyogenes – 8.7%. The level of bacterial pollution was high, varying within
105 to 1012. The highest sensibility was shown towards
Tienam (98.9%). The most acceptable and productive form of treatment turned out
to be the combination phtorchinolyns+aminoglycosides. Out of 105 patients, 34
amputations were performed + 6 tall, 10 large (more than a half) and 18 small
(up to the middle of the foot). In 71 cases, we successfully managed to stop
infectious processes and avoid amputation.
Auth.
8.g.13.2.33. Original technique
for left hemicolectomy. /B. Archvadze,
An original technique
for left hemicolectomy is proposed in this article. The originality of the
technique lies in the fact that the anastomosis between the afferent or oral
portion of the bowel and the efferent limb provides, through the retained
mucosa, protection of all layers of the anastomosis from faecal masses for 6-7
days after the surgery. During this period, the tract is emptied via a drained
colostomy. Necrosis of the retained mucosa within the anastomosis and
functioning of the anastomosis occur on the 5-7th days after the surgery. We
performed left hemicolectomy on 75 patients using the above-described
technique. There were no cases of suture failure of the anastomosis in the
post-operative period.
Auth.
8.g.13.2.34. Protective treatment of
peptic ulcer complicated with erosive hemorrhage. /A. Gugutsidze, M. Kheladze, D. Gugutsidze, G.
Gogiberidze/. Materials of
The peptic ulcer
complicated with erosive hemorrhage is met in 15% of the disease. Early and
active treatment of hemorrhage guarantees hemorrhage stop in 95%. Treatment
foresees special regime, diet, sedative and antimicrobial treatment. In the
rest 5%, the disease is coped with surgically.
Auth.
8.g.13.2.35. The modern tenets of talipes valgus X-ray
diagnosis and surgery treatment. /Z. Avazashvili,
It is stated than none
of the methods used in the treatment of talipes valgus is universal. The
operational method shall be selected in consideration of all elements. The
article covers main etiologic, intrinsic and extrinsic factors of talipes
valgus and minor influence of pes planus (flat feet) îï its formation. All the talipes valgus causative
elements, such as medial bursa, proximal phalanx valgus, angle increase between
first and second metatarsal bones, first metatarsal interphalangeal joint
congruence, sesamoid bones inferior dislocation, hallux pronation should bå surgically treated. The article describes Õ-ãàó examination and
roentgenometry methods, strain levels, surgery treatment selection criterion
according to the deformity type. Nowadays the following surgery treatment
methods àãå being used:
reconstruction of the first metatarsal interphalangeal joint soft tissues;
proximal and distal parts osteotomy of the first metatarsal bone; sphenoid bone
osteotomy; sphenoid metatarsal joint arthrodesis; first metatarsal
interphalangeal joint arthrodesis; excision arthroplasty; endoprosthesis
replacement. Summarizing the article, the authors conclude that talipes valgus
surgery mode should bå chosen taking into
consideration all elements (talipes valgus and first and second metatarsal
bones angle, hallux pronation, first metatarsal bone distal metaphysic angle,
medial bursa, inferior dislocation, age of the patient and etc.).
Auth.
8.g.13.2.36. The essential meaning of
toracoscopic sympatectomy during the reaction of peripheral arteritis diseases. /K. Kashibadze, A.
Beridze,
In the 60s peripheral
arteritis occlusion disease was widely cured with waist and thoracic
sympatectomy, although in the 80s, due to non grade state of curing and the
high traumatic operations, the above-mentioned amount of operations was notably
reduced. In spite of pharmacological improvement, in a case of peripheral
artery disease the results are not believable. The object of author’s research
included toracoscopic sympatectomy in parallel with drug-curing. In 2003-2009,
44 patients with the Reino’s syndrome disease were treated by vazoprostan in
the of surgery department of
N. Chkhaidze
8.g.13.2.37. Analysis of results
obtained by means of modern surgical methods in the treatment of bilateral
bullous emphysema. /L. Katsarava, V.
Katsarava, B. Oniani/. Proceedings of the
Our study was devoted to the improvement of the
tactics of surgical treatment of the patients with bilateral bullous pulmonary
emphysema (pneumonectasis). We analyzed the results of surgical treatment,
obtained on 32 patients with bilateral bullous pulmonary emphysema, which had
been performed in the thoracoabdominal surgery clinic in 1998-2008. The age of
the patients varied from 16 to 64 years. X-ay and CT examinations were carried
out to all patients. The single-stage operations with the transsternal approach
were performed in 18 cases, while not single-stage bilateral operations with
minimally invasive methods were performed in 20 cases. Considering the results,
the following should be noted: a bilateral operation with the transsternal
approach is the method of choice in case of large (more than 10 cm) and giant
pulmonary cysts, in other cases the best method of choice is single-stage
bilateral operations using the minimally invasive methods.
Auth.
8.g.13.2.38. Modified method of
cesarean section operation and its role in the prevention of obstetric
complications. /Sh. Koridze, T.
Kanchaveli, D. Jintcharadze , A. Koridze,
The authors made an analysis of archival material of
1577 case histories of the patients who were subjected to cesarean section
operation at
Auth.
8.g.13.2.39. Contemporary methods of hernioplasty and their efficiency. /G. Tukhareli,
G. Lomsadze/. Scientific Works of
Nowadays non-stretching
hernioplasty with flat polymeric net are successfully used in practice. We have
studied the treatment of 17 patients in the Medical Center Imedi in 2008. It
was settled that the method of Lichtenstein is preferential and it reduces
in-hospital treatment by 3-5 days.
Auth.
8.g.13.2.40. Hemorrhoidal
disease: pathogenesis, clinical aspects and treatment principles. /T. Abuladze, G. Korkelia, K. Shapatava, T.
Ivanishvili, B. Berishvili/. Collection of Scientific
Works of
Hemorrhoidal disease is the most frequent
pathology of anorectal region. It develops as a result of vascular abnormality
or a stretch and rupture of hemorrhoids fixating tendon. Principles of
treatment depend on accurate collection of the illness history, physical and
endoscopic procedures. Pharmacotherapy with phlebotropic drugs is efficient in
acute and chronic forms of I, II and partially III stages of the disease.
Ligation with latex rings, infrared photocoagulation and doplerometric
desarterisation are minimally invasive and less radical methods of the disease
correction. The choice of treatment depends on the stage and clinical manifestation
of a disease. Sclerotherapy becomes a less approved method of treatment
nowadays. The classic Miligan-Morgan hemorrhoidectomy and Parks operation are
the radical methods of choice. The Whitehead modification is a surgery for IV
stage of the disease. The Longos surgery is an efficient outcome of modern
technologies and needs some further modifications.
Auth.
8.g.13.2.41. Non-traumatic
splenic rupture: report of three cases. /G.
Azmaipharashvili, G. Tomadze, A. Megreladze, Z. Demetrashvili,
First case of non-traumatic spleen rupture
was described by Rokitansky in 1861. The most common reason of splenic rupture
is trauma. The aim of this article is to present three cases of non-traumatic
splenic rupture, which is a rare abdominal emergency that requires immediate
diagnosis and prompt surgical treatment. Main reasons of non-traumatic rupture
of spleen are: malaria, leukaemia, sepsis, hemodialysis etc. Since 2006 year
three cases of non-traumatic splenic were described including anamnesis,
symptoms, aetiology, method of diagnosis and laparotomy findings. There were
two males and one female with mean age 48 years (47-49 years). We report two
cases of septic spleen due to peritonitis (one was on peritoneal dialysis) and
one case of peritoneal dialysis and splenomegaly. Splenectomy has been
performed in all cases. Two patients died because of progression of main
disease, one discharged without complication on peritoneal dialysis.
Non-traumatic spleen rupture is rare and dangerous for life surgical condition,
which needs immediate diagnosis and emergency operation. In two of our cases
rupture of septic spleen was provocated probably due to intra-abdominal
hypertension.
Auth.
8.g.13.2.42. Pseudophakic presbyopia:
intraocular options. /M. Dvali,
The 3 groups of cataract patients (58 eyes),
who were undergone implantation of different types of IOLs to correct
presbyopia were compared in a prospective study. The first group (24 eyes) was
formed of patients who underwent cataract extraction bilaterally and had
aspheric IOL implants with 2 D anisocorrection to achieve pseudophakic
monovision. The second group (21 eyes) comprised patients with multifocal
(Acrysof ReSTOR, Alcon) and the third group (13 eyes) was formed of
Pseudoaccomodative IOLs (Crystalens HD, B+L and Tetraflex, Lenstec)
accordingly. Visual function and visual disturbances were evaluated in each
group during 6 months period. Mean distance UCVA was 20/35 or better in all
groups; in the group 1 and 3 mean UCVA for near was J2 and 20/35 - for
intermediate distance, group 2 achieved mean UCVA for near – J1; UCVA
intermediate was J5. Patients in all 3 groups could read and work on
intermediate distance without glasses but subjectively had different types of
visual disturbances: in the first group that was mainly neauroadaptation
problems resulting of altered binocularity, in the second group it was
increased disphotopsias, in the third group 3% of patients did not achieve good
near visual acuity. In all groups was achieved subjectively satisfactory UCVA
for all distances. Each group presented different types of visual disturbances
in postop follow up period and had various limitations in patient selection
process. Patients’ activity demands specification of optimal method of presbyopia
correction in every particular case.
Auth.
8.g.13.2.43. Wunderlich’s
syndrome, as rare reason of acute abdomen (case report). /G. Tomadze,
Wunderlich’s syndrome refers to spontaneous
non-traumatic renal bleeding into the subcapsular and/or perirenal space,
first described by the German doctor Reinhold August Wunderlich (1815-1877),
known also because of implementation of clinical thermometry. Most common
reasons of the Wunderlich’s syndrom are polycystic kidney, angiomyolipoma,
adenocarcinoma and simple cyst of kidney. Extremely rare manifestation of
Wunderlich’s syndrome is hemoperitoneum, which is very rare condition in
emergency surgery that needs a high index of suspicion for diagnosis. Absence
of a history of trauma can make it difficult to make a diagnosis, which causes
delay in treatment. Using ultrasonography or CT, and peritoneal aspiration of
fresh blood may assist in the diagnosis. Rapid diagnosis and surgical
intervention can lead to a successful outcome. A 60 year-old man was admitted
to the emergency department of our clinic in August 9th, 2008 complaining of
acute abdominal pain (Chart N 5335). The patient had 6 hours history of sudden
pain in right abdomen, nausea and vomiting. Pain occurred while driving the
car, without trauma. Isolated cyst of right kidney was diagnosed several months
before admission. Physical examination revealed diffuse tenderness in the right
upper quadrant of the abdomen, signs of peritoneal irritation. On laboratory
investigation, white blood count was 11900, Hb – 70 units, ESR - 51 mm/h.
Urinalysis: WBC – 3+, Protein – 1, RBC – 4+. Serum creatinine and liver tests -
in normal range. Preoperative ultrasound revealed fluid in the abdominal
cavity. The diagnosis of peritonitis was suspected and the patient underwent a
laparotomy exploration. We found about 300 ml of blood and right paranephral
hematoma. Bleeding "per diapetezim”. We opened retroperitoneal space,
right paranephrium and found out ruptured cyst of lower edge of right kidney
with no farther signs of bleeding. Residual blood has been removed. We
proceeded to a peritoneal lavage and drainage of right paranephrium and
abdominal cavity after debridement. Postoperative ultrasound revealed remains
of right kidney cyst without content. The postoperative course was uneventful,
and the patient was discharged from hospital on day 10th after operation.
Presented case is interesting because of its rarity
Auth.
8.g.13.2.44. Component
separation and triple-mesh combined method in the treatment of ventral hernias.
/N. Lomidze, I.
Gelashvili, G. Giorgobiani, K. Butskhrikidze, G. Kopadze, A. Abuladze/. Collection of Scientific
Works of
Postoperative incisional hernia has always
been one of the most complex options in herniology. Incisional hernias develop
in up to 5-14% of laparotomy incisions: the most difficult to repair are giant,
complex, multiply recurrent hernias. Giant incisional hernias should be considered as an independent
complex disease, which causes dysfunction of respiratory organs, the tissue
covering hernia, the muscles and the organs of abdominal cavity. Retrospective
analysis by standard proforma was carried out of a series of 17 patients
operated on in according to Ramirez with onlay mesh and Ramirez with so called
triple mesh technique between 2008 and 2010. First abdominoplasty by Ramirez
with so called triple mesh technique In Georgia was done by famous English
Surgeon, Prof. Andrew Kingsnorth on 14.04.2009. Ramirez with onlay mesh
abdominoplasty was applied in 11 patients and Ramirez with so called triple
mesh technique in 6 patients. We regard Ramirez with triple mesh technique as
an effective mean in maintaining anterior abdominal wall functional status
revealing in flexibility rather than using one massive mesh covering the whole
anterior wall and so drastically reducing physiologic functions of the muscles.
Auth.
8.g.13.2.45. Laparoscopic
cholecystectomy as "golden standard” (11-year experience in a single
clinic). /A. Megreladze, G. Tomadze, L. Gophodze, G.
Azmaipharashvili, Z. Demetrashvili, S. Kemoklidze/. Collection of Scientific
Works of
The aim of the article is to present 11-year
experience of a single surgical clinic since 2000. In total, 1821 cholecystectomies
have been performed. Out of them, 240 (13.2%) with open laparotomy and 1581
(86.8%) with laparoscopy. Among them 1071 (58.8%) were with chronic and 750
(41.2%) with acute cholecystitis. In the case of chronic chlolecystitis, an
open method was used in 9.6% and the laparoscopic approach – in 90.4% of cases.
In the case of acute Cholecystitis, an open was used in 18.3% and the
laparoscopic approach – in 67.7% of cases. During first two years, the
laparoscopic approach was used in 58%, and in last two years it made 98%. The
conversion rate in the case of chronic cholecystitis in 2000-2001 was within
10-20% range and in 2009-2010 it became 1.05-0.76%. The same parameters in the
case of acute cholecystitis were 13-35% and 1.15-1.92%. The reasons for conversion
were: massive postoperative adhesions, different type of anatomical anomalies,
bleeding due to portal hypertension, acute destructive cholecystitis
(perivesical abscesses). Based on our experience, we can conclude that
laparoscopic cholecystectomy is definitely a method of choice. It has much less
complications than the open laparotomy approach; we recommend all
cholecystectomies to begin with the laparoscopic approach and to make decision
about further steps intraoperatively. The main conversion inducing factors,
like perivesical infiltration or abscess, can be met not earlier than 5-6 days
after onset of acute pain; therefore it is better to perform the laparoscopic
cholecystectomy during the first 2-3 days. Upon availability of skilled
surgeons and modern laparoscopic technique, the conversion rate is very low
even in the case of acute destructive cholecystitis. The subtotal resection of
gallbladder on Hartman’s level with laparoscopic approach, including
demucozation and clipping can be used in case of acute destructive
cholecystitis, when identification of main elements of bladder is impossible
due to perivesical infiltration or suppuration.
Auth.
8.g.13.2.46. The role of
greater omentum in the development of post-laparotomic adhesions. /S. Kemoklidze, G. Tomadze/. Collection of Scientific Works of
586 cases of subsequent laparotomies were
analyzed. They were performed in a period from 7 days to 46 years after the
first laparotomy. The authors have found adhesions in 492 patients (84%). Two
case histories are discussed. One patient developed acute intestinal
obstruction 32 years after appendectomy. Another patient was operated for
canceromatous obstruction of colon cancer, but the reason of obstructions was
the adhesions after appendectomy performed 46 years earlier. Other patients
were operated for peptic ulcer, cholecystitis hernia and gynecology diseases.
The main reasons of adhesion development are incomplete clearing of abdominal
cavity and intestinal peristalsis disturbance. Authors recommend placement of
great omentum in the sub-diaphragmatic space and drug stimulation of
peristalsis during the early postoperative period. The authors observed that
bleeding is minimal after division of omentum adhesions. They conclude that
usage of great omentum for revascularization is not scientifically justified.
Auth.
8.g.13.2.47. On
post-cholecystectomy bile stenosis therapy (case description). /G. Chikobava, R. Eliger, L. Gophodze, M.
Chubinidze/. Collection of Scientific
Works of
The following anabasis of cholecystectomy in
spite of using spread of the new technologies in the last millennium (among
them endovideoscopy surgery) is one of the difficult and attentive problems in
surgery. According to the data of the world literature the next events of
0.2-0.5% cholecystectomy develops the damage of common bile (stenos, structure)
which maybe would be followed duodenostasy, pancreatic, high intussusceptions.
For the liquidation of duodenostasy the production of resection of 2/3 of the
stomach (because it was not made correctly) would not seem to be the correct
choice. Damaged common bile (structure, stenos) advantages are
choledochoduodenostomy formation of entero-entero anastomosy by the rule of
stream.
Auth.
8.g.13.2.48. Surgical solutions to
esophageal atresia. /P. Gvetadze, D.
Tsibadze, K. Khetsuriani, T. Michitashvili, I. Nadirashvili/. Second International Congress of Respiratory
Association of
In M. Iashvili
Children’s
N. Chkhaidze
8.g.13.2.49. Complications of
percutaneous nephrolithotripsy in staghorn nephrolithiasis. /S. Fanarjian/. Georgian Medical News. - 2010. - #10 (187). – pp. 7-12. –
rus.; abs.: geo., eng., rus.
The aim of the study was
to analyze the complications of percutaneous nephrolithotripsy (PCNL) in
staghorn nephrolithiasis. The analysis revealed that in case of
"full" staghorn stone risk of complications of percutaneous
nephrolithotripsy raises twice in comparison with cases of
"incomplete" staghorn stones. The choice of least invasive method at
treatment of patients with staghorn nephrolithiasis is one of challenges in
urological practice. Superiority began to belonged so-called, least invasive
interventions – percutaneous nephrolithotripsy, extracorporeal shock-wave
lithotripsy and also combined (“sandwich” - therapy) methods. In connection
with development of modern methods of visualization, complication of
percutaneous treatment methods of staghorn nephrolithiasis decrease, and
efficiency and possibilities of their use raise. The analysis revealed that in
aspect of development of complications after percutaneous nephrolithotripsy
presence of "full" staghorn stone plays defining role, raises risk of
development of complications twice in comparison with patients with presence
"incomplete" staghorn stones.
.Auth.
8.g.13.2.50. Using bone cement for
surgical treatment of bilateral osseous temporomandibular joint ankylosis. /Z. Gvenetadze, T. Danelia, G. Gvenetadze/. Georgian
Medical News. - 2010. - #10 (187). – pp. 13-18. – eng.; abs.: geo., eng., rus.
Temporomandibular joint
(TMJ) ankylosis with complete immobility of the lower jaw represents a maximal
functional impairment and causes malocclusion and impaired function of
mastication. The main goal of surgical treatment of patients with TMJ ankylosis
is the regaining of organ function and good cosmetic results. The authors
modified the implant of articular head by bone cement for surgical treatment of
TMJ ankylosis (five cases). The mandibular arch osteotomy on both sides was
performed under nasotracheal anesthesia. 1.5-2 cm bone conglomerate was removed
and articular fossa was formed in remaining part. Titan mini plate was formed
so that it was possible to hang it on osteotomized surface of the arch. Free
surface of plate was faced towards the artificial articular fossa, on which the
articular head was formed using bone cement. The plate on the other side was
fixed on mandibular arch with screws. All cases were followed by good cosmetic
and functional effect (period of observation 5 month-4 years). The method,
despite of small material size is advantageous due to its good outcome, low
cost and relatively simple surgical technique.
Auth.
8.g.13.2.51. Lymphatic drainage
of tissues and blood and lymph coagulability during mandible fractures. /E. Aliyev/. Experimental and Clinical
Medicine. – 2010. #1(56). - pp. 32-36. – rus.; abs.: eng.
The purpose of the
present research was to study blood and lymph coagulability, also lymphatic
drainage of tissues during mandible fracture in rabbits. Experiments were
carried out on 17 "Chinchilla” rabbits under narcosis. The research
results have shown that modelling of a mandible fracture in rabbits leads to
the activation of intravascular coagulation not only in the blood, but also in
the lymph. The received data comparison has shown that between the activation of
blood and lymph coagulability there is an accurate interrelation to what
testify unidirectional changes of coagulation indicators (the system of
coagulation, anticoagulation and fibrinolysis) both in blood and lymph.
Moreover, it is revealed that intravascular activation of blood and lymph
coagulability is accompanied by rather expressed oppression of lymphatic
drainage of tissues. It all testifies to the necessity of taking into account
the lymphatic link of microcirculation in treatment and prophylactic actions
for a mandible fracture.
Auth.
8.g.13.2.52. Influence of coronary
bypass surgery on autonomic regulatory mechanisms of heart rhythm. /A. Tsibadze, L.
Basiladze, T. Kavtaradze, T. Gotsiridze, L. Khutsishvili/.
Experimental and Clinical Medicine. – 2010. - #4(59). - pp. 71-73. –geo.; abs.:
eng., rus.
It has been concluded
that a decrease of heart rhythm variability in patients with chronic heart
failure is conditioned by raised activity of the highest vegetative regulation
centers. In the early post-CABG period, this activity, owing to increased
parasympathetic stimulation, is getting raised. Such alteration indicates
postoperative cardiac rhythm balance changes and possibility of complications.
Monitoring of the patients by the above-mentioned values is advisable to avoid
postoperative complications.
Auth.
8.g.13.2.53. Treatment by long
catheterization of lung abscess. /D. Maghalashvili, N. Lomidze, N. Khotenashvili, G.
Shanshiashvili, L. Saghinashvili/.
Experimental and Clinical Medicine. - 2010. - #4(59). - pp. 104-106. – geo.; abs.: eng., rus.
It must be mentioned
that one patient had antibiotic idiosyncrasy. In spite of this, his abscess
cavity was closed later against the background of corticosteroid involvement.
Out of 23 patients of the given group, 3 were taken to the ambulatory regimen,
7-8 days after the treatment had been started. One of them continued treatment
in another hospital and two - at home. During the process of treatment, two
catheters were transferred from the abscess cavity and because of that it
became necessary to carry out the reposition of the catheters. Prolonged
transnasal drainage of the lung abscess saves patients from repeated and
frequent bronchoscopy examinations, reduces the period of recovery and
treatment expenses.
Auth.
8.g.13.3. Pediatry. Obstetrics and Gynecology
8.g.13.3.1. Systemic
inflammatory response syndrome during acute respiratory infection in children. /N. Manjavidze, T. Barbakadze, I. Mamuchishvili,
A comprehensive assessment of three key links of the
systemic inflammatory response syndrome in children with acute respiratory
infections (ARVI) allows specialists to be well aware of manifestations, to
timely diagnose complications, to early predict patients’ worse health, and to
choose the optimum treatment protocols. A significant correlation has been
found in the level of medium-weight molecules in plasma and red blood cells with
the severity of a pathological process and the degree of major clinical
syndromes. The results of the studies provide a deeper insight into the
pathogenesis of viral and viral-and-bacterial infections and make it possible
to consider the plasma and erythrocytic levels of medium-weight molecules, the
value of the redox-potential of the energy supply system and the activity of
anti-oxidative defense enzymes to be a diagnostic and predictive criterion and a full recovery index in
children with ARVI. : systemic inflammatory response syndrome, acute
respiratory infections, medium-weight molecules, tissue hypoxia, the body’s
detoxifying systems.
Auth.
8.g.13.3.2. Digestive disorders in the population
of adolescents. /I. Phavlenishvili, M.
Chikava/.
One-stage epidemiological research was conducted in
the accidental and representative groups of 14-21 years aged 430 adolescents
(50% boys and 50% girls). There was used the primary questionnaire for
digestive disorders pre-morbid and morbid forms screening. The selected
contingent was interviewed, underwent a deep medical examination, clinical
laboratory and instrumental tests were carried out. For diagnosis of the
functional gastroenterologic disorders, the ’’Rome II criteria’’ was used.
According to the obtained results, the prevalence of digestive disorders in the
adolescent population was (p<0.05) – 19.5±1.9%; among girls – 20.9±2.8%,
among boys – 18.1±2.6%; among 14-16 year-aged adolescents – 17.7±2.6%, among
17-21-year aged ones – 21.4±2.8%. The pre-morbid status was defined – 23.5±2.0%
(p<0.05). Digestive disorders are mostly represented by means of functional
disorders. Choledyskinesia and esophageal disorders are most frequently
distributed. It’s necessary to inform adolescents about their digestive
disorders to increase appealability and timely perform adequate
treatment-preventive measures.
Auth.
8.g.13.3.3. Biflorac in the
treatment of intestinal dysbiosis. /I. Shalamberidze, M.
Khochava, T. Jokhtaberidze, L. Nebieridze, M. Kherkheulidze/.
During the recent years in pediatrics the problem of
micro-ecology is given special attention. The normal microflora is the quantity
and quality equivalence of different microorganisms which guarantees the
biochemical, metabolic and immune balance. This is essential to preserve human
health. There exist different reasons for emerged dysfunction of intestine’s
microflora. Infectious pathologies, antibacterial therapy provided for
different reasons and defective meals are among them. We have studied the
microflora of the gut in small group of patients (30 children). The study was
conducted in the clinic of Children Infectious Diseases. The main symptom of
patients was diarrhea (40%) or constipation (60%) that occurred after either
infectious disease or antibiotic therapy. The results were statistically
processed using computerized program SPSS 11.0. Patients were assessed using a
special questionnaire (collecting information about microflora); 32 wards were
treated with a pre-probiotic Biflorac (manufactured in
Auth.
8.g.13.3.4. Physiological development of blind
adolescents. /E. Paghava, K. Paghava/.
The goal of the study was to compare spatial
orientation in early and late blind adolescents. Orientation in locomotor space
was studied in a restricted territory of the room by means of changing location
of the poles with toys. Orientation in the manipulatory space was studied by
means of changing location of 4 objects on the square table with casters.
Participants had to make a guess from different positions. 8 early and 8 late
blind adolescents participated in the experiment. The experiments in the
manipulatory space were repeated 4 times every 2 weeks and the locomotor ones
were performed 3 times also every 2 weeks. Performance as well as strategy of
participants was studied and compared. Late blind adolescents showed higher
frequency of correct answers in both – locomotor and manipulatory tasks. The
average latency of correct response was also shorter in the late blinds,
especially in boys. Thus it 30 was concluded that late blind adolescents show
better spatial orientation in both, locomotor and manipulatory spaces.
Auth.
8.g.13.3.5. Prevalence of
wheezing in children of 12-18-month age. /E.
Kandelaki, M. Kherkheulidze, N. Khavlashvili,
The aim of the study was to identify the prevalence of
wheezing in infants in
Auth.
8.g.13.3.6. The parameters of physical growth in
5-6-year-old children in
The aim of the study was
to assess the nutritional status and anthropometric parameters in children aged
5-6 and to identify possible factors influencing the growth pattern of Georgian
children. The cross-sectional study
was performed on a sample of 754 children - boys and girls aged 5-6 attending
pre-school facilities and their main caregivers in the study sites. The study
covered the children population from 16 kindergartens of 2 districts
(Gldani-Nadzaladevi and Vake-Saburtalo) of
Auth.
8.g.13.3.7. The effect of Iodine deficiency in
the prenatal period on the learning ability in the postnatal period. /N. Rustamov, I. Kvatchadze, G.
Bekaia, Z. Sakhvarelidze,
The present study
analyzes the changes in the learning ability of the progeny of rats suffered
from iodine deficiency. Reduction of serum thyroxin in the mothers’ blood
during three months before mating and whole period of gestation to an average
level of 4.7±0.6 ng/ml, significantly worsened the learning ability in the
progeny, and the reduction to 1.1±0.4 ng/ml completely deprived the progeny’s
learning ability. Passage of the maze for these animals was purely
probabilistic in nature without any signs of learning. We can conclude that the
diet with very low iodine content results in a low level of thyroxin in
maternal serum and neurological deficiency in the progeny manifested by
learning disability during maze testing. Addition of the iodine to the diet
prevents development of the mentioned neurological deficiency.
Auth.
8.g.13.3.8. Significance of neurospecific enolase
determination in estimating severity of the hypoxic-ischemic injury of newborn
brain. /S. Mukhtarova/. Georgian Medical News. – 2010. – #4(181). –
pp. 49-54. – rus.; abs.: geo., eng., rus.
The
purpose of our research was the study of diagnostic possibility of
neurospecific enolase (NSE) as a marker of hematoencephalic barrier (HEB)
dysfunction in newborn infants of different gestational age with perinatal
injury of the central nervous system (CNS). The concentration of NSE in blood
serum was determined by the immunoenzyme method in 98 newborns of different
gestation age with hypoxic-ischemic injury of CNS in dynamics of the neonatal
period (0-1, 5-7, 12-14, 20-21, 28-30 days). It
was found that the concentration of NSE changed depending on the character of
the CNS injury (intraventricular hemorrhage, periventricular leucomalacia).
This change had a wavy character with maximum concentration at the 1st
and 3rd weeks of life.
Auth.
8.g.13.3.9. The role of permanent invasive monitoring of
intracranial pressure in the treatment of infants with post-haemorrhagic
ventricular dilatation after intraventricular haemorrhage (case report). /I. Tsirkvadze, M. Chkhaidze, D. Phruidze, G.
Nizharadze, D. Kanjaradze/. Georgian Medical News. –
2010. – #4(181). – pp. 55-58. – eng.; abs.:
geo., eng., rus.
Post-haemorrhagic
ventricular dilatation (PHVD) is a major complication of intraventricular
haemorrhages in very preterm infants. The post-haemorrhagic ventricular
dilatation is associated with a high rate of disability, multiple impairments
and adverse effects of shunt surgery for hydrocephalus. It may lead to an
impaired neurological prognosis caused by a raised intracranial pressure (ICP)
and concomitant decreased cerebral blood perfusion. Therefore, early
intervention to decrease the ICP may improve the long-term outcome. Different
treatment modalities have been studied, of which repetitive removal of
cerebrospinal fluid (CSF) seems to be the only effective one. Studies performed
in several institutions showed that intermittent CSF drainage in very preterm
infants with PHVD is an effective way to treat increased ICP and its negative
effect on cerebral blood perfusion. The cut off point for CSF drainage is about
6.0 cm H2O ICP, as drainage below that level no longer results in
improvement in perfusion. From this single case study it can be concluded that
in preterm infants with PHVD repetitive CSF tapping from a ventricular access
device guided by ICP measurements and ICP targeted treatment strategy is a
useful technique for determining the frequency and volume of CSF removal. In
neonatal intensive care units with poor capabilities and resources this is
possible even by placing the simple intravenous single lumen catheter.
Auth.
8.g.13.3.10. Morphological
peculiarities of endometrium in chronic endometritis associated with bacterial
vaginosis. /M. Beruchashvili, L.
Gogiashvili,
Most cervical cancers
begin where the endocervix and
ectocervix meet. Pap tests (also called Pap smears) are vital in the early
detection of cervical cancer. Ecto-endocervical
Pap-tests from 230 patients with verified bacterial vaginosis (BV) were
studied. Endometrial biopsy was also used in the evaluation of 95 patients (47
with primary diagnosis BV and 48 relapsing BV). Control specimens were obtained
from physically and gynecologically healthy females. Biopsy samples were
collected from endometrium of the uterine body. Morphological and morphometrical
analysis of data and Pap-test criteria indicate that chronic endometritis
(100%) as well as spontaneous abortion syndrome (20-25%) can be reasonably
considered as primary and relapsing bacterial vaginosis (BV) associated
pathologic processes. The chief morphological
phenomena of chronic endometritis involve the severe dystrophic – atrophic
alterations in lining and glandular epithelium, simultaneously with the
polymorphic cellular infiltration and stromal transformation of the different
intensity. Progressive atrophy of epithelium and fibroplastic
transformation of stroma evidently contributes to the evolution of the
condition preventing the implantation and development of the concept.
Auth.
8.g.13.3.11. Ways of optimization of pregnancy gingivitis
treatment. /M. Mdivani, M. Betaneli, V. Margvelashvili, M. Kharabadze/. Georgian Medical News. – 2011. - #1(190). – pp. 24-27. – eng.; abs.:
geo., eng., rus.
Pregnancy gingivitis is
developed in 30-75% of cases and is a result of complicated hormonal and immunological
changes in the organism. 100 pregnant women with various degree of severity of
gingivitis have been observed. Acute generalized gingivitis, gingival edema
with bleeding hyperplasia has been observed in all patients, while in bad cases
– with ulcers’ formation at gingival. A decrease in hemoreological index of
gingival tissue (down to 0.15-0.19 Ohm) has been observed too. Complete
clinical and laboratory studies, as well as the screening of obtained data have
been carried out before the treatment, in its process and after the course.
Pregnant women have been under the supervision and subjected to curative
discrete plasmapheresis according to various indications
(rhesus-imcompatibility, antiphospholipidic syndrome, early interruption of
pregnancy with disorder of the system of hemostasis basically towards
hypercoagulation). All pregnant women have been diagnosed with the gingivitis
of varying severity. After completion of the
treatment course of plasmapheresis evaluation of the patients’ condition was
carried out. The improvement of the subjective and objective data, regulation
of hemoreological data in gingival tissue (0.21-0.23 Ohm) was achieved.
Respectively, the period of recurrence-free course of disease has been
increased and the quality of patients’ life has been improved.
Auth.
8.g.13.3.12. Quantitative electroencephalography coherence
and dipole source index during various cognitive tasks in children with
attention deficit hyperactivity disorder. /S. Bakhtadze, M. Janelidze,
The
attention deficit hyperactivity disorder (ADHD) is one of the most important
disorders of childhood and adolescence. Debates about diagnostic approaches
requiring precise assessment of ADHD remains topical until nowadays. The role
of neurophysiologic methods for this purpose is controversial. Thus, the aim of
our study was to observe QEEG changes by means of the most modern software
analysis systems - coherence and brainwave activity dipole source localization.
We have assessed 39 children - 18 of them from control group (age range 9-12
years). QEEG was registered during the Raven test and adding of one digit
numbers. The results were analyzed by means of coherence measures and brainwave
bilateral synchronous activity dipole source generator localization detection
system (Brain Loc. 6). As a result, we observed high coherence measures for
ADHD compared to controls. As for dipole source generator, we have detected a higher
dipole equivalent index in the control group compared with ADHD children. Thus,
according to our results, it is obvious that QEEG can serve as a valid
neurometric tool in diagnosis of the attention deficit
hyperactivity disorder.
Auth.
8.g.13.3.13. Nutrition for children of puberty age in
Micronutrients are
nutrients required by humans throughout life in small quantities to orchestrate
a whole range of physiological functions, but which the human body itself
cannot produce. The most important micronutrients are iron, zinc and iodine.
Micro-elements are an essential part of nutrition. Among them particular importance
is attached to those microelements that are comparatively in low quantity in
the food (such as iron, iodine). Accordingly, occurrence of the iodine
deficiency, iron deficiency in adolescents requires particular attention so
that they are duly prevented. Monitoring of the nutrition of adolescents in the
present unstable economic conditions is absolutely necessary. We have studied
the diet of adolescents and conducted its analysis. The research was conducted
in the boarding house among the adolescents (aged 11 and 13) with the
participation of 36 adolescents (22 girls and 14 boys). The results are
compared to the norms of physiological requirements of adolescents, taking into
account the major substances and energy. Besides that, biochemical monitoring
of the Zn requirement in the adolescents has been conducted. The research on
the quality and quantity of the diet displayed an imbalance of certain
substances among them Zn, which may have a negative effect on the growth and
development of adolescents as well as on the puberty.
Auth.
8.g.13.3.14. The possible role of nitric oxide in
newborns’ weight gain disorder caused by prolonged dexamethasone therapy
(experimental study). /O.
Sinauridze,
Experimental studies on
rats revealed that the newborns; growth retardation caused by a long-term
treatment with Dexamethasone in the neonatal period can be prevented by the
simultaneous with dexamethasone administration of the nitric oxide donor -
L-arginine. This indicates that the mentioned Dexamethasone-induced growth
disorder is caused by inhibition of the nitric oxide synthase activity.
Auth.
8.g.13.3.15. A study of factual
nutrition of children’s home residents. /Sh. Tukvadze/.
Experimental and Clinical Medicine. – 2010. - #2(57). - pp. 35-39. – geo.;
abs.: rus., eng.
We studied the factual
nutrition of children living in a children’s home. The proper nutrition in
childhood can reinforce lifelong eating habits that contribute to children’s
overall wellbeing and help them to grow up to their full potential and healthy
life. Good nutrition means the body is getting all the nutrients, vitamins, and
minerals it needs to work at its best level. Energy (calories) should be
adequate to support the growth and development and to reach or maintain the
desirable body weight. Nutritional requirements rise as children attain puberty
in order to support sexual development. A diet that provided sufficient
calories and nutrients during childhood may no longer be sufficient for the
child in puberty. The dietary guidelines for Americans state: "Different
foods contain different nutrients and other healthful substances. No single
food can supply all the nutrients in the amount you need”. The qualitative and
quantitative analysis of children’s diet revealed some irrelevances: imbalance
between carbohydrate, lipid and protein composition and imbalance in
micronutrients (iodine, iron, zinc). Such an imbalance of micronutrients in the
diet can eventually lead to iodine, iron and/or zinc deficiency.
Auth.
8.g.13.3.16. EPR study of gallstones
in menopausal women. /M. Shengelia, E. Chikvaidze, M. Kiladze, T. Sanikidze,
The aim of the study was
to establish the gallstones content in menopausal women by EPR method. The
gallstones of 30 women aged 52.4±9.7 were studied (2 women with surgical
menopause (33-35 year); 19 women with menopause (39-56 year); 9 women in
postmenopause (59-79 years). The stone EPR spectrum was registered on the EPR
spectrometer ESR-V. In EPR spectrum of the stones, the intensive signal of
oxidized bilirubin (g=2.003, DH=1.0mmTl) was revealed; the statistically
important difference between the intensity of this signals in the stones of the
patients of different age groups was not revealed. In the EPR spectrum of some
gallstones, the 6-component EPR signal of Mn2+ ions was registered. It was concluded
that the deficiency of estrogens in menopausal women induces a decrease in the
antioxidant defense mechanism of the patient’s body and thus, in the condition
of oxidative stress (connected with different endogenous and exogenous
factors), promotes the oxidation of bilirubin and gallstone formation.
Auth.
8.g.13.3.17. The effects of hyperglycemia on
placental trophoblast functionality in rats in vitro. /M. Gongadze, A.
Sephashvili, N. Gogia, M. Esaiashvili,
Ts. Atamashvili, I. Mesropyan, M. Iobadze/. Experimental and
Clinical Medicine. – 2011. - #1(1). - pp. 8-13. – eng.; abs.: geo., eng.
The maternal diabetic
environment alters the embryo and the fetoplacental development. The results of
these alterations are: increased embryo resorption and malformation rates,
placental dysfunction. Cellular and molecular events in the uterine environment
that lead to successful blastocyst implantation require the endometrium to be
ready for being implanted. They include modified functions and populations of
leukocytes, cytokine activities, and growth factors. The trophoblast invasion
is a temporally and locally restricted process which regulates implantation and
oxygen arrival to the embryo through the dialog with spiral artery endothelium.
There are data which suggest that IL-10 and TNF-alpha are crucial cytokines in
implantation processes. We performed in vitro study influence of hyperglycemia on trophoblast functionality and
cytokines capacities to modulate proliferation, migration, and invasion of
trophoblastic cells in diabetic environment. Summarizing of the experimental
results, we can conclude that possibly IL-10 defends uterus and mediates
successful implantation by inhibiting TNF-α.
Auth.
8.g.13.3.18. The effects of phosphate slag on the
skeleton formation. /R. Mzhavanadze, N. Menagharishvili, R.
Datunashvili, M.Tchedia, M. Grigolashvili,
Since the phosphate slag consists of calcium by 47%,
it was of special interest to study its effects on the skeleton formation
processes. For this purpose, the embryos of white rats have been processed by
means of the Duson method. The bone-growing points of the breast, posterior and
extremity bones have been examined. It was ascertained that within the range
between the threshold and inactivity doses, in particular, at 10, 20, 50 mg/kg,
phosphate slag has not affected the processes of skeleton formation, compared
to the control group.
Auth.
8.g.13.3.19. The age
dynamics of a partial pressure of oxygen and its peculiarities during
intrauterine period. /D. Kobeshavidze,
Tissue cells of the fetus are evolutionally adapted to
existence under conditions of a low partial pressure of oxygen. Changing of the
placental membrane thickness may become a risk factor and endanger the fetus
viability. A high compatibility of the fetus hemoglobin toward oxygen promotes
the effective supply of the tissues with oxygen. Compensational-adaptive
reactions of the maternal-fetus system provide the adequate oxygen pressure in
the blood of the mother and the fetus.
Auth.
8.g.13.3.20. Radiological types of pulmonary tuberculosis
in infants. /N. Tskhakaia, D.
Sturua, Ò. Kotchlamazashvili,
As complications of
tuberculosis àãå frequent in infancy, a
correct diagnosis of tuberculosis in infants is important. The purposes of this
study are to summarize the radiographic and CT findings of pulmonary
tuberculosis and to determine the radiologic features frequently seen in
infants with this disease.
Auth.
8.g.13.3.21. Parvovirus infection or
the fifth disease in pregnant women and newborns. /B. Zenaishvili,
Epidemiology,
pathophysiology, clinical manifestations, diagnostics, treatment and prevention
of the disease caused by parvovirus have been described in the present article.
N. Chkaidze
8.g.13.3.22. Main principles of management and diagnostics
of certain perinatal infections. /E. Uberi,
Perinatal infection
implies infection of the fetus and newborn from mother. Diagnostics of
infection in pregnant women, fetus and newborn, echogenic signs of inherited
infections are given. Citomegalovirus infection, its results, diagnostics, treatment
and prevention are considered.
N. Chkaidze
8.g.13.3.23. Postnatal management of antenatal
hydronephrosis. /N. Kvirkvelia, G.
Chitaia/. Georgian Pediatrician. - 2010.
- # 1-2. – pp. 18-21. –
geo.
Diagnostics of foetus
hydronephrosis is carried out by antenatal ultrasonography. If an anomaly is
revealed, a postnatal research, which starts with ultrasonography, is needful.
Algorithm of children with antenatal hydronephrosis during the postnatal
period, which is based only on the application of necessary methods of research
in order to obtain maximum information, is presented. According to the study
results, optimum treatment is administered with consideration of seriousness of
hydronephrosis in order to avoid significant disturbance of kidney function and
danger of generalization of the disease
N. Chkaidze
8.g.13.3.24. Neonatal pneumonia. /T. Gotua,
Neonatal pneumonia makes
10% of global child mortality. Risk factors of neonatal pneumonia, ways of
distribution, clinical manifestations and treatment are considered in the
article.
N. Chkaidze
8.g.13.3.25. Recommendations
for management of pediatric gastroesophagic reflux. /Ts. Pharulava/. Georgian Pediatrician. - 2010. - # 1-2. – pp. 48-56. –
geo.
The present material was
developed by the joint commission of North America and
N. Chkaidze
8.g.13.3.26. Sustainable
development and child security. /G. Chakhunashvili,
Development of sciences
and monitoring on them appear to be a main task, which takes into account
creation of safe environment for human health, improvement of life conditions. At the
same time, it is
necessary to carry out possible ecopathological preventive measures, which
should be considered as a principal strategy of the 21th century. To sum up,
the foundation of regions’ sustainable development is children’s security,
which is based on united scientific governing of medicine, sports and education
which is itself based on new technologies, with consideration of the
socio-economic environment and essential healthcare determinants.
Auth.
8.g.13.3.27. The role of
bone marrow aspirate tests in hematological and non-hematological conditions in
children. /Z.Mtvarelidze, A.Kvezereli-Kopadze,
M.Kvezereli-Kopadze/. Social, Ecological
and Clinical Pediatrics. – 2011. - #13-8-7. - pp. 47-49. – geo.; abs.: geo.,
eng.
Bone
marrow aspiration represents one of the most valuable diagnostic procedures for
malignant and non-malignant hematological, systemic, certain parasitic
and other diseases in children. The work aimed at investigation of clinical-lab
indications for bone marrow aspirate test and analysis of data obtained as a
result of bone marrow puncture. 220 patients from 4 months to 15 years
underwent sternal puncture observing relevant rules in hematological department
of G. Zhvania Pediatric Clinic. Morphological examination of the bone marrow
punctate proved diagnosis of such rare conditions as blackfan diamond anemia,
side roblastic anemia, chronic granulocytopenia, Evans’, Wiskott-Aldrich
Syndromes, Di Guglielmo’s disease, Langerhans cell histiocytosis. Early
diagnosis of visceral leishmaniosis should be specially mentioned. Research
data analysis demonstrates that the manipulation should be done in case of
manifested bone marrow disorder symptoms: fever of unexplained origin, pallor,
weakness, enlargement of lymph nodes, liver, spleen, weight loss, bone and
joint, hemorrhage and hematomas, frequent infections. Peripheral blood count
reveals atypical cells or blasts, pancytopenia or excess blood cells,
unexplained anemia, leucopenia or thrombocytopenia.
Auth.
8.g.13.3.28. The pediatric
clinical pharmacology and rational pharmacotherapy. /R. Jashi/. Social, Ecological and Clinical
Pediatrics. – 2011. - #13-8-7. - pp. 49-55. – geo.; abs.: geo., eng.
The pediatric population is a dynamic group
with major changes in pharmacokinetics and pharmacodinamics taking place
throughout infancy and childhood. Therefore, the need for
the evolution and establishment of medication dosing regimens in children of
different ages is great. Special consideration must be taken into account when
dosing medications in pediatric patients. This review was developed with intent to serve as a
compilation of recommended pediatric doses found in the literature and to
provide relevant clinical information regarding the use of drugs in children.
Auth.
8.g.13.3.29. Marfan syndrom
in children. /T.Ghonghadze, M.Lekiashvili, T.Gogatishvili/. Social, Ecological and
Clinical Pediatrics. – 2011. - #13-8-7. - pp. 68-71. – geo.; abs.: geo., eng.
Marfan syndrome (MFS) is
a spectrum disorder caused by a heritable genetic defect of connective tissue
that has an autosomal dominant mode of transmission. The defect itself has been
isolated to the FBN1 gene on chromosome 15, which codes for the connective
tissue protein fibrilli. Abnormalities in this protein cause a myriad of
distinct clinical problems, including musculoskelet ones. Although there are
some unique signs or symptoms of Marfan syndrome, the constellation of long
limbs, the dislocated lenses and the aortic root dilation are generally
sufficient to make the diagnosis with reasonable confidence. There are more than
30 other clinical features that are variably associated with the syndrome, most
involving the skeleton, skin and joints. There may be considerable, cardiac and
ocular system problems predominate. We document a case of a patient - age 2
months. The patient was under treatment in the infant therapeutic department of
G. Zhvania Pediatric Clinic in
Auth.
8.g.13.3.30. Evolution of
acute bronchiolitis in breastfed and formula-fed infants and nebulizer therapy
by hypertonic solution. /T. Ghonghadze, E. Kutsia, T. Zhorzholiani,
Acute bronchiolitis is
the most common cause of lower respiratory tract infection in infants. In 90%
it is caused by respiratory sincitial virus (RSV). Impact of breast feeding on
evolution of acute bronchilitis in infants aged 1-12 month(s). Assessment of
results of treatment by nebulized theraphy with hypertonic (3%) saline and
necessity of administration of bronchodilatators and corticoosteroids. Exclusive
breast feeding improves health condition sooner than in formulated babies and
hospital stay day is lower in breastfed babies.
Auth.
8.g.13.3.31. Inherited thrombophilia
and pregnancy. /M. Abashidze, N.
Phirtskhelani, L. Makhaldiani,
There is growing evidence that environmental
and genetic risk factors often interact to induce clinically manifested venous
thromboembolism (VTE). Thrombophilia is an inherited or acquired predisposition
to thrombosis. Pregnancy is a hypercoagulable state with an increased
thrombotic risk throughout gestation and the postpartum period. Women with
inherited thrombophilia (factor V Leiden, prothrombin G20210A, and
methylenetetrahydrofolate reductase (MTHFR) TT 677 genotype) have a further
increased risk not only for pregnancy related venous thromboembolism (VTE), but
also for other pregnancy complications including fetal loss, particularly
recurrent early fetal loss or stillbirth, preeclampsia and intrauterine growth
retardation.
Auth.
8.g.13.3.32. Structure of congenital
anomalies in regions of
On the assumption of the existed demographic
situation in the country, children health is considered as one of the problems
of great importance. According to the statistical data, 4226 cases of separate
conditions revealed at prenatal period and 347 cases of congenital anomalies
have been recorded. The aim of the present study was the investigation of
congenital defect structure in children. After the conducted study the
following results have been revealed: the rate of heart (defect) disease was
significantly high within 1996 – 1997. As for the regions and cities of
Auth.
8.g.13.3.33. Assessment of
neuropsychological and social development of early-age children with iron
deficiency anemia by BINS. /N. Manjavidze, K.
Matiashvili, T. Ghonghadze/. Collection of Scientific
Works of
Peculiarities of neuropsychological
development of early-age Georgian healthy children and children with iron
deficiency anaemia were studied. Neurological, expressive, receptive and cognitive
clusters were assessed by the Nancy Beyley’s Infant neurodevelopment screener.
Study results from both groups revealed reliable difference of mean indices
from Beyley’s normal quantities. Results can be stipulated by incorrect
management of social adaptation steps, which is based on maternal, as on
standard persons’ role in child’s growth-development issues. Deviations shown
in the case of iron deficiency anemia, primarily sharp depression of cognitive
and expressive functions, are presumably stipulated by body iron deficiency.
Auth.
8.g.13.3.34. Prerequisites of
bacteriophage therapy in neonatology. /G. Metskhvarishvili, I.A. Korinteli, I.G. Korinteli,
K. Paghava/. Collection of Scientific
Works of
Generally, phage therapy is the therapeutic
use of bacteriophages to treat pathogenic bacterial infections. We have
analyzed the literature about the therapeutic use of bacteriophage in practical
medicine. The history of bacteriophage therapy is approximately one century
long. The majority of papers come from
Auth.
8.g.13.3.35. Hemodynamic,
electrocardiographic and physical properties of child athletes with various
degrees of mitral valve prolapse.
/T. Svanishvili, E. Tataradze, Z. Sopromadze, N. Tchabashvili, E. Tchumburidze,
M. Buleishvili/. Collection of Scientific
Works of
The purpose of the study was to assess the
impact of the degree of mitral valve prolapse on hemodynamic indicators and
physical working capacity in 9-11 year-old soccer players, as well as to reveal
any electrocardiographic differences. 54 children among the soccer players
examined in the frames of screening program were diagnosed with various degree
of mitral valve prolapse. Namely, 31 children out of 54 had mild degree of the
prolapse (<2 mm, Group I) and 23 children had relatively deep prolapse
(>2 mm, Group II). The children underwent anthropometric, echocardiographic
and electrocardiographic investigations before and after physical exertion, as
well as determination of physical working capacity. The study has revealed that
45% of the children in the Group I and 78% in the Group II had systolic
murmurs. The systolic click was observed in 94% of cases in the Group I and 78%
in the Group II. As for the hemodynamic signs, significant changes were
observed only in regards with alterations of heart rate in response to physical
exertion (mean heart rate: I Group-130; II-Group-138) and especially at 5th
minute of post exercise recovery (mean heart rate: I Group- 92; II-Group-102),
(P<0.01). The Body Mass Index was lower in the Group I but the difference
was not significant. As for the electrocardiographic data, differences were
mainly noted in repolarisation period. In both groups almost half of the
children had irregular heart rate. The indicators of physical working capacity
(PWC170) and maximal oxygen consumption (VO2max) were almost identical in both
groups. Obtained data demonstrate that degree of mitral valve prolapse does not
cause any significant differences in regards with hemodynamic indicators and
physical working capacity. Therefore, even relatively deep prolapse does not
present a contraindication for physical exertion in children in the absence of
symptoms or complains. Nevertheless, systematic medical control is required in
this category of children.
Auth.
8.g.13.3.36. Paediatric asthma management - contemporary
challenges. /R.Karseladze/. Second International Congress of Respiratory
Association of
Constantly increasing
and alarming epidemiologic indices of wheezy disease in the young-age group
during the last 15 years set before physicians and healthcare professionals an
issue of international cooperation in asthma study. Various expert groups
developed consensuses on pediatric asthma, which serve as guidelines for
European and American clinicians. Besides, it should be mentioned that
"asthma and allergy, unlike other diseases, are significantly influenced
by local, regional and individual factors.” Four newest international
documents: 1. The PRACTALL (practicing
allergology-2008), developed by European Academy of Allergy and Clinical
Immunology (EAACI) and American Academy of Allergy, Asthma and Immunology
(AAAAI), which provide practical recommendations for clinicians on asthma
diagnostics, management and monitoring in the young age group.
2. The European Respiratory Society (ERS) Task Force Paediatric Guideline
(2008). 3. The 2009 GINA Paediatric Guidelines. 4. The American Expert Panel
Report "National American Education and Prevention Program (2007)"are
considered in the paper.
N. Chkhaidze
8.g.13.3.37. Antibiotic therapy
during respiratory diseases in children. /N. Uberi,
Antimicrobial therapy is
one of the main components of treatment in case of bacterial nature of
respiratory diseases. Expediency of selection, timeliness and correct dosage
increases the effect of treatment. Directions and recommendations of a rational
antibacterial treatment are given in the article.
N. Chkaidze
8.g.13.3.38. Diagnostics of arias
syndrome and ways of correction. /M.
Kvezereli-Kopadze/. Georgian Pediatrician. -
2009. - # 1-4. – pp. 37. – geo.
A research was carried
out in order to reveal yellowness caused by maternal milk and development of
new approaches to its therapy. As a result preservation of breast-feeding for
babies became possible by means of simple correction of the feeding process.
N. Chkaidze
8.g.13.3.39. Contemporary
principles of management and prevention of congenital infection (toxoplasmosis,
listeriosis). /T.Gotua,
I.Phavlenishvili, Ts.Pharulava, E.Uberi,
Correct diagnostics of
acute infections of toxoplasmosis,
listeriosis during pregnancy is extremely important for prevention of the fetus
and newborn infection. The causes of infection, ways of transfer, clinical signs
and treatment are discussed in the article. Besides, recommendations for
prevention of inherited toxoplasmosis and listeriosis are given.
N. Chkaidze
8.g.13.3.40. Modern aspects of childhood idiopathic
thrombocytopenic purpura. /M. Kvezereli-Kopadze, A.
Kvezereli-Kopadze, Z. Mtvarelidze/. Georgian Pediatrician. - 2010. - # 1-2. – pp. 9-15. –
geo.; res. eng.
Idiopathic thrombocytopenic purpura is an autoimmune disease, which is caused by
numerical and qualitative disturbance of thrombocyte disks. Etiology of the
disease has not been interpreted completely as yet. A research in children with
the disease was carried out for the purpose of analysing the results of 20-year
study, diagnostics and specification of unsolved problems of treatment.
Obtained results were discussed and it was concluded that various methods of
treatment must be studied for reveal of comparatively optimal approach with
minimum side effects.
N. Chkaidze
8.g.13.3.41. Cardiovascular
system injury during acute viral respiratory infections in children.
/N. Tsintsadze, D. Tabutsadze, M. Ghutchashvili, T.
Gogilashvili, M. Topuridze, R. Ioseliani/. Cardiology and Internal Medicine. - 2010 - ¹ 3-4(31-32). . - pp. 17-20. - geo.; abs.: eng.
The purpose of our research was to investigate
cardiovascular system injury with acute viral
respiratory infection (AVRI) in 52 children. In 30% of patients mild
form of disease was identified, 50% were suffering from moderate and 20%
from severe form of the disease. The most frequent complications of the disease were: acute
bronchitis, pneumonia and otitis. Control group included 20 healthy children of the same
age. Besides regular medical investigation,
children underwent ECG. Based on the study
results we can conclude that: 1) ECG is not very informative method during AVRI; 2) Heart hypertrophy and
ventricular alterations in repolarization processes is identified only during severe form of AVRI; 3) All patients with
severe form of AVRI should be provided with ECG monitoring.
Auth.
8.g.13.3.42. Comparison of radiation background and
frequency of genetic abnormalities among infants of Adjara foreland. /N. Vepkhvadze, N. Kiladze, I. Tskhovrebadze,
Radioecological
situation of Adjara foreland and external irradiation doses of population have
been studied. A comparison of frequency of genetic abnormalities (congenital
abnormalities, underweight) among infants born in 2004-2008 and magnitude of
the radiation background (RB) of region was studied to establish the causal
connection between genetic abnormalities and RB. It was found, that relatively
high dose of external irradiation is not the determining negative factor
affecting the health of the newborns. At the same time, various factors of low
intensity in nature, the magnitude of the RB and total irradiation dose
contribute to the development of a congenital anomaly.
Auth.
8.g.13.3.43. Possible criteria for
early diagnosis of endometrial hyperplastic processes (EHP). /N. Guliyev,
L. Makashvili, D. Kobeshavidze/. Experimental and Clinical Medicine. – 2010 . -
#3(58). - pp. 15-19.-
rus.; abs.: eng.
Our aim was to develop a
systematic approach to early diagnosis for correction of EHP (150 women, in the
early reproductive period were 64 (42.7%), in the late reproductive - 86
(57.3%)). Disease duration in 54.8% of cases ranged from 3 months to 1 year.
The patients were divided into 3 groups: I group - 70 patients (46.7%) with
glandular and glandular-cystic hyperplasia of the endometrium; II group - 65
(43.3%) - with endometrial polyp; III group - 15 (10%) - atypical endometrial
hyperplasia (clinical, cyto- and histological techniques, ultrasound and
hysteroscopy were used). Based on the results, the following algorithm of
examination was made: clinical-anamnestic examination, evaluation of patients’
complaints, the overall clinical and biochemical analysis of the blood (Tumor
marker CA-125, CA 19-9), cytological and histological examination, pelvic
echography. A systematic approach to the correction of endometrial hyperplastic
processes will be developed.
Auth.
8.g.13.3.44. Dopplerometric description
of the uteroplacental-fetal circulation in pregnancies with fetoplacental
dysfunction. /K. Geydarova,
The major aim of the
investigation was to study the uteroplacental circulation specificity in
pregnant women with fetoplacental dysfunction and early pregnancy loss in
anamnesis. Equally important was the determination of the fetoplacental circulation
in pregnancy loss. Doppler velocimetry was performed in 122 pregnancies: in the
basic group n=82 and in the control group n=40. The age of the women was
between 22-33 years. In 51 (62,2 %) women with I-II level arterial circulation
dysfunction systolic ratio was increased by 7.7% as compared to the control
group, early diastolic ratio – by 17.3 % and medium reverse flow – by 6.4%.
Common changes in venous circulation of the women with fetoplacental failure
increased systolic flow during a decrease in the systolic period in the
atriums. The highest systolic flow was determined in 21.9% of the pregnant
patients without disturbances in the arterial part of the fetoplacental system.
Doppler index was lower than the control group or equal to it. During homodynamic
dysfunction in the arterial part of the fetoplacental system, an index of
resistance progressively increased in the venous flow and reached the maximal
level in 15.7% of the women. Doppler velocimetry index of the inferior vena
cava changes simultaneously with the increase in arterial flow dysfunction and
severity level of fetal condition.
Auth.
8.g.13.3.45. Up–to-date correction
methods for climacteric syndrome. /M. Ismailova, I. Shamkhalova, L.
Makashvili,
Pathological conditions
caused by the age-specific changes accompanied by hormonal reconstruction are
considered in the article. The climacteric syndrome in combination with
metabolic disorders requires obligatory correction not only via hormonotherapy,
but using exchange processes as well. The literary data of different researches
devoted to the study of the efficiency of the substitutive hormonotherapy (SHT)
implementation with climacteric syndrome are described in this article.
Numerous researches have proved that the use of substitutive hormonal therapy
in combination with different analogues of sexual steroid hormones and
medicines improves exchange processes in the basic procedure of menopause
prophylaxis and treatment, thus improving living activities of women at this
age-specific period. Presently, various phytotherapeutic medicines are widely
introduced into practice and implemented along with SHT.
Auth.
8.g.13.3.46. Placenta of pregnant women
with urine fibromyoma. /N. Asadova/.
Experimental and Clinical Medicine. – 2010. - #2(57). - pp. 17-20. – rus.;
abs.: eng.
The purpose of the
present research is to study features of the placenta in women with uterine
fibromyoma during the third period of their pregnancy. There were 153 women
under investigation: 46 of them without uterine fibromyoma – group 1 (control),
group 2 – 57 women with fibromyomectomy performed before the present pregnancy,
group 3 - 50 pregnant women with uterine fibromyoma. It was established that
the absolute majority (95.6%) of the control group women had the placentary
structure without any changes. The majority of the pregnant women (89.4 %) with
myomectomy in the medical history also had the placentary structure unchanged,
and only 80% of the women with uterine fibromyoma had the placentary structure
without changes (p<0.05).
Auth.
8.g.13.3.47. 2006-2009 dynamics of the ehtiological
structure of vaginites. /E. Kikacheishvili,
Aim of the study was to
investigate the etiological structure of vaginitis dynamics in 2006-2009.
Vaginal flora in 250 females during the inflammatory vaginitis was investigated
by bacteriological analysis. By the rate of excretion, staphylococci came the
first, the second was T. vaginalis, Ñ albicans being the third. One third of the
microorganisms were detected in a form of monocultures, two-thirds - as
associations, the most frequent combinations being: S.epidermidis+T.vaginalis,
T.vaginalis+C.albicans, T.vaginalias+E.coli.
Auth.
8.g.13.3.48. The role of oxidative stress in the development of
atherosclerosis in postmenopausal women. /L. Ratiani, G. Pharkosadze, T. Sanikidze,
The article aimes at the establishment of a correlation between
diagnostically important atherosclerosis markers and intensity of oxidative
stress in blood of postmenopausal women. It was revealed that dislipidemy and
obesity induce the intensification of atherosclerosis in postmenopausal women.
In the hiperoxidative environment, the oxidation of vasodilatator nitric oxide
takes place. As a result, the free nitric oxide content decreases in blood;
annihilation of the vasodilating activity of blood induces the development of
hypertension in postmenopausal women.
Auth.
8.g.13.3.49. Protecting the
environment from pollution by application of nitric fertilizer of a prolonged
action. /M.Gurgenishvili,
A method has been
developed to obtain nitrogenous fertilizers of prolonged action with the
purpose of protection of environment from pollution. Such fertilizers are
highly efficient, they contribute to efficient assimilation of nutrients by
plants, impede washing out of nutrients and protect environment from pollution.
The new type nitrogenous
fertilizer obtained by us – structured carbamide is characterized of great
advantage compared with the non-structured type. Economy by application of such
fertilizer equals to 50%.
Auth.
8.g.13.3.50. Correction of physical conditions and
functional indices of different age children.
/D. Chitashvili, E. Korinteli, G. Zubitashvili,
The methods of observing
sport results for youth are described in the article. Part of the children who
were examined, were exercising by means of general physical preparation, while
the other group – with specific exercises. The dynamics of their physical and
functional development is a basis for giving interesting and helpful
recommendations to couches for correction of the process of exercising.
Auth.
8.g.13.3.51. Study of factual nutrition in children from
children’s house. /Sh. Tukvadze/. Experimental and
Clinical Medicine. – 2010. - #4(59). - pp. 128-132. – geo.; eng., rus.
We studied factual
nutrition in children living in children’s house. Proper nutrition in childhood
can reinforce lifelong eating habits that contribute to children’s overall well
being and help them to grow up to their full potential and a healthy life. Good
nutrition means body is getting all the nutrients, vitamins, and minerals it needs
to work at its best level. Energy (calories) should be adequate to support
growth and development and to reach or maintain desirable body weight.
Nutritional requirements rise as children begin puberty in order to support
sexual development. A diet that provided sufficient calories and nutrients
during childhood may no longer be sufficient for a child beginning puberty.
Qualitative and quantitative analysis of children’s diet revealed some
irrelevances: disbalance between carbohydrate, lipid and protein composition
and disbalances in micronutrients (Iodine, iron, zinc). Such disbalance of
micronutrients in the diet can eventually lead to iodine, iron and/or zinc
deficiency.
Auth.
8.g.13.3.52. EPR Study of Bile Stones in Menopausal Women.
/M. Shengelia, T. Sanikidze, E. Chikvaidze, N. Gogebashvili,
The aim of the study was
establishment of role of FSH in pathogenesis of bile stone disease in menopausal
women blood. The bile stones of 30 women aged 52,4 ± 9,7 year was studied (2
women with surgimenopause (33-35 year). Stone EPR spectra registered on the EPR
spectrometer ESR-V. In stones EPR specter the intensive signal of oxidized
bilirubine (g=2.003, H=1.0ìmTl) was revealed. The
statistical important negative correlation was revealed between content of
bilirubine EPR signal intensity in the stones and content of FSH in blood of
menopausal women. It was concluded, decreasing of the level of FSH in blood of
postmenopausal women decreases secretion of melatonis level, which by itself
induces oxidation of bilirubine, causes initiation of oxidative stress and
development of bile stone disease in postmenopausal women.
Auth.
8.g.13.3.53. Menopause and depression. /Sh. Vashadze/. Experimental and Clinical Medicine. – 2010. - #5(60).
- pp. 46-48. –rus.; res.:eng.
Menopause is also known
as "the change of life” and for some women it can be the most challenging
time in their life both physically and mentally. Often due to the psychological
effects, menopause can affect the whole family. It is mainly connected with the
last menstrual period. For western women the average age of its occurrence is
51 (although women between the ages of thirty and sixty experience menopause).
Menopause occurs when the ovaries cease responding to the controlling hormones
that are released by the pituitary gland situated in the brain. Women
experience menopause differently. Some hardly notice the change apart from
irregular periods whilst others suffer from all the symptoms which can affect
their life considerably. It is established the tendency to level decrease in
blood serotonin (205.72; 6.74 ng/ml). The beginning of the disease is in
positive correlation with depression by uneasiness and an index of instability
of marriage. Menopause, in general, is not associated with an increased risk of
depression. In fact, while once considered as a unique disorder, research has
shown that depressive illness during menopause is not different from other
ages. The women with a history of past depressive episodes are more vulnerable
to the change-of-life depression.
Auth.
8.g.13.4.1. Acroseal in the
treatment of periodontitis. /N. Abashidze, N.
Tatishvili, Kh. Gogishvili, Q. Alania, T. Tsintsadze/. Tbilisi State Medical
University’s Collection of Scientific Works. – 2009. – #43. – pp. 5-7. –
geo.; abs.: eng.
The aim of our research was to evaluate the efficiency
of Acroseal during the treatment of periodontitis. 150 teeth of 106 patients
were used for this study. Patients were treated and observed for a substantial
period of time (1month, 3months, 6 months and 12 months). 86 (57.33±2.0%) were
single-channel and 64 (42.67±2.0%) multirooted. We divided patients into two groups.
In every group were 75 teeth, 25 of them had periodontitis chronic granulaus,
25 -periodontitis chronic granulomatosa and 25 – periodontitis chronic
exacerbate. In the first group we used Acroseal and in the second Endometasone.
We can resume that the usage of Acroseal (Septodont) during the treatment of
the chronic forms of periodontitis is very effective.
Auth.
8.g.13.4.2. Two-stage
treatment method of odontogenic cysts penetrated with the maxillar sinus
without soft tissue plastic. /O. Bregadze, K. Metreveli/.
Tbilisi State Medical University’s Collection of Scientific Works. – 2009. – #43. – pp.
18-20. – geo.; abs.: eng.
The purpose of our research was to offer a two-step
original surgical procedure to dentists, who have a successful practice in oral
surgery, which helps in surgical treatment of small- and medium-size cysts,
which are in or have contact with the upper maxillar. This procedure is used
for treatment of odontogenic cysts, when we cannot make a resection of the root
apex, because the most part of it is in cyst. So, we can successfully utilize
this two-step original surgical method in the treatment of small and medium
size cysts.
Auth.
8.g.13.4.3. The effect of
halothane on the number of the GAD65/67 positive cells in rat hippocampus at the background of Midazolam
premedication. /Z. Vadachkoria, L. Dzidziguri, E. Bakuradze, I. Modebadze,
D. Dzidziguri/. Tbilisi State Medical University’s Collection of Scientific
Works. – 2009. – #43. – pp. 50-52. – geo.; abs.: eng.
The experimental results of halothane effect on
GAD65/67 positive cells, number in ÑÀ1 and ÑÀ3
fields of white rat hippocampus are presented in the proposed work. It has been
shown that the number of GAD65/67 positive cells are decreased in the CA3 field
of hippocampus after 24 hours of halothane anesthesia. Simultaneously, the
number of the same cells is increased in the CA1 field of hippocampus.
Midazolam premedication promotes the normalization of activity of GAD65/ 67,
which is substantiated by an increased number of GAD65/67 positive cells in the
CA3 field of rat hippocampus after 24 hours.
Auth.
8.g.13.4.4. The use of
polcortolon cream in the treatment of tropical lichen. /M. Iverieli, N. Abashize, KH. Gogishvili, Q. Alania,
N. Tatishvili/. Tbilisi State
Medical University’s Collection of Scientific Works. – 2009. – #43. – pp. 63-64. –
geo.; abs.: eng.
The aim of our research was to determine the
efficiency of 0.1% polcortolon in the treatment of tropical lichen. We studied
48 patients aged from 32 to 64. 42 of them (87.5±4.5%) were women and 6
(12.5±4.5%) were men. The typical form of the disease was in 30 (62.5±2.6%)
patients, exudative hyperemical - in 12 (25.0±2.45%), ulcerosa - in 6
(12.5±2.14%). Patients were divided into two groups, 24 in every group. 15 of
them had typical form of the disease, 6 – exudative-hyperemical form, and 3 –
ulcerosa form. All patients had the traditional scheme of treatment. Patients
in the first group were additionally given Polcortolon. The positive results
were achieved in both groups, although in the first group we needed less visits
than in the second one. Also, remission in the first group took longer than in
the second group. Our research proved the high effectiveness of Polcortolon in
the treatment of tropical lichen.
Auth.
8.g.13.4.5. Burning mouth
syndrome (BMS), differential diagnostics and algorithm of complex treatment. /R. Kenchadze, M. Iverieli, N. Geladze, N. Abashidze,
Kh.Gogishvili/. Tbilisi State Medical University’s Collection of Scientific
Works. – 2009. – #43. – pp. 72-77. – geo.; abs.: eng.
Glossalgia, glosodinia, glossopirose - a term used by
different authors to define Burning mouth syndrome (BMS) is still considered as
one of most serious facial pains, etiologic factors and pathogenic mechanisms
of which are not always possible to determine. 60 patients, aged 45–70, have
been examined by the authors under conditions of stomatologic and neurologic
clinics. The carried studies have allowed selection of 4 clinical groups
according to the supposed etiologic factors and the obtained paraclinical data
taking into consideration both the clinical manifestations and the presence of
visceral or endocrine pathologies, mental condition and society in each
separate case. The algorithm of the complex approach to BMS therapy in each of
the selected groups was developed. Long-term remission (6-10 months of
duration) was reached in 42% of the patients and full remission - in 18%,
respectively. Temporary improvement during the treatment was seen in 12% of the
cases. The authors are planning further actions for more profound studying of
BMS syndrome.
Auth.
8.g.13.4.6. Use of Trachisan
in the postoperative period of dental implantation and oral surgery. /K. Metreveli, O. Bregadze/. Tbilisi State Medical University’s Collection of Scientific Works.
– 2009. – #43. – pp. 112-113. – geo.; abs.: eng.
The purpose of our investigation is an evaluation of
efficiency of TRACHISAN used in the postoperative stage of 24 dental
implantations and oral surgery. Our research was carried out on 60 patients (28
females and 32 males) aged from 20 to 61 years and divided into two groups.
Amoing them, implantation was performed in the case of 18 patients, extraction
of retented wisdom teeth - in 26. and root apex resection with cystectomy due
to odontogenic cysts with the various dimensions and localization – in 16
patients. In the complete treatment of both groups, we additionally, in the
first group, postoperatively, for a week, were using TRACHISAN. Generally, the
treatement results were positive. Only two cases of controlled patients were
complicated with longer postoperative oedema. In the first group of
investigated patients, sutures were removed after 7-9 days, instead of 8-12
days in the second control group. So, according to our research, it can be
concluded that TRACHISAN improves the oral hygienic condition and decreases the
wound healing period. It has antimicrobial and painrelieving activity and can
effectively be used in the complex treatment during the postoperative period of
dental implantation and oral surgery.
Auth.
8.g.13.4.7. Clinical aspects of removable laminar
dentures. /A. Safarov/. Georgian Medical News. – 2010. – #2(179). –
pp. 15-18. – rus.; abs.: geo., eng., rus.
One
of the main goals of modern orthopedic dentistry is the development of high-quality
removable laminar dentures. Some
materials used in making removable laminar dentures consist of polymethyl
methacrylate, which causes serious pathological process in the tissue of
denture’s zone and low adaptation ability of the organism. There is a growing
interest in the production of different types of removable dentures made of
thermoplastic material, which is biocompatible with the organ and tissues of
the oral cavity. The interest in the manufacture of removable laminar dentures
of thermoplastic materials has significantly grown lately. The aim of this
study was to examine the properties of thermoplastic materials in orthopedic
dentistry. The results of this investigation revealed good functional and
adaptation properties of removable laminar dentures made of thermoplastic
materials.
Auth.
8.g.13.4.8. The effect of
tobacco-smoke components on a-ketopropionic acide
concentration in teeth of tobacco smokers. /D.
Zurabashvili,
The composition of
cigarette-smoke is relatively well known in spite of its tremendous complexity.
But the analysis of cigarette smoke toxicological effect on biochemical
components of tooth enamel, dentine and pulpe has not been completely studied.
The present study was designed to characterize the pulpe biochemical component
(-ketopropionic acide) by acute serous pulpit. The
total number of 140 patients, age 35-40 (Tobacco-smokers 80, non-smokers – 60)
have been investigated. The results suggested that tobacco-smokers incisor
teeth and molars contain less -ketopropionic acide
than those of non-smoker individuals. These studies support the hypothesis of
the cigarette-smoke’s important role in the tooth support mechanisms. The
biochemical activity and function of tooth proteins and amino acids composition
must by compared to concentration of tobacco-smoke components.
Auth.
8.g.13.4.9. Chemiluminescence of whole saliva in
antioxidant treatment of prosthetic bed tissues. /M. Tunyan, B.
Lalayan, A. Zakaryan, K. Grigoryan,
G. Poghosyan, H. Yeghiazaryan/. Georgian
Medical News. – 2010. – #3(180). – pp. 20-25. - rus.; abs.: geo., eng., rus.
This
study aimed at determining the effectiveness of adaptogens, antioxidants in the
complex treatment of diseases of tissues prosthetic field and their influence
on the processes of LPO in whole mixed unstimulated saliva. The effect of antioxidants in combination with traditional
treatment in 70 patients with periodontal disease and prosthetic bed was
assessed by chemiluminescence analysis of the whole mixed unstimulated saliva.
The level of lipid peroxidation and chemiluminescence activity exceeded the
normal values by 1.5-2 times before the treatment. After the treatment with
antioxidants, these parameters decreased and increased again during remission.
Auth.
8.g.13.4.10. The need of orthopedic and dental help for
aged and old persons in Georgia. /L. Morchadze, V.
Margvelashvili/. Georgian Medical News. – 2010. – #5(182). pp. 12-15.
– rus.; abs.: geo.,
eng., rus.
According the
demographic changes taking place in the world, we are experiencing the process
of radical aging. It is very essential to evaluate the quality of orthopedic
treatment. For this purpose, we should identify the prosthesis of different
constructions in the patient’s mouth cavity and assess their fitness and use
terms. The necessity of orthopedic treatment in 50-59- year-age groups was
equal to 54% and in 80-89-year-age groups this number increased to 84%. In the
case of loosing all the teeth, only quality prostheses can guarantee normal
chewing of food and avoid gastrointestinal disturbances.
Auth.
8.g.13.4.11. Correlations between complications after
cosmetic veneer treatment and initial parameters of oral cavity. /R. Ivanishvili, V. Margvelashvili, M. Kalandadze/.
Georgian Medical News. – 2010. –
#5(182). – pp. 16-20. – rus.; abs.: geo., eng., rus.
The aim of the study was
to define interrelations between complications after veneer treatment with
initial parameters of the oral cavity, the state of the organism and social and
biological factors. 65 patients with veneers treated between 2005 and 2009 at
Margvelashvili Dental Clinic (Tbilisi) were investigated. Correlation analysis
on Spearman was spent with application of the package statistical programs SPSS
11.5. A chip of veneers finds out significant positive correlation with the
following factors: a crossbite - r=0.2543, p<0.0409; decompensative caries -
r=0.3189, p<0.0096; exhibiting of a pathological microflora - r=0.2879,
p<0.0163; discoloration - patient aged 41-60 - r=0.3877, p<0.0014; focal
infection contamination - r=0.2599, p<0.0366; frequent use of coffee -
r=0.2819, p<0.0229; ulitis up to veneer - r=0.2444, p<0.0498; appearance
line of demarcation - with the mechanical factor - r=0.3479, p<0.0045; use
of synthetic fluids, - r=0.3823, p<0.0017; recurrence caries - with gastrointestinal
pathologies r=0.2924, p<0.0181; of a focal infection contamination -
r=0.2756, p<0.0263; by feeding priority by carbohydrates - r=0.2324,
p<0.0625; decompensate caries - r=0.2583, p<0.0377; exhibiting of a
pathological microflora – among males - r=0.2772, p<0.0254; by smoking -
r=0.3227, p<0.0087; gastrointestinal pathologies - r=0.2365, p<0.0579; by
endocrine diseases - r=0.2546, p<0.0407; by focal infection contamination -
r=0.5416, p<0.0000; decompensate caries - r= 0.2530, p<0.0420; by an
ulitis – r=0.4551, p<0.0001; by a hygienic index - r=0.4611; p<0.0001;
periodontal index - r=0.4611, p<0.0001; PMA index - r=0.3529, p<0.0039.
The correlation circuit of the factors of complications after veneers will help
the practical stomatologists with realization of purposeful prophylaxis.
Auth.
8.g.13.4.12. Assessment of prevalence and risk
factors of aesthetic dental defects and identification of need of veneers in
the population of Tbilisi. /R. Ivanishvili, V.
Margvelashvili, M. Kalandadze/. Georgian
Medical News. – 2010. – #6(183). – pp. 13-17. – rus.; abs.: geo., eng., rus.
The work is fulfilled on
the basis of investigastion of 330 persons aged from 14 to 70 from the common
population of Tbilisi. The patients entered the clinic in 2005-2009. Criteria
of exception: general diseases, diabetes, autoimmune diseases, serious forms of
parodontosis caused by somatopathies. The relative chance of need of veneers is
defined by the following factors: smoking - OR=1.82 (95%CI=1.13-12.37);
pathologies gastrointestinal of a path - OR=1.94 (95%CI=1.22-14.26); the focal
infection contamination loci - OR=65.57 (95%CI=8.80-76.22); the mechanical
factor - OR=2.23 (95%CI=1.27-58.95); drug treatment - OR=2.14
(95%CI1.34-24.56); carbohydrates-rich food - OR=2.89 (95%C=I.51-13.15);
excessive consumption of sweet - OR=1.87 (95%CI=1.07-9.85); frequent drinking
of coffee OR=1.75 (95%CI=1.10-12.51); distal occlusion - OR =2.26
(95%CI=1.09-18.68); - subcompensated caries - OR=2.04 (95%CI1.28-23.48);
pre-veneer ulitis - OR=1.62 (95%CI1.02-19.20); post-veneer complications:
partial or direct filling decomposition - OR=34.12 (95%CI7.98-52.11); filling
discoloration - OR=80.67 (95%CI19.15-509.48); appearance of a line of
demarcation - OR=95.23 (95%CI12.86-714.61); recurrent caries - OR=25.75
(95%CI=7.69-39.87); ulitis - OR=11.22 (95%CI=3.22-68.99); pathological
microflora maifestations - OR=123.16 (95%CI=16.68-726.40).
Auth.
8.g.13.4.13. Theoretical and
practical principles of dentinogenesis: hypotheses and clinically confirmed
reality. /M. Mamaladze, M.
Ustiashvili/. Georgian Medical News.
– 2010. – #9(186). – pp. 22-27. – rus.; abs.: geo., eng., rus.
The problem of maintaining dental vitality and
stimulating reparative processes is a priority in modern odontology.
Restorative processes depend not only on the type and size of tissue damage,
but also on the protection capacity and integrity of the structural/functional
pulp-dentin boundary. Primary dentin that is initiated in the intrauterine
period has the unique structure and composition. Secondary dentin continues to
form after the tooth is erupted, after the root formation is finished, and
throughout life. Actually, the primary and secondary dentins have similar
tissue structures developed at different stages of dentinogenesis. Primary
dentinogenesis is initiated by odontoblasts located in the periphery of dental
pulp. Secondary dentin as a structure already exists once root formation is
complete, but at that stage is has low levels of mineralization. Formation of
tertiary dentin is always reactionary to different pathologies and is initiated
by so called transitional odontoblasts (odontoblast-like cells) and partially
fibroblasts. Odontotropic and anti-inflammatory medications strongly change
structural characteristics of the dentin. Pulpal ability to produce dentin-like
matrix (tertiary dentin) is an important component of the pulp-dentin
reparative capacity. Only specific characteristics of the dentin can account
for indications and contraindications for using restorative liners and explain
the impact of adhesive systems on these. In this context, the interest is high
to the dentin and its response and change in reaction to different stimuli.
Dental caries and other pathological processes (abrasion, erosion, attrition)
seriously affect dentin vital activity causing it to change to the
"emergency" mode. This process is viewed not as resulting from pulp
medication but as reactionary, aimed for self-preservation. In such cases the
major focus is not on drug composition but on pulpal response. The pulp may be
said to "form tertiary dentin for self-protection". In conclusion,
the tertiary dentin that forms as a result of pathological processes
(express-dentin, reparatory dentin) could be identified as a perfect barrier
for the pulp necessary for keeping it vital. And investigation of mechanisms
causing primary stimulation of odontoblasts and triggering the reparative
processes remains a pressing problem in modern odontology.
Auth.
8.g.13.4.14. Demyelination - the
problem of pulpitis. /Kh. Davarashvili/.
Experimental and Clinical Medicine. - 2010. - #2(57). - pp. 48-50. – rus.;
abs.: eng., geo.
We paid great attention
to the peripheral nervous system when studying pulpitis. The connection between
demyelination and the cytopathogenic effect proves that this disease is of a
viral etiology.
Auth.
8.g.13.4.15. Endothelium in
parodontitis against the background of cardioischemia. /L. Phorchkhidze, N. Khvitia, S.
Zurabashvili, T. Zhvitiashvili, G. Danelia, Kh. Davarashvili/. Experimental and
Clinical Medicine. - 2010. - #3(58). - pp. 20-24. – geo.; abs.: eng.
A study of the
endothelium against the background of ischemia showed that both diseases –
parodontitis and cardioischemia are sinergetic. These diseases are widely
spread pathologies. The treatment of these diseases is very difficult as it
requires medicines that can cure both of them.
Auth.
8.g.13.4.16. Clinical effects of Camelin in patients with
parodontitis. /I. Katchkatchishvili, M. Bakradze/. Experimental and Clinical Medicine. – 2010. - #5(60).
- pp. 8-11. – geo.; abs.: eng., rus.
The thesis highlights
findings concerning the clinical application of the preparation Camelin in the
treatment of inflammatory diseases of the parodontium. Produced in Georgia,
Camelin is a curative-prophylactic medication made of an original, special type
of honey. The medication has anti-inflammatory, anti-septic, and pain killing
effects. It regulates the performance of the local immune system, stimulates
regeneration processes, strengthens the functioning of the local immune
barrier, and has antibacterial and antifungal effects. 40 patients were divided
into 2 observation groups: a group for examination (21 patients, monotherapy)
and a group for control (19, traditional treatment). We conducted a clinical
assessment of the parodontal pockets and determined their depth before and 1
month after the treatment. We used 5% Camelin cream for 15-minute long
applications. The observation showed a significant decrease in the depth of
parodontal pockets and in the extent of teeth loosening. Therefore, we think it
expedient to translate the discovery into clinical benefit and to use Camelin
for the treatment of inflammatory diseases of the parodontium.
Auth.
8.g.13.4.17. Endothelium in acute
pulpitis against the background of parodontitis. /L. Phorchkhidze/. Experimental and Clinical Medicine. – 2011. – #1(1). - pp. 31-34.
– rus.; abs.: eng., geo.
The endothelium has been
studied with the help of light and electron microscopy. Ten patients and three
healthy persons were investigated. Both pulpitis and parodontitis destroy the
epithelium, homeostatic regulation is destroyed as well. Vessel tonus in
capillaries is also changed; trans-capillary permeability is weakened; the
aggregation of formed elements and adhesion intensify. Endothelial destruction
during pulpitis against the background of parodontitis denotes a heavy
complication of the disease. Thus, endothelial destruction predicts lots of
complicated diseases.
Auth.
8.g.13.4.18. Some structural
peculiarities of collagen during acute pulpitis. /T. Zhvitiashvili, Kh.
Davarashvili/. Experimental and
Clinical Medicine. – 2011. – #1(1). - pp. 38-40. – rus.; abs.: eng., geo.
Collagen and its
proliferation were studied in patients suffering from pulpitis (the material includes
20 clinical cases). It was shown that normally fascicles of collagen are wound
up into a superspiral and are held together with the help of chelate
(hydrogenous) connections. A possible interest of non-specific antigens in the
destruction of collagen fascicles is considered.
Auth.
8.g.13.4.19. Microflora of mucous membrane of upper
respiratory tracts during rhinitis and pharyngitis. /A. Dedabrishvili, M. Dzagnidze, E. Mirelashvili, E.
Kikacheishvili/. Materials of Sukhishvili University International Scientific
Conference. – 2010. – pp. 209-212.
- geo.; abs.: geo., eng.
In 2007-2009, total of
327 patients with rhinitis and phargnigitis were investigated. Investigations
were carried out using modern standard technology of the French firm
BioMerieux. In the etiologic structure prevailed S. epidermidis (42.3%), H.
infloenzae (10.5%); in associations were mainly revealed S. seroyroup G+C.
albicans – 12.7%. According to the data obtained, the true picture of
microecology of the upper respiratory tracts became evident.
Auth.
8.g.13.4.20. NO – marker
of denture-induced
inflammation
of paradont
tissue.
/Z. Nakudashvili, S. Mghebrishvili, I.
Datunashvili, T. Sanikidze/. Materials of Sukhishvili
University International Scientific Conference. – 2010. – pp. 230-233. - geo.; abs.: geo., eng.
The aim of the study was
the establishment of denture-induced alteration of concentration inflammatory
marker, NO. 60 patients with dentures were investigated (1 group – 30 patient
with dentures on the plastic basis, who used specific hygienic liquid for the
denture cleaning and oral cavity washing (1a) and not (1b); 2 group – 30
patients with dentures on the metal basis, who used specific hygienic liquid
for denture cleaning and oral cavity washing (2a) and not (2b)). The 3rd
control group – 30 volunteers with the healthy oral cavity. Alterations of free
NO content in patients’ saliva was studied by the EPR method (1 - before
denturing; 2 – 3 days after denturing; 3 – 1 month after denturing). The study
results testify that in the patients with metal basis dentures the process is
less intensive. The employing of a specific hygienic liquid for denture
cleaning and oral cavity washing decreases the intensity of inflammation.
Auth.
8.g.13.4.21.
Etiopathogenesis and pathanatomy of acute periodontitis. /G. Eliava, I. Chikobava,
M. Rekhviashvili/. Gaenati Herald. –
2010. – vol. 3, #3. – pp. 55-60. – geo.; abs.: geo.; eng., rus.
Various types of periodintitis are discussed
periodotypes, including the drug-induced priodontitis that may be cuased by the
action of biogenic amines. The pathanatomical presentation changes in the early
and late stages of acute periodontitis. Microabscesses and distrophical changes
in the bone tissue are characteristic of the late stage.
Auth.
8.g.13.4.22. Myelin fibers
of dental pulp and their partial demyelinization during acute pulpitis. /T. Zhvitiashvili, Kh. Davarashvili/. Bulletin of the
Georgian National Academy of Science. – 2011. – vol. 5. - #1. – pp. 130-132. –
eng.; abs.: geo., eng.
One of the factors of
pain is damage of nerve fiber structure. Due to the fiber damage, passive
penetrability of Na+ion is increased, leading to the change of membrane
polarization and additional local currents with the pain syndrome
strengthening. Thus, two moments in the occurrence of the pain syndrome play an
important role: disfibering of myelin and growth of Na+ -ion penetrability.
Auth.
8.g.13.4.23. The theoretical
possibility of the textile dental cords formation by untwisted yarns. /T. Moseshvili, I. Kldiashvili/. Science and Technologies. – 2009. - #10-12. – pp. 119-122. – geo.,
abs.: eng., rus.
The textile materials such as flosses and retraction
cords are used in stomatology for cleaning the tooth and treatment of
parodontosis and gingivitis by transfer the medicines in gum furrow. They are
made of 100% cotton fibers and have a high level of absorption, flexibility and
resilience. There are three types of dental cords: twisted, braided and
ultrapak knitted. The twistless yarn has a different structure. The twistless
yarn is formed at pasting of separate fibres as a result of interaction of
binding substance with fibabs. As researches have shown, they on all length are
extended in parallel of an axis of a yarn and basically are located close to a
product axis. Durability of twistless yarn, as well as the absorption of this
yarn is higher than all types of dental cords and they can be easily placed
between teeth.
Auth.
8.g.13.4.24. Study of denture
materials toxicity on the Jurkat cell model system. /Z. Nakudashvili, S. Mgebrisvili, M. Matchavariani, M.
Enukidze, T. Sanikidze/. Proceedings of the Georgian National Academy of
Sciences. Biomedical Series. – 2010. - # 1-2 (36). – pp. 91-97. - geo.; abs.:
rus., eng.
The main problem of modern orthopedic stomatology appears
to be the restoration of teeth which is associated with the entry of a
foreigner body (denture prosthetic appliance) in the patient’s mouth cavity. As
a result of mechanic and toxicallergic interaction between dentures and mouth
mucosal tissue, the development of allergic-inflammatory, traumatic disorders
is possible. Prevention and correction of these negative effects are the main
task of modern stomatology. The aim of our study was the investigation of
toxicity of denture materials on the model system of Jurkat cell culture. As a
result of our study, it was revealed that although the studied denture
materials did not manifest toxic effects, they induced an increase in the
antioxidant enzymes’ activity (especially in the case of joint action of the applied
substances) in Jurkat cells.
Auth.
8.g.13.4.25. Dental
demyelinization and its association with caries. /N. Zhvitiashvili, N. Khvitia, T. Zhvitiashvili, G.
Danelia/. Experimental and Clinical Medicine. – 2010. - #1(56). - pp. 22-23. -
rus.; abs.: eng.
The dental pulp has been
studied during caries. Myelin fibers are damaged and morphologically changed,
and Schwann cells undergo the cytopathogenic effect.
Auth.
8.g.13.4.26. Lymphatic link of
microcirculation in the pathogenesis of parodontitis. /O. Aliyev/. Experimental and Clinical
Medicine. – 2010. - #1(56). - pp. 23-27. – rus.; abs.: eng.
The purpose of the
present research was to study blood and lymph coagulability, and also the
condition of lymphatic drainage of tissues during parodontitis in a rabbit
model. Experiments were carried out on 21 "Chinchilla” rabbits of both
sexes weighing 2.5-3.0 kg. Solutions of Kalipsolum (8mg/kg) and Dimedrolum
(0.15ml/kg) had been introduced intravenously as narcotic agents before the
experiment. The research results have shown that modelling of parodontitis in
rabbits leads to a rather expressed activation of intravascular coagulation not
only in the blood, but also in the lymph against the background of an
appreciable oppression of lymphatic drainage of tissues. Comparing our data
with the literary data, we drew the conclusion that the activation of
intravascular lymph coagulation eventually promotes the impairment of lymphatic
drainage of tissues (particularly of parodontium tissues) and plays an
important role in the pathogenesis of parodontitis.
Auth.
8.g.13.4.27. Biochemical
investigation of orthodontic complications. /A. Safarov/. Experimental and Clinical Medicine. –
2010. - #1(56). - pp. 30-31. – rus.; abs.: eng.
The study of literature
shows that pathological processes resulting from the use of orthopaedic
constructions prevail in the oral cavity. The quantitative and qualitative
content of the oral cavity changes because of the negative action of
orthopaedic constructions.
Auth.
8.g.13.4.28. Dental caries and
its connection with demyelinization. /N. Khvitia,
KH. Davarashvili, T. Zhvitiashvili, G. Danelia/. Experimental and Clinical
Medicine. – 2010. - #1(56). - pp. 36-38. - rus.; abs.: eng.
We used light and
electron microscopy to study the dental pulp during caries. The study showed
that some parts of the myelin fibers got damaged, this factor negatively
influencing their conductivity. Clinically, the process is understood as pain.
Changes were also found in the cylinder: a great number of small vesicles and
destructed mitochondria were detected there.
Auth.
8.g.13.4.29. On the problem of
demyelinization in the dental pulp. /KH. Davarashvili, T. Zhvitiashvili, N. Khvitia, G.
Danelia/. Experimental and Clinical Medicine. – 2010. - #1(56). - pp. 53-55. -
geo.; abs.: eng.
A great attention is
paid to the peripheral nervous system when the dental pulp is studied. For this
study we have used light and electron microscopy. Demyelinization is connected
with the cytopathogenic effect in the Schwann cells. The occurrence of myelin
depolarization should also be mentioned.
Auth.
8.g.13.4.30. The effectiveness
of removable dentures fabricated from thermoplastic. /A. Safarov/. Experimental and Clinical Medicine. -
2010. - #2(57). - pp. 39-42. - rus.; abs.: eng.
The achievements of
orthopaedic dentistry in the fabrication and use of thermoplastic removable
denture constructions provide patients with the prosthesis that is more
bio-compatible, stronger toward attrition and lighter in weight. Acrylic resin
used clinically for a long time results in serious pathologic changes.
Therefore, patients have more difficulties in adapting to those orthopaedic
constructions. The performed clinical investigations show the organism’s high
ability to adapt to flowable thermoplastic.
Auth.
8.g.13.4.31. Collagen in
periodontitis. /N.Lobzhanidze, T.Lobzhanidze,
N. KHvitia, G. Danelia/. Experimental and Clinical Medicine. – 2010. - #2(57).
- pp. 53-55. – rus.; abs.: eng.
Light and electron
microscopy was used to study collagen in the diseased periodontium. The
collagen fibres appear to be structurally changed during periodontitis: the
fibroblasts are greatly changed, euchromatin is strongly expressed, and the
cytopathogenic effect is clearly visible.
Auth.
8.g.13.4.32. Endothelium in
periodontitis. /N. Lobzhanidze, N. Khvitia, T. Lobzhanidze, G. Danelia/. Experimental and Clinical Medicine. -
2010. - #2(57). - pp. 58-59. – rus., abs.: eng.
The endothelium has been
studied by light and electron microscopy in the diseased periodontium. The endothelial
cell contacts appear to be damaged, and the erythrocytes penetrated through the
damaged contacts. Growing collagen fibres replaced the existing tissue.
Auth.
8.g.13.4.33. Normal dental
pulp. /Kh. Avarashvili, N.Khvitia,
T.Zhvitiashvili, G.Danelia/. Experimental
and Clinical Medicine. – 2010. - #3(58). - pp. 43-44. – geo.; abs.: eng.
Normal dental pulp has
been studied with the help of light and electron microscopy. The structure of
the pulpal innervation and vascularization were investigated. A great deal of
attention was also paid to the pulp structure.
Auth.
8.g.13.4.34. Atmospheric air feature
indicators and their impact on the mineralization of tooth hard tissues. /T. Shishniashvili, N. Suladze/. Experimental and Clinical Medicine. – 2010. -
#4(59). - pp.17-20. – geo.; abs.: eng., rus.
The influence of quality
indicators of atmospheric air on junior children’s dental status was studied by
us on 3-4 years old 350 children examined by standard methods provided by
Health Care Organizations (tooth caries spread, intensity and non-caries
damages). According to our study high indicator of tooth caries (averagely
89.9%) was manifested in all districts of city of Tbilisi and several occasions
(8 in total) of tooth non-caries damages, especially hyperplasia that to our
opinion is not depended on coefficient of pollution of atmospheric air.
Simultaneously, ecological indicators make important influence on intensity of
tooth caries and it is higher in the districts where the level of pollution of
atmospheric air exceeds by several times to the limit established by
international standards than in ecologically more reasonable districts and
respectively amounts to 6.0 and 3.9. As a result of data analysis we can make
conclusion that high composition of ecotoxins in the atmospheric air makes
significant influence not only on organs and systems of human organism, but
represents serious risk-factors of dental pathologies generation and
development too.
Auth.
8.g.13.4.35. Stomatologic desease and
the basic aspects of medical aid to the population of frontier regions of
Georgia. /I. Zarnadze, D.
Raminashvili, Sh. Zarnadze, D. Kitovani,
L. Lomtadze/. Experimental and Clinical Medicine. – 2010.-
#4(59). - pp. 31-33. – geo.; abs.: eng., rus.
By means of sociological
inspection and an expert estimation stomatologic disease among 3000 respondents
of frontier areas of Georgia has been studied. By virtue of distinction and
features risk-factors, heavy social and economic situation in country and
absence of specialized (stomatologic) social programs and the insurance, the
noted population, especially in zones of the conflict, is deprived the
qualitative and accessible stomatologic help. In prevention a stomatologic
pathology it is important to involve various mechanisms of medical and social
aid. In particular, carrying out of the primary stomatologic help within the
framework of humanitarian actions for inhabitants of frontier areas can
partially solve this problem.
Auth.
8.g.13.4.36. Bow prosthesis fixation
elements and problems connected to them. /S.
Mgebrishvili, I. Barbakadze/. Experimental and
Clinical Medicine. – 2010. - #4(59). - pp.161-162. – geo.; abs.: eng.,
rus.
There were 53 patients
under observation, from whom 28 people from I group were prepared bow prosthesis
of NEI system with I, II and III type catcher supporter clasps, and II group 25
patients were made bow prosthesis, fixation of which were made by the help of
attachments. As a result of research it was revealed that bow prosthesis
fixation in I and II group patients was satisfactory and chewing efficiency was
high. But from I group patients 17(60%) of patients after finishing of
orthopedic treatment mentioned raising of sensitivity from the side of abutment
teeth, and 8 (28%) patients who had parodontopathy in 10-14 months after
finishing of treatment had abutment teeth I quality shaking. It is also
considerable that for all the patients of I group, catcher supporter clasps
were aesthetically unacceptable. For II group patients the aesthetic side of bow
prosthesis was satisfactory. But as a result of research it has been revealed
that from II group 12 (48%) patients having parodentium, shaking of abutment
teeth was mentioned in 14-17 months after finishing of treatment, and in the
patients having healthy parodentium, shaking of abutment teeth was mentioned in
2-3 years after treatment. So, while orthopedic treatment of partial adentia,
fixation elements of bow prosthesis – as NEI system catcher supporter clasps as
attachments require further improvement.
Auth.
8.g.13.4.37. Osteoblasts and Collagen
during acute pulpitis developed against the background of parodontitis. /T. Zhvitiashvili, Kh. Davarashvili/. Experimental and Clinical Medicine. – 2010.
- #5(60). - pp. 13-15. – rus.; abs.: eng.
Collagen has been
studied with the help of light and electron microscopy. During pulpitis
developed against the background of parodontitis, collagenic fibers assist in
restructuring extracellular matrix and forming scars in the damaged area.
Phibroblasts synthesize collagen and its growth negatively affects the general
structure of the pulp and, as a result – its functionality.
Auth.
8.g.13.5. Roentgenology and Radiology
8.g.13.5.1. Diagnostic possibilities of multilayer
computer tomography in blunt abdominal trauma. /G. Nemsadze, O. Urushadze, L. Tokhadze, N.
Khipshidze/. Georgian Medical News. – 2011. - #2(191). - pp. 12-18. – rus.;
abs.: geo., eng., rus.
The purpose of our study
was to determine MDCT diagnostic possibility in blunt abdominal trauma. Our
work was based on MDCT results of 84 blunt abdominal trauma patients with
stable homodynamic status (28 (33.3%) female and 56 (66.6%) male). Age ranged
from 17 up to 64 years. The CT scan showed obvious organ and system injuries in
82 poly-trauma patients. Injuries of the craniocerebral region, also of facial
bones, chest and spine were detected in two patients; in one of which, however,
it was not possible to differentiate subcapsular spleen hematoma accurately
because of the left upper joint metallic holder artifacts. In the second
patient, the liver injury was accurately diagnosed, but there were
visualization problems caused by the massive retroperitoneal hematoma from the
right adrenal gland injury. The investigation showed that sensitivity of CT
scan data was 98%, specificity - 97% and the accuracy rate- 98%. All the
above-mentioned clearly state the importance of MDCT in the emergency
department. MDCT ensures precise diagnosis in maximally short period of time
and thereby helps to choose proper treatment and decreases post-traumatic
complications.
Auth.
8.g.13.5.2. Modern CT
parameters in polytrauma patients’ research. /G.
Nemsadze, O. Urushadze/. Tbilisi State Medical University’s Collection of
Scientific Works. – 2009. – #43. – pp. 122-127. – geo.; abs.: eng.
The role of multi-detector CT is very important in
diagnosis and management of patients with polytraumatic injury. During the
research period, there were 168 cases of polytraumatic injury in the emergency
department. Identification of injuries of organs and systems is highly
important for the management of patients with polytraumatic injury. The study
results showed that the developed MDCT polytrauma protocol can facilitate
detection of all major or minor injuries. The results of our study are in
agreement with the results of the studies by Wintermark, et al. This study may
have direct influence on CT application in the emergency department. Since the
completion of the study, CT has been routinely applied in our clinic in the
polytraumatic mode. All the above-mentioned is aimed at accurate detection of
injuries in the shortest possible time, ensuring the right choice of management
and minimizing posttraumatic complications.
Auth.
8.g.13.5.3. Hygienic
assessment of the external irradiation doses of children caused by the
radiation backgraund of educational institutions in Didgory district of
Georgia. /N. Vepkhvadze, T.
Kochoradze, N. Kiladze/. Tbilisi State Medical University’s Collection of
Scientific Works. – 2009. – #43. – pp. 53-55. – geo.; abs.: eng.
The radiation background (RB) of educational
institutions of the Didgori district of Georgia has been studied and the doses
of external irradiation of children caused by indoor and outdoor irradiation
were estimated. The RB of the studied institutions composes 99,5-134 nGy/h, the
average annual doses of external irradiation of children caused by RB of day
nurseries, kindergartens and schools, public dwelling-houses and open areas
compose 0,15-0,16 mSv/y, 0,79-0,89 mSv/y, 0,12-0,14 mSv/y, respectively. For the
purpose of reduction of irradiation dose, the recommendation foi a prolonged
outdoor stay of children is given.
Auth.
8.g.13.5.4. Characteristic
of clinical use of halogen and diode phototherapy. /M. Mamaladze, N. Chipashvili, D. Vadachkoria, M.
Shanidze/. Tbilisi State Medical
University’s Collection of Scientific Works. – 2009. – #43. – pp. 101-104.
– geo.; abs.: eng.
Phototherapeutic lamps are the necessary devices for
polymerization of composite filling materials. One part of such devices is
working on halogen lamps, another - on light-emitting diodes. The article deals
with relative characteristics of these two types of light-curing lamps. First
of all, radial collimation and polymerization deepness in composite samplers
with using Demetron 500 (Kerr) and LED 5 (Ultradent) were studied. The study
results show that polymerized test composite cylinders, with light curing lamp
– LED 5, after cutting in 2mm pieces were less intensively colored with
"Stable Seek” than the test composite cylinders with light-curing lamp –
Demetron 500. "Stable Seek’s” penetration indicated on imperfect
polymerization. Despite Demetron 500 better collimation, LED 5’s lamp has more
power. That was the reason why the composite test samplers were much deeper
cured with LED 5 (Ultradent) than with Demetron 500 (Kerr). Thus, the study
results show better light transmission of LED 5.
Auth.
8.g.13.5.5. Using plasma
radiations for prevention and treatment of the critically ill patients with
ventilator-associated pneumonia. /Z. Kheladze, S.
Jaiani, Zv. Kheladze, G. Chakhunashvili, D. Chakhunashvili/. Tbilisi State
Medical University’s Collection of Scientific Works. – 2009. – #43. – pp. 167-169.
– eng.
The treatment of 50 patients in the critical condition
with ventilator-associated pneumonia by using plasma radiations is analyzed and
shown in this article. An improvement of the patients’ condition and lowering
of the duration of treatment shows the advantages of this method. The achieved
result gives us the opportunity to recommend the plasma radiations in the
treatment and prevention of the ventilator-associated pneumonia 34.
Auth.
8.g.13.5.6. Importance of color Doppler analysis
in diagnosis of brest diseases. /S. Kavtaradze, T.
Mosidze/. Georgian Medical News.
– 2010. – # 1(178). – pp. 15-19. – rus.; abs.: geo., eng., rus.
The breast cancer
occupies one of the first places among women’s malignant neoplasms. Breast
cancer case rate annually increases in the majority of the countries of the
world. Early diagnosis and active revealing of breast pretumor diseases are of
much importance. For the purpose of determination of the value of color
Doppler, 127 patients with various breast pathologies were examined. Breast
ultrasonic research, color Doppler and power Doppler allowed obtaining the
essential additional data for carrying out differential diagnoses. According to
the results, the concentration of vessels in a zone of tumor unit with a
primary locating on periphery is characteristic for malignant formations of
breast. It is, accordingly, cause of rising vascularisation of tissues of
breast, and also high parameters of linear speed of blood-flow – Vmax -
0,34±0,05 m/s, Pi (Pulls index )- 1,42±0,04, Ri (Resistance index) - 0,71±0,02.
Parameters of linear rate of blood-flow are lower for non malignant nodal
formations – Vmax from 0,14±0,02-0,19±0,02 m/s, Pi - 1,42±0,12-1,42±0,06, Ri -
0,60±0,02-0,62±0,02. In the cases of weakly vascularised nodal formations the
method of power Doppler was used. The maximal rate in circumflex vessels of the
pathological formations in most cases did not exceed 0,25m/s, when size of
formation was up to 1,5cm and 0,7m/s, when the size of formations was more than
3cm. Upon use of ultrasonic intervention combined with color Doppler and power
Doppler, the sensitivity of diagnosis made 93.8% and specificity – 88.6%.
Proceeding from the above, color Doppler, especially in a combination with
other methods of research, is the effective method allowing for an increased
diagnostic accuracy. Dopplerography, allowing for visualization of blood flow
in fine vessels and even perfusion in the tissue of breast is to undoubtedly
soon occupy one of the leading positions in diagnosis of breast diseases.
Auth.
8.g.13.5.7. The action of electromagnetic field on
movement and emotional-motivate behaviour of animals in the "open field”
and stimulating effect of a Seratonus
plant preparation. /D. Zurabashvili, M.
Nikolaishvili, N. Mindiashvili,
The aim of the work is a
detailed analysis of the effect of Seratonus
on motional and emotional-motivational behaviour of rats. The conducted
quantitative and qualitative analyses show that rats fed on the plant substance
Seratonus are characterized of low
emotionality being manifested with less "urinates” and "boluses” and
high "grumming” effects. The plant substance seratonus is a function
activating substance, takes off the emotional responsibility and takes an active
part in metabolism of biological necessary components. The obtained data are
very important from the point of assessment of the environment and individual
sensitivity to the components contained in seratonus substances.
Auth.
8.g.13.5.8. Quantative EEG
during baseline and various cognitive tasks in children with attention deficit/hyperactivity
disorder. /S. Bakhtadze, M. Janelidze/. Georgian Medical News. –
2010. – #9(186). – pp.
50-56. – eng.; abs.: geo., eng., rus.
It is known that
attention deficit/hyperactivity disorder is a widely spread condition in school
aged childhood population. Making of precise diagnosis is a serious problem of
modern pediatric neurology. In spite of large amount of guidelines and
questionnaires the unified consensus of diagnosis is still absent. Thus it is
important to search additional diagnostic criteria which can help physicians to
confirm ADHD. For this purposes we have used quantitative EEG (QEEG)
parameters. There are numerous papers regarding QEEG changes of ADHD children
during baseline (resting with closed eyes, resting with opened eyes, photic
stimulation, hyperventilation).But information concerning QEEG evidences during
cognitive tasks is insufficient. For this purposes we have used QEEG during
Raven test, reading and calculation in children with ADHD and control group.
QEEG was carried out according to standard 10-20 electrode placement rule from
the following derivations: F3, F4, C3, C4, P3, P4, O1, O2. We have observed
that in controls fulfilling of Raven test is more difficult than reading. Thus
they are eulectic, but in ADHD children reading is more difficult than Raven
test. Thus they are dyslexic. By means of alpha and delta bands analysis it
became apparent that alpha band is inversely proportional to mental effort and delta
band is directly proportional to mental activity.
Auth.
8.g.13.5.9. Evaluation of the effectiveness of
the modified method of cesarean operation with the method of ultrasonography
research. /T.Kanchaveli,
N.Kintraia, D.Jintcharadze, I.Mukhadze/. Georgian Medical News. – 2010. – #10(187). – pp. 26-29. – rus.; abs.: geo.,
eng., rus.
On the basis of a
retrospective analysis of 160 clinical cases, the effectiveness of the modified
method of cesarean section with ultrasonography and immunological technique has
been evaluated. The clinical-ultrasonography analysis proved that involution
rate after using of traditional method of cesarean section is markedly behind
in comparison with the results received in the patients of main group. At the
same time, the changes in echo-parameters prevailed the clinical manifestations
which allow to carry out preventive measures in proper time and correspondingly
to avoid the possible complications.
Auth.
8.g.13.5.10. Influence of
electromagnetic fields and vegetable preparation Seratonus on the passive avoidance reaction. /M. Nikolaishvili, G. Iordanishvili, G. Jiqia, V. Museliani,
V. Beria, J.Khubutia,
N. Mindiashvili, K. Archvadze, S. Zenaishvili/. Experimental and Clinical Medicine. – 2011. - #1(1).
- pp. 21-25. – geo.; abs.: eng., rus.
Currently, organic
medications derived from plant material make up almost one third of the
register. Many of them contribute to the synthesis of biogenic amines, improve
memory and behaviour in animals. It was interesting to study the effect of such
composites on different stress factors, in particular, the effect of
electromagnetic fields. It is known that communication frequency of EMF causes
difficulties and suppresses the production of passive avoidance response in
animals. The studied preparation has a protective effect hindering the
development of excitation in rats, thus helping them to adopt the correct
solution to a problem, i.e. to improve the acquired reflex reaction.
Auth.
8.g.13.5.11. Pneumographic
imaging of potential cleavage planes within the ventricular myocardium in
histology and CT. /K. Redmann, P.
Lunkenheimer, S. Stöppeler, U. Spiegel, M. Smerup, P. Nielsen, P.
Niederer, S. Weiss, R. Batista/. Bulletin of the Georgian National Academy of
Science. – 2011. – vol. 5. - #1. – pp. 115-120. – eng.; abs.: geo., eng.
We distended the relaxed
porcine left ventricular myocardium by inflating the coronary arteries with
compressed air, using rising pressures between 1 and 3 atmospheres. Computed
tomographic analysis revealed a feathered arrangement of the myocardium
aggregated together within the walls, with an overall system of spatially
netted lamellar structures. Histological examination in orthogonal planes
revealed the lamellas themselves to be made up of endless chains of myocytes,
which show the well recognised systematic change in helical angle when traced
through the thickness of the walls. The pneumatic distension had opened clefts
between the lamellas, with sparse and loosely aligned fibrous tissue present
within the clefts. The lamellar structure itself is continuous through the
walls via a system of interlamellar connections from epicardium to endocardium,
and from the ventricular base to the apex. The ventricular walls, therefore,
which appear compact when sectioned without pneumatic distension, are shown by
distension to be composed of a system of three-dimensionally curved and nested
blades, with the individual blades taking their origin from a central circular
myocardial collar, Krehl´s Triebwerkzeug, and then extending with
opposing curvatures towards the endocardium and epicardium.
Auth.
8.g.13.5.12. Plasma flow treatment of the acute
gastro-duodenal ulceration in artificial pulmonary ventilation-dependent
patients. /Z. Kheladze, S.
Jaiani, B. Tsutskiridze, Zv. Kheladze, D. Chakhunashvili, G. Chakhunashvili/.
Critical Care & Catastrophe Medicine. – 2009. - #5. – eng.; abs.: eng.,
geo.
In 48
ventilation-dependent critical patients with acute gastro-duodenal ulceration
and subsequent bleeding, the plasma flow treatment efficacy was studied. The
patients were divided into main and control groups. Medication treatment
program was identical in both groups, but in the main group progenitor
precursors’ committing activate plasma flow therapy (Zv.Khelade at all.
"New usage of Plasma flow” producer 2008.06.26 #4825) was also used; in
particular, sternal bone marrow’s plasma irradiation during 10 minutes and 2
times per day was done. The bleeding activity and hemostasis were estimated by
Forrest’s classification. After a repeated endoscopy and histological analysis
of biopsy material it was proved that at acute gastro-duodenal ulceration the
progenitor precursors’ committing activate plasma flow therapy considerably
improved ulcer cicatrisation as compared to control.
Auth.
8.g.13.5.13. Bioelectrical
brain activity in chronic daily headache.
/N. Laitadze, M. Tchanturia, D. Berulava/. Georgian Journal of Radiology. -
2010. - #1-2 (34-35) – pp. 25-29. - rus.;
abs.: eng.
Eighty-two patients with
chronic daily headache were studied. Chronic migraine was diagnosed in 34 and
headache of tension – in 48 patients. EEG was registered before treatment,
using evaluation by methods of visual and spectral analyses. The EEGs of all
the patients were characterized by diffuse bioelectrical activity changes. In
patients with chronic headache of tension – the reduction of alpha-rhythm with
simultaneous increase of other frequency bands were the main EEG features,
spectral analysis revealed an increase of theta-band power in frontal regions.
In migraine EEGs were characterized by synchronization of alpha rhythm,
increased presentation of bilaterally synchronous alpha- and theta-activity.
Spectral analysis revealed a total increase of spectral power of theta-band.
Auth.
8.g.13.5.14. Dopplerography
monitoring of cerebral blood flow during spontaneous subarachnoid bleedings. /R. Fanarjian/. Georgian Journal of Radiology. - 2010.
- #1-2 (34-35) – pp. 30-32. - eng.; abs.: rus.
Evolution of the AS corresponds to the dynamic
degradation of patients and the deepening of neurological deficit. The increase
in linear velocity of blood flow in MCA was accompanied by the development of
the clinical picture of cerebral ischemia. The simultaneous significant
increase in linear velocity of blood flow in the opposite MCA and the BA showed
the development of diffuse AS and foreshadowed adverse outcome - death or
disability of the patient. The level of impairment of consciousness directly
corresponds to the state of blood flow in the vessels of vertebro-basilar
basin. Normalization of blood flow preceded the clinical improvement. Permanent
neurological deficit, depression of consciousness down to the level of coma,
was associated with high or extremely depressed rates of blood flow leading to
ischemic complications and emergence of more focal and diffuse neurological
symptoms. In patients with moderate and severe AS, linear velocity of blood
flow increased from the third day and remained elevated throughout the week to
reduce the level of normal values by the end of the second week. The
improvement of general condition of patients with SAH could occur against a
background of continuing TCD signs of vasospasm. There is a certain correlation
between the degree of severity of the AS and clinical manifestations of certain
ischemia. Dynamic monitoring helps identify the degree of metabolic needs of
the brain, indirectly judge the state of intracranial pressure, as well as the
effectiveness of treatment. Distribution of the AS and the state of blood flow
in the BA, determine the level and degree of impairment of consciousness, and
can serve as an objective prognostic sign.
Auth.
8.g.13.5.15. Òhå role of multisectional
CT and magnetic resonance tomography in the diagnosis of cerebellopontine angle
lesions. /S. Tchedia/. Georgian
Journal of Radiology. - 2010. - #1-2 (34-35) – pp. 33-41. - geo.; abs.: eng.
The aim of this study
was to evaluate the importance of multisectional computed tomography (MSCT) and
magnetic resonance (MR) imaging in the diagnosis of cerebellopontine angle (ÑÐÀ) extra-axial lesions. From January 2006, 44 patients
(16 men and 28 women, age ranged: 39-76 years) with the tumor of
cerebellopontine angle were examined. All the patients underwent MR examination
îï à GÅ, Signa (l,5T) and 32
patients underwent ÑÒ examination îï à Somatom Sensation
Cardiac 64, (Siemens). Results: 26 (60%) out of 44 patients had vestibular
schwannomas, 12 (27%) patients - meningiomas, 1 (2%) patient - epidermoid cyst,
1 (2%) patient - arachnoid cyst, 2 (5%) patients - metastasis, 1 (2%) patient -
aneurysm, 1 (2%) patient - neurofibromatosis type 2. ÑÒ and MRI reliably demonstrate typical features of meningiomas
or vestibular schwannomas in the vast majority mass lesions responsible for ÑÐÀ syndrome. However, à large variety of unusual lesions ñàï also be encountered in the ÑÐÀ. MR diffusion- and perfusion-weighted imaging ñàï provide critical information îï the vascularity of tumors which is useful in the
preoperative differentiation between benign and malignant tumors.
Auth.
8.g.13.5.16. Ultrasound diagnosis of plantar area
pathologies. /T. Gurgenidze, Ì. Mizandari, G. Gadelia/. Georgian Journal of Radiology.
- 2010. - #1-2 (34-35) – pp. 52-56. - geo.;
abs.: eng.
150 patients (age ranges
from 8 to 70 years) underwent the radiological study of the plantar area.
Pathology types: inflammatory pathology - 38%, traumatic injuries - 11 %,
degenerative-dystrophic diseases - 30%, soft tissue neoplasms -14%. other - 7%.
Unilateral pathology was diagnosed in 80%, bilateral - in 20% of cases. The
diagnostic studies include: a) Ultrasound, performed îï digital ultrasound system using high frequency
(7,5-12.0 MHz) linear probe with Doppler capability (all patients) b) X-ray
filming in lateral projections (6 patients) and ñ) MRI - T1 and Ò2 weighted images in saggital and transverse planes (9
patients). Ultrasound was successful in plantar area pathology diagnosis in 138
cases (92%). It was ineffective in vertebral problems (6%) and osseous
pathology (2%) definition. In vertebral problem diagnosis MRI was critical,
osseous pathology was diagnosed using X-ray filming. The advantage of
ultrasound in diagnosis of plantar area pathologies are high spatial
resolution, possibility of real-time dynamic study with simultaneous
Dopplerography. It should bå used as à method of choice for diagnosis of plantar area
pathologies, manifested bó pain. X-Ray should bå used when the bony pathology is suspected and MRI
should bå considered if the pain
cause could not bå identified bó ultrasound.
Auth.
8.g.13.5.17. Magnetic resonance imaging of the brain
during acute ÑÎ poisoning. /F. Todua, Ì. Beraia, Ì. Okujava, S. Leiashvili, Ò. Antia/. Georgian Journal of Radiology. - 2010. -
#1-2 (34-35) – pp. 67-71. - rus.; abs.: eng.
We examined à 28-year-old woman with ÑÎ poisoning bó MRI. Àt the moment îf the investigation, symptoms of poisoning were
nausea, repeating vomiting, confusion, disorientation; verbal contact was
complicated. MRI abnormalities were detected as T2-hyperintensities and Ò1-hóðîintånsitås in the globus pallidus
bilaterally. ÑÎ poisoning should bå included in the list of differential diagnosis in
cases of bilateral symmetrical pallidar lesion.
Auth.
8.g.13.5.18. Bilateral striopallidodentate calcinosis. /D. Gigineishvili, D. Gugutsidze, R. Shakarishvili/.
Georgian Journal of Radiology. - 2010. - #1-2 (34-35) – pp. 72-76. - geo.; abs.: eng.
Calcification of basal
ganglia (BGC) and other subcortical nuclei has resulted in à considerable dilemmaà as to its significance and relationship to varieties
of disorders. Current classification of clinically manifested conditions
associated with the neuroradiological findings includes primarily idiopathic
(Fahr's disease) and secondary (Fahr's syndrome) cases, not uncommonly caused bó metabolic abnormality, especially
hyperparathyroidism. We describe two patients with radiologically detectable
BGC admitted to our intensive ñàãå unit with convulsive
status epilepticus. Clinical and laboratory findings, however, did ïît completely fulfill criteria fãî à secondarily metabolic
striopallidodentate calcinosis. We suggest that from à clinical viewpoint tòåãå is à narrow distinction
between primary and secondary BGC and this should bå taken into àññîunto during differential diagnostic process.
Auth.
8.g.13.5.19. Characterization of data acquired during
cardiointervalography and capillaroscopy. /N.
Jobava, G. Chakhuanshvili/. Pediatric Cardiology. - 2011 - ¹ 5. - pp. 16-24. - geo.; abs.: geo., eng.
Capillaroscopic data in
children gives us additional trustworthy information, including for getting
differential diagnosis; additionally, it is a cheap bloodless method, which can
be used like a treatment as well as during prognosis of diseases. Based on
cardiointervalography, we revealed big differences of different vegetative nervous
system‘s starting tonus variants (vagotonia, simpaticotony, eutony).
Conclusion: after having non-rheumatoid carditis and different forms of
rheumatoid arthritis, this can be risk factor of ischemic diseases of heart.
Miocardiodistrophy, prolapse of mitral valve and other diseases in children
need to be observed dynamically and need further analysis.
Auth.
8.g.13.5.20. Radioecological
situation in Adjara region and rate of genetic disorders in infants. /I. Kugoti, N.
Vepkhvadze, T. Gelovani, N. Kiladze, N.
Tskhovrebadze, I. Tskhovrebadze/. Collection of Scientific
Works of Tbilisi State Medical University. - 2010. - # 44. – pp. 65-68. –
geo.; abs.: eng.
The purpose of this study was to explore the
genetic disorders rate in infants of Adjara region and manifestation of
dose-response relationship between the radiation background and rate of genetic
disorders. It was determined that the radiation background of the investigated
territories is not the only reason of increased genetic disorders in infants. A
relatively high radiation background, combined with the existing low level
hazardous factors, has an adverse effect on the health status of population,
including infants. Thus, it is necessary to implement measures for reduction of
irradiation doses of population
Auth.
8.g.13.5.21. Radioecological
situation of Adjarian mountain region and hygienic assesment of external
irradiation doses of population. /I.
Kugoti, N. Vepkhvadze, N. Tskhovrebadze, B. Zurashvili/. Collection of Scientific Works of Tbilisi State
Medical University. - 2010. - # 44. – pp. 68-71. – geo.; abs.: eng.
The radio-ecological situation of the
Adjarian mountain region and doses of external irradiation of population have
been studied. The average annual external irradiation dose of population
(without radon component) for mountain region of Adjara is 1,1 mSv/y, which is
relatively high and requires the taking of preventive measures for its
reduction. To reduce the external doses of irradiation of population, it is
necessary to exercise strict control over radioecological investigations, usage
of fertilizers according to the instructions, radionuclide identification of
food products and their standardization, mandatory control of imported
products, observance of radiological standards for constructive materials,
restriction of radon and thoron entrance into buildings, frequent ventilation
of living premises and their provision with ventilation, educational activities
among population regarding the radiation safety and hygiene.
Auth.
8.g.13.5.22. The radiation
background and hygienic assessment of external irradiation doses of population
in some mountainous regions of Georgia. /I.
Kugoti, N. Vepkhvadze, N. Kiladze/. Georgian
Medical News. – 2010. – #10(187). – pp.61- 65. – rus.; abs.: geo., eng., rus.
The radioecological
situation of Mtskheta-Mtianeti region of Georgia has been studied. Doses from
external irradiation were determined and estimated. The average value of
radiation background (RB) of open areas in Mtskheta-Mtianeti region accounts
84,6 nGy/h, which is nearly equal to the average values in the countries of
western Europe. This shows that investigated territories have high natural
radiation background, which, considering the geographical position and
geophysical situation of Georgia, is normal. The average value of radiation
background of buildings in the investigated territories accounts 120,4 nGy/h,
which is little more than the worldwide average value. The average annual dose
from external irradiation (without radon component) for population of
Mtskheta-Mtianeti region accounts 0,99 mZv/y, which is slightly more than the
worldwide average value. Since approximately 2/3 of effective equivalent dose
comes from internal radiation and 1/3 – from external radiation, it is
reasonable to suppose that the radiation load of population of
Mtskheta-Mtianeti region is significant and requires implementation of
radiation dose reduction measures.
Auth.
8.g.13.5.23. X-ray methods potentialities for diagnosis of
mediastinal lymphomas. /S. Babayeva/. Georgian
Medical News. - 2010. - #10 (187). – pp. 19-23. – rus.; abs.: geo., eng., rus.
The target scientific
research studies the results of clinico-roentgenological examination among 100
patients with mediastinal lymphomas. The most typical X-ray and CT signs were
demonstrated. The investigation proves CT to be highly informative method in
diagnosis of mediastinal lymphomas. CT provides a more complete picture, making
it easier to diagnose problems, determine the extent of disease, prescribe
treatment, and track progress. The mediastinal lymphomas must be diagnosed
based on clinical, observation and laboratory, roentgen logical, CT and
morphological diagnostic testing.
Auth.
8.g.13.5.24. Preventive maintenance
and complex therapy for tracheal cicatricial stenosis using Diprospan and
infrared low-intensity laser radiation. /S. Israfilova, Ch. Jafarov, R. Mamedov/. Experimental
and Clinical Medicine. – 2010. - #1(56). - pp. 19-22.– rus.; abs.: eng.
The frequency of
cicatricial stenosis of the trachea continues to grow, which can be explained
by a wide application of long-term artificial ventilation of the lungs.
However, the consequences of this manipulation very negatively affect the
tracheal wall, which subsequently cause the formation of cicatricial stenoses.
The methods offered earlier are not successful in relieving this complication.
Depending on the terms of postintubation and posttracheostomy stenosis, our
patients have been divided into 2 groups: early complications – about 3 months
(38 patients) and later complications – more than 3 months (10 patients). In
both groups of the patients, diprospan along with the application of
low-intensity infrared laser irradiation reduced the formation of cicatricial
tissue which could lead to tracheal stenosis and to the lesion of the external
breath function, and considerably reduced the number of patients requiring
repeated reconstructive operations.
Auth.
8.g.13.5.25. Review of radiation impact stipulated by
potable water from some mountainous regions of Georgia. /I. Kugoti, N. Vepkhvadze, K. Gelashvili, B. Zurashvili, T. Gelovani, M.
Giorgobiani, N. Kiladze/. Experimental and
Clinical Medicine. - 2010. - #4(59). - pp. 163-167. – geo.; abs.: eng., rus.
The specific activity of
radionuclides in the waters of the studied territory in some cases is more than
acceptable (in some cases – very high). Therefore, internal dose of irradiation
of population will presumably be high. To reduce the internal irradiation dose
of population, it is necessary to prohibit the use of high activity water for
drinking and provision of the population with new sources of low activity
water. To reduce the total irradiation dose of
population, it is also necessary to control and minimize irradiation doses from
artificial sources, including means of regulation of medical radiological
procedures and rational use of fertilizers with K-40 content.
Auth.
8.g.13.6.1. Some aspects
associated with rational use of drugs. /N.
Kvizhinadze, D. Tophuria, N. Kiknavelidze/. Tbilisi State Medical University’s
Collection of Scientific Works. – 2009. – #43. – pp. 69-72. – geo.; abs.: eng.
The aspects of rational use and prescription of drugs
in Georgia and in some countries of were studied using the qualitative and
quantitative technique – with a detailed description of social reality. It is
established that the use of drugs with less expenditures (by applying
video-computer facilities, conduct of seminars) leads to a sharp increase in
consumer services. In addition to medical and social factors, the economic
factors also play a significant role in the rational use of drugs. Improvement
on the supply of drugs to population and their rational use is a topical and
many-sided problem. It is closely associated with not only population’s
morbidity, but also with the quality of adaptation to the environment, mode of
life, education, interrelations, existing healthcare system, cultural, social
and economic factors.
Auth.
8.g.13.6.2. The level of
awareness in cancer patients in Georgia. /M.
Shavdia, I. Bakradze, R. Ghvamichava, I. Abesadze/. Tbilisi State Medical
University’s Collection of Scientific Works. – 2009. – #43. – pp. 148-152.
– geo.; abs.: eng.
The objective of our study was to determine whether
the cancer incurable patients wanted to know true information concerning their
state. The study was based on contracts (539) signed between the Palliative
Care Unit and patients or their families in 2006–2007. The authors of this
article provide advices for medical personnel how to communicate with the
incurable patient/his family and make the communication of sad news to them
less painful both for the patient/his family and themselves.
Auth.
8.6.3. Epidemiology of gastroenterologic diseases in
Georgia. /M. Chikava, I.
Phavlenishvili /. Tbilisi State Medical University’s Collection of Scientific
Works. – 2009. – #43. – pp. 162-164. – geo.; abs.: eng.
The prevalence of gastroenterological diseases (GD)
appears to be increasing in the whole world. The aim of the research was to
study the dynamics of GD morbidity in Georgia according to the statistical data
of the National Center of Diseases Control and Public Health of the Ministry of
Health of Georgia. The epidemiological research was conducted in parallel in
adolescents of Georgia aged 14-21, selected by the randomization technique.
According to official statistics, the incidence of GD in Georgia sharply
decreased, especially in children – from 88.9% in 1994 to 7.3% in 1997. In
2006-07, the GD prevalence increased in the Georgian population from 32.1% to
49.37%, in children – from 18.79% to 30.89%, respectively. The admission of
patients with GD over 15 years in polyclinics of Tbilisi significantly
decreased, but the prevalence of GD in adolescents is still quite high. The
prevalence of functional disorders is relatively low. The authors recommend the
reorganization of the treatment-educational work. The earlier developing of
gastroenterological functional disorders, right diagnosis and purposeful
complex treatment are also of great importance for preventing
gastroenterological organic diseases in adults.
Auth.
8.g.13.6.4. Composition of erythrocytic (ABO,
Rh-Hr, Kell, MN) group antigens characteristic of the Ozurgeti district
population. /M. Nagervadze, A.
Diasamidze, R. Khukhunaishvili, L. Akhvlediani, M. Koridze, G. Dumbadze, S.
Tskvitinidze/. Georgian Medical News.
– 2010. – #11(188). – pp. 51-55. – rus.; abs.: geo., eng., rus.
Erythrocytic group
antigens represent a genetically stably determined trait. Investigation of
antigens of the said system in different regions is of the greatest importance
in terms of both the creation of demographic data of the region, as well as
practical medicine, especially for transplantology and transfusiology. The
peripheral or venous blood of 232 local natives (healthy donors) of Ozurgeti
district of Guria region has been taken as the test subject. The test subject
was taken by random methods in different villages (Bakhvi, Mshvidobauri,
Ozurgeti, Likhauri, Gurianta, Bokhvauri, Dvadzu, Pampaleti) To identify the
ABO, Rh-Hr, Kell, MN system antigens, an express-method, using monoclonal
antibodies, has been applied. In studying the ABO system, it was fixed that the
highest distribution frequency was characteristic of the 0(I) group
(52.3±3.2%), then follows the group A (II) (38.5±3.2%). The distribution
frequency of the B (III) group is (8.2±1.8%) and that of AB (IV) – (0.8±0.5).
The population’s 85.2±2.32% is the carrier of the Rh+ phenotypic group, while
14.7±2.3% belongs to the Rh-phenotypic group. In studying the concentration of
alleles, the low concentration of p (K) allele was detected that equaled 0.2;
the concentration of q (K) allele made 0.8, that of p (M) – 0.65, and that of q
(N) – 035.
Auth.
8.g.13.6.5. Gender
differences in medical activities and self-evaluation of the health status
among IDPs from Abkhazia. /T. Zukhbaia, T.
Kvirtia, O. Gerzmava/. Georgian Medical News. –
2010. – #11(188). – pp. 56-60. – rus.; abs.: geo.,
eng., rus.
A growing scientific
literature highlights concern about the influence of social bias in medical
care. Differential treatment of male and female patients has been among the
documented concerns. Yet, little is known about the extent to which
differential treatment of male and female patients reflects the influence of
social bias or of more acceptable factors, such as different patient
preferences or different anticipated outcomes of care. This paper attempts to
ascertain the underlying basis for an observed differential in physicians’
tendency to advice activity restrictions for male and female patients. We
explore the extent to which the gender-based treatment differential is
attributable to: (1) patients’ health profile, (2) patients’ role
responsibilities, (3) patients’ illness behaviors, and (4) physician characteristics.
These four categories of variables correspond to four prominent social science
hypotheses concerning gender differences in health and health care utilization.
Data are drawn from the longitudinal observational study more of the 2000 IDP
patients from Abkhazia. Gender differences in illness behavior and medical
activities of the patients both appear to contribute to the observed
differential. Female patients exhibit more illness behavior than males, and
these behaviors increase physicians’ tendency to prescribe activity
restrictions.
Auth.
8.g.13.6.6. Contamination of some food products with
salmonella in Georgia. /T. Mchedlishvili, D.
Gelovani, I. Mchedlishvili, N. Barnabishvili/. Georgian Medical News. – 2011. -
#2(191). - pp. 37-40. – rus.; abs.: geo., eng., rus.
Salmonella infections in
Georgia are usually caused by S.
enderitidis and S. typhimurium.
Food products represent a leading vehicle in transmission of S. enderitidis, which predominates over
other serotypes. The goal of our research was to study contamination of
chickens and chicken eggs with S.
enderitidis and S. typhimurium.
Overall, 90 chicken eggs, obtained from various poultries, 100 eggs, sold by
peasants, and 30 chicken and their excrements were tested. Cer Test Salmonella
– immunochromatography one stage analysis were employed for detecting the
salmonella microbe. Chickens and chicken eggs were contaminated with bacteria S. enteritidis. The microbe isolation
rate from eggs was 4.2±1.4%. It was 1.1 for eggs from poultries and 7.0±2.5 for
eggs from peasant vendors. Chicken contamination was found to be high -
26.7±8.1%. The research data showed the
prevalence of S. enteritidis in
etiology of salmonella infections in Georgia.
Auth.
8.g.13.6.7. Supply of the Georgian
pharmaceutical market with analgesic drugs. /N. Gorgaslidze, N. Gongadze, N. Nizharadze, N.
Phruidze, T. Makharadze/. Collection of Scientific
Works of Tbilisi tate Medical University. - 2010. - # 44. – pp. 32-35. –
geo.; abs.: eng.
The aim of our investigation was to study the
quantity of analgesic drugs authorized in Georgia, including their forms and
ingredients. It has been shown that related 196 medicines predominantly
comprised non-steroidal anti-inflammatory drugs, drugs for musculoskeletal and
joint diseases. The leader foreign countries were presented as follows:
Germany, France, Bulgarian, Ukraine, USA, Australia, Belarus, Slovenia and
Egypt. Among registered 196 medicines 32 refer to essential drugs. During
analysis of narcotic drugs it was clarified that among 16 registered products 7
is morphine and codeine, 5-methadone, 1-promedol, 1-tramadol and 2 combine
medicines produced by different countries. Most of medicines related to solid
pharmaceutical forms, such as tablets, capsules and liquid substances. After our
investigation we came to the conclusion about improving of rational use of
analgesic drugs. It was also revealed a lack of some pharmaceutical forms on
Georgian market such as plasters, drops and otorhinolaryngological drugs and
drugs which are used in stomatology and for spinal anaesthesia, which must be
provide in near future.
Auth.
.
8.g.13.6.8. Georgian priority list
for rare diseases management. /I.
Korinteli, M. Korinteli, D. Shonvadze, K. Paghava/. Collection of Scientific Works of
Rare diseases are of the most important
public health problems of the 21st century. Early diagnosis and follow-up
require expert medical competence. However, if diseases are rare, experts are
rare as well. Health professionals have insufficient knowledge of the majority
of rare diseases. This lack of knowledge underlies diagnostic error - a great
source of suffering for patients and their families - and delayed care
provision. Rare Diseases are life-threatening or chronically debilitating
diseases which are of such low prevalence that special combined efforts are
needed to address them (European Commission. Retrieved 19 May, 2009). A rare
disease, also referred to as an orphan disease, is any disease that affects a
small percentage of the population. The nosologic units with prevalence not
exceeding 0.05% of general population belong to the group of the rare diseases.
According to the present European regulation, a disease is classified as "rare”
if it affects less than 1 in 2,000 people. Although this figure seems to be
very low, between 5,000 and 7,000 distinct rare diseases have so far been
described, and this number is expected to increase. It is not easy to study all
these forms of rare diseases. The identification needs and priorities for rare
diseases for each country are of great importance. By special questioner
distributed among doctors we have performed identification of the priority list
for rare diseases in
Auth.
8.g.13.6.9. The etiological structure of
salmonellosis in Georgia. /T. Mchedlishvili, D. Gelovani, P. Imnadze, I.
Mchedlishvili/. Collection of Scientific Works of Tbilisi State Medical
University. - 2010. - # 44. – pp. 87-88. – geo.; abs.: eng.
We have studied the etiological structure of
salmonellosis in
Auth.
8.g.13.6.10. Epidemiology and risk
factors of allergic rhinitis in schoolchildren of
The present publication
comprises a qualitative and quantitative assessment of epidemiology and
development risk factors of allergic rhinitis (AR) in the schoolchildren
population of Tbilisi and West Georgia in 2007-2008. The obtained data show
that the share of manageable risk factors is high, providing basis for
development of targeted and effective preventive measures for the children
population.
N. Chkhaidze
8.g.13.6.11. Technology of
obtaining a substance used for production of Emoxipin and Mexidol drugs. /O. Baidoshvili, J. Phutkaradze, P. Baidoshvili, T.
Alavidze/.
The technology for simplification of technology
process and purification of the intermediate product – 3 oxo-2-ethyl
6-methyl-pyridine (Pyridinol) for production of Mexidol and Emoxipin was that
the optimal conditions for production of Pyrinidol need temperature – 185 0C
and duration of the process – 4 hours. During passing on the temperature regime
into the autoclave, the pressure riches up to 38-40 atmosphere, falling down
during 4 hours to 28-30 atmospheres. Residual pressure is 7-2-3 atmospheres
after cooling of the autoclave. 6.9 kg of technical pyrinidol has been produced
after filtration and washing of the suspension. Purification of the produced
technical pyrinidol is carried out through trans-crystallization from ethyl
alcohol. The purification of Pyrinidol by existing technologies is reached
through resettling and needs additional use of potassium hydroxide and
hydrochloric acid. The produced sediment is of paste-like consistence and slows
down the filtration and washing processes. As a result of crystallization, the
washing and drying processes yield 53% of pure Pyrinidol, which significantly
exceeds the results given by existing technologies (41%).
Auth.
8.g.13.6.12. Experimental
study of toxic effects of nitrogen compounds on embryos. /Ts. Gigineishvili, I. Ghvineria, V. Berishvili,
M.Tchipashvili, N. Imnadze, N.Lomtatidze E. Abzianidze/. Tbilisi State Medical
University’s Collection of Scientific Works. – 2009. – #43. – pp. 37-39. –
geo.; abs.: eng.
The study was devoted to the effects of the toxic dose
of Paarlan (8.0 mg/kg) in animals. The substance was given to animals orally
during 1-20 days of fertile period. This chemical causes alterations in the
length and weight of embryo, the difference between the yellow body and
embryonic cells, without influencing the mass of placenta and sex conjunction,
increasing overall lethality/morbidity rates in embryonic, pre- and
post-implantation periods. Based on the data received by this study, the
necessary preventive measures should be strictly followed. Otherwise,
incautious spread of Paarlan and pollutions with this substance can be
hazardous not only for human health, but also can harm the biodiversity of
organic environment.
Auth.
8.g.13.6.13. Aflatoxins and
aflatoxicoses. /G. Gogichadze,
Aflatoxins are naturally occurring mycotoxins that are
produced by many species of Aspergillus,
a fungus, most notably Aspergillus flavus
and Aspergillus parasiticus.
Aflatoxins are toxic and among the most carcinogenic substances known. After
entering the body, aflatoxins are metabolized by the liver to a reactive
intermediate, aflatoxin M, an epoxide. The occurrence of aflatoxins is
influenced by the weather (temperature and humidity-warm and wet is worst!); so
the extent of contamination will vary with geographic location, agricultural
and agronomic practices, and the susceptibility the peanuts (etc.) to fungus
before they are harvested and during storage and or processing periods.
Aflatoxins have received greater attention than any other mycotoxins because
they clearly have a potent carcinogenic effect in laboratory rats and their
poisonous effects in humans. Studies have shown that concurrent infection with
the Hepatitis B virus (HBV) during aflatoxin exposure increases the risk of
hepatocellular carcinoma (HCC). Aflatoxin is associated with both toxicity and
carcinogenicity in human and animal populations. Acute aflatoxicosis results in
death, whereas chronic aflatoxicosis results in more prolonged pathologic
changes including cancer and immunosuppression.
Auth.
8.g.13.6.14. Factors
influencing drug circulation from drugstores. /N. Gorgaslidze, N. Gongadze, N. Nizharadze, G.
Gorgaslidze, D. Tabatadze/. Tbilisi
State Medical University’s Collection of Scientific Works. – 2009. – #43. – pp.
43-46. – geo.; abs.: eng.
The article presents materials created on the basis of
a questionnaire received from 50 pharmaceutical institutions of Tbilisi. It is
shown that all drugstores have the private status, which are divided by us
conditionally into 3 groups: 1.Good-category drugstores, where the
collaborators pay attention to the consumers questions and fully satisfy them;
2. Middle-category drugstores, where the collaborators pay attention to the
consumers questions but fail to answer them adequately; 3. Bad-category
drugstores, where the collaborators ignore and fail to answer the consumers
questions. In the last case, we can suppose that such personnel have little
competence and are oriented only to business. It is established that most
people (46%) prioritize the drug manufacturing company and country and the
subjective assessment of drug effectiveness. The conducted monitoring has
revealed that drugs should be placed according to their social, information and
visual effects, that economically facilitating measures need to be taken and
introduced, that active relations with medical and preventive institutions
should be maintained, that the professional level of medical staff and the
doctor-patient communication culture need to be improved.
Auth.
8.g.13.6.15. Natural
silk-producing enterprise - clinical-hygienical parallels. /R. Kverenchkhiladze, L. Bakradze, M.Tsimakuride/.
The subject of our research was to study and to
estimate an influence of natural silk industry’s workplace conditions on the
workers disability, the general and occupational morbidity and the health
state. The main occupational injuries are industrial dust, the high temperature
and high moisture of the workplace air, industrial noise, and general workplace
vibration. The main diseases in the structure morbidity are respiratory,
cardiovascular diseases, and cardiovascular system and allergosis (45% of
general morbidity).
Auth.
8.g.13.6.16. Morphological
and anatomical study of the white flower onion (Allium leucanthum C. Koch). /L.
Mskhiladze, D. Tchintcharadze, K. Mchedlidze, J. Kuchukhidze/. Tbilisi State
Medical University’s Collection of Scientific Works. – 2009. – #43. – pp 107-109. –
geo.; abs.: eng.
Allium leucanthum C. Koch’s morphological and anatomical structure has
been investigated. The micro diagnostic signs of the plan are defined: flower
cover - cells of epidermis, for flowering stem - disordered disposition of
collateral intact bunches, for leaves- isolateral structure, right walled
epidermis.
Auth.
8.g.13.6.17. Estimate of
risk factors of some diseases among Chiatura mining workers. /M. Mirtskhulava, R. Javaxadze, N. Mebonia, N.
Chakvetadze, M. Zhuruli, I. Ghvineria, M. Tsereteli/. Tbilisi State Medical
University’s Collection of Scientific Works. – 2009. – #43. – pp. 110-111.
– geo.; abs.: eng.
An analytical epidemiological study to investigate
occupational risk factor among the Chiatura mining workers was carried out. 330
respondents participated in the study: 165 mining workers and 165 control
persons, who have never worked at the mine. All respondents were questioned
through standard questionnaires. The collected data were analyzed with Epi
Info. According to the results, gastritis, bronchitis and pneumonia had high
prevalence among mine workers. The relative risk for developing specific
diseases and symptoms was high among the mine workers as compared with the
control groups. The above-mentioned diseases and symptoms include: bronchitis,
pneumonia, gastritis, sexual weakness in males, giddiness, weakness in legs,
weakness in hands, and difficulties in walking.
Auth.
8.g.13.6.18. The role of Candida spp. in patients with otorhinolaryngology
pathologies. /N. Sharashenidze,
An increasing tendency of candidosis has been revealed
among the patients with otorhinolaryngological pathologies. The microbiological
investigation of the ear, upper respiratory ways showed high percent of the
candidosis among patients with recurrent inflammatory diseases. The fungus Candida appeared in 62 cases out of 65
patients, 22 of them being monocultures and others associated with different
microorganisms.
Auth.
8.g.13.6.19. Physical growth
of children aged 5-6 in Tbilisi. /M. Kherkheulidze, N.
Khavlashvili, N. Adamia, E. Kandelaki/. Tbilisi State Medical University’s
Collection of Scientific Works. – 2009. – #43. – pp. 170-173. – geo.; abs.: eng.
The aim of the study was to assess the nutritional
status and anthropometric parameters of children aged 5-6 in
Auth.
8.g.13.6.20. Cytotoxic
alcaloids from Galanthus krasnovii. /M. Jokhadze, J. Kuchukhidze, D. Tchintcharadze, D.
Berashvili, T. Murtazashvili/. Tbilisi State Medical University’s Collection of
Scientific Works. – 2009. – #43. – pp. 176-177. – eng.
The aerial parts of dried Galanthus krasnovii were extracted with a range of solvents. The
advantages of this extractive method are a more complete extraction of all
classes of metabolites, including acidic and basic compounds and a better
fractioning of the non-polar metabolites that are obtained partially separated
in three early fractions. All extracts were first assayed and only the active
extracts were submitted to further fractioning. All the fractions from each
step of the purification procedure were assayed for brine shrimp lethality, and
the active ones were further fractioned and purified using different methods to
obtain pure active compounds. The high cytotoxic activity is characteristic of
alkaloids: lycorine (IC50 4.5±0.05 mg/ml), haemantaimene (IC50
9.5±0.08 mg/ml), crinine (IC50 11.3±0.1 mg/ml), narwedine (IC50
15.7±0.12 mg/ml) and hamaine (IC50 9.7±0.15 mg/ml).
Auth.
8.g.13.6.21. Chromatographic analysis of tobacco
smoke condensate in biologic tissue. /D. Zurabashvili,
Specialized analytical
instrumentation for a detailed analysis of nicotine, benzypyren, pyridine and
benzene in tooth enamel and pulp of inveterate tobacco smokers is created. The
Waters PPY-24 liquid chromatograph is equipped with model M660 solvent
programmer and model U6K sample injector is used. The model 440 dual-wavelength
detector is used to obtain absorbance ratios on dualpen recorder. Our data show
that the concentration of tobacco smoke components in tooth cavity of
inveterate tobacco smokers is different. The chisel tooth pulp contained
considerably more nicotine and pyridine as compared with molars. The level of
benzene does not change the analyzed structures. The assumption of linearity
between the calculation of predicted retention times and concentration has been
shown to be valid up to 8.0% for all the studied compounds.
Auth.
8.g.13.6.22. Human rights to a better quality of
life. /P.Dzotsenidze, N.Chikhladze, M. Jorbenadze,
N. Phitskhelauri/. Georgian Medical News. –
2010. – # 1(178). – pp. 68-72. – rus.; abs.: geo., eng., rus.
This article reviews
problems of pain relief for incurable patients in the context of human rights
and international standards in this field. In respect to international and
national human and patient rights, regarding achievement of a better quality of
life, the governments should identify and determine the problems and obstacles
that impede the use of opioids as adequate pain relief for incurable patients.
The introduction into practice of relevant new legislative documents and normative
acts in Georgia will further to overcome the existing barriers and make it
possible for incurable patients to live the last days under medical care and as
much as possible without pain and with dignity.
Auth.
8.g.13.6.23. Indices of
immune reactivity of sportsmen organism after one-time physical
load of different intensity and duration. /G.
Iashvili, M. Chkhikvishvili, D. Kobelashvili, L. Kakiashvili, M.
Chkhartishvili/. Georgian Medical News. –
2010. – #2(179). – pp. 30-33. – rus.; abs.:
geo., eng., rus.
The aim of this research was to determine and to compare the indices of
immune reactivity of sportsmen during one time physical load of different
intensity and duration. Observation was carried out on 15 wrestlers of average
qualification during the annual cycle after three one time physical loadings of
different intensity and duration (15 sec.-maximum intensity; 60 sec.-maximum
intensity; stepped growth loading), spontaneous rosette-formation, G.A.M.-
concentration of immunoglobulin, neutrophil/lymphocyte ratio were determined.
Immune reactivity of organism was decreasing after one time physical load.
Expressed dependence of the sportsmen organism upon the duration and intensity
of one time physical loadings was not revealed.
Auth.
8.g.13.6.24. Alcohol use in
Georgian students. Pilot study rigorously following criteria of European School
Project on Alcohol and other Drugs. /L. Sturua, L.
Baramidze, A. Gamkhrelidze, G. Galdava/. Georgian Medical News. – 2010. – #2(179). – pp. 52-61. – eng.; abs.: geo., eng., rus.
The main purpose of the
European School Survey Project on Alcohol and Other Drugs (ESPAD) is to collect
comparable data on substance use among 15–16 year-old European students in
order to monitor trends within as well as between countries. In the article the
results of the pilot study of Alcohol Use among Georgian Students, rigorously
following Criteria of European School Project on Alcohol and Other Drug (ESPAD)
are presented. The survey was conducted according to a standardized methodology
and with a standardized questionnaire. Data were collected during February 2009
and the target population was
Auth.
8.g.13.6.25. Hydrophilic and
lipophilic antioxidant capacities of Georgian spices for meat and their
possible health implications. /V.
Rodov, Y. Vinokur, N. Gogia, I. Chkhikvishvili/. Georgian Medical News. – 2010. – #2(179). – pp. 61-66. – eng.; abs.: geo., eng., rus.
Georgian cuisine is
famous for its spices for meat dishes. Many spices are rich in polyphenols and
other antioxidants that reduce the formation of carcinogenic products during
thermal processing of meat and counteract its adverse health effects. In spite
of the relative popularity of meat dishes,
Auth.
8.g.13.6.26. The effect of toxic components in
tobacco smoke on the fatty acid profile of dental pulp. /D. Zurabashvili, I. Tchanturia, B. Kikalishvili, G.
Danelia/. Georgian Medical News.
– 2010. – #3(180). – pp. 25-29. - rus.; abs.: geo., eng., rus.
The aim of the present
study was to characterize fatty acid
profile of dental pulp in non-smokers’ and tobacco-smokers’ with acute serous
pulpitis. The fatty acid composition in the pulp of molars, pre-molars and
chisel tooth in 80 tobacco-smokers and 60 non-smokers were analyzed by
Gas-Chromatography with glass capillary columns. Linoleic acid was revealed in
both - tobacco-smokers and non-smokers; the concentration of linoleic acid in
tooth pulp of non-smokers was significantly higher. Non-smokers’ tooth pulp
contained linoleic, linoleic and arachidonic acids; tobacco-smokers’ – only
linoleic acid. The linoleic and arachidonic acids in pulp of tobacco-smokers
were not discovered.
Auth.
8.g.13.6.27. The motoric features of the
neuro-muscular apparatus and the maximum working capacity of athletes. /G. Sulaberidze, E. Feroyan, L. Kokaia/. Georgian Medical News. – 2010. – #3(180). –
pp. 33-38. - rus.; abs.: geo., eng., rus.
The purpose of the
research is to study the functional reconstruction of the motoric units of the
motoneyronic pool in the process of trainings of athletes. 164 athletes have
been participated in the studies: the representatives of the high-speed,
high-speed- power, power forms of sport and also the athletes, who develop the
endurance. With the aid of stimulation of electromyography
bioelectric M-reply/answer has been fixed that appears to the strictly dosed,
graduated in the frequency electrical irritation of the motoric fibers of
nerve. Under the effect of the directed training process occurs the
differentiated combinational regrouping of the motoric units of neuron-muscular
apparatus, which to a considerable degree increases the maximum development of
one or another motoric quality.
Auth.
8.g.13.6.28. Illicit drug
use in Georgian students; pilot study rigorously following criteria of European
School Project on Alcohol and other Drugs. /A.
Gamkhrelidze, L. Baramidze, L. Sturua, G. Galdava/. Georgian Medical News. – 2010. – #3(180). – pp. 39-46.
- eng.; abs.: geo., eng., rus.
The
main purpose of the European School Survey Project on Alcohol and Other Drugs
(ESPAD) is to collect comparable data on substance use among 15–16 year-old
European students in order to monitor trends within as well as between
countries. This summary presents
key results from the Alcohol Use in Georgian Students, pilot study rigorously
following Criteria of European School Project on Alcohol and Other Drug
(ESPAD). The survey was conducted according to a standardized methodology and
with a standardized questionnaire. Data were collected during February 2009 and
the target population was
Auth.
8.g.13.6.29. Posttraumatic stress disorder and
insomnia development in IDPs from
Recent evidence suggests
that posttraumatic stress disorder (PTSD) is associated with sleep disturbances
following the traumatic events. However, the exact nature of the relationship
between disturbed sleep and PTSD is unclear. The present study examined the
development of PTSD and insomnia in the population subjected to force
displacement from
Auth.
8.g.13.6.30. The influence of tobacco-smoke toxic
components on glucosaminoglikans in biologic tissue. /D. Zurabashvili, I. Tchanturia, L. Kapanadze, B.
Kikalishvili, G. Danelia/. Georgian Medical News.
– 2010. – #4(181). – pp. 24-27. – rus.; abs.:
geo., eng., rus.
The aim of the work is
detailed analysis of glucosaminoglikans and glucuronic acid in chisel tooth and
molars of tobacco-smokers and non-smokers. The total number of 140 patients
(tobacco-smokers – 60) by acute serous pulpit is investigated. The conducted
quantitative and qualitative analyzes show that tobacco-smokers tooth contains
les glucosaminoglikans (chondroitinsulfats A and C) and more glucuronic acid
than non-smokers individuals. The chisel tooth pulp contained considerably more
glucuronic acid as compared with molars. These studies support the hypothesis
of important role of cigarette smoke toxic components in the tooth support
mechanisms. The studies are necessary to be held in different directions.
Auth.
8.g.13.6.31. Psychophysical and physical methods in the
treatment of dermatoses accompanied with skin dryness and itching. /N. Tsiskarishvili, M. Eradze, Ts. Tsiskarishvili/. Georgian Medical News. – 2010. – #4(181). –
pp. 28-32. – rus.; abs.: geo., eng., rus.
Traditionally, the
exacerbation of skin diseases accompanied by itching and dryness is cutting off
by using of antihistamines, indifferent ointment (sometimes together with
topical corticosteroids) and antipruritic local means. For the continuous
application in inter-relapsing period, patients, as a rule, are offered variety
of lipid-recovery beauty creams, ointments and emulsions. At the same time,
such measures do not have a significant impact on the severity of itching and
the cost of these drugs is quite high. Based on the above, we propose an
alternative method of treatment, including use of the variety of psychophysical
method of therapy (dotted self-massage) and paravertebral UV - irradiation in
combination with topical emollients for treatment of chronic dermatoses,
involving dryness and itching of the skin. As the results of research in the
study group of patients, compared with control group receiving traditional
treatment, the main symptoms (dryness, a feeling of tightening the skin,
itching) subsided considerably faster (on average 5 days), 85% patients of the
study group pointed to the improvement of the general emotional state, reducing
severity of depression, related to skin condition, which certainly indicates an
improvement in their quality of life. After 3 weeks use of the drug
"Secalia” a distinct reduction in severity of flaking skin has been
revealed. By the end of the observation period (1.5 months) in patients of a
main group no resumption of itching or worsening of the skin was revealed. A
real advantage of this method is absolute security to the absence of
contraindications (except for general contraindications for physiotherapy
procedures) and unwanted side effects, excellent tolerability, simplicity and
ease of use. Unlike other methods of physiotherapy the complex of
psycho-physical exercises can be used in the home. Availability, simplicity,
and possibility of using at home, absolute safety, effectiveness against
dryness and itching relief of the proposed method, allow to recommend it as a
basic tool for continuous use in patients with dermatoses, which are
accompanied by dryness and itching, both in combination with other basic drugs,
and as a monotherapy.
Auth.
8.g.13.6.32. Speech impairment
predisposes to cognitive deterioration in hepatic encephalopathy. /M. Meparidze, T. Kodua, K. Lashkhi/. Georgian Medical News. – 2010. – #4(181). –
pp. 43-49. – rus.; abs.: geo., eng., rus.
Hepatic encephalopathy
is a reversible neuro-psychiatric syndrome that complicates liver
insufficiency. The changes are complex and disorders are detected in digestive
and neural systems. Disturbed consciousness and intellectual deterioration, particularly
communicative difficulties are observed: speech is slurred, voice monotonous,
writing disturbances, amimic face and rigid posture. Difficulties of
socialization and tendency to self-isolation are observed. Memory, attention
and perception are decreased. We suppose that disorders of cognitive functions
are determined by impairment of speech and other communicative abilities.
According to the theories of linguistic determinism and linguistic relativity
thought categories move through the mould of native language. That means that
speech impairment causes misperception of the real world. To confirm this
hypothesis we investigated 106 patients with following diseases: peptic ulcer –
46, fatty liver – 30, liver cirrhosis – 19, viral hepatitis – 11 and 19
controls. Brain magnetic resonance tomography was carried out and psychometric
tests were performed to patients with symptoms of hepatic encephalopathy.
Atrophic changes in frontal, temporal and insular area of brain cortex were
revealed in most cases. Those regions are responsible for actor observation,
imitation and emotion, i.e. for empathy and sociability. They are very
sensitive to the increased levels of ammonia and glutamine. In case of early
treatment only slight atrophic changes are presented but without treatment
atrophic processes become stable and expressed by impairments of speech and
entire communicative ability. Human beings are very much at the mercy of the
particular language, which has become the medium of expression for their
society. They do not live in the objective world alone or in the world of
social activity alone. Accordingly, damage of speech in hepatic encephalopathy
is primary and predisposes to cognitive dysfunction.
Auth.
8.g.13.6.33. Mobility of the cardiorespiratory system
under conditions of tiredness in cycling sprinters and stayers of identical
qualification. /M. Chkhikvishvili, G.
Iashvili, D. Kobelashvili, M. Chkhartishvili, M. Pataraia/. Georgian Medical
News. – 2010. –
#5(182). – pp. 21-24. – rus.; abs.: geo., eng., rus.
The aim of this research
work was to determine and to compare the dynamics indices of the mobility
function of the cardio-respiratory system (CRS) under different conditions of
functioning of the cyclist’s organism. The indices of mobility of the CRS functioning
at various levels of organism functioning were determined and compared on 24
cyclists- sprinters and stayers in each period of annual cycle (at the end of
the transition and comparative periods and at the middle of the competition
period). It has been revealed that mobility of the CRS functioning straight
away after the limbering-up in the initial stage of physical loading is
developed in sprinters more than in stayers. Under conditions of light
tiredness especially with increasing of sporting form these differences are
leveling. Mobility of the CRS functioning in the process of rehabilitation is
developed in stayers in greater degree than in sprinters. After loading under
conditions of light tiredness the differences in the indices characterizing
mobility of the CRS functioning in the period of rehabilitation with the
sporting form growth increase.
Auth.
8.g.13.6.34. The development of bioethics as a scientific
discipline and its essence. /Archimandrite Adam –
V. Akhaladze/. Georgian Medical News.
– 2010. – #5(182). – pp. 25-31. – rus.; abs.: geo., eng., rus.
The author examines the
patterns and predictors of newly emerging branch of science such as bioethics
that originated on the background of a revolutionary situation in the history
of biomedicine as the need for a new ethic that would confront the challenges
brought about by scientific and technological development to humanity.
Exploring many different kinds of bioethics issues, the author concludes that
the essence of bioethics is that it is not only a scientific and practical
discipline, but it is also a weltanschauung. Only with such an approach the
spectrum of functions inherent in bioethics is expanded.
Auth.
8.g.13.6.35. The anatomical and morphological description
of Phellodendron Lavallei Dode stem bark. /M.
Meskheli, K. Mchedlidze, Ts. Gogitidze/. Georgian Medical News. – 2010. – #5(182). – pp.
32-38. – eng.; abs.: geo., eng., rus.
Phellodendron lavallei
Dode (Rutaceae) is native to
Auth.
8.g.13.6.36. Deformability of red blood cells and human
aging. /R. Khetsuriani, G.
Lomsadze, M. Arabuli, T. Sanikidze/. Georgian Medical News. – 2010. – #5(182). – pp.
42-46. – eng.; abs.: geo., eng., rus.
The goal of the research was to study the mechanisms of the
regulation of deformability of RBCs in various aged people. Morphological,
biophysical and biochemical parameters of RBCs were studied in 50 practically
healthy men – volunteers (divided in two age groups: adults (22-30 years old),
and old people (75-89 years old)). It was concluded that excess number of
large-sized matured (aged) erythrocytes is revealed in the blood of old people.
RBC ageing is closely related to a progressive decrease in ADP/ATP ratio, which
provides decrease in activity of Na+/K+-, Ca2+-
ATP-ases and accumulation of intracellular Na+ and Ca2+
ions, which determine series of events as disorders of osmotic balance, cells’
swelling, activating signal transduction system, which affects properties
regulating RBC deformability and finally leads to the removal of old cells from
the circulation by macrophages at spleen level. Received results show different
rheological characteristics of RBCs in various aged volunteers.
Auth.
8.g.13.6.37. Investigation of the use of phytodrugs by
Azeri population. /N. Zulfugarova/.
Georgian Medical News. – 2010. –
#5(182). – pp. 50-55. – rus.; abs.: geo., eng.,
rus.
The study showed that
the majority of people between 14-25 years have information about 5-20 names of
phytodrugs. People in active age (between 26-50 years) have got information
about 21-40 phytodrugs. Out-patients are interested about all additional
information about phyto-medicines. Needs to the phytomedicines are varied
between two different section of people. People prefer to use ready to use
drugs produced at the pharmaceutical plants, because instructions for the
preparations of phitodrugs are not informative enough to make phytoforms at
home conditions.
Auth.
8.g.13.6.38. Science and conscience. /G. Javashvili, G. Kiknadze, T. Kurtanidze/. Georgian Medical News. – 2010. – #7-8(184-185). – pp. 7-20 – eng.; abs.: geo., eng., rus.
Many historical facts,
describing exploitation and discrimination of research subjects which have been
justified by the importance of research aims, are known. Today the protection
of the rights and safety of persons involved in biomedical research (research
subjects) is the necessary precondition for contemporary biomedical researches
and correspondingly, development of the science. An integral responsibility of
researchers working in the field of biomedicine is to ensure the protection of
safety and rights of research subjects. In
Auth.
8.g.13.6.39. Hypoglycemic activity of Berberin and extract
obtained from the bark of Ðhållodendron Lavalei introduced in subtropical areas of
The goal of this study
was to evaluate hypoglycemic activity of Berberin and extract obtained from the
bark of Ðhållodendron Lavalei, which is introduced in sub tropic
areas of Georgia – Kobuleti. The study was carried out to reveal comparative
hypoglycemic activity and acute toxicity of alkaloid Berberin and bark extract
of Phellodendron Lavalei. Effects of Berberin hydrochloride and bark extract on
blood glucose level was studied on mice. Measurement of blood glucose level was
carried out on fasting animals using glucose meter GlucoLab – auto-coding. The
study showed that Berberin hydrochloride dose 150 mg/kg, extract (obtained from
the bark of Phellodendron Lavalei) dose 400 mg/kg and glybenclamid dose 0.25
mg/kg practically decreased blood glucose level of mice in a same pattern.
Received data allows us to suggest that Ðhållodendron Lavalei,
introduced in sub tropic areas of
Auth.
8.g.13.6.40. Peculiarities of the circulatory system
response to the effect of modern tantalum manufacture factors in workers. /D. Omarova, A. Ismailova, Z. Sultanbekov/. Georgian
Medical News. – 2010. –
#7-8(184-185). – pp. 70-76 – eng.; abs.: geo., eng.,
rus.
Objective of this study
was to examine functional condition of cardiovascular system among workers at
"Ulba Metallurgical Plant” JSC (located in Ust-Kamenogorsk, Eastern
Kazakhstan) - one of the world largest enterprises with the full production
cycle from processing of tantalum containing raw materials to finished
products. All workers that participated in the examination were divided into
three groups: (I) - up to 5 years of occupation; (II) - from 5 to 9.9 years of
occupation; and (III) - more than 10 years of occupation experience in the
tantalum industry. The cardiovascular system, health concern and their
contributing factors were assessed. In group I the factor of profitability of
blood circulation was up to 3000 conventional units, which corresponds to the
optimal fatigue; In group II the factor of profitability of blood circulation
was increased up to 3525±327,3 conv. units - critical values zone. In group III
the factor of profitability of blood circulation was up to 3000 conv. units. A
relative improvement in the central hemodynamic indices compared with those in
group II may be due to the development of adaptation. The assessments of
functional condition of cardiovascular system among the workers specialize in
different stages of tantalum production revealed the necessity of paying
special attention at the cycle of tantalum processing and the years of work
experience in an occupation.
Auth.
8.g.13.6.41. The possible mechanism of behavioral
disorders in rats under long-term treatment with Dexamethasone in the neonatal
period. /O. Sinauridze,
Despite the fact that
the side effects of prolonged treatment with dexamethasone are well known,
information about its effects on the central nervous system is very limited.
Experimental study of long-term effects of dexamethasone administration in the
neonatal period on behavioral activity of rats in the open field was conducted.
Four groups of newborn males were selected from the offspring of pregnant rats.
The first group was left intact, the animals of second group were injected
saline solution, the third group – with the dexamethasone and the fourth group
- along with dexamethasone received L-arginine. Tests in an open field for all
groups of animals were carried out on the 45th (first test) and 60th (second
test) days after birth. The results showed that the decrease in motor activity
of animals and in the number of sectors crossed in the open field with a high
statistical significance was observed only in the group of animals, which for
four days in the neonatal period underwent dexamethasone treatment. At the same
time, another group of animals, which was also injected dexamethasone in the
same doses, but additionally was injected L-arginine, the behavior in the open
field did not differ from the intact animals or animals which were injected (as
a control) saline solution. It was concluded that it is the lack of nitric
oxide in the early neonatal period, which occurs as a result of dexamethasone
treatment that causes observed changes in animals’ behavior.
Auth.
8.g.13.6.42. Modulating
effects of androgens on the development of adaptive-compensatory processes in
the organism of experimental animals - males. /N. Didebulidze, Ts. Sumbadze, E. Melikadze, S.
Gvidani, M. Kakabadze/. Georgian Medical News. – 2010. – #9(186). – pp. 62-67. – rus.; abs.:
geo., eng., rus.
The purpose of research
is the definition of androgens role and myocardial androgen receptors and sex
steroids in males under metabolic and hormonal "stress” induced by the
experimental diabetes. Research was carried out on 60 rats-males, mass
180,0-200,0 g. The diabetes reproduced by single injection of alloxan
(200mg/kg). Androgen receptors were revealed by the radiometric and
radioautography methods. The content of glucose, immunoreactive insulin,
testosterone, estuarial, corticosteron and somatotropin were defined in
animals’ blood plasma. On the early terms of alloxan diabetes estradiol
concentration increase against a background of testosterone decrease which
causes the "feminization” of the sexual hormonal balance. On the other
side the increase of androgen receptors expression by cardiomyocytes causes the
intensification of myocardium tissue physiologic ability to androgens
perception positively influencing on the metabolism. Consequently, androgens
provoke stimulating effect on the myocardium metabolism in males at early
stages of the experimental diabetes.
Auth.
8.g.13.6.43. The radiation background
and hygienic assessment of external irradiation doses of population in some
mountainous regions of Georgia. /I.
Kugoti, N. Vepkhvadze, N. Kiladze/. Georgian
Medical News. - 2010. - #11 (188). – pp. 61-65 – rus.; abs.: geo.,
eng., rus.
The
radioecological situation of Mtskheta-Mtianeti region of
Auth.
8.g.13.6.44. Peculiarity of consumer-preference shaping in
the pharmaceutical market in Azerbaijan. /L.
Mansurova/. Georgian Medical News. –
2011. - #1(190). – pp. 56-60. – rus.; abs.: geo., eng., rus.
Pharmaceutical market
researches in terms of consumer behavior are
topical in current social-economical conditions. Thereby the goal of these
researches is studying of particular properties of consumer behavior on the
drug market and identifying of factors affect on its formation. The method of
questioning was used. The questionnaire has been completed from the point of
view of possibilities and interests of common consumer. One part of
questions was concerned to demographical and personal characteristics of customers.
For the analysis of consumer behavior have been used parameters such as frequency of visits to definite pharmacy, attraction
of pharmacy, types of purchases. The survey had been determined the basic
factors of pharmacy visitors’ consumer behavior. According to the consumers
opinion the main criteria of choice of pharmacy were professional knowledge and
experience of pharmacy’s workers. Some of economical factors, such as
affordability and etc. have been analyzed.
Auth.
8.g.13.6.45. Radioecological situation of Racha-Lechkhumi
region of Georgia and hygienic assessment of external irradiation doses of
population. /I. Kugoti, N.
Vepkhvadze/. Georgian Medical News. – 2011. - #2(191). - pp. 40-43. – rus.;
abs.: geo., eng., rus.
Radioecological
situation in Racha-Lechkhumi region of Georgia (Ambrolauri, Oni, Lentekhi,
Tsageri districts) and annual effective doses of external irradiation of population have been studied. It was found
that outdoor radiation background in Racha-Lechkhumi region is 58.0-169.0 nGy/h;
average index is 108.9 nGy/h. Indoor radiation background is 68,0-192,0
nGy/h; average index is 137,4 nGy/h. The
average annual effective dose of external irradiation of population in
Racha-Lechkhumi region is 0.81 mSv/y, which exceeds the dose of similar type
registered in most of countries. The implementation of adequate preventive
measures for its reduction is required.
Auth.
8.g.13.6.46. Working out of technology and rationing
quality of "glysocal” granules. /S. Mekhralieva/.
Georgian Medical News. – 2011. - #2(191). - pp. 68-72. – rus.; abs.: geo.,
eng., rus.
The technology of
"Glysocal” granules on the basis of biologically active substances
extracted from plants having wound healing, regenerative and antioxidant
properties has been developed for treatment of gastroenteric diseases. Quality
rationing of Glycyrrhiza, Sophora, and Calendula granules (condition and period
of storage, pharmacological activity and microbiological cleanliness) has been
defined.
Auth.
8.g.13.6.47. The fatty acid
composition of Rkatsiteli grape seed oil and its effect as a food supplement. /B. Kikalishvili, D. Zurabashvili, M. Nikolaishvili,
Z. Zurabashvili, I. Giorgobiani/. Georgian Medical News. – 2011. - #2(191). -
pp. 73-76. – rus.; abs.: geo., eng., rus.
In this paper high fatty
acids in the Rkatsiteli grape seed oil were qualitatively and quantitatively
identified. In the Rkatsiteli grape seed oil linoleic, oleic, palmitic,
stearic, palmito-oleic, linoleic and arachidonic acids were identified. The
impact of Rkatsiteli grape seed oil as a dietary supplement on the contents of
fatty acid synthase and lipids in the livers of mice were determined.
Investigations were carried out on 120 inbred mice: for 15 days to a standard
diet grape seed oil was added as a food additive. The investigation showed that
the optimal use of food additives in the form of oil from Rkatsiteli grape seed
plays an important role in maintaining the physiological needs of the human
organism.
Auth.
8.g.13.6.48. The age-related structure and
dynamics of some diseases of the elderly in
Georgia belongs to the
demographically aged countries and is one of the first among the developing
countries. It reflects on the age structure and dynamics of diseases. This
conclusion is based on the archive data of The Republic Hospital of Tbilisi,
The Ministry of Economic development of Georgia and The Department of
statistics of the Ministry of Labour, Health and Social Affairs of Georgia.
It’s important that the number of old patients with several chronic diseases
has increased in hospitals and ambulatories. Especially frequent among them are
cardiovascular and respiratory patients. For the perfection of health
maintenance and treatment of elderly population the social, palliative care and
geriatric service system improvement is needed.
Auth.
8.g.13.6.49. Hygienic estimation of
air pollution in the industrial environment of Tbilisi underground. /N. Khunashvili/. Experimental and Clinical
Medicine. – 2010. - #2(57). - pp. 42-48. – geo.; abs.: eng., rus.
Among the adverse
occupational factors in the industrial environment of the Tbilisi underground
the leading one is air pollution by industrial aerosols of dust and toxic
substances. The concentration of dust and toxic substances in most cases
exceeds (1.3-3.4 and 1.2-5.2 times accordingly) the corresponding MPF (job
hazard class 3.1-3.2). An admissible concentration (hazard class 2) of dust and
toxic substances is observed rather seldom. Higher hazardous classes (3.3-3.4)
have not been revealed. The adverse condition of air of the industrial
environment at the studied object is determined by the character of industrial
operations carried out and the kind of processed material, also by the
structure of exhaust ventilation and its efficiency. The established adverse
conditions in the working environment represent a potential danger of the
occurrence of certain shifts in workers’ state of health. The basic directions
have been developed for the improvement of the working conditions in the
Tbilisi underground.
Auth.
8.g.13.6.50. The influence of natural zeolites on the
intestinal and lymphoid systems of white mice. /B. Korsantia,
S. Kupradze, V. Malatsidze, L. Dzotsenidze, J. Mkervalishvili, L. Kajaya/. Experimental and Clinical Medicine. – 2010.
- #5(60). - pp. 11-13. – rus.; abs.: eng.
Our previous studies
revealed antiviral and antitoxic effects of zeolite dietary supplements in the
modeling of influenza infection in white mice. "Zeolite diet” enhances
immune-competence of the organism, especially of the interferon system. The
results of these experiments showed that the particles of clinoptilolite (in forage)
are able to induce a more active immune morphogenesis in the intestinal
tissues, regional lymph nodes, spleen and thymus.
Auth.
8.g.13.6.51. The quantitative evaluation of pesticides in
water, riverside soil and bottom sediment of the Alazani River. /T. Mchedluri,
M. Metreveli, M. Nikolaishvili/.
Experimental and Clinical Medicine. – 2010. - #6(61). - pp. 34-38. – geo.;
abs.: eng., rus.
The use of pesticides is
one of the most important methods for harvest protection, but they also can
bring negative consequences. Remnants of the pesticides Karate, Decis and DDT
were found in the riverside soil, bottom sediment and water of rivers. A
chemical research has shown a certain amount of pesticides only in Tsnori and
Gurjaani, but there was no DDT in the water of Alazani. In the riverside soil,
the quantity of pesticides is high, which can be explained by hot summers and a
high content of copper in the soil. Pesticides are abundant in the villages:
Artana, Shakriani, and Tsnori. As for bottom sediment, a certain quantity of
pesticides is found near Shakriani, Tsnori, and Gurjaani. In the riverside soil
and bottom sediment of Alazani are also found some remnants of DDT.
Auth.
8.g.13.6.52. The influence of a biologically active
compound – grapes oil - on the metabolism of biogenic amines in rat blood. /M. Nikolaishvili, T. Mchedluri, D. Margalitashvili,
M. Ghagholishvili, Z. Zurabashvili/.
Experimental and Clinical Medicine. – 2010. - #6(61).- pp. 28-31. – geo.; abs.:
eng.
Feeding on grapes oil –
a biologically active compound - induces such quantitative distribution of
amino acids in rat blood that removes emotional strain in animals, decreases
sense of fear, develops and increases attention, memory and cognition,
activates the process detoxication, ceases formation of free radicals, supports
fat destruction and transfers it in the muscular energy. It stops balding
process, takes part in regeneration; in case of contamination reinforces thymus
function, also promotes protein formation and procreation.
Auth.
8.g.13.6.53. From the history
of public health service in Adjara. /O. Gogorishvili, G. Tsetskhladze/. Experimental and Clinical Medicine. –
2011. – #1(1). - pp. 27-31. – geo.; abs.: eng.
On August 25, 1878,
Russian troops entered the town of
Auth.
.
8.g.13.6.54. Production of amino
acids
for using
microorganisms
and previous
substances.
/M. Kuridze, N.
Mamardashvili/. Materials of Sukhishvili
University International Scientific Conference. – 2010. – pp. 216-218. - geo.; abs.: geo., eng.
Biotechnological methods
give an opportunity to produce amino acids for using in different spheres. The
present study deals with some biosynthetic previous substances and ferments
which are used in the syntheses of some amino acids as well.
Auth.
8.g.13.6.55. The medico-biological
importance
of
vitamins
and
their
content in berry plants. /Q. Goginashvili/. Materials of Sukhishvili University International
Scientific Conference. – 2010. – pp. 219-222. - geo.; abs.: geo., eng.
The content of vitamins
inn berry plants (Rosa canina L., Fragaria vesca L.,
Vaccinium vitis – ideaea L., Rubus ideaus L., Hippophae rhamnoides L., Ribes
nigrum L., Ribes vulgare Lam., Grossularia reclinata (L.) Mill.) is considered. This content is rather dynamic
and varies according to the kind of plants. Hippophae rhamnoides L. is noted
for its maximum accumulation of carotene, while the content of vitamin C in
Ribes nigrum L. takes the first place among the above-mentioned berry plants.
Auth.
8.g.13.6.56. Biocide properties of phenol compounds. /M. Nadirashvili/. Materials of Sukhishvili University International
Scientific Conference. – 2010. – pp. 248-249. - geo.; abs.: geo., eng.
Several phenylacetilenic
alkylphenols, keto phenols and corresponding organometallic compounds have been
synthesized. Some of these products possess the biocide activity.
Auth.
8.g.13.6.57. The halogenated
preparation
in medicine.
/E. Tskrialashvili/.
Materials of Sukhishvili
University International Scientific Conference. – 2010. – pp. 250-252. - geo.; abs.: geo., eng.
The following
halogenated preparations used in medicine are discussed and characterized –
hydrochloric acid; sodium and potassium chlorides bromides, iodides, and
iodine.
Auth.
8.g.13.6.58. Study of
efficiency of medical poultices on living organismus. /E. Buadze, N. Phailodze, R. Sakandelidze, O.
Metreveli/. Georgian Scientific News. – 2010. - #1(5). – pp. 31-34. – rus.,
abs.: geo., eng., rus.
The article discusses
the results of toxicological and antimicrobial studies on the efficiency of
medical poultices with specific properties. The study of efficacy of the
obtained poultice action in healing wounds (of different size and kind) on
white Wistar rats demonstrated: the
medical poultice is nontoxic and does not have any influence on the internal
organism and the weight of rats; in the place of the substance injection no
allergic signs are noticed; the best results in terms of wound healing and
antimicrobial status are obtained when using the recipe No. 3; the ingredients
of the medical composition are as follows: methyluracil – 18%, chloramphenicol
– 24%, aktovegil –0.6%, filling agent -57.4%.
Auth.
8.g.13.6.59. The green world
around us. /Z. Vadachkoria, E.
Buadze,
The questions of herbal
medicine are considered in the article. It has a survey character. The value of
herbal medicine for treatment of various diseases is specified. The sources and
questions of treatment by plants of different countries and peoples in various
time, since prehistoric times, including the modernity are surveyed. Based on
the study results it is concluded that prospects of phytotherapy are great.
Auth.
8.g.13.6.60. Living organism as a single functional
system
and
hesitant character of its function. /A. Isakadze, G. Eliava/. Gaenati Herald. – 2010. – vol. 3, #4. – pp. 62-68. – geo.; abs.: geo.;
eng., rus.
Definition of
various stages in processes of temporary adaptation promotes adequate
estimation of functional condition of a human organism in the time of influence
of physical loadings. Breathing of various types promotes to increase of
activation of breathing and heart-blood-vessels functional system –
actualization and ''broadening of structures'' - increasing of labilization.
Auth.
8.g.13.6.61. Bioethical questions
of interrelation with the patient. /G. Eliava,
In interrelation between doctor and patient must be
foreseen age of the patient, it is necessary densely interrelation with near
relations of the patient, in the age of childhood it is necessary to
interrelation with parents of a child patient, and it is especially foreseen
that a word of the doctor "medicinal influence” has a big meaning on
course and outlet of illness except conservative and surgical treatment.
Auth.
8.g.13.6.62. Public healthcare trends in Georgia. /T. Inasaridze/.
Caucasus International University Herald. – 2010. - #2. – pp. 207-212. –
geo.; abs.: geo, eng., rus.
The reforms aimed at
transformation of the financial and institutional settings of the healthcare
and social sectors have lasted over ten years in Georgia. However the reforms
are still on the agenda. The absence of the market stimulation and the
competition became the core for the healthcare reform, which, based on the
principles of the market economy, foresees the regulations. The main trend of
the public healthcare is to be focused on the issues of the health and
respective human rights protection of the socially vulnerable (disadvantaged)
people. In this regard, for protection the interests of this group, it is
possible to involve the civil society in the planning of the public health care
policy and in assessment/monitoring of quality of the public health care
service provision. This involvement of the civil society would contribute to
the transparency of the State's activities and would increase its
accountability to the society.
Auth.
8.g.13.6.63. Influence of
the environment, lifestyle and gender on the health status of long-lived
persons. /N. Khipshidze, T.
Zubiashvili/. Bulletin of the Georgian National Academy of Science. – 2011. –
vol. 5. - #1. – pp. 133-138. – eng.; abs.: geo., eng.
Since 2004, the
nationwide Georgian Longevity Study has been undertaken by Department of
gerontology and geriatrics at the National Center of Therapy. Interesting
features have emerged regarding gender, geography and diet. The female-to-male
longevity ratio is more than six to one and it is not uniform throughout
Auth.
8.g.13.6.64. Aggressiveness of sportsmen and its bological
background. /Z. Zurabashvili, G.
Pharulava, Kh. Lasareishvili, M. Kldiashvili/. Bulletin of the Georgian
National Academy of Science. – 2010. – vol. 4. - #2. – pp. 155-157. – eng.;
abs.: geo., eng.
Blood corpuscles of
junior sportsmen while training have been studied by means of the method of
light and electron microscopy. Different structural interest of blood
corpuscles before and after training was shown. Structural indices from the
side of blood corpuscles were examined from the position of functional indices
of an organism. Different behaviour of a- and dense granules of thrombocytes
was noted.
Auth.
8.g.13.6.65. Biodefender™ - new generation of
nanotechnology-based biological warfare means /M. Danielov, A. Sepper/. Critical Care &
Catastrophe Medicine. – 2009. - #5. – eng.; abs.: eng., geo.
Based on scientific
advancements in Nanotechnology MD Science, Inc. in collaboration with BIONOVA
researches developed a new generation of biological warfare protective agents.
BioDefender™ represents an entirely new nanotechnological approach to enhance
Skin Barrier System. It naturally increases skin's resistance to microorganisms
due to exclusively balanced ‘Antimicrobial - Antioxidant - Self-Healing
Nano-Complexes™’ with synergistic effects on multiple microorganisms and
recognized to be more powerful when acting in concert. BioDefender™ is a
comprehensive formula that helps to fight germs and other microscopic invaders.
It is designed to work on first contact with the skin, where it comes in touch
with microbe-laden surface or air.
Auth.
8.g.13.6.66. Progenitor precursors’ committing during a
post-resuscitation disease. /Z. Kheladze, K.
Mumladze, Zv. Kheladze/. Critical Care & Catastrophe Medicine. – 2009. -
#5. – eng.; abs.: eng., geo.
In the Critical Care
Medicine Institute during last years the numbers of patients with
post-resuscitation disease have increased. Mortality and disability have high
rates as well as the treatment costs. The total number of treated patients with
post-resuscitation disease constituted 49, mortality has reached 68.7%,
survivors – 31.3% and patient-days have reached 323. Most of the patients with
post-resuscitation disease had heart dysfunction and myocardium infarction. Men
were more than women; the first 48 hours were the most difficult to survive
during the critical condition. Invalidity reached 6.7%; the number of
discharged from hospital without disability made 93.3%. The average number of
the patient-days was 6.7, whereas the costs made USD 3.500 per patient on
average. The use of the therapy of progenitor precursors’ committing, patented
by the author, was the reason for low rates of mortality and cost effectiveness
in the management method.
Auth.
8.g.13.6.67. Critical care medicine resources’ program
design. /Z. Kheladze, N.
Ramishvili, Kh. Phruidze, D. Tabaghua, Zv. Kheladze/. Critical Care &
Catastrophe Medicine. – 2009. - #5. – eng.; abs.: eng., geo.
The Critical Care
Medicine Institute’s long-term experience that makes critical care medicine
service operation more effective. For activating a critical care medicine
service work it is necessary to ascertain disposable reserve and to create a
cost-effective resources’ program based on the data of the patients loading,
mortality and maintenance charges. Currently, admission rate amounts to 5939
patients (100%) and mortality rate is equal to 35.6 %. Maximum admission occurs
per season in spring - 27%, per month in May - 10%, per week in the first week of
the month - 27% and per hour during 18-24 hrs – 35%. Maximum mortality takes
place per season in spring - 28%, per month - in April and December - 12%.
Among critical patients, nervous system pathology is leading - 24%; rate of
polytrauma is also high - 22%.Maximum mortality (36%) occurs during the nervous
system pathology. Mortality during polytrauma is about 20%.
Auth.
8.g.13.6.68. Staffing of intensive care units and outcomes
– national and New York City experience.
/V. Kvetan/. Critical Care & Catastrophe Medicine. – 2010. - #6. –eng.;
abs.: eng., geo.
Staffing of intensive
care units varies in quality and quantity of personnel. It is adjusted to the
dynamics of the major delivery systems of patients which may be the emergency
room burn and trauma bays, operating room or hospital ward. Most manpower
studies in the
Auth.
8.g.13.6.69. Protection of child rights in the process of
medical care. /I. Manjavidze/.
Georgian Pediatrician. - 2010. - # 1-2. – pp. 3-8. – geo.; res. eng.
It is important to
support protection of the child's rights in many world countries. On April 21,
1994, Georgia joined the Convention on the Rights of the Child, adopted by
General Assembly of the United Nations, undertaking the liability to protect
and to take care of children below 18. Protection of child rights implies first
of all healthcare and is based on the four main components: life, development,
protection and participation. Each component is considered in the article
within social and individual context.
N. Chkaidze
8.g.13.6.70. Assessment of athropological, pysical and
functional indices in sportsmen receiving amino acid rich beverage
"Iveriuli Phyto” during training. /G.
Chakhunashvili, N. Jobava, N. Topuridze, N. Badriashvili, Z. Shakarashvili, G.
Tskhvediashvili, I. Kalandia, Z. Pkhaladze, K. Chakhunashvili/. Pediatric
Cardiology. - 2011 - ¹ 5. -
pp. 24-32. - geo.; abs.: geo., eng.
Objective of the work:
amino acid, mineral and vitamin rich natural energetic beverage
"Iveriuli-phyto” and study its role in sportsmen rehabilitation
considering the initial health indices. Conclusion: 1. Medical examination and
comparison of heart cycle parameters before and after physical load identified
low physical adaptation ability in the both study groups of the sportsmen. 2.
Medical examination identified that in sportsmen drinking beverage
"Iveriuli Phyto” had better physical parameters then in control group
sportsmen. 3. Use of beverage "Iveriuli Phyto” in sportsmen was found to
improve work ability, adaptation mechanisms for trainings and contest by
helping restoring processes during intensive physical load.
Auth.
8.g.13.6.71. Polyvitamins
and polyvitamin-mineral complexes and their prophylactic utilization. /K. Beridze/. Social, Ecological and Clinical
Pediatrics. – 2011. - #13-8-7. - pp. 60-62. – geo.; abs.: geo., eng.
Vitamins and
microelements are of vital importance for organism which synthesis is not
produced in organism, but some vitamins production is less significant. Food
products are the main source for organism. According to spread idea, food
products can not fully satisfy organism’s demands on vitamins and micro
elements, that’s the reason why it is considered advisable to supplement with
polyvitamin-microelements. It is necessary to point out that, contemporary food
industry enriches food products with vitamins and microelements, farm industry
uses cattle and bird that are full of vitamins that, in case of valuable
nourish conditions must fully ensure human demands for these substances.
Despite of polyvitamin-microelement complexes high technological quality that
exists in the market, given preparations do not foresee synergistic-antagonist
dependency, vitamins and microelements mutual influence, population’s different
necessaries on separate vitamins and microelements, etc. That’s why it is
considered to conduct laboratory and clinical researches before conducting
hypovitaminoz prophylaxis and vitamin therapy. After analyzing individual daily
nutrition time-keeping it is necessary to define the inevitability to prescribe
polivitamin and vitamin-mineral complexes, select them individually in order to
prevent the contravention of physiological processes in organism.
Auth.
8.g.13.6.72. Telegony. /M. Tchipashvili, E. Imnaidze, C. Gigineishvili/. Social, Ecological and Clinical Pediatrics. –
2011. - #13-8-7. - pp. 63-64. – geo.; abs.: geo., eng.
The first description of
the telegony, as a concept, explained the correlation and interdependency
between the spiritual purity/virginity and the ability of having healthy future
generation. The telegony is based on the one unique feature of DNA called
teleportation which explains the transit of information through the
electromagnetic fields. This can be used in the modern medicine as an
innovative direction in treating the patients with various dangerous diseases,
like HIV/AIDS, cancer, mental and genetic disorders.
Auth.
8.g.13.6.73. Subutex and its analysis
methods (literature review). /L.
Adeishvili-Andguladze, N. Mzhavia/. Collection of Scientific
Works of Tbilisi State Medical University. - 2010. - # 44. – pp. 7-11. –
geo.; abs.: eng.
Subutex is the prolonged form of buprenorphin
(Norphin). Which is produced as tablets in 0.4,2 and 8 mg of buprenorphin
hydrochloride by
Auth.
8.g.13.6.74. Some features of working
conditions of the Chemical Industry workers of in Georgia. /L. Bakradze, G. Kverenchkhiladze, M.
Tsimakuridze/. Collection of Scientific
Works of Tbilisi State Medical University. - 2010. - # 44. – pp. 15-17. –
geo.; abs.: eng.
The factors of the industrial environment and
labor processes at
Auth.
8.g.13.6.75. For improving the
pharmacognostic analysis of Chelidonium
majus L. /A. Bozhadze, K.
Mchedlidze, J. Kuchukhidze/. Collection of Scientific
Works of Tbilisi State Medical University. - 2010. - # 44. – pp. 17-19 –
geo.; abs.: eng.
Chelidonium majus L. (greater celandine) is a
medicinal plant and is the one of species of the tribe Chelidonine of
Papaveraceae family. Ch. majus contains various isoquinoline alkaloids: protoberberine,
tetriazy and quaternary benzo (c) phenantredine structure. The commercial drug
(herb of Chelidonium) consists of the dried aerial parts harvested during
flowering time and is described in several European, Russian and Georgian
pharmacopoeias. Major consistence of the drug are the alkaloids chelidonine,
chelerithrine, sanguinarine, coptisine, protopine, desstylopine and similar.
The cytotoxic activity of these compounds on human and animal tumour cell
cultures in vitro are considered with great interest and can be considered
promising in cancer therapy. For raw material (herba) of celandine was
elaborated methodological description of the microscopic system. Plants,
organs, micro diagnostic signs are defined: for leave, flower, stem and fruit.
Auth.
8.g.13.6.76. Botanical-geographical
review of the genus Galanthus L. /R. Gagnidze, Ts. Ghviniashvili, J. Kushukhidze, M.
Jokhadze/. Collection of Scientific
Works of
The variation in climate in different regions
of Georgia has resulted in a very rich flora and a long history of many
beautiful bulbous plants. Some of them have been cultivated in European and
American gardens as an ornamental plant for centuries. A number of them have
also some importance for their biological activities. The bulbs of Galanthus,
Narcissus and Leucojum have an interest because of their content of
galanthamine in order to be used in the treatment of poliomyelitis. Georgia
exports geophytes for horticultural purposes mainly collected from the wild.
The amount of material exported from Georgia has increased each year. Saving,
studying and using are the three basic elements of the conservation of
bio-resources. There are 10 species of genus Galanthus L. spread in Georgia,
which are merged into two sections. Among them Georgian endemic species are G.
shaoricus Kem.-Nath., G. ketzkhovelii Kem.- Nath., G. kemulariae Kurhatheladze;
Caucasian endemic species are G. angustifolius Koss., G. platyphyllus Taub et
Moldenko., G. lagodechianus Kem.- Nath.; remaining 4 species are widespread in
Asia Minor.
Auth.
8.g.13.6.77. Age-related changes of
ISOL-positive hepatocytes. /S. Giorgadze, N. Tevzadze, N. Gujabidze, R. Rukhadze/.
Collection of Scientific Works of Tbilisi State Medical University. - 2010. - # 44. – pp. 24-26. –
geo.; abs.: eng.
Being the main organ of the metabolic system,
the liver, whose function undergoes numerous changes in the course of life, is
an important object of investigation. This organ is constantly exposed to a
variety of potentially apoptogenic, immune, inflammatory and metabolic stimuli.
Apoptosis and its modulation are crucial factors for the maintenance of liver
health. A deficiency in apoptosis is one of the key events in pathophysiology.
On the other hand, overefficient apoptosis, as observed in fulminant liver
failure, may be equally harmful for the organism indicating that a tight
regulation of the apoptotic machinery is essential for survival. Quantisation
of hepatocyte apoptosis is an emerging and evolving research area that will
require evaluations as thoroughly as those performed with cell proliferation in
order to understand all the variables that might influence its occurrence,
measurement, and interpretations. Due to the rapid clearance of apoptotic
cells, detection and quantification of apoptotic cells is prone to
underestimation. A review of the different methods used for detecting apoptotic
cells demonstrates that most of these techniques are not entirely specific.
According to above-mentioned, we decided to study the changes of apoptotic
hepatocytes in white mice during ageing. 30 white mice were distributed in four
– newborn, juvenile, adult and senescent - age groups. Apoptosis was detected
in liver sections by the in situ oligo ligation (ISOL) assay, using an ApopTag
ISOL assay kit (Serologicals, Norcross, GA). This assay relies on the selective
binding of biotin-labelled hairpin oligonucleotide probes to the types of
genomic DNA ends that are characteristic of the double-strand breaks in
apoptotic cells. Received data indicate that the number of ISOL-positive
hepatocytes increases in juveniles, decreases in adults and increases in
senescent mice. The rate of apoptosis is most intensive in senescents.
Auth.
8.g.13.6.78. Problems involving
self-medications with antibacterial agents. /N. Gorgaslidze, N.
Gongadze, N. Nizharadze, N. Phruidze, L.
Makhatadze/. Collection of Scientific Works of Tbilisi State
Medical University. - 2010. - # 44. – pp. 29-32. – geo.; abs.: eng.
Our investigations were carried out on
citizens from different towns of
Auth.
8.g.13.6.79. Hygienic estimation of
pollution with heavy metals of surface waters and sediments connected with
mining and processing industry in Chiatura. /M. Grdzelishvili, M.
Mirtskhulava, N. Chakvetadze, M. Giorgobiani, M.
Lashkhauri/. Collection of Scientific
Works of Tbilisi State Medical University. - 2010. - # 44. – pp. 35-36. –
geo.; abs.: eng.
Pollution degrees of the river Kvirila,
connected with mining and processing production, of its tributary streams and
their bottom sediments have been examined in Chiatura town. According to the
obtained results, the Kvirila water before and after the central processing
factory, and also the stream Darkveti, due to exceeding Mn content, belong to
the objects of "extremely high degree” of pollution, while the streams
Rgani and Shukruti belong to the objects of "temperate degree” of
pollution. "Severe pollution” of the Kvirila sediments was fixed in all
places with "extremely high degree” of water pollution. It was found out that
polluted sewage waters of central processing factories affect the degree of the
Kvirila bottom sediments.
Auth.
8.g.13.6.80. Implementation of
principles of GPP in
The International Pharmaceutical Federation
(FIP) in adopting international guidelines for Good Pharmacy Practice (GPP) at
its Council Meeting in Tokyo on September 5, 1993 believes that standards based
on these guidelines should be used by national pharmaceutical organizations,
governments, and international pharmaceutical organizations for nationally
accepted standards of Good Pharmacy Practice. This revised version of the
statement was endorsed at the thirty-fifth meeting of the WHO Expert Committee
on Specifications for Pharmaceutical Preparations in April 1997 and approved by
the FIP Congress in September 1997. The Good Pharmacy Practice guidelines are
based on the pharmaceutical care given by pharmacists. The guidelines recommend
that national standards are set for: the promotion of health, the supply of
medicines, medical devices, patient self care, and improving prescribing and medicine
use by pharmacists’ activities. FIP urges pharmaceutical organizations and
governments to work together to introduce appropriate standards or, where
national standards already exist, to review these standards in the light of the
guidelines set out in the Good Pharmacy Practice document. Many developing
countries lack an effective drug regulatory system, which puts the main
responsibility for the quality of pharmaceutical products on the pharmacists.
These then have to rely on their own, or their pharmacists’ association’s,
quality assessment and must make sure that they procure medicines only from
reliable sources. FIP has developed special guidelines for drug procurement.
There are numerous reports of an unacceptable prevalence of substandard and counterfeit
pharmaceutical products in international trade. Developing countries are the
ones most frequently exposed to such products which may be inefficacious or
toxic products, and which threaten to erode confidence in the health care
system. It was for this reason that in May 1994 the Forty-seventh World Health
Assembly, in adopting resolution WHA47.12 on the role of the pharmacist in
support of the WHO revised drug strategy, drew attention to pharmacists’
responsibilities in assuring the quality of the products they dispense.
Auth.
8.g.13.6.81. Spread of food-borne
diseases in
Morbidity by food-borne diseases of the
population of Georgia in last period and ways of their prevention has been
studied. During the period from 2004 till 2009 the frequency of food poisoning
among the population increased from 383 to 2050 cases. At the same time number
of people with salmonellosis decreased from 326 (2007) to 166 (2009), and
morbidity from botulism decreased from 43 (2008) to 12 (2009) cases. To prevent
food poisoning among population it is necessary to ensure food-stuff safety,
solve the problem concerning carrying of adequate control over locally produced
and imported products with the aim of preventing uncertified products from
getting of the consumers’ market. It is also necessary to carry out the permanent
control of microbe pollution, toxic substances, pesticides and chemical
fertilisers’ levels in food products.
Auth.
8.g.13.6.82. Eating behavior in
different age groups of Georgian population. /Sh. Zarnadze, T. Darsania,
The type of person’s nutrition is determined
by his eating behavior. The last one must provide all necessary nutrients/food
substances’ consumption to maintain energetic and plastic balance and health
preservation. Several factors have influence on people’s eating behavior. Among
them are demographic, social- domestic, climatic, welfare position, awareness,
products’ accessibility, stress, etc. Moreover, eating behavior is defined by
some medical-biological features of a body and its health state. The main
objective of this investigation is scrutinizing any violations of eating
behavior among population in Georgia. Based on an example of the big city and
on the ground of received data the goal of the research is to create a
conception of health promotion. The relevance of the research is grounded on
the fact that at the moment nutrition optimization is the one of the most
significant direction in processes of health improvement, extension of
population lifespan and reduction of morbidity and disability.
Auth.
8.g.13.6.83. Problems in prevention
of arterial hypertension in the primary healthcare system. /A. Isakadze, Sh. Shurghaia, M. Noniashvili/.
Collection of Scientific Works of Tbilisi
State Medical University. - 2010. - # 44. – pp. 52-54. – geo.; abs.: eng.
Assessment of the quality of follow-up of
patients with arterial hypertension (AH) within the framework of primary health
care system. A retrospective analysis of outpatient case histories of 927
patients with AH at 6 health centers in the city of Tbilisi in 2007-2009 was
carried out. A special table was created in order to assess the quality of
follow up. This table included all data on the follow-up. The study revealed an
insufficient volume of examinations of target organs over the latest two years:
total analysis of the urine was carried out in only 572 patients, total
cholesterol measured in 228, the fundus oculi examined in 384, and ECG
performed in 615 patients, echoCG of the heart and major vessels was carried
out in only 111 patients and loading tests in 24. Antihypertensive therapy was
administered to 759 patients; only 216 of these took drugs regularly, 163 used
none at all, and 543 patients took drugs only during exacerbations of disease.
Very often they used ineffective drugs longer used now and caused numerous side
effects: clonidine, adelphan, rawolphine, dibasole, papaverine, magnestum,
sulfate. The quality of follow-up of patients with AH does not meet the modern
requirements to follow-up due to various causes: 1. Social neglect of patients;
2. physicians neglect modern recommendations on the diagnosis and treatment of
AH; 3. physicians efforts are not aimed at the prevention of disease
complications, prolongation of the life span of patients, and improvement of
the quality of their life; 4. patients are not ready to active treatment
Auth.
8.g.13.6.84. Evaluation of
demographic development of the Georgian population. /D. Kitovani, L. Lomtadze, I. Zarnadze, M. Khajrishvili/. Collection of Scientific Works of Tbilisi State
Medical University. - 2010. - # 44. – pp. 61-63. – geo.; abs.: eng.
Based on the 2002 census data, de jure
population was 4371.5 thousand, while de facto population was 4355.7 thousand;
thus, the difference between them made 15.8 thousand; negative net migration
was 930 thousand and the majority of migrants went to labor migration in order
to improve their economic conditions and, at the same time, their 81.1%
retained Georgian citizenship, then the difference between de jure and de facto
population should have been greater then 15.8 thousand. It is evident that
based on both Department of Statistics data and our estimations, total
fertility rate reflects similar trends. The only difference is that total
fertility rate by our estimate (1.7) is higher than that of the Department of
Statistics (1.4). Such a discrepancy is mainly caused by incomplete
registration of live birth and over-representation of fertility rate is less
then replacement level fertility (2.1).
Auth.
8.g.13.6.85. Quality control of
Georgian propolis according to flavonon–pinostrobine. /L. Kunchulia, T. Chikviladze, N.
Shengelidze, A. Bozhadze/. Collection of Scientific
Works of Tbilisi State Medical University. - 2010. - # 44. – pp. 71-73. –
geo.; abs.: eng.
The great interest concerning propolis
results from its content of a large amount of biologically active substances,
especially bioflavonoids. Propolis is characterized of the antimicrobial,
analgesic, antioxidative and anticancer properties. Georgian propolis is known
for its high content of flavonoids, especially flavon–pinostrobin. It has the
antioxidative activity, which is correlated to anticancer effect. The Georgian
propolis is reach in flavanon-pinostrobine with antioxidative effect, which is
used for manufacturing of medicines containing biologically active substances.
Auth.
8.g.13.6.86. Peculiarities of the
working conditions of modern cement industry workers in Georgia. /R. Kverenchkhiladze, V. Rokva, A. Chikovani,
M. Kvatadze, M. Rizhinashvili/. Collection of Scientific
Works of Tbilisi State Medical University. - 2010. - # 44. – pp. 74-76. –
geo.; abs.: eng.
Harmful occupational factors were studied at
the Kaspi Cement Plant» Georgia ZEMENT". Degree of danger was estimated.
Technological process of the modern cement industry characterized by high level
of mechanization and automatization which makes operation work more
convenience. However, during processing, complex of harmful factors impacts on
workers including dust, microclimate, noise, chemicals, vibration and
non-rationale lightening. High concentration of dust is considered as a work
place priority pollutant. Among 330 air samples 210 (63.6%) exceeded the maximum
allowable concentration (MAC). In some cases, concentration of Mn, NOx, oil and
Cr+6 exceeded the MAC, either. As well, parameters of noise, vibration and
lightening are not desirable. Work condition by the air dust belongs to the
Class 3.4. (IV degree of danger). Fitness measures for workers were elaborated
under results of the study.
Auth.
8.g.13.6.87. Estimation of the
manganese effect on the population in Chiatura. /N. Mebonia, M. Mircxulava, N. Chakvetadze, G.
Katsitadze, R. Javaxadze, M. Zhuruli, I. Ghvineria, T. Chachava, Q. Kiknadze/. Collection of Scientific Works of Tbilisi State
Medical University. - 2010. - # 44. – pp. 88-90. – geo.; abs.: eng.
The most common health problems in population
exposed to high levels of manganese involve the nervous and respiratory system.
Exposure to excess levels of manganese may occur from breathing air,
particularly where manganese is used in manufacturing, and from drinking water
and eating food. The population descriptive study was conducted in Chiatura in
2009. The main goal of the study was to estimate the exposition of manganese on
the population. Cluster sampling method was used to select population under
study, 30 clusters were selected and 30 respondents were interviewed in each
cluster. All respondents were questioned by using the standard questionnaires.
Collected data were analyzed with Epi Info. In Chiatura and other villages in
Chiatura district in which prevalence of manganese is different the
distribution of different diseases and symptoms was estimated. Study results
show that, in Chiatura, where manganese mines are mostly distributed, and the
prevalence of respiratory and neurological diseases is high. In Chiatura
district the early detection of disease symptoms by using regular examination
of the population is essential for prevention of respiratory and neurological
disorders.
Auth.
8.g.13.6.88. Treatment of
gastroduodenitis by means of new minertal water "Zanavi”. /N. Saakashvili, I. Tchabashvili/. Collection of Scientific Works of Tbilisi State
Medical University. - 2010. - # 44. – pp. 100-102. – geo.; abs.: eng.
50% of able-bodied population of the
developed countries is disturbed by chronic gastroduodenitis. There is a real danger
that this disease may turn into ulcerous disease. Stable chemical composition
is an indispensable condition for the organism’s normal functioning. There are
natural sources of microelements in kind of mineral waters. "Zanavi”
mineral water is of low salinity (3,6 g/l), sodium hydrocarbonate water with F,
B, Ba, Fe microelements and rich in boric acid, location – region of Borjomi.
Study of therapeutic effect of "Zanavi” mineral water was carried out by
us over 48 patients, who suffer from chronic gastroduodenitis. Monotherapy by
means of "Zanavi” mineral water in patients, suffering from chronic
gastroduodenitis, has given a beneficial effect not only upon dynamics of
clinical signs of the disease, but it significantly improved structure of
mucous coat of stomach and duodenum, provoked normalization of hormonal background
and restoration of acid-forming function. "Zanavi” mineral water provokes
increase of metabolism and reparation processes that is showed by enlargement
of superficial epithelium of stomach’s mucous coat. High efficiency,
availability, economy, ecological purity gives us a right to use actively
"Zanavi” new mineral water in treatment of the patients, who suffer from
chronic gastroduodenitis.
Auth.
8.g.13.6.89. Peculiarities of
sanatorium-and-spa treatment of chronic acalculous cholecystitis patients under
conditions of Nabeghlavi spa resort. /N. Saakashvili,
Nowadays chronic diseases of biliary system
are considered as "century diseases” and are the main social problem. The
grounds of the work are observations carried out over 60 patients, who suffer
from chronic acalculous cholecystitis (in the phase of remission) in the
conditions of Nabeghlavi Spa Resort. Against the background of dietary
nutrition the patients were treated by means of monotherapy with
"Nabeghlavi” mineral water. Mineral water "Nabeghlavi” (spring No 2)
(Chokhatauri region), average salinity (6.6 g/ dm3), silicium carbonic acid,
sodium hydrocarbonate water, which contains microelements: Mn, Ti, As, Ni. To
achieve a long-term therapeutic effect in patients, who suffer from chronic
acalculous cholecystitis, it is enough to use "Nabeghlavi” drinking
mineral water of spring No 2 as a main therapeutic factor, high efficiency of
which is conditioned by obvious stimulating effect upon blood circulation of
liver, by improvement of hepatocyte trophism, by elimination of damming
processes in gallbladder, and improvement of gall composition is concurrent
with reduction of reflex effect from gallbladder on heart and other organs,
which are involved in the pathologic processes.
Auth.
8.g.13.6.90. The effectiveness of
mineral water "Khareshi” in the treatment of co-existent diseases;
duodenal ulcer and osteochondrosis of the spine. /N. Saakashvili, I. Tchabashvili/. Collection of Scientific Works of Tbilisi State
Medical University. - 2010. - # 44. – pp. 103-105. – geo.; abs.: eng.
Reflexive reaction in functioning block of
vertebral column often appears at exacerbation of ulcerous diseases of duodenum
that conditions rehabilitation slowing-down. 40 patients at the age of 30-60
were under observation. Their medical complex was the following: Table No1,
with low salinity (1.28 g/l) carbon acid hydrocarbonate sodium-calcium-magnesium
mineral water "Khareshi” and procedures of sparing manual therapy. All the
patients had favorable improvement as a result of multimodality therapy.
According to endoscopic findings, complete healing of ulcer by epithelization
was observed in 35% of patients. Pains and paravertebral tension has decreased
in 76.2%. Complete restoration of vertebral column’s function was observed in
39.4 patients. Stimulation of tropism processes of mucous coat of
gastroduodenal zone was notable during compounding diseases as a result of
rehabilitation, relying on gastroscopic findings (that was invoked by ions of
Ca2+ containing in mineral water), reduction of gastrostasis and reduction of
gastric indigestion occurrence was also notable. Functional recovery of gastrointestinal
tract invoked reduction of pathological impulse transfer from visceral organs
to vertebral column that was expressed in improvement of function of
neuromuscular segments. That’s why we should give advantages to ecologically
pure mineral water "Khareshi”, which provokes restoration of disturbed
functions in organism by means of microelements balance correction, at
treatment of ulcerous diseases in compound with vertebral osteochondrosis.
Auth.
8.g.13.6.91. Peculiarities of the working conditions of classical ballet dancers.
/M. Kvartskhava, L.
Bakradze, M. Tsimakuridze, N. Khachapuridze, D. Zurashvili/. Collection of Scientific Works of Tbilisi State
Medical University. - 2010. - # 44. – pp. 110-112. – geo.; abs.: eng.
Our research was aimed at studying classical
ballet dancers and choreographic school students working conditions and
organism functional state peculiarities, followed by working out measures for
labor optimisation. The research was conducted on the basis of Zakaria
Paliashvili Tbilisi Opera and Ballet State Theatre and Vakhtang Chabukiani
Choreographic School. It has been stated that dancing is a form of significant
physical and psycho-emotional labor, characterised by various combinations of
body motion and state, significant relocation in the space, mandatory poses and
bending of the body, extensive energy consumption, etc. Strained and acute
attention, as well as emotional tension is also very important. During the
classical ballet dancer professional activities, following the physical load,
production dust holds the leading position among other professional factors.
Chemical analysis revealed that content of silicon dioxide, the leading
component of dust from the classical medicine point of view, in the
precipitated dust varies in the range of 4.2% - 8.6%. Stemmed from this, dust
concentration in the rehearsal halls represents certain professional risk
factor due to its chemical composition.
Auth.
8.g.13.6.92. Principles of
risk assessment of the occupational impact of chemical
factors on the reproductive health.
/I. Ghvineria, V. Saakadze, M. Zhuruli, N.
Khatiashvili, M. Tsimakuridze/. Collection of Scientific Works of
According to international demands and taking
into consideration national legislative basis there were collaborated
guidelines on estimation of correlations between chemical factors occupational
exposure on reproductive health damage for possible risk assessment. These
include the hygienic criteria, the getting rules of epidemiologic testimonies,
and the analysis of received information. On the bias of these principles,
there were carried out "Caspicement” LTD and Joint Stock Company
"Chiatura Manganese" women workers epidemiological studies.
Auth.
8.g.13.6.93. Foodstuffs as health
risk factor and problems of its mitigation in Georgia. /B. Khurashvili, K. Sokhadze, G.
Kverenchkhiladze/. Collection of Scientific
Works of Tbilisi State Medical University. - 2010. - # 44. – pp. 118-120. –
geo.; abs.: eng.
We have analyzed a situation in the sphere of
safety of foodstuffs in
Auth.
8.g.13.6.94. Comparison of
conventional and rapid test methods of honey analysis to determine rapid test
reliability probability. /T. Chikviladze, A.
Vartanov, D. Tchintcharadze, T. Otarashvili, M. Jorjikia, H. Ioramashvili/. Collection of Scientific
Works of Tbilisi State Medical University. - 2010. - # 44. – pp. 121-123. –
geo.; abs.: eng.
Honey is a sweet food made by honey bees
using nectar from flowers. High quality honey can be distinguished by
fragrance, taste, and consistency. For at least 2700 years, honey has been used
by humans to treat a variety of ailments through topical application, but only
recently have the antiseptic and antibacterial properties of honey been
chemically explained. Besides the high sugar content (41.0% fructose; glucose
35%; sucrose 1.9%) honey also contains other components, such as pollen and
other digestive enzymes, vitamins - A, B1, B2, minerals such as calcium,
sodium, potassium, magnesium, iron. Honey is a food that contains various
nutrients, such as carbohydrates, proteins, amino and organic acids, pigments
and other. Honey adulteration is a complex problem which currently has a
significant economic impact and undeniable nutritional and organoleptic
consequences. This paper describes the development of rapid, effective methods
for honey analysis and adulteration detection, comparison of conventional and
rapid test methods of honey analysis to determine rapid test reliability
probability. The principle of different methods is given and the advantages and
the shortcomings of each method are discussed. Ten different honey samples,
belonging to the following floral origin: acacia, tilia, chestnut and
wildflower were purchased from different Georgian regions. The following
organoleptic, physical and chemical determinations were carried out on honey
samples: Moisture was determined measuring the refractive indices by
refractometer; ash was indirectly determined using the measured electrical
conductivity; free acids and pH were measured by titration, according to official
method (AINO 17792-2001), reduced sugars, diastase activity and
hydroxymethylfurfural content were determined by spectrophotometric and
photoelectrocolorimetric methods. The research established the following: for
the screening of honey samples, it is reasonable to employ rapid methods; the
rapid method for determining quality of honey is characterized by average
sensitivity; its reliability is 75%. After determining quality of honey,
samples must be re-tested using standard methods. The rapid methods developed
by us can be applied for tentative determination of honey quality.
Auth.
8.g.13.6.95. HPLC analysis of
cannabinoids for determining hashish abuse time. /T. Chikviladze, B. Tchumburidze, L. Kunchulia, M.
Jorjikia, H. Ioramashvili, T. Otarashvili/.
Collection of Scientific Works of
Ascertaining the fact of hashish abuse is
mainly based on defining D9THC COOH – the main metabolite of D9 THC, in the
urine of suspected users. Revealing this metabolite in the urine is not always
indicative of narcotic intoxication; ascertaining this is sometimes very
important in forensic practice or in doping control procedures for athletes.
The aim of the investigation was quantisation of D9 THC and its metabolites in
the urine of a hashish user in order to determine the time of drug abuse.
Research methods included immunoenzyme screening method and HPLC method. As a
result of the study, the following has been established: The presence of D9 THC
and its primary metabolite D9 THC-OH in the urine is indicative of the state of
narcotic intoxication, as these substances are detected in the urine during 2-6
hours after the last abuse; Presence of the ultimate metabolite of D9 THC–D9
THC COOH in the urine, if simultaneously presence of D9 THC and D9 THC-OH is
not detected, is not indicative of the state of narcotic intoxication and only
confirms the fact of hashish abuse during the last one month; Over 50 ng/ml
concentration of D9 THC COOH in the urine indicates narcotic abuse within the
last 3-4 weeks; Less than 50 ng/ml concentration of D9 THC COOH is not
considered a positive result, for it is possible that there was a passive
consumption of hashish (cannabis).
Auth.
8.g.13.6.96. State of meteorological
conditions of
Based on complex investigations there are
established the unfavourable state of meteorological conditions of
Auth.
8.g.13.6.97. Peculiarities of health
and working conditions of Georgian tobacco industry employees. /R. Javakhadze, R.
Kverenchkhiladze, M. Arabidze, N. Rukhadze, Kh. Chigogidze/. Collection of Scientific
Works of Tbilisi State Medical University. - 2010. - # 44. – pp. 134-136. –
geo.; abs.: eng.
We have studied working and health conditions
of Georgian modern tobacco industry employees. In the process of technical
operations workers are influenced by complex of harmful risk factors, such as
tobacco dust, methyl spirit, microclimate, industry noise. The tobacco dust
concentration in the air of working zone is in 1,6-4,7 higher than threshold
limit values, which corresponds to the harmful working hygienic condition as
3.1-3.2 class. Harmful noise level fits to 3.1-3.2 class. Different somatic
diseases are diagnosed in the case of 25% workers. We attracted our attention
to cardiovascular, dermal, gastrointestinal, lung, neurologic and
skeleton-muscular diseases. The revealed structure of diseases is in
correlation with common working conditions. Nowadays we have got slightly
changes of work and health conditions in comparison with last years, which
could be the result of implementation of new technologies as well as the
prevalence of employees with short length of service. On the basis of carried
out research there were elaborated the complex of sanitation measures.
Auth.
8.g.13.6.98. Textile bandage
materials in the treatment of diabetic foot. /E.
Buadze, N. Abuladze, L. Chkhaidze/. Georgian Scientific News. – 2010. - #1(5).
– pp. 22-30. – rus., abs.: geo., eng., rus.
The materials for using
the textile bandages in treatment of diabetic foot are searched. It is revealed
that among the applied treatment methods are bondage materials made of textile
and that in pharmaceutics market there are not materials meeting all
requirements essential in the treatment of diabetic foot
Auth.
8.g.13.6.99. Plasma flow treatment of the diabetic foot. /Z. Kheladze, A. Kistauri, S. Jaiani, B.
Tsutskiridze, Zv. Kheladze, G. Devidze/. Critical Care & Catastrophe
Medicine. – 2009. - #5. – eng.; abs.: eng., geo.
Combineduse of plasma
flow (Zv.Khelade at all. "New usage of Plasma flow” producer 2008.06.26
#4825) and the traditional methods gave the opportunity to achieve the high
effectiveness of the treatment: decreased dryness of the skin, paleness of the
skin and cyanosis, and warming up of the extremity if the ischemic form takes
place; decreased pain in the damaged extremities, and total vanishing of the
pain in 7 cases; decreased swollenness in 11 patients, and total liquidation in
6 cases; it lowered demarcation zone in 15 patients; in 12 cases the size of
ulcers was decreased, and in 5 cases – they were completely treated; recovered
pulsation of the art. tibialis post. and art. dorsalis pedis in 17 patients.
The use of given method in the patients with DM and DFS allows the
stabilization of the level of glycemia and lowers the dose of hypoglycemic
drugs, or lowers the level of sugar in the blood when using the previous doses
of the hypoglycemic drugs. The combined treatment improves hemodynamics,
increases the level of energy shift in the nervous tissue, widens the
contracted blood vessels, gives anti- inflammatory effect and improves the
subjective self-appraisal of the patient.
Auth.
8.g.13.6.100. Prevalence and
factors influencing cigarette smoking among medical and non-medical university
students in Tbilisi, Georgia: a cross-Sectional study. /N.Maghlakelidze, I.Chkhaidze, T.Maglaklekidze/. II
International Congress of Respiratory Association of Georgia. – 2010. – geo.; abs.
geo., eng.
This study shows that smoking prevalence in medical
and non-medical students of Georgia is extremely high. The gap in smoking
related education among medical students was evident and this highlights the
need to identify factors to be included for improving anti-smoking education in
the universities and planning effective anti-smoking programs.
Auth.
8.g.13.6.101. The prevalence
of the chronic obstructive pulmonary disease in the town of Telavi, Georgia: a
cross-sectional study. /M.Maghlakelidze,
I.Chkhaidze, T.Maghlakelidze/. II
International Congress of Respiratory Association of Georgia. – 2010. – geo.;
abs. geo., eng.
The results of the study can serve as the good
baseline data for broader studies on COPD prevalence, which should focus on the
impact of various risk factors. Specific public policy issues need to be
re-examined from the angle of environmental contribution to the burden of COPD.
Introduction of spirometric examination for diagnosing COPD should be ensured
at all relevant health facilities. Anti-tobacco policies need to be reinforced.
Definition of COPD has to be included in Georgian State Medical Standards list.
Awareness needs to be raised on COPD among healthcare personnel.
Auth.
8.g.13.6.102. Pain perception among depressed heroin
addict patients. /V. Kenchadze, E.
Tchkonia, Z. Beria, N. Okribelashvili, G. Naneishvili, G. Sikharulidze/.
Georgian Medical News. - 2010. - #10 (187). – pp. 43-47. – eng.; abs.: geo., eng., rus.
Investigation of heroin
addict patients in post-abstinent state reviled that low mood, anxiety, tension
and guilt feeling increased sensitivity toward pain, which mostly experienced
as algetic, coenestetick and hypochondria sensations. Algetic symptoms highly
correlated with psychopathology. Efficient treatment of psychopathological
symptoms decreased pain. It is concluded that atypical antipsychotic quetiapin
monotherapy could be used for treating such conditions.
Auth.
8.g.13.6.103. Treatment characteristics in elderly. /S. Dalakishvili, N. Bakuradze, M. Ghughunishvili, R.
Jojua, E. Areshidze/. Georgian Medical News. - 2010. - #10 (187). – pp. 48-51.
– eng.; abs.: geo., eng., rus.
The pharmacodynamics and
pharmacokinetics of medications, their therapeutic and toxic effects are age
dependant. In the treatment of old people polypharmacy is widely used. The most
common results of polypharmacy are increased adverse drug reactions, drug-drug
interactions. In this study the use of different medications at the Departments
of General Medicine and Cardiology (
Auth.
8.g.13.6.104. Ecological problems caused by global warming
and population health risks. /B. Zurashvili, M.
Giorgobiani/. Experimental and
Clinical Medicine. – 2010. - #4(59). - pp. 14-16. – geo.; abs.: eng.
Climate change is a
change in the statistical distribution of weather over periods of time that
range from decades to millions of years. The Earth’s climate has changed
throughout history. From glacial periods (or "ice ages”) where ice covered
significant portions of the Earth to interglacial periods where ice retreated
to the poles or melted entirely – the climate has continuously changed. Factors
that can shape climate are climate forcing. These include such processes as
variations in solar radiation, deviations in the Earth’s orbit, mountain-building
and continental drift, and changes in greenhouse gas concentrations. Levels of
carbon dioxide, methane and nitrous oxide gases are rising, mainly as a result
of human activities. Carbon dioxide is being dumped in the atmosphere at an
alarming rate. Since the Industrial Revolution, humans have been pumping out
huge quantities of carbon dioxide, raising carbon dioxide concentrations by 30%
and average global temperature appears to have risen between 10C and
20C. Obviously, climate has a big influence on plants and animals in
the natural environment, on oceans, and on human activities, such as
agriculture, water supplies, and heating and cooling. The effects of climate
change depend upon how much change there is, how fast it occurs, and how easily
the world can adapt to the new conditions. These problems are mortified and
needs them to be solved. This needs different specified professional relations,
for example the scientists which are working in this medical sphere. G. Natadze
Scientific-Research Institute of Sanitary and Hygiene created on its base a
scientific practice center for global warming and for the health of the
population. The target is to avoid the changing of the climate and the risks,
treatment and rehabilitation of the deceases which can be created.
Auth.
8.g.13.6.105. Biodegradation of egsogenous phenol in the
organism of rat. /B. Arziani, G.
Lekishvili, Ts. Chikhladze, M. Nadirashvili/. Experimental and Clinical Medicine. – 2010. - #4(59).
- pp. 21-24. – geo.; abs.: eng., rus.
Biodegradation process
of 1-6-14C-phenol in organism of rat has been studied. It was established that
metabolism of its molecule proceeds at high rates at intraperitoneal injection
of the aforementioned xenobiotic. Extent of degradation of the aromatic ring
was also high. Major contribution to radioactivity has to be attributed to the
conjugation product of phenol with glucuronic acid. Phenol sulfate as an
outcome of biotransformation was not found among conversion products. Part of
the injected phenol is excreted untransformed.
Auth.
8.g.13.6.106. Toxicological
issues connected with lead-containing substances. /N. Lobzhanidze, N. Tchavchanidze, T.
Giorgobiani, L. Rusieshvili, E. Kourdadze/. Experimental and Clinical Medicine. - 2010. - #4(59).
- pp. 24-27. – geo.; eng., rus.
The harmful effects of
lead intoxication were well-known as early as in the 1940 years. Nowadays, lead
is still the leading substance among those causing industrial poisoning. This
article reveals and discusses a clinical case of intoxication by lead. Several
recommendations for prevention and treatment of such cases are also provided.
Auth.
8.g.13.6.107. Supercritical Co2 extraction
of food colorants from vegetable matrices. /M. Tsitsagi, G. Kvartskhava, M. Chkhaidze,
I. Jinikashvili, M. Khachidze/. Experimental and Clinical Medicine. – 2010. -
#4(59). - pp. 34-38. – eng.; abs.: eng., geo.
Natural food colorants
are favored over the synthetics in recent years. Production of synthetic dyes
is cheaper; their products have bright, vivid color and are stable, but natural
ones considered as healthy products. The most abundant natural food colorants
are anthocyanins, carotene and
lycopene. Grape skin, mandarine, orange and persimmon peels, tomato paste waste
are good source of natural colorants in Georgia. Supercritical fluid extraction
is advanced separation technique for receiving food colorants.
Auth.
8.g.13.6.108. Rational use of plant raw materials for
obtaining medical means. /N. Kavtaradze, T.
Alavidze, I. Mikadze, R. Uridia, A. Dolidze/. Experimental and
Clinical Medicine. – 2010. - #4(59). - pp. 38-41. – geo.; abs.: eng., rus.
Getting compounds on the
basis of plant metabolites and their derivatives isolated from local plant raw
materials (groundsel, coniferous plants, alpine sorrel, grape stones) makes it
possible to obtain and use new natural hydrocarbon, anthraquinone and alkaloid
block-syntones. It gives an opportunity to receive variety of interesting
biologically active substances. Obtaining of new medical preparations on the
basis of them is possible.
Auth.
8.g.13.6.109. Use of natural resources of
The aim of this work is
the use of natural resources of Georgia - mud (pelloidy), bentonite clay,
mineral water, alcoholic and oil extracts of medicinal plants for cosmetic
purposes. Based on these ingredients for the first time to obtain new
formulations of cosmetics - cream-mask, toothpastes and shampoos.
Auth.
8.g.13.6.110. Biologic activity of grape products. /N. Antelava, M. Okujava, K. Pachkoria, M.
Ghonghadze/. Experimental and
Clinical Medicine. - 2010. - #4(59). - pp. 47-50. – geo.; res.:eng., rus.
The article deals with
the antioxidant role of grape polyphenolic compounds in prevention of free radical
related diseases. The review of the literary data of red wine polyphenols
protector activity on molecular, sub-molecular levels and whole human body
depending on wine brand, preparation technology and volume of consumption was
performed. According to the reviewed literature, polyphenolic extracts and
separate compounds of wines are used as medicines in clinical practice for
prevention of free radical diseases, as well as in cosmetology and spa therapy.
A further investigation of the biological activity of different brands of
wines, wine extracts, grape compounds and alcohol free beverages is desirable.
Auth.
8.g.13.6.111. Zeolite medical preparations. /V. Tsitsishvili, N. Dolaberidze, M. Alelishvili, G. Tsintskaladze, N.
Mirdzveli, M. Nizharadze/.Experimental and
Clinical Medicine. – 2010. - #4(59). - pp. 50-53. – rus.; abs.: eng., geo.
Natural and synthetic
zeolites are used in medicine as sorbents and ion exchangers in different
forms, in the US, Japan and several other countries "liquid zeolites” are
marketed mainly, Megamin – "tribomechanically activated”
clinoptilolite-containing preparation is popular in Europe, China prefers
traditional powders, in Russia original Litovit in many modifications has been
developed. Georgia is rich by natural zeolites (clinoptilolite, phillipsite,
etc.), their physical and chemical properties are well studied, showing
possibility of application for medical uses.
Auth.
8.g.13.6.112. New zeolitic materials for increasing the
reduction process of damaged bone tissue. /G. Tsintskaladze, M. Gersamia, V.
Tsitsishvili, K. Ebralidze, M. Burjanadze/. Experimental and Clinical Medicine. - 2010. - #4(59).
- pp. 53-56. – geo.; abs.: eng., rus.
Clinoptilolite, natural
zeolites located in Georgia, enriched by phosphorus and calcium was studied.
Investigations on the rabbits show the possibility of using these materials in
clinical practice for treatment of osteomelite, odontogenic cist, for
completion of defects of jaw bones.
Auth.
8.g.13.6.113. Minerals and glutamininic acid containing a
biologically active food additive. /I. Beshkenadze, M.
Gogaladze, N. Zhorzholiani, N. Osipova, I. Lomtadze/. Experimental and Clinical Medicine. – 2010.- #4(59).
- pp. 56-59. – geo.; abs.: eng., rus.
We synthesized the
chelate type compounds which contain glutaminic acid and minerals. The
synthesized compounds were identified and a series of physical and chemical
properties (melting, solubility in various solvents, and nature of metal-ligand
bond) were defined. Powder form biologically active additive was prepared on
the basis of the synthesized compounds. It can be used as a dietary supplement
and can provide for: nutrition rationalization (compensation of mineral
deficit); psycho-stimulation effect and heightening of capacity for work, improvement
of mood and sleep; decrease of ration caloric content, decrease of body weight;
satisfaction of physiological demands of a man for food; and restoration of
reduced immune system in men.
Auth.
8.g.13.6.114. The role of rehabilitation and valeology in
the health management system. /I. Dolidze/. Experimental and Clinical Medicine. - 2010. -
#4(59). - pp. 80-83. – geo.; abs.: eng., rus.
The development of
health management system requires integrated collaboration of scientists from
various fields, including of rescusciutators, valeologists, with participation
of pathologists and sanologists. The First problem is organization of the
collaboration between the scientists from deferent fields, who are working on
the problematic issues of healthy and ill people. Secondly, with integrated
method of approach have to be worked out criterions of scientific knowledge
systems, and on the bases of these, should be determined the special purpose
and development strategy of field.
Auth.
8.g.13.6.115. Correction of non-modifiable risk factors in
adults. /N. Burkadze, A.
Isakadze, Sh. Shurghaia/. Experimental and Clinical Medicine. - 2010.
- #4(59). - pp. 83-85. – geo.; abs.: eng.,
rus.
1. Identification of
arterial hypertension, overweight, low physical activity, smoking, alcohol and
salt over usage, psycho-emotional stress and drug addiction in the same
populations. 2. Stratification of examined populations to risk-groups (low,
middle and high risk groups). 3. Development and implementation of
differentiated preventive intervention programs for middle and high risk
groups. 4. Development of measures for healthy lifestyle principles promotion
(development and distribution of educational literature taking into
consideration specific features of the population, trainings with active
participation of adults, information and involvement of mass media). 5. Dynamic
supervision of the whole population (with examination of focus groups) and
implementing preventive activities. 6. Assessment of regular dynamic
supervision and active intervention significance for risk-factor correction
(repetitive testing of population, examination to detect risk factor
frequency). 7. Development of the model for youth education on healthy
lifestyle principles and its recommendation for implementation in public health
Auth.
8.g.13.6.116. State of physical factors of environment of
Tbilisi subway. /N. Khunashvili, R. Kverenchkhiladze, M. Tsimakuridze, L.
Bakradze/. Experimental and
Clinical Medicine. – 2010. - #4(59). - pp. 92-98. – geo.; abs.: eng., rus.
Based on complex
investigations there are established the unfavorable state of environment
physical factors of Tbilisi subway – noise, vibration, and lighting. Parameters
of noise and common vibration in most of cases exceed the acceptable levels.
The noise is broadband, exceeding the level, basically, on middle and high
frequencies of the spectra. The degree of exceeding the noise level depends on
noise regime of premise - at movement of rolling-stock the noise level reaches
up to 108 dB, exceeding the limit acceptable level by 28 dB. The parameters of
common vibration at movement of
rolling-stock exceed the limit acceptable level by 9 – 20 dB. State of
lightening is characterized by unfavorable parameters that require the
significant effort of visual analyzer function. The level of satisfaction of
the lightening standards in average consists 88-95%. Investigations conducted
became the basis of elaboration of complex sanitary measurements on regulation
of the noise, vibration and lightening in premises of Tbilisi subway.
Auth.
8.g.13.6.117. Bottom sediments in the downstream sections
of the
Bottom sediments of the
rivers of the Georgian Black Sea basin have been studied. The grain size
parameters, the content of metals (Fe, Mn, Cu, Zn, As, Ni, Cr), organic carbon
and total petroleum hydrocarbons have been determined. On the basis of a
comparison with previous studies, tendencies in the alteration of the content
of metals have been established; a linkage between the lithology and the
chemical composition of the bottom sediments has been established.
Auth.
8.g.13.6.118. Modern dynamics of the eastern coastal zone
of the Black Sea at the town of Poti. /B. Lebanidze, I.
Papashvili, V. Gvakharia/. Experimental and
Clinical Medicine. - 2010. - #4(59). - pp. 112-117. – rus.; abs.: eng., geo.
The
Auth.
8.g.13.6.119. Determination of petroleum hydrocarbons in
the Georgian sector of the Black Sea. /N. Gelashvili, G.
Maisuradze, V. Gvakharia/. Experimental and
Clinical Medicine. - 2010. - #4(59). - pp. 117-121. – geo.; abs.: eng., rus.
The article delivers
materials which may be useful for people involved in surveys of oil and oil
products in the environmental elements and assessment of their ecological role.
It also delivers findings of our researches relating to oil pollution level
within the Georgian sector of the Black Sea, as well as pollution sources and
nature (technogenic, natural).
Auth.
8.g.13.6.120. Peculiarities of cytogenetic disorders from
the impact of the ecological chemical mutagens on the human organism. /A. Zedginidze, M. Antelava, Kh. Gvimradze, M. Gagoshidze, N. Manjavidze/. Experimental and Clinical Medicine. - 2010.
– #4(59). - pp. 121-123. – geo.; abs.: eng., rus.
The investigation of the
chemical mutagens’ impact on the organism of children and adolescents living in
the arsenic-polluted environment gave us the opportunity to detect that the
character of the cytogenetic disorders differed from the earlier detected
disorders upon the impact of the physical mutagens. The level of acrocentric
chromosomal associations did not give us the chance to ascertain the fact of
the mutagen impact. Chromosomal aberrations are presented mainly as exchange
disorders, and as micronuclei only detect the fact of the mutagen impacts, not
giving the chance to judge their quantitative parameters.
Auth.
8.g.13.6.121. Estimation of
risk factors at children’s age under conditions of arsenic action. /M. Gagoshidze, N. Manjavidze, L. Aladashvili, K.
Gogberashvili, V. Shanidze/. Experimental and Clinical Medicine. – 2010. -
#4(59). - pp.124-127. – geo.; abs.: eng., rus.
The work purpose is:
studying the influence of the environment polluted by arsenic on indicators of
health and disease of children and teenagers and an estimation of risk factors.
Research of children and teenagers has been carried out a current of 10 years
for the purpose of studying of influence of the environment polluted by arsenic
living in Lukhuni gorge in the territory adjoining to a point of production
factory of mountain-chemical arsenic, and a children’s cohort of the same age
and with the same social and economic conditions living on rather remote
territory, in the conditions of the weakened action of arsenic (Randomization
control) - In total 878 children. The assessment of a risk factor with use of a
quality monitoring has been given; relative and attribute sizes of risk of
conditions of the environment polluted by arsenic and an authentic interval on
their groups for each factor are estimated. An assessment of a difference
between groups spent criterion 2 (Pearson). For quality indicators and for
quantitative criteria t, the difference was considered authentic if 2>3,84, p<0,05 and
t>1,96, p<0,05. The Software is carried out with use of package SPSS of
11,5 programs. On our researches in conditions environment polluted by arsenic
in Luhuni gorge, in comparison with Ambrolauri and near location villages,
marked increase in risk of pathological pregnancy, in particular premature
birth; the average data of the basic indicators of physical development
specifies on statistically authentic left; at children of school age
considerable deviations in health, authentic growth of disease by acute
respiratory and other infections are marked.
Auth.
8.g.13.6.122. The effect of pollution of Kvemo Kartli
region’s rivers on the health of population and ways of its prevention. /D. Ioseliani, N. Kalabegashvili, G. Balarjishvili, L. Samkharadze, T. Alavidze, K.
Ebralidze/. Experimental and
Clinical Medicine. - 2010. - #4(59). - pp. 132-135. – geo.; abs.: eng., rus.
The work considers
indices of hydrosphere and soil pollution as the result of activity of JSC
Madneuli Mining Company (ore mining and processing enterprise), the largest
enterprise in the one of the most important agricultural regions of Georgia,
and results of its effect on the health of the region’s population. The new
technological method of purification of quarry sour waters is offered that
secures selective separation of heavy metals and improvement of ecological
situation in the region and, respectively, of the health of population.
Auth.
8.g.13.6.123. Self-medication with antibiotics and related
problems. /N. Gorgaslidze, K. Bakuridze, N. Gongadze, N. Nizharadze,
N. Shengelidze, N. Surmava, T. Makharadze/.
Experimental and
Clinical Medicine. - 2010. - #4(59). - pp.135-139. – geo.; abs.: eng., rus.
Our investigations were
carried out on citizens from different towns of
Auth.
8.g.13.6.124. The influence of the product of
3-(2’-P-methoxyphenylvinil)-ih-pyrrolo[2,3-]-quinoline on the morphological
pictures, functional parameters (Alt, Ast) of liver, on the coagulation system
of rats. /B. Arziani, M.
Tsitsagi, N. Gongadze, L. Gabunia,
Sh. Petriashvili/. Experimental and
Clinical Medicine. - 2010. - #4(59). - pp.139-142. – geo.; ress.: eng., rus.
Since derivate of
3-(2’-p-methoxyphenylvinil)-IH-pyrrolo[2,3-]-quinoline by its chemical
structure is similar to indirect anticoagulants such as warfarine, we have
studied the action of this substance on the coagulation system and on the liver
of rats. It was shown that using of 3
-(2’-p-methoxyphenylvinil)-IH-pyrrolo[2,3-]-quinoline in a dose o,o6 mg./kg.
manifested anticoagulative effect without toxo-morphological and functional
parameters in rats. It was shown that using of 3-(2’-p-methoxyphenylvinil)-H-pyrrolo
[2,3-]-quinoline in a dose 0,06 mg./kg. manifested anti-coagulative effect
without toxic changes of liver morphological picture and functional parameters,
which was correlated to its chemical structure. It was suggested that the new substance
with closely relationship by chemical structure to warfarin revealed the
similar anticoagulative effect without any pronounced changes of liver
morphological picture and functional parameters.
Auth.
8.g.13.6.125. Peculiarities of health state of the
chemical industry workers in Georgia. /M. Tsimakuridze, G. Kverenchkhiladze, R. Zabakhidze,
D. Zurashvili, E. Maisuradze/. Experimental and
Clinical Medicine. - 2010. - #4(59). - pp. 152-154. – geo.; abs.: eng., rus.
A study has been
conducted regarding the influence of working conditions on workers’ state of
health at an enterprise "AZOT” in
Auth.
8.g.13.6.126. Peculiarities of the immunological state of
occupational diseases caused by manganese. /N.
Khachapuridze, D. Zurashvili, M. Tsimakuridze, M. Kvartskhava, P. Tsimakuridze,
M. Khajrishvili/. Experimental and
Clinical Medicine. - 2010. - #4(59). - pp. 155-157. – geo.; abs.: eng., rus.
The aim of the research
is to find immunologic indicators in patients suffering from occupational
pathology caused by manganese. Peculiarities of immunological shifts have been
determined, such as the diminishing quantity of T-lymphocytes, violation of the
ratio of helper and suppressive sub-population, while the quantity of
B-lymphocytes stays the same; disimmunoglobulinemia,
characterized with decreasing IgG and IgA and increasing IgE levels, while IgM
remains the same in the case of workers with bronchial asthma. Patients
suffering from manganese are characterized of decreasing numbers of
T-lymphocytes, helpers and suppressors; increasing number of B-lymphocytes,
decreasing IgG and IgA, while IgM being the same. The obtained information
allowed us to determine the immunologic background of the examined patients. It
gave a start to subsequent research towards preventive pathogenetic measures of
an occupational pathology caused by manganese.
Auth.
8.g.13.6.127. Hygienic
estimation of pollution of drinking and surface waters with heavy metals
connected with mining and processing industry in Chiatura. /M. Grdzelishvili, M. Mirtskhulava, N.
Chakvetadze, M. Giorgobiani, M. Lashkhauri/. Experimental and Clinical Medicine. - 2010. - #4(59).
- pp. 167-169. – geo.; rus.: eng., rus.
The study of pollution
of basic environmental objects - water, soil and free air with toxic heavy
metals, has become very important lately,. The purpose of this work was to
study the pollution degrees of environmental objects (water, bottom sediments,
air) connected with the mining and processing production in Chiatura, to
estimate risks, and to introduce innovative technologies. As a result of this
work, it was found out that pipeline drinking water in Chiatura is polluted and
it is not safe from the epidemiological standpoint. High content of dissolved
manganese is noted in the well water of general use. An increased alkaline
content of surface water, increased electric conduction and temperature of
water point to an intensive growth of pollution of the river Kvirila by sewage
from central processing factories and by ore remainders, the so-called
"tails”, located on the banks of the rivers and streams Shukruti and
Darkveti.
Auth.
8.g.13.6.128. Nutrition survey of primary school students
in some selected vulnerable schools of
The rapid
non-representative nutrition survey was carried out in 2005 by the State
Research Institute of Hygiene and Sanitary of Georgia (SRIHS) with the
financial and technical support of the United Nations World Food Programme
(WFP). The survey aimed at obtaining data and information on the nutrition
status, iron and iodine deficiencies, short-term hunger, concentration and
learning capacity, the enrolment and attendance rate of primary school children
in ten schools located in the most disadvantaged communities of the six most
vulnerable regions of Georgia.
Auth.
8.g.13.6.129. Influence of magnetic field and plant
preparation on passive avoidance reaction and its neurochemical correlates in
the brain of rat. /M. Nikolaishvili, T. Mchedluri, N. Mindiashvili, M.
Tchitchakhua, G. Iordanishvili/.
Experimental and Clinical Medicine. - 2010. - #4(59). - pp. 172-174. – rus.;
abs.: eng., geo.
Influence of power
frequency electro-magnetic field (EMF) in rats induces some deviations in the
formation and retention of passive avoidance reaction. In particular, during
actions of power frequency EMFs animals behavioral act‘s implementation is
hindered and affects the passive avoidance reaction in rats. The animal‘s
nervous tension, amazement and disability to solve the given task are clearly
evident. As to the impact of a plant composite, the influence of this elixir is
obvious. In animals, it inhibits emotion and increases the probability of right
decision-making as compared to the control.
Auth.
8.g.13.6.130. The rare case of acute intravenous
intoxication by copper sulfate. /G. Katsitadze, S. Kutubidze, M. Tandilashvili,
The cases of
intoxication by copper sulfate (CuSO4) are known in the countries where
viticulture is developed and copper sulfate is used as a pesticide. There are
also the cases of poisoning by copper sulfate through traditional (injective)
way of intoxication. Poisonings usually are accidental or suicidal in nature.
Our case is absolutely unique because the copper sulfate was administered
intravenously in a suicidal attempt. The case is about a 21 year-old man, who
took with suicidal intentions 5 ml concentrate solution of copper sulfate by
means of a syringe. In this case all the symptoms of acute intoxication by
copper sulfate were obvious. The only indication which is not typical for the
acute per oral intoxication by copper sulfate was the fast developing of
respiratory distress-syndrome. The patient was subjected to a complex treatment
and left the hospital in a good condition of health.
Auth.
8.g.13.6.131. Coordinated admixtures of some metals with
hydrazines and their products: research and application prospects. /N. Didmanidze, R. Machkhoshvili/. Experimental and Clinical Medicine. – 2010.
- #5(60). - pp. 43-46. – geo.; abs.: eng.
The increased interest
toward the research of coordinated admixtures of metals with hydrazines and
their products is preconditioned by the specific physical and chemical
properties of hydrazines, hydrazones and their relevant coordinated admixtures,
as well as their application prospects in medicine, agriculture and industry.
Hydrazines and hydrazones contain biologically active peptide groups and are
more interesting for the research as medial models of biological fixation of
azote. Hydrazines and their products in coordinated admixtures with biometals
are medically proven as anti-tuberculosis, psychotropic and anti-cancerogenic
medications. The recent discoveries have also pointed out their anti-anemic,
bactericidal, bacteriastatic and cardio therapeutic activity, with a wider
spectrum of both treatment and prophylactic impact. Acilhydrazone compounds are
used in medicine and agriculture as herbicides, insecticides and regulators of
vegetation growth. The researches in this direction are apparently interesting
and prospective. Prior to the research we carried out a study of hydrazine and
hydrazone compounds of some metals (formil-, acetyl-, phenylacetyl -, benzoil-,
nytrobenzoil-, and other products). We have synthesized the compounds at
different conditions of pH: Coordination compounds: of Cu (II) with formyl-,
acetyl- and benzoilhydrazones of salicylic aldehyde; of metals- Cu (II), Zn,
Co(II) with formyl-, and benzoilhydrazones of acetone; of metals- Cu (II), Zn,
Co(II) with colchicine; of metals- Cu (II), Zn, Co(II) with
brombenzoilhydrazone of benzaldehide; of metals- Cu (II), Zn, Co(II) with
brombenzoilhydrazone of salicylic aldehyde; of Cu, Zn, Cd, Co, Ni, with acetone
brombenzoilhydrazone; of Cu (II) with ortho-hydroxibenzoilhydrazone of
benzaldehyde and other compounds. The synthesized coordinated compounds are
studied with the use of physical, chemical, magnetic-chemical,
thermo-gravimetrical, spectroscopic and roentgen-structural methods. The
studies ascertained the nature of chemical valency and chemical structure of
the realized metallacycles. The study drew conclusions to the specific part of
the synthesized bio-metal compounds as relevant for application with medical,
prophylactic and herbicide purposes.
Auth.
8.g.13.6.132. Study of antioxidant properties of Saperavi grape oil on rats. /M. Nikolaishvili, T. Mchedluri, D. Margalitashvili,
M. Gagolishvili/. Experimental and
Clinical Medicine. – 2010. - #6(61). - pp. 17-22. geo.; abs.: eng.
Our researches have
shown that oil extracted from the seeds of Saperavi
grapes administered to Vistar rats daily for a week (3 ml of 25% elixir
intraperitoneally) increased their survival, and the factor of dose alteration
was equal to 1,23.
Auth.