Contents
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Natural Sciences |
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Mathematics |
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Computer and information sciences |
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Physical
sciences |
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Chemical
sciences |
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Earth and related environmental sciences |
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Biological
sciences |
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1.7 |
Other
natural sciences |
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Engineering and
Technology |
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Civil
engineering |
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Electrical
engineering, electronic engineering, information engineering |
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Mechanical
engineering |
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Chemical
engineering |
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Materials
engineering |
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Medical
engineering |
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Environmental
engineering |
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Environmental
biotechnology |
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Industrial
Biotechnology |
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Nano-technology |
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Other
engineering and technologies |
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Medical
and Health Sciences |
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Basic
medicine |
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Clinical
medicine |
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Health
sciences |
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Health
biotechnologies |
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Other
medical sciences |
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Agricultural
Sciences |
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Agriculture,
forestry and fisheries |
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Animal
and dairy science |
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4.3 |
Veterinary
science |
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Agricultural
biotechnologies |
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4.5 |
Other
agricultural sciences |
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Social Sciences |
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5.1
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Psychology |
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Economics
and business |
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Educational
sciences |
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Sociology |
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Law |
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Political
Science |
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5.7 |
Social
and economic geography |
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5.8
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Media
and communications |
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Other
social sciences |
b14.1.1.1.
On a pricing model under conditions of uncerainty. /M. Salukvadze, V. Zhukovskiy/. Proceedings of A. Eliashvili Institute of Control Systems. – 2014. – #18. – pp. 125-129. – geo.; abs.: geo., eng., rus.
The pricing modeling problem is considered
taking into consideration the expected excise, the level of which is previously
unknown. In 1929 American scientist
Harold Hotelling created pricing model in a duopoly which takes the spatial
arrangement of firms into consideration. In the given work the model of Hoteling
under uncertainty in case of two players - firms is considered. Conditions of
Pareto-guaranteed balance are received and their construction is shown;
internal minimum by Pareto is found; the balance situation according to Nash is
constructed; the guaranteed profits of players are built. Ref. 5.
Auth.
The problem of parameter identification of
linear dynamic systems with variable parameters is considered. The system of
linear ordinary differential equations of a normal kind is considered as a
structure of model structure; in addition, the elements of output matrix are variables. The problem of parameter identification is stated
as, in a certain sense, an inverse problem of Cauchy’s problem for linear
ordinary equations. Under some restrictions on the system’s parameters, and
input and output variables the existence theorem of such interval, in which a
continuous matrix of coefficients is identified, is formulated and proved. The
parameter estimation algorithm is investigated by the example of the
second-order system identification. Ref. 14.
Auth.
b14.1.1.3. Determination
of optimal proportions of drums and optimal amount of production upon
restrictions on raw materials. /D.Sikharulidze/. Proceedings of the A.
Eliashvili Institute of Control Systems. – 2014. – #18. – pp. 147-151. – geo.; abs.: geo., eng., rus.
Two practical problems are considered in the
paper. First of them is concerned with determination of optimal proportions of
cylindrical containers/drums, required for liquid service, when shipping cost
for one container in spite of dimension is constant. Container capacity should
not exceed the predetermined value. This problem is reduced to the problem of
geometric programming. The solution is obtained in an analytical form. The
second problem concerns the determination of optimal production amount in the
case of perishable raw material: several types of products, the shelf life of
which nears expiration and their maximal utilization are desirable to avoid
loss. Several specific types of product are manufactured. The sale price of
each manufactured unit is predetermined, as well as the raw material stock for
the planning period. This problem is reduced to the linear programming problem.
The solution of given example is obtained using MATLAB. Tab.
1, Ref.1.
Auth.
b14.1.1.4. Using numerical methods for real-time calculations. /D. Tsintsadze, K.Omiadze/. Proceedings of the A.
Eliashvili Institute of Control Systems. – 2014. – #18. – pp. 180-184. – geo.; abs.: geo.,
eng., rus.
Computer simulator is a primary node in the
modern control system; this includes the mathematical model of the dynamic
object, and in the control loop - people. So, for perfecting performance
calculations must be carried out in real time. The principles of computational
mathematics suggest various methods for drawing mathematical schemes. In this
case, a numerical method of calculations applied. The article describes how to
move an object in space. Argumentation: numerical integration formulas, the
table sequence instruction execution. The paper provides programs to calculate
coordinates and plotting the motion of point made by BASIC. Tab. 1, Fig. 3, Ref. 4.
Auth.
b14.1.1.5. The
optimal selection of the shape, size and orientation of a building. /O. Kighuradze, G.
Ketelauri/. Proceedings of the A. Eliashvili Institute of Control Systems. –
2014. – #18. – pp. 105-110. – geo.; abs.: geo.,
eng., rus.
The shape, size and orientation must be
chosen so as to maximize the climate’s positive impact on the thermal balance
of the building and to neutralize the negative environmental impacts.
Dimensions of the building change upon optimization and by calculation the
ratio of basic building’s sides 52m/13m is changed to 31m/23m; also, given
solar radiation, heat losses in the heating area and the heating capacity
reduce by 31%. Tab. 3, Ref. 2.
Auth.
b14.1.1.6. Fundamental
property of optimal betting odds. /V. Khutsishvili/. Proceedings of the A.
Eliashvili Institute of Control Systems. – 2014. – #18. – pp. 136-141. – rus.; abs.: geo., eng., rus.
A new - H-model of transition from the
betting odds to probabilities and back is substantiated; its advantages over
the classical E-model are listed. Based on the H-model, the phenomenon of the
favorite-longshot bias is explained. ltimately, a fundamental property of
optimal betting odds, providing the opportunity for a qualified transition from
coefficients of events to their probabilities and vice versa, is identified. It
is represented in the form of the axiom, which states that for the optimal
coefficients the payout
Auth.
b14.1.1.7. Relation
between the probabalities of events and bookmakers’ odds. /V. Khutsishvili/. Proceedings
of the A. Eliashvili Institute of Control Systems. – 2014. – #18. – pp. 142-146. – rus.; abs.: geo., eng., rus.
The theory of the transition from the betting
odds of events to their probabilities and back is proposed based on the axiom
stated in [1]. The theorem about the non-optimality (understated) of the odds
on the popular classic double and no draw results is proved. The general scheme
for calculating the optimal derivatives odds is also given. In particular, the
process of mass production of the odds for virtual games type Liverpool –
Federer is described. Links to Web pages, where the described schemes are
implemented, are given. On one of these, from the odds, describing the chances
of tennis players before the start of a match, the root probabilities’
identification and the automatic calculation of the basic and all kinds of
derivative in play odds is organized. Ref. 3.
Auth.
b14.1.1.8. On
testing the hypothesis of equality of two Bernoulli regression functions. /E. Nadaraia, P. Babilua, G. Sokhadze/. Bulletin of the
Georgian National Academy of Sciences. – 2014. – vol. 8. – #1.– pp. 18-26. –
eng.; abs: eng., geo.
The limiting distribution of an integral
square deviation between two kernel type estimators of Bernoulli regression
functions is established in the case of two independent samples. The criterion
of testing is constructed for both simple and composite hypotheses of equality
of two Bernoulli regression functions. The question of consistency is studied.
The asymptotics of behavior of the power of test is investigated for some close
alternatives. Ref. 7.
Auth.
b14.1.1.9. Problem of elasticity and plasticity
for a plate with a shape of n-angle weakened by n-holes. /Z. Abashidze/. Bulletin of
the Georgian National Academy of Sciences. – 2014. – vol. 8. – #1.– pp. 27-31.
– eng.; abs: eng., geo.
A homogeneous, isotropic plate with a shape
of rectilinear n-angle weakened by n-cyclic symmetric holes is considered. The
plate is in a stressed state; a region of plasticity contains only contours of
holes and does not spread inside of the plate. A problem of elasticity and
plasticity for this plate is reduced to a boundary problem of linear
relationship for a unit circle with sectionally constant coefficients. The
equation of unknown contours of holes is presented; the solution of this
problem is obtained. Fig. 1, Ref. 6.
Auth.
b14.1.1.10. Clark’s representation of Wiener
functionals and hedging of the barrier option. /O.
Glonti, O. Purtukhia/. Bulletin of
the Georgian National Academy of Sciences .– 2014. – vol. 8. – #1.– pp. 32-39.
– eng.; abs: eng., geo.
Bachelier’s model of financial market is the
payoff of Knock-Out Barrier Option, the Clark’s integral representation with
explicit form of integrand is obtained. This functional represents the product
of European Call Option payoff and indicator of some event. It is impossible to
use directly the Clark-Ocone’s formula because the indicator of event is
Malliavin differentiable if and only if probability of this event is equal to
zero or one. We use our integral representation of functionals of Wiener
process, which slightly generalizes the Clark-Ocone’s formula, and obtain the
explicit form of integrand. This integrand is the optimal hedging strategy replicating
the Knock-Out Barrier Option in case of Bachelier’s model. Ref. 4
Auth.
b14.1.1.11. Non-local contact problem for
two-dimensional linear elliptic equations. /D. Gordeziani, I. Meladze/.
Bulletin of
the Georgian National Academy of Sciences .– 2014. – vol. 8. – #1.– pp. 40-46.
– eng.; abs: eng., geo.
A non-local contact boundary problem for
two-dimensional linear elliptic equations is stated and investigated. The
uniqueness of the solution is proved. The iteration process is constructed,
which allows one not only to prove the existence of a regular solution of the
problem, but also to develop an approximate algorithm of its solution. The
solution of a non-local contact problem is reduced to the solution of classical
boundary value problems, in particular to the solution of Dirichlet problems.
Fig. 1, Ref. 22.
Auth.
b14.1.1.12. New approach to global optimization
based on PSO. /B. Meparishvili, Ts. Koroglishvili/. Automated Control
Systems. – 2014. – #1(17). – pp. 17-22. – eng.; abs.:
geo., eng., rus.
This paper is devoted to one of the global
optimization algorithms, which especially focuses on evolutionary computation
by discussing Particle Swarm Optimization (PSO). Swarm intelligence is an
exciting new research field still in its infancy compared to other paradigms in
artificial intelligence. Particle swarm optimization algorithms have gained
popularity in recent years. PSO is a population-based method, a variant of
evolutionary algorithms with moving towards the target rather than evolution,
through the search space. The movements of the particles around in the
search-space are guided by their own best known position in the search-space as
well as the entire swarm’s best known position. The improvement of positions is
necessary condition to guide the movements of the swarm. The gradient of
fitness or cost function, which must be optimized, is not known. The goal is to
find a solution in the search-space, which would mean is the global optimum.
The process is repeated and by doing so it is hoped, but not guaranteed, that a
satisfactory solution will eventually be discovered. Ref. 10.
Auth.
b1.2
Computer and information sciences
b14.1.2 1. The
comparative analysis of data processing in the LabView and MathCad environments. /I. Chkheidze,
L.Tokadze/. Transactions of Technical University of Georgia.
– 2014. – #4(494). – pp. 38-42. – geo.; res.: geo., eng., rus.
The article provides a comparative analysis
of the data in the software environments MathCad and LabView to identify the
advantages and disadvantages of each. One-dimensional (signals) and
two-dimensional (image) objects were subjected to study. According to the
analysis, both media MathCad and LabView are found to be the most visible and
adapted for practical solutions, engineering and research applications based on
computer technologies. The desirable implementation of algorithms in the -300C
program environment is simpler because of the given functions and modules, but
the spectrum of solving engineering problems in the LabView environment is
wider than in the MathCad environment. Fig. 5, Tab. 1, Ref. 3.
Auth.
b14.1.2.2. Knowledge
organization in intelligent information systems for solving unformalized
problems of diagnosing. /V.Radzievski, M. Mikelaze, N. Jaliabova, D. Radzievski/. Proceedings of the A. Eliashvili
Institute of Control Systems. – 2014. – #18. – pp. 50-56.
– geo.; abs.: geo., eng., rus.
The question of knowledge organization in
intelligent information systems for solving non-formalized problems of diagnosing
is considered. The method of diagnosing the state of complex systems that works
with both quantitative and qualitative data is offered. The descriptions of
classes of states resulting from the application of this method are
high-informative predicates – a disjunction of conjunctions, each of which is
characterized by the certainty factor. It allows using the production model
with certainty factors for representation of heuristic knowledge which
effectively works under conditions of fuzziness, uncertainty and incompleteness
of data and knowledge. Tab. 1, Fig. 1,
Ref. 8.
Auth.
b14.1.2.3. Application
of modern principles of transformation of information to solve various types of
control problems of dynamic objects. /O. Labadze, N. Kavlashvili/. Proceedings of
the A. Eliashvili Institute of Control Systems. – 2014. – #18. – pp. 31-36. – geo.; abs.: geo., eng., rus.
The use of electromagnetic fields to solve
various types of problems of dynamic control is discussed. These include:
three-positional contactless indicator renderer of information that changes
periodically; controllable varying in a wide range direct current source;
control system of resettable brushless synchronous generator; combined and
adjustable multi-channel receiver-transmitter antenna. Fig. 8, Ref. 8.
Auth.
b14.1.2.4. Determining
priorities of the tasks in real-time systems. /L. Petriashvili, T. Zhvania,
M. Kiknadze/. Proceedings
of the A. Eliashvili Institute of Control Systems. – 2014. – #18. – pp. 239-243. – geo.; abs.: geo., eng., rus.
Real-time systems are used for the operation of various technical units or technological processes. Such systems are characterized by extremely acceptable time response to external events, during which the reaction may be executed by the control program of the unit. Determination of the real-time system priority tasks and planning thereof is important to the said systems. The tasks are periodic and independent. The paper deals with the prioritization of the real-time system tasks and their solution by means of a mathematical model, which makes it possible to duly detect, correct an error in the ongoing processes in order to obtain the relevant result. Tab. 3, Fig. 4, Ref. 3.
Auth.
b14.1.2.5. Development
of a remote control mine clearing system.
/D.
Purtskvanidze/. Proceedings of the A. Eliashvili Institute of Control Systems.
– 2014. – #18. – pp. 176-179. – geo.; abs.: geo.,
eng., rus.
The paper describes a remote control mine
clearing system, the application of which allows neutralization (explosion) of
mines in the ground from the distance safe to lives. The system consists of a
radio-controlled car, to which three heavy cylinders are attached. The car is
equipped with a video eye, through which the image is transmitted to the
control panel. The control of movement and turnarounds of the car is done from
the control panel. The system design and transmitter–receiver equipment for
system remote control is described. Fig. 3,
Ref. 2.
Auth.
b14.1.2.6. Cause-effect
model of knowledge in intellectual systems of medical forecasting. /V. Radzievski/.
Proceedings of the A. Eliashvili Institute of Control Systems. – 2014. – #18. –
pp. 252-257. – geo.; abs.: geo., eng., rus.
A problem of constructing a model of
knowledge for intellectual systems is considered. It is shown that the
application of a cause-effect network for such systems is the most suitable. A
notion of the probabilistic cause-effect network is defined. Such networks are
capable to represent knowledge about stochastic pathological
processes in a sick organism. Pathological process as a Markov
stochastic process is also considered. The method
presenting determinate and probabilistic systems as common (determinate) and
stochastic matrices, correspondingly, is proposed. The application of the
matrix allows reducing a process of the construction of logical deductions, to
vectors and matrix algebraic operations. Fig. 6,
Ref. 6.
Auth.
The problem of structure identification of nonlinear
dynamical systems is considered on the set of continuous block-oriented models.
The problem of structure identification is posed according to L. Zadeh classical definition of identification.
The worked methods and algorithms are investigated by computer modelling. Ref. 17.
Auth.
b14.1.2.8. Analysis of hand-written symbols and
formation of comparison processes based on the mini-max
principle. /O. Shonia, I. Kartvelishvili, L. Shonia/. Proceedings of the A.
Eliashvili Institute of Control Systems. – 2014. – #18. – pp. 244-246. – rus.; abs.: geo., eng., rus.
This work presents
the formation process of a comparison method of original and unknown
hand-written symbols based on the mini-max principle being the basic stage of
the identification of hand-written symbols. The proceses of comparision are
describe stage by stage and each of them is characterized in accordance with
their functions. Ref. 2.
Auth.
b14.1.2.9. On a method of Georgian text compilation synthesis. /A.
Tushishvili , M. Tushishvili/. Proceedings of the A. Eliashvili Institute of Control
Systems. – 2014. – #18. – pp. 210-212. – geo.; abs.: geo.,
eng., rus.
The present work shows
that the intensive use of personal computers in all fields of human activities
puts questions for improving methods of interaction with them. It is manifested
in the intonation of Georgian text files stored in the computer memory
(information databases, electronic books, newspapers, etc.) with their
consequent visualization on the screen. Even a partial solution of such problem
would greatly facilitate the communication with different types of dialog
systems: emergency service, ambulance, patrol police, military activity,
linguistic researches, and especially the service of blind people. Analyzed is
one of the methods of the Georgian text compilation synthesis, i.e. the method
of artificial speech implying the obtainment of continuous sounding based on
the jointing of relatively short reference sound elements (phonemes,
syllables). Ref.
7.
Auth.
b14.1.2.10.
Issues of development of control algorithm
regulating frequency and tension in hydroelectric power stations. /T. Trokashvili/. Proceedings of the A. Eliashvili Institute of Control Systems. –
2014. – #18. – pp. 37-42. – geo.; abs.: geo., eng., rus.
The issues of
development of control algorithms regulating frequency and tension are considered. A structural scheme
and the value of frequency regulators for internetwork sustainability are
given. The scheme of wrong signal and its first derivative calculation are also
considered. Fig. 7, Ref. 3.
Auth.
b14.1.2.11. Computer
linguistics and language modeling. /G. Chikoidze, L. Lortkipanidze, N. Javashvili/. Proceedings of the A. Eliashvili Institute of
Control Systems. – 2014. – #18. – pp. 43-49.
– geo.; abs.: geo., eng., rus.
Language modelling is a fundamental component of the computer
linguistics: on the one hand, it would not exist without computer; on the other
hand, its development will lead to the perfection of the practical systems of
computer linguistics, its approximation to human verbal activity. The key
problem of modelling is presenting the content and its “trailing” to expression and vice versa. This describes dynamics of language, the
characteristic without which language becomes senseless, which, for some reason, has
not been given much attention up to now;
consequently, modelling can be considered as one of the important steps of the
development of linguistics. Fig. 2, Ref. 7.
Auth.
b14.1.2.12. Database of derivational affixes. /N. Amirezashvili, L. Samsonadze, N. Javashvili/.
Proceedings of the A. Eliashvili Institute of Control Systems. – 2014. – #18. –
pp. 194-203. – geo.; abs.: geo., eng., rus.
A computer database of derivational affixes is described. The goal of
the database is to gather all the
morphemes needed for derivation, as well as arranging them by certain rules and forming new words automatically from a long list of words provided with the appropriate information. Adding derivational affixes causes certain linguistic processes in
the words. Some affixes are synonymous/homonymous, so solving this problem is very important for building computer-based
models. Phonetic processes and root changing must be taken into account while constructing algorithms and
further programming as well. In the database, there are combined native Georgian morphemes, also the valid morphemes entered from other languages. We believe that such database will facilitate discovery in
the in the root or in the affixes proper the changes caused by phonetic or other linguistic processes. Tab. 1, Ref. 7.
Auth.
b14.1.2.13. On the
improvements of DHCPV6 protocol. /P. Karchava, G. Asanishvili/. Proceedings of
the A. Eliashvili Institute of Control Systems. – 2014. – #18. – pp. 234-238. –
geo.; abs.: geo., eng., rus.
The existing addressing methods in the IPv6
network are discussed. An idea of one improvement of the DHCPv6 protocol is
given. In the improved model, the number of packages necessary for the device
to dynamically receive the address IPv6 and other necessary parameters of a
configuration are decreased by half. In addition, there is no need to check
whether this address IPv6 is occupied by some other device. It also becomes
simpler to detect the next (neighbor) devices. Fig. 3, Ref. 4.
Auth.
b14.1.2.14.
Project ”Development of a Georgian language semantic search
engine algorithm”. /M. Khachidze, M. Archuadze, G. Besiashvili, M.
Tsintsadze/. Proceedings of the A. Eliashvili Institute of
Control Systems. – 2014. – #18. – pp. 224-229. – geo.; abs.: geo., eng., rus.
The project is aimed at developing the
algorithm to be used as a basis for semantic search engine for semantic search
systems, specially focused on the Georgian language searching problems, and its
testing. To achieve these goals, the following work will be performed: the new
method for non-structured document labeling based on analytical heuristics
method will be presented. This method is using the concept “pattern” for
appropriate knowledge base formation. A semantic engine development algorithm
based on the concept patterns objective ontology will be provided. The concept
patterns objective ontology base will, along with machine learning, allow using
the mentioned retrieval engine for structured, non-structured or semi-structured
documents of an electronic storefront. Ref. 10.
Auth.
b14.1.2.15.
On a new M-file for vector-valued optimization problem. /N. Kilasonia/. Proceedings of the A. Eliashvili
Institute of Control Systems. – 2014. – #18. – pp. 152-154. – geo.; abs.: geo.,
eng., rus.
Computer realization for a new vector-valued
optimization method is presented. The program has been written in MATLAB
programming language. The presented M-file is not interactive (interactivity is
implemented only at the initial stage upon data input from the keyboard)
although it implies a step-by-step specification of the compromise solution by
generating certain values by the algorithm. Taking into account the fact that
some of the method’s blocks are similar to the certain blocks of other vector-valued
optimization problem methods, the object-oriented programming was used and two
new “user-defined” type classes were created. The classes can
be used in future for creating new programs for vector-valued optimization.
Ref. 5.
Auth.
b14.1.2.16. Construction of management information systems
of distributed business processes based on Petri nets and object-role modeling. /G. Gogichaishvili,
G. Surguladze, N.
Topuria, B. Urushadze/. Bulletin of
the Georgian National Academy of Sciences. – 2014 . – vol. 8. – #1. – pp. 58-64. – eng.; abs: eng.,
geo.
A model of the service organs optimum number
of client-server architecture based on Markovian processes and algorithmic
schemes of its solution are worked out. On the ground of certain facts the
Object Role Model (ORM) is created. A concept of the distributed databases
creation for various financial structures based on service-oriented
architecture is offered. The forms of web application on Ms Visual Studio.NET
platform by NORMA software and Ms SQL Server package are realized. The issues
of modeling for business processes of corporate systems, automatization of
designing the database structures and the consumers’ interfaces are considered.
Tab. 1, Fig. 1, Ref. 12.
Auth.
b14.1.2.17. State space method in digital control
systems. /N. Narimanashvili, D. Narimanashvili, V. Tsverava/.
Automated Control Systems. – 2014. – #1(17). – pp. 23-26. – eng.; abs.: geo.,
eng., rus.
A state space method is applied for analyzing
digital control systems. The paper recommends methods to solve the equation of
state of digital systems. These methods are easily realized by means of modern
computer software. Ref. 4
Auth.
b14.1.2.18. Design of an information system based
on the object-role modeling and service-oriented architecture. /G. Surguladze,
N. Topuria, K. Bakuria,
M. Lomidze/. Automated
Control Systems. – 2014. – #1(17). – pp. 32-45. – eng.; abs.: geo., eng., rus.
The work considers the issues of design and
software implementation of a distributed information system of a university,
and user interfaces based on the hybrid technology and service-oriented
architecture. Proposed are the results of the processes of constructing
database MsSQL Server via the serial automated conversion components “Facts
/ORM /ERM /DDL", also the development of web-services user interfaces
using Workflow and Windows Communication Foundation technologies. Fig.
11, Ref. 14.
Auth.
b14.1.2.19. Threats coming from insiders to an
organization and log management. /D.Gomelauri/. Automated Control Systems. – 2014. – #1(17). – pp. 52-55.
– eng.; abs.: geo., eng., rus.
The article discusses issues related to the protection of
computer networks from insiders. The article deals with a developed scheme of
information security including the newest information security methods. The
criticality of log management is also discussed. Fig. 1, Ref. 4.
Auth.
b14.1.2.20. Three-factor authentication – increase of the confidence level. /D. Gomelauri, K. Odisharia, T. Kaishauri/. Automated Control
Systems. – 2014. – #1(17). – pp. 55-58. – eng.; abs.: geo., eng., rus.
In the modern business environment information systems are
actively applied. Therefore, information security becomes one of the key
factors in an organization’s business processes. In the development process of
an organization its information system becomes complicated and destruction of
integrity of information may cause catastrophic consequences for the business
activity. The article describes a specific mechanism of information protection,
such as the three-factor authentication for increasing confidence and
information security levels. Ref. 3.
Auth.
b14.1.2.21.
Development
of an automated normative-legal documents and business processes management system
and protection. /O. Shonia, I. Kartvelishvili, L. Kolbaia/. Automated Control
Systems. – 2014. – #1(17). – pp. 59-63. – eng.; abs.: geo., eng., rus.
The article presents
the stages of construction and protection in public and private agencies of an automated
normative-legal documents and integrated business processes management system.
The structure of the automated normative-legal documents and business processes
management system is presented schematically and is described by the functional
purpose. The factors to be implemented carried out in order to create a safe
cell infrastructure are given. Fig.1,
Ref. 4.
Auth.
b14.1.2.22.
Modern information technologies in the management of marketing processes and production. /G. Surguladze, M. Okhanashvili, M. Kashibadze,
M. Neparidze/. Automated Control Systems. – 2014. – #1(17). – pp. 64-71. –
eng.; abs.: geo., eng., rus.
The basic criteria of
success in production management is professional management - ensuring
effective performance of the personnel, proper identification, projecting,
realizing and improving business processes, effective leading of the
organizational-administrative and economic activities. Under these conditions,
modern information technologies and the integrated information systems created
on their basis become the irreplaceable tool in ensuring the achievement of
strategic goals and sustainable development of companies and organizations. The
present article discusses the theoretical aspects of managing marketing
processes, as well as its model and software implementation issues using
client-server architecture on the basis of Petri net workflow, WPF and WCF
technologies. Fig. 3., Ref. 10.
Auth.
b14.1.2.23.
Application
of IT and virtual marketing in firms. /O. Gabedava, S. Pochovyan,
N. Gabedava/. Automated
Control Systems. – 2014. – #1(17). – pp. 72-75. – eng.; abs.: geo., eng., rus.
The article discusses
the issues of application of IT and virtual marketing in a modern firm. The
application of IT significantly changes the nature of marketing activity of the
firm. In this regard, a concept of virtual marketing has arisen, which gives
the chance to firms to rebuild in a short period of time and with the minimum
resources to reconstruct the firm and build a new structure of its development,
as well as to create a client database. Fig. 2, Ref. 6.
Auth.
b14.1.2.24.
Analysis
of Microsoft web-technologies and their development trends for information
systems. /N. Kiviladze, G. Surguladze, M.
Gulitashvili/. Automated Control Systems. – 2014. – #1(17). – pp. 84-89. – eng.; abs.:
geo., eng., rus.
The article
introduces a Microsoft Silverlight development platform. Modern Microsoft
technologies and their business applications are discussed. Analyzed are the
ASP.NET, Silverlight and other development packages, their advantages and
disadvantages. The applications of the Silverlight technology versus other
Microsoft technologies are compared and analyzed. To illustrate the Silverlight
technology, the task management business application Issue Tracker is proposed,
as well as the required development tools and the database structure. Fig. 3,
Ref. 3.
Auth.
b14.1.2.25.
Practical aspects of tone correction in digital graphics. /E. Kamkamidze, T. Apkhadze, M. Janelidze/.
Automated Control Systems. – 2014. – #1(17). – pp. 90-95. – eng.; abs.: geo.,
eng., rus.
Significant feature of any image is the tone. Photos,
digital images, pictures printed digitally can be bright, dark or have a balanced
coordination of areas of light and shadow. This work offers two means of tone
correction of digital images, two commands of the Adobe Photoshop program -
Adjustment and Histogram. Using appropriate examples and illustrations, the
methods of their practical use and the results that experienced retoucher can
reach using them properly are given. Fig. 6, Ref. 4.
Auth.
b14.1.2.26.
The specialized timer-controller. /B. Bendeliani, G. Dgebuadze, I. Metskhvarishvili/. Science and
Technologies. – 2014. – #2(716). – pp. 9-12. – geo.; abs.: geo.,
eng., rus.
The developed timer-controller enables to
define the time of termination of the ongoing technological process upon an
unscheduled outage, for further continuation of an experiment by proper
modification of the algorithm. Fig. 2, Ref. 3.
Auth.
b14.1.2.27. On
the learning pattern recognition system and the method of solving one of its
tasks. /N.
Tkemaladze, V. Jikhvashvili, G. Mamulashvili/. Science and Technologies. – 2014. – #2(716).
– pp. 13-18.
– geo.; abs.: geo., eng., rus.
A brief information
about the learning pattern recognition system (LPRS) elaborated by the authors
and realized on a personal computer is given. The system was used for
recognizing different class objects. The method of solving one of the tasks of
this system, i.e. the method of determination of artificial (formal) parameters
by the three-fold usage of
Auth.
b14.1.3.1. Boiling
– the special case of convective heat transfer. /I. Shekriladze, J.
Rusishvili, E. Machavariani, G. Gigineisvili, D. Shekriladze, M. Meparishvili/.
Proceedings of the A. Eliashvili Institute of Control Systems. – 2014. – #18. –
pp. 90-96. – geo.; abs.: geo., eng., rus.
The paper submitted to scientific conference
devoted to 100th anniversary of the Academician Vakhtang Gomelauri
considers the history of boiling heat transfer research in Georgia and some
aspects of the fulfilled investigations. The fundamental significance of
uncovering the controlling role of nucleation is emphasized. The international
situation in this field of science is discussed. The obtained fundamental
results still remain unrecognized on the international arena, although the
crucial problem of boiling heat transfer enhancement is solved based just on
these results (without reference to the basics in the publications). The sharp
criticism and requirement for the general discussion, expressed by us on
international arena, they have not yet led to any results. The hope is
expressed that existing abnormal situation will be overcome in the future. Fig.
2, Ref. 15.
Auth.
b14.1.3.2. Measurement,
transformation and application of low-frequency signals. /T. Trokashvili, G.
Urushadze, N. Shengelia/. Proceedings of
the A. Eliashvili Institute of Control Systems. – 2014. – #18. – pp. 171-175. –
geo.; abs.: geo., eng., rus.
Low-frequency signal measurement by applying
an impulse-forming circuit is considered. It is shown how to transform a pulsed
signal into the corresponding permanent voltage. A scheme, according to which
it is possible to increase sensitiveness, is given. The Chebishev active filter
of the second row is used for transformation. Fig. 7, Ref. 3.
Auth.
b14.1.3.3. Three-positional contactless dynamic indicator. /O. Labadze, P. Stavrianidi, M. Tsertsvadze/.
Proceedings of the A. Eliashvili Institute of Control Systems. – 2014. – #18. –
pp. 167-170. – rus.; abs.: geo., eng., rus.
The paper discusses the practically implemented original
method of contactless three-positional changes of the fixed state of a control
system. The system operates only when there are pulse control signals. Between
changes in the visual information, the system does not consume electrical
energy because of absence of kinematic transmission between the rotating
triangular prisms, and the plane display has a closed magnetic field of
permanent magnets and magnetic circuits. The proposed method has a significant
advantage in comparison with similar known dynamic indicators. Fig. 4, Ref. 2.
Auth.
b14.1.3.4. Classical motion of a relativistic test
particle in the static cylindrically symmetric metric. /M. Yavari/. Bulletin of the Georgian
National Academy of Sciences .– 2014. – vol. 8. – #1. – pp. 51-57. – eng.; abs: eng., geo.
The paper
considers the gravito-electric and gravito-magnetic fields in the threading formalism. The motion of a
relativistic test particle in the static cylindrically symmetric metric is
studied by applying the Hamilton-Jacobi method. In threading formalism the
gravito-electromagnetic force in this spacetime is also calculated. Ref. 15.
Auth.
b14.1.3.5.
Method of determining the mass of liquid gas in a closed reservoir and its realization. /Z.
Azmaiparashvili, N. Otkhozoria, M. Narchemashvili/. Automated Control Systems.
– 2014. – #1(17). – pp. 96-99. – eng.; abs.: geo., eng., rus.
A system of measuring
the mass of liquid gas and the algorithm of its performance are discussed. The
system enables to measure the mass of liquid gassed by means of electromagnetic
waves raised by the resonator put in a reservoir. The system has high precision
of measuring and it is distinguished with its simple construction. The high
precision of measuring is provided by the type of a resonator and the
microprocessor in which three own frequencies of a resonator are shown and the
algorithm of measuring the mass of liquid gas is realized. Fig. 22, Ref. 2.
Auth.
b14.1.3.6.
The
alternative model of the controlled thermonuclear synthesis. /G.
Beria/. Automated Control Systems. – 2014. – #1(17).
– pp. 145-159.
– eng.; abs.: geo., eng., rus.
The energy problems
of Georgia are components of global problems. The energy crisis will threaten
our civilization in several decades as a result of exhaustion of mineral
resources. One of the radical ways out of this situation is the controlled
thermonuclear synthesis (CTS). However, its implementation faces serious
challenges, the overcoming of which is still problematic. The reason of this is
so-called “scientific viruses” – dogmatized axiomatic errors. Their overcoming
is possible by means of anomalous events and fundamental discoveries. An
anomaly of such universal character is a rare atmospheric phenomenon – ball
lightning, which includes in itself the yet unknown for science fundamental law
of nature. Analysis of its properties enabled to understand the nature of this
phenomenon, to trace and get rid of the “virus”, following which a new, alternative
way of the CTS implementation will be open. Fig. 3, Ref. 12.
Auth.
b14.1.4.1. Thermodynamic analysis of interaction
of B2O3 with carbon. /J. Bagdavadze, K.
Ukleba, Z. Tsikaridze, F. Tavadze/. Bulletin of the Georgian National Academy of Sciences.
– 2014. – vol. 8. – #1.– pp. 65-67. – eng.; abs: eng., geo.
The work presents full thermodynamic analysis
(FTA) of the B-O-C system at atmospheric pressure and in vacuum for the
reaction 2B2O3 + 7C = B4C+6CO. The main
results of FTA are plotted in graphs. A comparative analysis of the obtained
results shows that carbon reduction of B2O3 occurs at
much higher temperature at atmospheric pressure than similar processes
conducted in vacuum. Fig. 2, Ref. 1.
Auth.
b14.1.4.2. New formulas of spectral-line
excitation profiles for coherent anti-stokes Raman scattering by molecules in
solutions. /M. Zakaraya, G.
Chonishvili/. Bulletin of the Georgian
National Academy of Sciences. – 2014. – vol. 8. – #1.– pp. 72-77. – eng.; abs: eng., geo.
The inhomogeneity of the surrounding of
scattering molecules significantly affects the intensity distribution in
coherent anti-Stokes Raman scattering (CARS) spectra and excitation profiles. A
theoretical expression is obtained that describes the excitation profile of an
arbitrary relationship between the relaxation constant G
of the vibronic levels of the excited electronic state and parameter s,
characterizing the inhomogeneity of the environment. The possible influence of
inhomogeneity on the CARS spectral lines is also discussed in the paper. Ref.
9.
Auth.
b14.1.4.3. Synthesis of some derivatives of
N-(1-Adamantyl) Carbonyl-N’-Benzyliden-Ophenylendiamine. /Sh. Samsonia, D. Zurabishvili, T. Bukia, G. Buzaladze, M. Lomidze, E.
Elizbarashvili, U. Kazmaier/. Bulletin of the Georgian National Academy of Science.
– 2014. – vol. 8. – #1. – pp. 78-84. – eng.; abs: eng., geo.
N-(1-adamantyl)carbonyl-o-phenylenediamine
and 4-methoxy-2-aminophenyl-N-(1- adamantyl) carboxamide are synthesized.
Condensation reaction of the synthesized compounds with aldehydes of salicyl-,
5-bromo salicylic- and 3,5-dibromo salicylic is studied. As a result
N-(1-adamantyl)carbonyl-N’-(2-hydroxybenzylidene)-,
N-(1-adamantyl)carbonyl-N’-(2-hydroxy-5-bromobenzylidene)-,N-(1-adamantyl)carbonyl-N’-(2-hydroxy-3,5-dibromobenzylidene)-,4-methoxy-N-(1-adamantyl)carbonyl-N’-(2-hydroxybenzylidene)-,
4-methoxy- N-(1-adamantyl)carbonyl-N’-(2-hydroxy-5-bromo
benzylidene)-,4-methoxy-N-(1-adamantyl)carbonyl-N’-(2-hydroxy-3,5-dibromobenzylidene)-ophenylenediamines
are obtained. Structures of the compounds are confirmed by IR, UV and NMR
spectra. Fig. 2, Ref. 13.
Auth.
b14.1.4.4. Quantitative
determination of sulfur in sodium and
lithium tetrathioantimonate (V). /K. Rukhaia, M. Kikalishvili/.
Proceedings of Georgian National Academy of Sciences. – Chemical Series. –
2014. – vol. 40. – #1. – pp. 9-11. – geo.; abs.: geo.,
eng., rus.
Studied was a method of quantitative
determination of sulfur in sodium and lithium tetrathioantimonate (V) by means
of iodometric titration. It is established that the mass concentration of
sulfur in the suspension can be easily calculated based on the amount of the
oxidizing titrant (I2) consumed for the titration. A corresponding
mathematical formula was derived to calculate the percentage of sulfur. Ref. 7.
Auth.
b14.1.4.5. The use
of chromatographic packed columns for determination of aromatic hydrocarbons in
gasoline. /T.
Kordzakhia, L. Eprikashvili, M. Zautashvili, N. Pirtskhalava, M. Dzagania/.
Proceedings of Georgian National Academy of Sciences. – Chemical Series. –
2014. – vol. 40. – #1. – pp. 45-49. – rus.; abs.: geo.,
eng., rus.
A simplified method of identification of
hydrocarbons in the fuel by gas chromatographic method has been developed. The
use of capillary columns is very problematic and expensive, but the use of
packed columns in the common analyses is more accessible and reasonable. Fig.
2, Tab. 2, Ref. 5.
Auth.
b14.1.4.6. The
quantum-chemical description of physico-chemical properties of the acyclic
amino acids. /N.
Shengelia, J. Kereselidze, Z. Pachulia/. Proceedings of Georgian National
Academy of Sciences. – Chemical Series. – 2014. – vol. 40. – #1.
– pp. 65-67. – rus.; abs.: geo., eng., rus.
The physico-chemical characteristics of the
acyclic amino acids by the quantum-chemical method - density functional theory
(DFT) are calculated. The regular and quantitative description of influence of
side R-group on acidity and basicity properties of amino acids is made. For
some amino acids the correlation between acidity and dipole moment of the
hydroxyl group is found. A conclusion on the possible forecasting of acidity
and basicity of amino acids. Fig. 1, Tab. 1, Ref. 5.
Auth.
b14.1.4.7.
Cluster structure of atomic nucleus. /M. Jibladze, T. Batsikadze/. Science and
Technologies. – 2014. –
#1(715). – pp. 11-40. – geo.; abs.: geo., eng., rus.
The article deals with the problem of structure and composition of
various nuclei of chemical elements and the possibility of existence of their
cluster structure is shown. It is found that upon building of nuclei the basic
elements together with proton and neutron are the nuclei of helium, carbon and
oxygen. It is also shown that the nuclei are generally built of carbon and
oxygen clusters, while heavy-nuclei have a layered structure. The reasons,
which limit number of stable and unstable elements, are also considered. It is
shown that the leading role in forming nuclei has the proton-created coulomb forces rather
than strong nuclear attraction forces. Fig. 30, Tab.
1, Ref. 13.
Auth.
b14.1.4.8. Structurally
specific features of the coordination compounds of some metals with
sulfanilamide preparations. /E. Miminoshvili, L. Beridze/. Nano Studies. – 2014. – #9. – pp.
9-20. – rus.
The paper deals with a comparative
characterization of the structures of studied sulfanilamide-containing
compounds, revealing of the differences in the composition of their structural
elements and of significant changes in the geometric parameters characterizing
the structure. In the crystalline compounds we studied, sulfanilamides in the
deprotonated state (the proton breaks from N–H, and the corresponding anion is
formed) are external-spherical acidic anions and very rarely participate in the
formation of coordination bonds. The explanation of the obtained results by a
steric effect prompts that, if these compounds participate in complex
formation, only trans-forms of polyhedrons are formed. In the described
crystalline coordination compounds (M(II) = Mg, Mn, Co, Cu, Zn), sulfanilamides
are external-spherical acidic anions, while in the compounds [M(Aet)(OH2)5](Aet)*kH2O
(where M(II) = Sr and Ba, Aet- – the etazol anion, k = 3 and 2) – one
of two anions is coordinated to the metal, playing the part of bridge bidentate
– cyclic ligand. According to the obtained data, the bath angle varied within
the range of 55–1000,
and the torsion angle– within the range of 55–70o.
The exception was the compound [Ni(R)2(OH2)2] (where R – sulfapyridazine anion), for which
torsion angle equals to 7.2o.
Fig. 7, Tab. 1, Ref. 22.
Auth.
b1.5
Earth and related environmental sciences
b14.1.5.1. Effect
of earthquakes on the biosphere and human health. /E. Sakvarelidze, Z.
Sharadze, K. Mirianashvili/. Modern aspects of medical rehabilitation,
prevention and healthy lifestyle. Int. Symp. – Sairme. 9-13 Oct. – 2014. – pp. 136-140.
– geo.; abs.: eng., geo.
It is known that before, during and after an
earthquake, ultralow-frequency (0.001-10Hz) weak electromagnetic fields
generated in the earthquake area can be registered in areas far from the
epicenter. These fields superimpose the electromagnetic fields of Schumann
resonance frequencies, causing in the biosphere changes of the low frequency
electromagnetic situation. Values of the resonance frequency of
Schumann and Alven may also be changed by propagation of the generated by
earthquake acoustic-gravity waves (AGW). the AGW generated by earthquake and
the associated propagation of disturbances in the Schumann and Alven resonators
alter the background ultralow frequency electromagnetic situation of the
biosphere and the related with this changing bio-effect. Ref. 4.
Auth.
b14.1.5.2. Sub-volcanic and extrusive bodies of Bolnisi area
as non-traditional raw materials in production of glassware. /G. Nadareishvili, M. Tkemaladze, E. Shapakidze/. Mining Journal. – 2014. – #2(33) – pp.10-17. – geo.; abs.: geo., eng., rus.
The geology of rhyolitic extrusives (Kochulo,
Rachisubani) and sub-volcanic bodies of dacitic structure (Kvemo Bolnisi), and
also of the Upper Cretaceous Age of a volcanic-sedimentary number of their
structure in Bolnisi area (Kvemo of Kartli) and their localization in various
types of structures, with the appendix of cards and cuts are considered. Also
considered are the mineralogical-petrographic features of bodies and their
material structure. The possibility of using these raw materials in the
production of glassware is proposed. Three- and four-component glasses are
synthesized from bodies of Kochulo and Kvemo-Bolnisi fields. Fig. 1, Tab. 4,
Ref. 8.
Auth.
The article shows that the use of ground
anchors make it possible to find efficient design solutions in the construction
of open underground facilities and safe arrangement of deep hollows with
lessening the period of construction under conditions of restricted urban
development. A classification of ground anchors, model construction and
technological sequence of temporary ground anchor device, as well as the
results of calculation of a tilted ground anchor by the Krantz method are
given. Fig. 5, Tab. 1, Ref. 10.
Auth.
The paper noted that the stability of slopes
ground slipping is mainly observed during earthquakes of 5.5 to 8.8 magnitudes,
when the distance to the epicenter is several hundreds of kilometers. The
question is particularly relevant for the whole territory of Georgia where
seismicity is estimated at 7-9. An algorithm for calculating the seismic load,
which takes into account the impact of the earthquake dynamic stresses on the
state of repose and the strength of its soil, is given. The Fh
horizontal and Fv vertical inertia are acting in concert with the
ground mass weight of the slope sliding triangle with due regard for the
seismicity ratio determined on the basis of seismic data. With the use of
pseudo-statistical method, the minimum value of the safety factor
is calculated taking into account the static horizontal and vertical forces of
shear resistance of the slope. Fig. 2, Tab. 1, Ref. 13.
Auth.
The article considers the new trends recently
developed in the area of production of manganese ore that seriously affect the
Chiatura Mining-Enrichment company’s production activities and competitiveness
of its products. One of major solutions to these problems is to improve
planning of mining activities and mining technologies by using modern computer
simulation methods. The article deals with technological schemes for the
extraction of manganese ore and tasks of developing economic-mathematical
models for estimating cost-effectiveness of investment for exploitation of new
fields of mine. Fig. 3, Ref. 7.
Auth.
b14.1.5.6. Issues of selection of concentrate of
flotation in copper cluster in ore field. /N. Jikia, R.
Sturua, D. Talakhadze, Z. Arabidze, A. Abshilava, G. Gelovani/. Mining Journal. – 2014. – #2(33) – pp. 31-34. – geo.; abs.: geo., eng., rus.
The work deals with the processing
technologies of a collective, copper-containing pyrite concentrate produced as
a result of processing stored tails of copper ore, as well as the possibilities
and advantages of processing the said concentrate in the alkaline medium using
the Albion method. Based on the conducted studies, a scheme of selection of the
collective concentrate is developed. According to the parameters of iron
sulphide concentrate established by the Albion method, a small-grained iron
mineral goethite is produced as a result of processing in the alkaline medium,
from which gold extraction is possible by cyanidation. Fig. 2, Tab. 1, Ref.
1.
Auth.
b14.1.5.7. Devices with control methods for
continuous measurement of perturbing values in concentration processes. /M. Gamtsemlidze, R. Enageli, M. Tutberidze/. Mining
Journal. – 2014. – #2(33).
– pp. 35-38. – geo.; abs.: geo., eng., rus.
In the article the operation principles of
original devices for measuring perturbing, particularly the operating
parameters of concentration, are considered. The of the devices is that they
can continuously measure concurrently two perturbing values at a time, in
particular the pulp density and viscosity; consistency of minerals with magnetic
properties and clay materials in the pulp. At the same time, by measuring the
operating parameters, the physical properties of the concentration material can
be determined. The regulation of control parameters for processes of flotation,
jigging and separation in heavy medium cyclone due to the new control methods
ensuring maximum output of conditioned concentrate based on changes of values
of disturbing parameters is also discussed. Fig. 1, Ref. 7.
Auth.
b14.1.5.8.
Management
of fire-caused emergencies under conditions of a combined ventilation system in
two-way traffic tunnels /O. Lanchava, N.
Bochorishvili, G. Nozadze, M. Jangidze, N. Arudashvili, S. Demetrashvili/.
Mining Journal. – 2014. – #2(33) – pp. 43-47. – geo.; abs.: geo.,
eng., rus.
The paper deals with semi-transverse and
transverse schemes of a system of ventilation for two-way traffic for single
tunnel. At the same time, the expected phases of fire-caused emergencies are
investigated. For conditions of Rikoti road tunnel an accumulation of
deviations from the normal course of natural and anthropogenic processes is
established. As a measure to prevent hazards in the tunnel, the establishment
of a schedule for dangerous goods, which is of much importance in removing
smoke and preventing ignition of toxic material and saving human lives in a
transport tunnel. In developing proper ventilation system, of much importance
is the establishment of functional properties for controlling an emergency both
at the initial stage of fire, as well as during its progress. As it is well
known, each emergency is characterized by own rate of development. An emergency
situation, due to the presence of fire, is a rapidly developing phenomenon.
According to its scale, the fire situation is object-based, the consequences of
which do not go beyond the object and their liquidation is possible by means of
the object-available strengths and resources. The conclusions and results given
in this work might be useful to the tunnel’s administration for adequate implementation
of the measures aimed at saving human lives under emergencies. Fig. 2, Ref. 9.
Auth.
b14.1.5.9. Effects
of global climate change on agriculture. /G. Khomasuridze/. Agrarian-economic
Science and Technologies. – 2015. – #1(26). – pp. 36-40. – geo.; abs.: geo., eng.
Effects of global climate change on agriculture and ecosystems’ condition is infinitely large. Some scientists believe that an increased amount of carbon dioxide in the atmosphere and temperature increases will have positive effects on plants, but further increases in temperature and moisture deficiencies will affect agricultural crops. The climate change results are already noticeable on cereals and grapes, for example. Simulated experiments have made possible to predict negative effects of global warming that will cause many problems to mankind in the future. Ref. 7.
Auth.
b14.1.5.10. Natural
radioactivity of some springs in the territory of Tbilisi and Kartli artesian
basins. /N. Kekelidze, T. Jakhutashvili, E. Tulashvili,
M. Chkhaidze, L. Mtsariashvili, Z. Berishvili, N. Khikhadze/. Proceedings of
Georgian National Academy of Sciences. – Chemical Series. – 2014. – vol. 40. – #1.
– pp. 79-86. – rus.; abs.: geo., eng., rus.
Investigation of content of radioactive gas
radon – Rn-222 in water of some springs located in the territory of settlements
in Tbilisi (9 springs) and Kartli (4 springs) artesian basins were carried out.
Researches were conducted t in the January-March period, 2013. The radon
content measurements were carried out using a modern radon detector RAD7. It
was established that in the territory of Tbilisi artesian basin the radon
content in spring water varied from several units of Bq/L up to 100 Bq/L and
more; in the territory of Kartli artesian basin size of changing is much less –
in the range from units of Bq/L up to 13 Bq/L, that is attributed to the
differences of soil-geological structures of these regions. A comparison with
the available literary data has been carried out. Fig. 1, Tab.4, Ref. 17.
Auth.
b14.1.6.1. Formation of the phenolic compounds in
the tissue culture of Rhododendron
caucasicum Pall.
/D. Bagratishvili, R. Jikia/. Bulletin of the Georgian
National Academy of Sciences. – 2014. – vol. 8. – #1.– pp. 85-88. – eng.; abs: eng., geo.
Callus cultures are obtained from the leaf
and stem of Rhododendron caucasicum
Pall. growing at passages. The primary callus was formed in 10-15 days on
Heller’s modified nutrient medium. For selection of the best conditions of
growth for the callus, different concentrations of some nutrient medium
components were tested. It was found that 5 and 10mg/l of 2,4D supported tissue
growth, while 0.5mg/l suppressed it. Kinetin suppressed growth in both 1 and
5mg/l concentrations. The yeast extract of 1000–2000 mg/l and 20mg/l of
mioinositol increased the yield of biomass, while 100 mg/l of yeast extract and
2mg/l of mioinositol decreased it. Three phases of callus growth were
identified: monotonous (up to 20 days), linear (20-40 days) and reduced (40-50
days). Besides, the stem callus outstripped the leaf tissue in growth.
Preliminary analysis showed that the Rhododendron leaf and stem cultures
maintain the ability to synthesize biologically active phenolic compounds
typical of an intact plant. However, their amount and composition were
considerably less in callus tissues, which is characteristic of most cultures.
The content of phenolic compounds is 4-5% of dry weight. Besides, the main part
(85-90%) consists of (+) catechine, (-) epicatechin and proanthocyanidines.
Fig. 3, Ref. 9.
Auth.
b14.1.6.2. the influence of smitin on
fermentative activity of actomyosin in different area conditions. /N. Gachechiladze, J. Gogorishvili, R.
Kupatadze, K. Kuridze, T. Eristavi, M. Zaalishvili/. Bulletin of
the Georgian National Academy of Sciences. – 2014. – vol. 8. – #1. – pp. 89-93.
– eng.; abs: eng., geo.
The influence of smitin (C-titin) on
Mg2+-activated ATPase activity of chicken smooth muscle (stomach) actomyosin in
different area conditions (ionic strength, pH, different concentrations of
smitin) was studied. It was shown that smitin, likewise titin, causes the
increasing of Mg2+-activated ATPase activity of actomyosin. Mg2+-activated
ATPase activity in the presence of smitin has maximal value in 30mM KCl and
minimal - in 100mM KCl. Mg2+-activated ATPase activity of actomyosin in the
presence of smitin reaches maximal value at pH 8 and at pH 9 it decreases.
ATPase activity increases according to the growth of smitin concentration and
is maximal when it makes up 40% of myosin by weight. Obtained results confirm
that in smooth muscle smitin has the same effect on actomyosin ATPase activity
as titin has on skeletal muscle ATPase activity. Smitin stipulates muscle
elastic properties, on the one hand, and on the other hand it is the “scaffold”
for the proteins participating in muscle contraction, forming the
supermolecular complex with these proteins. Fig. 3, Ref. 20.
b14.1.6.3. Susceptibility of salmonella strains to
antibiotics and r-plasmids profiling. /T. Gabisonia, M. Loladze, T. Katamadze, G.Melashvili, K.
Didebulidze, N. Tamarashvili/. Bulletin of the Georgian National Academy of Sciences.
– 2014. – vol. 8. – #1. – pp. 114-117. – eng.; abs: eng., geo.
At present, gram-negative bacteria start to
take up leading position in common structure of zoonotic infections, displacing
other infections to the sideline. This study was conducted to investigate the
occurrence of Salmonella sp., to determine their susceptibility to antibiotics
and plasmid profiling. In this research, the material for bacteriological
investigation was taken out of tracheae of the chickens from two poultry farms.
A total of 72 Salmonella sp. were isolated from samples, from which 48 strains
were serotyped as S. typhimurium and 24 strains – as S. enteritidis. It has
been established that isolated salmonella strains are characterized by high
resistance to antibiotics of broad spectrum. Their antimicrobial susceptibility
was tested to 9 antibiotics. All salmonella strains were found to be resistant
to penicillin, ampicillin, erythromycin, whereas, they were susceptible to
streptomycin, chloramphenicol and slightly susceptible to kanamycin and
gentamicin. Plasmids determining resistance to streptomycin, chloramphenicol,
tetracycline, gentamicin, carbenicillin, kanamycin and belonging to the
incompatibility groups T, I, M, N were revealed by the methods of elimination
and conjunction. Salmonella strains contain also plasmids of group IncPI having
wide spectrum of hosts.Tab. 3, Ref. 4.
Auth.
b14.1.6.4. New
antiviral herbal remedies for herpes simplex and herpes zoster. /M.
Abutidze, N. Omiadze, J. Rodriguez-Lopez, T. Sadunishvili, S. Chazarra, G.
Kvesitadze/. Annals of Agrarian Science. – 2014. – vol. 12. – #3. – pp. 15-17.
– eng.; abs: eng., rus.
Antiviral paramedical herbal remedies in the
form of ointment and tincture mix have been prepared on the basis of medicinal
plants and natural products for only external application in cases of Herpes
simplex and Herpes zoster diseases. Chemical composition and some properties of
these antiviral natural herbal remedies have been studied. They do not contain
synthetic additives such as colorants and flavors. All the natural components
included in this remedies act together as preservatives, emulsifiers and solubilizers.
They protect skin from harmful effect of UV-radiation. Tab. 1, Fig.
2, Ref. 9.
Auth.
b14.1.6.5. Biological and physico-chemical properties of X-phaseoli specific phages. /T. Sadunishvili, N. Sturua, M. Gamkrelidze, D.
Gaganidze, N. Amashukeli/. Annals of Agrarian Science. – 2014. – vol. 12. – #3. –
pp. 44-48. – eng.; abs: eng.,rus.
Some biological and physical/chemical
properties of the three lines of lytic bacteriophages specific for Xanthomonas phaseoli causing haricot
brown spot in Georgia was studied. The bacteriophages belong to the Tailed
phages, family Myoviridae. The
adsorption time and latent period were short and nearly identical for the three
phages. Influence of solution of blue vitriol and copper oxychloride to phages
mixture was studied. Influence of high temperature on the phages and their
mixture was investigated. It was found that tested bacteriophages belong to the
high temperature resistant phages.Tab. 3, Ref. 18.
Auth.
b14.1.6.6. Anthropogenetic model as a conceptual basis of the theory
of medicine. /G.Elkania, L. Dilenian, I. Gvinjilia, E. Matiashvili,
Ts. Jaiani, A. Bagrii, L. Puchalska/. Social,
Ecological & Clinical Pediatrics. – 2013 – #16-11-10. – pp. 97-104. – rus; abs.: geo.,
eng., rus.
From the standpoint
of gravitational biology and anthropology is justified the value of determined
biological qualities of the man – walking upright as a basic form of adaptation
to living in the earth's gravity. The value of this factor in biology of human
beings is manifested in the formation of a characteristic ontogenetic phasing
of the growth process and the implementation of anti-gravity function of the
basic body systems, as well as in the typical nosological profile of morbidity,
which is definitely associated with these stages throughout postnatal
development. From the standpoint of anthropogenetic approach it substantiates
the possibility of a more complete picture of the human body life in all its
range states - health - illness - pre-existing disease - disease. Key words:
gravitational biology, anthropology, ontogenesis, walking upright, antigravity
function, speech, anthropophysiological approach, energy metabolism,health,
illness. Fig. 6, Ref. 48.
Auth.
b14.1.6.7. Expression of epidermal growth factor receptor and
plasmatic levels of epidermal growth factor and melatonin in simple and complex
endometrial hyperplasia. /N. Dznelashvili, D.
Kasradze, A. Tavartkiladze/. Social, Ecological & Clinical Pediatrics.
– 2013 – #16-11-10. – pp. 105-109. – geo; abs.: geo., eng.
The goal of our research was to find the
prognostic significance of the epidermal growth factor receptor
(EGFR) expression in endometrium and plasmatic levels of epidermal
growth factor (EGF) and Melatonin in simple and complex endometrial
hyperplasia. Immuno histochemical study of morphological material (endometrial
scrap) was conducted in order to reveal the EGFR expression (in 35 patients).
Measurement of EGF blood plasma content was carried out using HPLC (High
performance liquid chromatography) method. The study of melatonin
concentration in patients’ blood plasma was performed using ELISA
method). The numeric data of the investigation were processed statistically
using the SPSS-12 and IBM SPSS-20 programs. As
it has been revealed, in endometrial hyperplasia (regardless of the
different EGF blood plasma levels) with weak expression of EGFR melatonin
levels are normal, which is predictively favorable, and vice versa, with
strong expression melatonin levels are decreased (even with normal
values of EGF blood plasma content). It is the case when every change towards
the increase (especially significant or marked) of EGF blood plasma
levels is particularly dangerous against the background of strong
EGFR expression. Finally, melatonin - the universal anti-proliferation
and antineoplastic hormone is far more responsive to EGFRendometrial
expression than to plasmic levels of EGF. This directly indicates
that in the given situation EGFR is more carcinogenic than EGF per se. That is, if merely EGF blood
plasma content increased while endometrial EGFR expression was weak,
this would be a predictively better variant than with strong EGFR
expression in the endometrium and moderately increased EGF blood
plasma content. Ref. 8.
Auth.
b14.1.6.8. Investigation of proteins in the process of
stabilization of wines. /N. Baghaturia, T.
Nanitashvili, N. Begiashvili, T. Shilakadze, B. Baghaturia/. Agrarian-economic Science and Technologies. –
2014. – #3 (24). – pp. 52-57. – geo.; abs.: geo.,
eng.
The results of the study of protein compounds during processing and
stabilization of wines using an electrophoresis method are given. Individual wine
processing methods are found to act differently on the quantitative and qualitative
properties of protein compounds. The values of
isoelectric points of some protein fragments are found and their different
roles in the promotion of wine turbidity are shown. Tab. 1.
Ref. 7.
Auth.
b14.1.6.9. Chemical components of overground parts of ononin
arvensis from Georgian flora. /М. Sichinava, M. Sutiashvili, M. Alania, V. Mahiou-Leddet, E. Ollivier/. Proceedings of
Georgian National Academy of Sciences. – Chemical Series. – 2014. – vol. 40. – #1.
– pp. 68-70. – rus.; abs.: geo., eng., rus.
Chemical content of the overground parts of Ononis arvensis is studied. It is established that the plant
contains triterpenoidal alcohol and flavonoids. Isolated and identified are
triterpenoidal alcohol a-onocerin and isoflavones –
daidzein, daidzin, formononetin and ononin. These compounds are for the first
time isolated from the gown plant in Georgia. Tab.1, Ref. 16.
Auth.
b14.1.6.10. Isolation
and identification of selected flavonoids from the saperavi wine. /T. Mitaishvili, N.
Zambakhidze, I. Targamadze, D. Chrikishvili, A. Shalashvili/. Proceedings of
Georgian National Academy of Sciences. – Chemical Series. – 2014. – vol. 40. – #1.
– pp. 74-78. – geo.; abs.: geo., eng., rus.
Summary fractions of phenol compounds – catechines,
flavonols, antocyanins and phenolic acids were isolated from Saperavi wine made
by Kachketian technology. The isolated summary fractions were divided into
sub-fractions by chromatography on Sepadex LH-20 and poliamide columns, where
from the individual flavonoids were isolated by paper and thin layer
chromatography. The following flavonoids were identified in the Saperavi wine: quercetin, quercetin-3-O-monoglucoside (isoquercitrin) and
quercetin-3-O-rutinoside (rutin); anthocyanins:
malvidin-3-O-monoglucoside (oenin)
and peonidin-3-O-monoglucoside (peonin). Tab.2, Ref. 14.
Auth.
b14.1.6.11. Use of
X-ray spectrometer for studying chemical contents and some aspects of
ecological chemistry. /Al. Chubinidze, N.
Endeladze, N.
Bregadze/. Proceedings
of Georgian National Academy of Sciences. – Chemical Series. – 2014. – vol. 40. – #1.
– pp. 87-89. – geo.; abs.: geo., eng., rus.
Using
X-ray
spectrometer (Skyray EDX Packet III. X-ray Fluorescence Spectrometer), chemical
analysis of patterns sprinkled with contact and system (Corsuber) pesticides
has been carried out. At that time, grain of grapes has been investigated. The
data on 28 chemical elements are given. On the basis of the obtained results,
it is presumed that chemical fragments of a system (Corsuber) pesticide
accumulate in the plant’s fruit. Fig. 1, Tab.1, Ref. 5.
Auth.
b14.1.6.12. Water as a
material substrate of memory. /N. Aleksidze/. Science and Technologies. – 2014. – #2(716). – pp. 23-29. – geo.; abs.: geo.,
eng., rus.
The biological role of water and structures of
water after various psycho-emotional influences are discussed. The structures
of holy and drinkable water before and after Christian prayer are shown. Fig.
15, Ref. 2.
Auth.
b14.1.6.13. The ways of improvement of the ecological properties of
internal combustion engines. /R.
Kavtaradze, M. Glonti, T. Natriashvili/. Science and Technologies. – 2014.
– #2(716). – pp. 33-40. – geo.; abs.: geo.,
eng., rus.
The ways of simultaneous solution of the ecological
and power problems of the automobile transport equipped with internal
combustion engines, taking into account features of the engine thermo-dynamical
cycle, operational conditions and social problems are considered. The use of
natural gas as fuel for the automobile internal combustion engines is
considered as the most acceptable and rational way of solution of the problem
for the first half of the 21st century. The ways of conversion of
modern diesels on natural gas and advantages of conversion of the diesel into
double-fuel engine are analyzed and shown. In spite of the fact that the use of
electroengines in automobiles becomes more and more popular, it is shown that
the internal combustion engines will retain the dominant position in the automobile
transport for a long time. Consequently, the elaboration of all the measures
contributing to a decrease in the environmental pollution is of urgency. Tab. 1, Ref. 6.
Auth.
4b14.1.6.14. Estimation of water quality of the rivers (Vere,
Digmula, Gldanula) on the territory of Tbilisi. /G. Zeikidze, S. Invia, L. Khurtsia, D. Mchedlishvili, M.
Berishvili, L. Gogaladze, T. Gigauri, R. Gaprindashvili, N. Buachidze/. Science and Technologies. – 2014. – #2(716). – pp. 41-45. – geo.; abs.: geo.,
eng., rus.
The ecological condition of some
Mtkvari River tributaries (Vere, Dighmula, Gldanula) is discussed. The observation points were selected
on all these tributaries. A schedule of pollutant components and methods of
their determination in the water were worked out. The quality of the
rivers under study was estimated in a complex way. The physical-chemical features, hydrochemical parameters and microbiological
parameters
of the water were measured. Respectively, on the basis of
the obtained data, a rather polluted section of the River Vere was fixed, which was confirmed with all chemical and microbiological analyses made. Fig. 2, Tab. 3, Ref. 4.
Auth.
b14.1.6.15. The basic mudflow tributaries and their main
parameters. /Z. Charbadze/. Science and Technologies. – 2014. – #2(716). – pp. 46-53. – geo.; abs.: geo.,
eng., rus.
The mudflow tributaries of the River Rioni in
the Racha region are discussed. For lessening the mudflow activity, the major
geometrical, hydrologic and hydraulic parameters were estimated, which is the
prerequisite for successful implementation of anti-mudflow measures. Tab. 3,
Ref. 11.
Auth.
b2. ENGINEERING AND
TECHNOLOGY
b2.1
Civil engineering (construction)
The article
deals with an artificial or emergency
heating “intermittent” duty
of a building, the energy consumption optimization in order to
minimize the energy for heating, management of heating duty, the heat-balance equation; the thermo-physical
properties of building materials and structures and their heat
storage capacities. Fig. 1, Tab.
1, Ref. 3.
Auth.
b14.2.1.2.
Simulation modeling and management of the urban functional-spatial development. /M. Akhobadze, E. Kurtskhalia, T. Bakhtadze, N.
Vardziashvili/. Transactions of Technical University of Georgia. – 2014. –
#4(494). – pp. 49-55. – geo.; res.: geo., eng., rus.
A simulation model of the functional-spatial development of cities
has been created on the basis of a macro-system modeling principle. The
simulative model enables the creation of an expert system for evaluating an urban
development plan. Fig. 3, Ref. 4.
Auth.
b14.2.1.3. Review, analysis and synthesis of
researches on creep and shrinkage of concrete. /G. Baliashvili, D. Jibladze, T.
Rukhadze/. Mining Journal. – 2014. –
#2(33) – pp.68-74. – geo.; abs.: geo., eng., rus.
In the article a review, analysis and
synthesis of results of researches on creep and shrinkage of concrete are
presented, also the research methods, the factors affecting the shrinkage and
creep, their deformation mechanism, and prediction models. The main factors
affecting the creep and shrinkage of concrete are as follows: the grade and
amount of cement and aggregate used in the concrete mix, value of water-cement
ratio, environmental relative humidity, theoretical thickness of the concrete
element, age of concrete and loading time, concrete strength, availability of
reinforcement, which lead to deformation of concrete structural elements,
reduction of their carrying ability, in many cases their breakage and damage,
increase expenses on construction maintenance unit and reduction of safe
operating life. Therefore, the research of creep and shrinkage of concrete is a
novel actual scientific- technological problem. Ref. 13.
Auth.
b14.2.1.4. Studying
natural hydrological complexes in the arid zones of the mountainous regions in
East Georgia for the purpose of supply of urban areas with drinking water. /T. Tevzadze, G. Omsarashvili, D. Potskhveria/. Mining Journal. – 2014. –
#2(33) – pp.75-78. – geo.; abs.: geo., eng., rus.
The article proposes an innovative method –
the accumulation of underground waters in alluvial ground by means of the
under-bed diaphragm and regulation of their delivery during the period of low
water level with the purpose of water supply. Identification of complex
hydrogeological systems will give the opportunity and real conditions to create
new structures for supplying drinking water by using the mentioned energy
saving technology. Such structures can be: Telavi ravine, Shroma ravine, Kisi
ravine, Turdo ravine, Kardenakhi ravine, etc. – the sections situated on high
hypsometric levels, where, based on the proposed technology, the precedents of
a significant accumulation of water masses, water withdrawal and transportation
via natural flow will be created. Fig. 1,
Tab. 2, Ref. 5.
Auth.
b14.2.1.5. Spatial planning and construction. /D. Egiashvili, A. Meskhishvili/. Agrarian-economic
Science and Technologies. 2014. – #3 (24). – pp. 19-38.
– geo.; abs.: geo., eng.
After gaining independence and recognition of private property, privatization of urban land began. The process of spatial planning in Georgia is slowly being developed, but is very far from the desired development and needs to be activated. The issue of building permits takes a reasonable period of time. The article further deals with the problems of spatial planning and construction in Georgia fuel to the lack of skilled spatial planners. Tab. 1.
Auth.
b14.2.1.6. Prospects
of involvement of Georgia into the
world transport-logistic system. /G. Lagvilava/. Business-Engineering. 2014. – #4. – pp. 60-63. – geo.; abs.: geo., eng.
The article considers an issue of Georgia’s
participation in the Global World. The article states that Georgia should use
its geographical location as much as possible. The country should serve the
passenger and goods flow from Asia to Europe and vice versa effectively by the
appropriate development of transport. The article reviews the possibilities of
further development of rail and air transport in terms of greater involvement
of Georgia in the global transport economy. Ref. 7.
Auth.
b14.2.1.7. Some problems of
mountain railway capacity. /T. Kupatadze, N.
Kupatadze, B. Didebashvili, Z. Kupatadze, G. Guramishvili/. Science and Technologies.
– 2014. – #1(715). – pp. 75-78. – geo.; abs.: geo., eng., rus.
The article is dedicated to problems of mountain railway capacity in terms of train traffic safety. In the dead ends arranged at separate ыефпуы of mountain railways and long slеep crossings the train needs to be stopped, which impedes the train traffic capacity. The article raises the issue of developing and arranging
special speed control mechanisms at the stages to be directly connected with
representatives of traffic service, which will avoid the necessity of full stop
when moving at the established speed. Fig. 2, Ref. 3.
Auth.
b14.2.1.8. Investigation of rock composition and
relief effect on the slope stability considering the structures to be built and
seismic loads. /P. Menabdishvili/. Science and
Technologies. – 2014. – #1(715). – pp. 91-97. – geo.; abs.: geo., eng., rus.
The proposed method of slope stability
calculation makes it possible to evaluate the mode of deformation of a
rockslide slope and its stability factor under conditions of any relief, steepness and rock composition, as well
as to identify the
stability field, slickenside, to select the optimum alternative of the
foundation arrangement and to assess the he structures’ landslide
effectiveness. Fig. 2, Ref. 9.
Auth.
b 2.2. Electrical
engineering, information engineering
b14.2.2.1. Application of virtual computers while training in
network technology. /M. Gegechkori, N. Narimanidze, M. Odiladze, V. Bakhtadze, M. Archuadze, T.
Burchuladze/. Proceedings of the A. Eliashvili Institute of
Control Systems. – 2014. – #18. – pp. 216-219. –
geo.; abs.: geo., eng., rus.
One of the possible ways to improve
education–scientific process in both content and quality is the introduction of
modern information technologies (IT). The advantage of using virtual computers
involved in a network of educational institutions is substantiated. In
particular, the ways of more effective and qualitative solution of training
problems in the field of network technologies by using of VMware Workstation -
the popular software product are considered. Ref. 7.
Auth.
b14.2.2.2. A source of great three-phase direct current
controlled by opto-thyristors. /L.Gvaramadze,
O.Labadze, N.Kavlashvili, T.Saanishvili, G.Kiknadze/. Proceedings of the A.
Eliashvili Institute of Control Systems. – 2014. – #18. – pp. 161-166. – geo.; abs.: geo., eng., rus.
An assessment of the
problem of generating large current over a wide dynamic range is given. A sub-class
of this problem characteristic of some practical cases is selected:
research and grading of primary plating and magneto-optical
current transducer, power and energy, debugging and
management of high-current relays, circuit breakers,
the differential protection devices. The
way of solving these problems in a simple and compact calibrator has high
metrological characteristics. One of the principles of the compact high-current
calibrator and examples of the implementation of
individual nodes are considered. Also shown is a simple
electronic circuit of the calibrator – one of the main control units of the
opto-thyristor. Fig. 4, Ref. 2.
Auth.
b
14.2.2.3.
Analysis of defining the quantity of consecutively
engaged pumps in a multistage hydro transporting pipeline and their location
across the pipeline. /L. Makharadze, A. Tavelishvili/. Mining Journal. – 2014. – #2(33) – pp. 51-58. – geo.; abs.: geo., eng., rus.
An analysis of defining the quantity
of consecutively engaged ground pumps in a multistage hydro transporting
pipeline and their location across the pipeline, which differs from the
previous methods by foreseeing pressure changes during pumps’ start-ups and
stoppages in the pipeline, is given. The analysis-based recommendations, which
guarantee that pressure change during transient behavior, will go smoothly,
without abrupt pressure waves and without splitting (breakage) of the hydro
mixture flow that might result from the change within significant pressure
values in the whole pipeline with the corresponding undesirable outcomes. Fig. 1, Tab. 4, Ref. 8.
Auth.
b14.2.2.4. Questions of making
an analytical instrument to control water purification with a coagulant. /R. Semionov, V. Padiurashvili, T. Dzagania, N. Iashvili/. Automated Control
Systems. – 2014. – #1(17). – pp. 100-104. – eng.; abs.: geo., eng., rus.
The methods
determining (measuring) the coagulant doses in the drinking water and the appropriate
devices designated for measuring of the big doses of coagulant (or flocculent),
i.e. for determining big changes in electro-conductivity of drinking water are
known. The article presents a new method of determining the micro-concentration
dose of coagulant in drinking water and the structure of the device. The
principle of operation of the device is given. Fig.2 Ref. 6.
Auth.
b14.2.2.5. On the
necessity of equipping apartments and multistorеy
apartment houses with gas alarms and monitoring systems. /V. Padiurashvili, T. Dzagania, Z. Azmaiparashvili, Z. Jokharidze, N. Iashvili/. Automated Control Systems. – 2014. – #1(17). – pp. 105-110.
– eng.; abs.: geo., eng., rus.
The necessity of
equipping the apartments with gas alarms is considered. The principles of
operation of such devices and the types of applied adapters, as well as the
possibility of equipping multistory apartment houses with monitoring systems
are shown. Fig. 4, Ref. 7.
Auth.
b14.2.2.6. Findings of investigation of
self-excitable three-phase asynchronous generators. /A. Rikrikadze, A. Shermazanashvili/. Science and Technologies. – 2014. – #1(715). – pp. 63-69. – geo.; abs.:
geo., eng., rus.
The findings of investigation of self-excitable three-phase one- and two-coil asynchronous generators are discussed. Their comparative
and theoretical analyses are carried out. As a result of a multiplied
experiment, two empiric formulas are obtained, which allow defining by the coil current
rate the rate of current in the actuating coil. Two cases are considered: when
a capacitors battery is switched on and switched off in the actuating coil
circuit. Fig. 1, Ref. 2.
Auth.
b14.2.2.7. Investigation and detection of powerful hydro generators rotor
shape and electromagnetic state by new integrable sensors. /L. Gugulashvili, Z. Azmaiparashvili, I. Metskhvarishvili/. Science and
Technologies. – 2014. – #2(716). – pp. 19-22. – geo.; abs.: geo.,
eng., rus.
The problems connection with enhanced trustworthiness
and operating life of powerful hydro generators are discussed and
it is shown that all it depends on their vibrational state. The equipment
presently employed for studying the vibrational state of generators fails to
distinguish rotor shapes and detect short-circuits winding. A new
electromagnetic rotor shape detecting sensor can be easily included in a
network of computer monitoring of the generator. Fig. 3, Ref. 4.
Auth.
b14.2.2.8. Optimum reactive-power compensation in
distribution networks based on co-financing. /P. Akhaladze/. Bulletin of
Akaki Tsereteli State
University. – 2014. – #2(4). – pp. 66-76. – geo.; abs.: geo., eng.
The article analyzes the optimal compensation
of reactive load in the distribution networks by co-financing principle.
Conducted calculations and analysis of the results of these calculations show
that the principle of co-financing gives economic stimulus to the companies
with low voltage networks to consider more actively within their networks the
power of reactive load compensating plant and the site-selection task. Tab. 2,
Fig. 1, Ref. 2.
Auth.
b2.3 Mechanical
engineering and applied mechanics
b14.2.3.1. Electrization
of clouds formed during aircrafts flight. /A.
Apkhaidze, M. Mamsirashvili/. Air Transport. –
2014. – #1(9). – pp. 8-13. – rus.; abs.: geo., rus., eng.
The article considers an aircraft as
generator of cloud’s large electric charge. The produced charge is
characterized of the relaxation time that equals existence of the cloud proper.
Based on it, given the peculiarities of electric discharges in clouds, definite
intervals of aircraft movement in clouds are proposed. Fig. 2, Ref. 6.
Auth.
b14.2.3.2. Efficiency
enhancement of ergatic systems. /S.Khoshtaria, K. Bareladze, Ts. Khoshtaria/. Air
Transport. – 2014. – #1(9). – pp. 14-18. – rus.; abs.: geo., rus., eng.
The article describes analytical approaches
to typical ergatic operations; formulas defining the probability of error-free performance
of operations and the integral algorithm and the availability value are given.
Ref. 2.
Auth.
b14.2.3.3. Two-stage refrigeration cycle with one rotary
compressor, regeneration economizer and refrigerant steam splash. /T. Megrelidze, T.
Isakadze/. Transactions of Technical University of Georgia. – 2014. – #4(494).
– pp. 28-33. – geo.; res.: geo., eng., rus.
An innovative refrigerator enables obtaining
the refrigerant’s boiling-point below 300C with only one compressor. As is
generally known, for classic refrigeration cycles the obtaining of such
refrigeration regimes is possible only with a two-stage cycle. In this case,
the classic refrigeration cycle is replaced by the economizer refrigeration
cycle. The Innovative refrigerator is noted for a simple design, low cost,
economy and reliability. Fig. 5, Tab. 1, Ref. 7.
Auth.
b14.2.3.4.The cascade-type thermoelectric refrigerator. /T. Megrelidze, T.
Isakadze, G. Gugulashvili, G. Megrelidze/. Transactions of Technical University of Georgia. – 2014. – #4(494).
– pp. 33-37. – geo.; res.: geo., eng., rus.
The cascade-type thermoelectric refrigerators
are considered. It is shown that by cascade location of thermoelements the
maximum efficiency of a thermoelectric-type refrigerator can be obtained, which
is expressed in the possibility of achieving the maximum difference between the
temperatures of the hot and cold surfaces of the design, enhancement of the
performance and refrigerating efficiency. Fig. 2, Tab. 1, Ref. 4.
Auth.
b14.2.3.5. Hydrodynamics and
heat transfer of turbulently overflowed rough surfaces. /T. Magrakvelidze, N. Bantsadze, A. Mikashavidze, Kh. Lomidze, N. Lekveishvili/.
Proceedings of the A. Eliashvili Institute of Control Systems. – 2014. – #18. –
pp. 67-73. – geo.;
abs.: geo., eng., rus.
Works dedicated to hydrodynamics and heat
transfer of turbulently overflowed rough surfaces in channels and stirred tanks
are analyzed. Focused are important results obtained by Georgian scientists. In
particular, classical experiments of I. Nikuradze and very important results
obtained by V. Gomelauri and his students. The results yet not published by
authors are also presented. Fig. 7, Ref. 19.
Auth.
b14.2.3.6. Investigation
of liquid and solid fuel calorific value measurement equipment. /K. Chkhikvadze, O. Kiguradze, T.
Chkhikvadze/. Proceedings of the A. Eliashvili Institute of Control Systems. –
2014. – #18. – pp. 111-115. – geo.; abs.: geo.,
eng., rus.
The working principle of solid and liquid
fuel calorific value measurement equipment – XRY-1C is considered in the work.
For measuring fuel calorific value through relative method 99.24% purity
exemplary substance – STU-1 is introduced, created on the basis of benzoic acid
brand “STANCHEM”. Its calorific value is equal to 26437 j/g ±0,78%. The
experiment is performed on coal sample from Tkibuli-Shaori layer, during which
the calibration of calorimeter was performed by exemplary substance – STU-1.
The calorific value of experimental substance is equal to 20590 j/g with the
standard error of 0.62%. Fig. 3, Ref. 1.
Auth.
b14.2.3.7. Static analysis of a double-chamber
tunnel built using cut-and-cover construction. /L. Japaridze/.
Bulletin of
the Georgian National Academy of Sciences .– 2014. – vol. 8. – #1.– pp. 47-50.
– eng.; abs: eng., geo.
The worldwide shortage of life and transport
spaces makes it necessary to utilize underground space of the cities by
construction of tunnels and near surface facilities using the so-called
cut-and-cover method. Calculation of such structures is a responsible task. Now
there are lots of numerical computer programs that are used in designing the
underground constructions. However, the numerical methods sometimes yield
results that can vary significantly from those obtained by classical methods.
Therefore, in some cases classical methods of forces and displacements are
recommended to be used in the structural analysis of cut-and-cover tunnel
structures. The concept is right not only for cut and cover, but for other
types of tunnels and underground facilities. Tasks, which can be solved
analytically, must be worked out by classical computer methods. The qualified
specialists must use numerical methods in parallel with analytical methods, if
possible. Such approach can be useful for facilitation of the work, testing the
calculation results in order to avoid potential errors. It is often difficult
to find the appropriate analytical apparatus for solving typical schemes of
such structures. The analytical apparatus for static analysis of one or
two-span frame of the tunnel structures using methods of forces and
displacements is elaborated and presented in the paper. Fig. 1, Ref. 4.
Auth.
b14.2.3.8. Results
and analysis of theoretical, experimental and computer investigations of vacuum
drives’ frictional units.
/N. Molodini, R. Molodini/. Mining
Journal. – 2014. – #2(33). – pp. 47-50. – geo.; abs.: geo., eng., rus.
The article gives
conclusions and recommendations received by studying designs of drive
vacuum-drums of belt transporter and frictional units of their contact
surfaces; analyzing the vacuum producing processes upon macro elastic
hydrodynamic regime in the contact annular gap with the belt; by theoretical
and experimental investigation and computer modeling of the liquid layer
thickness and its drainage effect. Ref. 4.
Auth.
b14.2.3.9. The
technology of quarrying facing block stones by explosion and the role of acad. A. Dzidziguri in its
propagation. /R. Mikhelson/. Mining Journal. – 2014. – #2(33). – pp. 58-63. – rus.; abs.: geo., eng., rus.
The essence, parameters and
peculiarities of the technology of quarrying block stones by explosion
developed G.Tsulukidze Mining institute during 1965-1985 are given. The basic
stages of the work were implemented under conditions of strict prohibition of using
the explosion energy that interfered with the propagation of the novel
technology in the Soviet Union. Acad. A. Dzidziguri has a great role in the
widening its application area; he succeeded in consolidation of the appropriate
government institutions and research centers for reviewing the outdated
provisions of the effective state standard. Fig. 2, Tab. 2, Ref. 8.
Auth.
b14.2.3.10. The
possibility and example of the tension originating upon reeling a silk thread
on the spindle. /Z.
Jokharidze/. Automated Control Systems. – 2014. – #1(17). – pp. 27-31. – eng.;
abs.: geo., eng., rus.
This article presents solution to the problem
of tension and shape originating upon reeling of silk thread on the spindle,
which is achieved through the respective mathematical model and solution
algorithm. Fig. 3, Ref. 3.
Auth.
b14.2.3.11. Forming
differential equations for additional motions of optimal brake lever
control of a driving car. /G. Sharashenidze, V.
Margvelashvili, G. Usanetashvili, S. Sharashenidze/. Science and Technologies. – 2014. – #1(715). – pp. 70-74. – geo.; abs.:
geo., eng., rus.
The article, given the non-technological
gap in the joints, provides the sequence of formation of the differential
equation of motion to determine
the output parameters of the
transmission brake. In order to
set up the dynamic equations, a
transmission model is used. The types of additional motions are considered and
general differential equations are formed. Fig. 1, Tab.
1, Ref. 5.
Auth.
b14.2.3.12.
Scientific-technical
research of highly effective motor brake of internal combustion engines. /B.
Kordzadze, R. Demetrashvili/.
Science and Technologies. – 2014. – #2(716). – pp. 77-88. – geo.; abs.: geo., eng., rus.
The results of a scientific-technical research
of the working process of a highly effective motor brake for internal
combustion engines are presented. The motor brake made in R. Dvali institute of
Machine Mechanics is of a simple design, light weight, economic and can be
installed on serial automobiles. Fig. 9. Ref. 2.
Auth.
b14.2.3.13. Development
of optimal brake leverage transmission of an electric locomotive. /G.
Sharashenidze, A. Sharvashidze, L. Tediashvili, S. Sharashenidze/. Science and Technologies. – 2014. – #2(716). – pp. 89-93. – geo.; abs.: geo., eng., rus.
The optimal brake leverage transmission for
VL 10 type electric locomotive is developed. The optimal brake transmission
provides for the reliable braking effect with less number of lever rods and
joint connections. The value of the brake shoes pressing force is obtained in
an analytical form, taking into account the brake cylinder pressing force and
system transmission ratio. Fig. 2, Ref. 4.
Auth.
b14.2.3.14. Definition of rail-car kinetic energy taking into account
the asymmetric arrangement of bogies. /G. Sharashenidze, I. Zakutashvili, L. Tediashvili, S.
Sharashenidze/. Science and Technologies. – 2014. – #2(716). – pp. 94-99. – geo.; abs.: geo., eng., rus.
The inequalities of rail-car wheels and rail
that cannot affect the kinetic energy of rail-car motion are considered. The
scheme of rail-car movement to calculate the kinetic energy of rail-car is
constructed. An analytical expression for the kinetic energy of rail-car motion
taking into account the kinetic energies of bogies is obtained. Fig. 2, Ref. 5.
Auth.
b14.2.3.15. The
effect of electrohydraulic discharge for high dispersive magnetic nanofluid
synthesis. /V.
Mikelashvili, J. Markhulia, Sh. Kekutia, R.Tatarashvili/. Nano Studies. – 2014. – #9. – pp. 87-92. – eng.
Experimental studies have shown the
effectiveness of electrohydraulic processing on the high dispersive magnetite
nanofluid synthesis. The concentration enhancement of magnetite nanoparticles
was caused by an instant increase of pressure and effect of other physical
phenomena, which accompanied the electrohydraulic effect. The effective use of
this effect is closely related to the control of some physical parameters. The
recorded hysteresis loops show that the particles are superparamagnetic at room
temperature, which is characteristic of a soft ferromagnetic material such as
magnetite. Fig. 4, Ref. 12.
Auth.
b14.2.3.16. Non-stationary
problem of beams’ deformation at thermo-mechanical loading. /O. Kikvidze, G. Baisarova/. Bulletin of Akaki Tsereteli
State
University. – 2014. – #2(4). – pp. 77-82. – geo.; abs.: geo., eng.
The work presents a system of nonlinear differential equations of the thermo-mechanic non-stationary task. The temperature field is considered as two-dimensional and non-stationary. The beam deformation is described by means of nonlinear ordinary differential equations system, foreseeing deformation of thermoelastic line. Ref. 3.
Auth.
b2.4 Chemical
engineering and technologies
b14.2.4.1. Influence of alkaline metal oxides on the process of joint reduction of
manganese and silicon. /Z. Simongulashvili, S. Nebieridze/. Ceramics. – 2014. – #1(31). – pp. 3-6. –
rus.; abs: rus., geo., eng.
On the basis of the executed researches, a resource saving technology of
tuff application in the silicomanganese
production has been developed, mastered and introduced. The
substitution of quartzite with tuffs of different origin, which together with silica contain alkaline metal oxides, allowed increasing the useful usage of manganese
and silicon, improving technical and economic process indicators and reducing
the cost of silicon manganese by 5-6%. Tab. 1, Ref. 5.
Auth.
b14.2.4.2. Research of the gold-bearing lead and zinc ore dressing by physical methods. /Z. Sherazadishvili,
M. Mchedlishvili, N. Shekriladze/. Ceramics. – 2014. –
#1(31). – pp. 7-11. – geo.; abs: rus., geo., eng.
The process of concentration of the gold-bearing lead and zinc ore by physical
methods in Georgia is researched. The test method for granulometric analysis of
ore showed that the distribution of gold and base metals in fractions
practically corresponds to the mass composition of the ore. Consequently, we
have found that it is impossible to concentrate ore by a granulometric method.
The process of ore concentrate by heavy suspensions is studied. It is stated
that dressing of precious metals: gold, silver and base metals: copper, zinc
and lead by this method is possible. Ore testing on the concentration table
showed that ore is also amenable to gravity concentration. Tab. 4, Fig. 3, Ref.
5.
Auth.
b14.2.4.3. Research of the element and
phase composition of the gold-containing ore. /Z. Sherazadishvili, M. Mchedlishvili,
N. Shekriladze/. Ceramics. – 2014. –
#1(31). – pp. 12-15. – geo.; abs: rus., geo., eng.
Elemental and phase composition of gold-containing ore existing in
Georgia is researched. It was determined that non-ferrous metals: copper, lead
and zinc are mainly presented in the form of sulfides. It is estimated that
gold, silver and non-ferrous metals removal from ore can be justified
economically. Also we have investigated the forms of gold and silver in the
ore. It is estimated that precious metals are in the free, splice and
associated forms. The existence of precious metals in various forms should be
considered when developing technological scheme of ore processing. Fig. 1, Tab. 3, Ref.4.
Auth.
b14.2.4.4.
Research of content of toxic elements in tomato paste at Georgian market. /N. Duchidze, M. Mchedlishvili/. Ceramics. – 2014. –
#1(31). – pp. 28-31. – geo.; abs: rus., geo., eng.
The content of toxic elements in tomato paste
produced by different countries and imported to Georgian market is examined. By
the example of Marneuli Food Factory, the content of toxic
elements content in tomato paste was found to depend on different factors,
including the content of tomato and technological water. Besides, their getting
into the tomato paste is also possible from the equipment used in the plant. It
has been established that the products of all the firms that get on the market
satisfy the requirements presented to them concerning the content of toxic
elements, although some of them are approaching the maximum permissible norms. Tab.3, Ref. 4.
Auth.
b14.2.4.5. The current carbo and
aluminothermal processes on the base of geopolymer in the
nitrogen environment. /Z. Kovziridze, N.
Nizharadze, N. Darakhvelidze, G. Tabatadze, Z. Mestvirishvili/. Ceramics. – 2014. –
#1(31). – pp. 32-36. – geo.; abs: rus., geo., eng.
The possibilities of production of cialon by carbo- and alumothermal
method on the base of geopolymer (caolyne) and processes taking place in
mixtures in nitrogen environment at 14000 C were studied. The study
was conducted by the methods of optical and X-ray analysis. Fig. 2, Tab.3, Ref.
16.
Auth.
b14.2.4.6. Study of the
influence of binders on physical-technical features of a highly refractory
dolomite-serpentine clinker. /Z. Kovziridze, N. Nizharadze, M. Balakhashvili, M.
Mshvildadze/. Ceramics. – 2014. –
#1(31). – pp. 42-45. – geo.; abs: rus., geo., eng.
The study was conducted to study the influence of binders on the
physical-technical features of a highly refractory dolomite-serpentine clinker.
There have been used water-soluble binders: magnesium sulphate solution,
technical lignosulphonate, methyl cellulose liquor, polyvinyl alcohol and
water. It has been stated that samples of dolomite-serpentine clinkers with
methyl cellulose liquor as binder have the best physical-technical properties. Tab. 3, Fig. 2, Ref. 6.
Auth.
b14.2.4.7.
Producing manganese dioxide from carbonate manganese ores. /B. Purtseladze, T. Chkonia, E. Shoshiashvili, M. Avaliani, I.
Chkhaidze, M. Svanidze, L. Svanidze, T. Lezhava/. Proceedings
of Georgian National Academy of Sciences. – Chemical Series. – 2014. – vol. 40.
– #1. – pp. 12-15. – geo.; abs.: geo.,
eng., rus.
A method to obtain manganese dioxide from
Chiatura carbonate manganese ore is proposed. The process
of leaching of ore is executed by means of nitric acid, after cleaning by
ammonium at pH = 4-5. The technological scheme permits to obtain manganese
concentrates Mn2O3, the processing of which enables to produce manganese dioxide. Tab.3, Ref. 5.
Auth.
b14.2.4.8. Simultaneous
electrosynthesis of oxidizers - hydrogen peroxide, sodium perborate and sodium
hypochlorite in the membrane electrochemical reactor. /P. Nikoleishvili,
G. Tsurtsumia, V. Kveselava, G. Gorelishvili, M. Avaliani, R. Kurtanidze, D.
Sharabidze/. Proceedings of Georgian National Academy of Sciences. – Chemical
Series. – 2014. – vol. 40. – #1. – pp. 24-31. – geo.; abs.: geo., eng., rus.
An original electrochemical cell was
developed for simultaneous generation of hydrogen peroxide (H2O2)
at the carbon gas-diffusion electrodes (GDE) covered by “Black Pearls 2000”
layer and/or sodium perborate (NaBO2·H2O2·3H2O)
in the cathode compartment, and sodium hypochlorite (NaCIO) at the
dimensionally stable anode (DSA) which was the meshed titanium plate, coated
with mixed TiO2-RuO2 oxide layers . The scheme for the
extraction of sodium perborate from the reactor was designed. Operational
conditions for the cell were selected at comparing of the work of the anion-
(MA-40,
Auth.
b14.2.4.9. Impact of mixed
mobile ions on electroconductivity of borosilicate glasses doped with A2B6
and A1B7 compounds components. /R. Janelidze, Y. Blagidze, G. Mshvelidze, O. Gogolin, E.
Tsitsishvili/. Proceedings of Georgian National Academy of Sciences. – Chemical
Series. – 2014. – vol. 40. – #1. – pp. 35-40. – eng.; abs.: geo., eng., rus.
The results of measurements of
dynamic (a.c.) electrical conductivity in borosilicate glasses doped with A2B6
(CdSSe, CdSe and CdTe) and A1B7 (AgI, CuBr and CuI)
semiconductor compounds at a wide temperature range below the glass transition
temperature Tg are given. The concentration of the mobile dopant
ions is governed by specific heat treatment conditions of the glass samples leading to a creation of semiconductor
nanocrystals. At temperatures higher than 1500C – 2000C
the a.c. conductivity exhibits the Arrhenius behaviour and the mixed mobile ion
effect in all the examined glasses. Fig. 7, Tab.1, Ref. 16.
Auth.
b14.2.4.10. The possibility of producing synthetic diamond crystals
with predetermined properties under conditions of spontaneous crystallization. /N. Loladze,
E.
Qutelia, M. Tserodze,
N.
Maisuradze, I. Dzidzishvili, S. Zaslavski/. Proceedings
of Georgian National Academy of Sciences. – Chemical Series. – 2014. – vol. 40. – #1.
– pp. 50-54. – rus.; abs.: geo., eng., rus.
The basic requirements
of the physical-chemical and physical-mechanical properties of diamond crystals
for their effective application in diamond tools are stated. Experimentally is
shown that using the developed composition of the reaction mixtures at constant
P – T conditions allows significant control over the nucleation density and
thus increase the yield of crystals with preset forms and morphology. Fig. 3, Ref. 14.
Auth.
b14.2.4.11. Influence of the
thermal treatment on the chromatographic characteristics of diatomite. /K. Khachaturian, L.
Makharadze/. Proceedings of Georgian National Academy of Sciences. – Chemical
Series. – 2014. – vol. 40. – #1. – pp. 55-61. – rus.; abs.: geo., eng., rus.
Chromatographic investigations of the initial
forms of diatomits (Kisatibi deposit), their thermally treated (at 500 and
Auth.
b14.2.4.12. Removal of impurities
from metallurgical silicon by crystal pulling from melt. /L. Gabrichidze, E. Khutsishvili, N. Kobulashvili, N.
Khutsishvili,T. Gigitashvili, R. Kharati, G. Urushadze, I. Kupreishvili, N.
Kekelidze/. Proceedings
of Georgian National Academy of Sciences. – Chemical Series. – 2014. – vol. 40. – #1.
– pp. 94-100. – geo.; abs.: geo., eng., rus.
The process of
purification of metallurgical
–grade silicon КР-1 with 98 Siwt % and 2%
of unwanted Fe,
Al, Р, Са, Cu, Mg, Mn, Ni, Ti impurities is considered. Because of small values of impurities segregation
coefficient (10-4-10-6) in
Si for purifying of technical silicon we applied a method based on segregation
of impurities at solidification - Czochralski crystal pulling from
melt. By X-ray spectral microanalyzer and emissive spectral analysis the content of contaminating impurities before and after
purification and purification efficiency have been established. It has been shown,
that pulling speed has a big influence on the quality of purification.With pulling speed increase the purification efficiency grows. Technical silicon
has been purified effectively up to ~99.99 wt %. Fig. 3, Tab.2, Ref. 19.
Auth.
b14.2.4.13. Sulfur-containing
zeolite supplements for anti-corrosive and biocide special concretes. /G. Tsintskaladze, O.
Lomtadze, M. Burjanadze, T. Sharashenidze, V. Gabunia, N. Shalvashvili, V.
Tsitsishvili/. Proceedings of Georgian National Academy of Sciences. – Chemical
Series. – 2014. – vol. 40. – #1. – pp. 104-108. – rus.; abs.: geo., eng., rus.
By using the method of fusing a new
sulfur-zeolite material was obtained. The structure and adsorption properties
of the material were studied by X-ray diffractometer and studying the
adsorption properties of water vapor. Concrete samples were prepared by using
sulfur-zeolite material and their resistance to different cultures of molds
fungi was determined. Based on these results, the developed sulfur-zeolite
material can be used as an additives for the cement to produce biocidal and
anticorrosive concretes of special purpose. Fig. 2, Tab.2, Ref. 11.
Auth.
b14.2.4.14. Some peculiarities of
phase formation in Ti-Cr-C-Me system by SHS. /Z. Aslamazashvili, G.
Oniashvili, G. Zakharov, G. Tavadze, G. Urushadze/ Science and Technologies. – 2014. – #1(715). – pp.
45-50. – geo.; abs.: geo., eng., rus.
Some peculiarities of phase formation in Ti-Cr-C-Me system by
Self-propagating High-temperature Synthesis (SHS) are described. It is found
that during synthesizing materials in Ti-Cr-C-X18H15 system three phases are formed:
Titanium-Chromium Carbide, Chromium Carbide and metal alloy. By entering the
molybdenum in chasm of the mentioned system hard composite materials with ring
structure is obtained, which ensures an increase in the strength
characteristics. Fig. 5, Tab. 2, Ref. 5.
Auth.
b14.2.5.1. On the history of zinc in Georgia. /G. Tsirekidze, R. Chagunava/. Air
Transport. – 2014. – #1(9). – pp. 73-84. – rus.; abs.: geo.,
rus., eng.
Written sources and archeological data
evidencing that zinc alloys were used B.C. are considered. Aristotle’s
statement: “Mossinik’s copper, is most white and shiny… that some kind of soil
is mixed and dissolved in it” is cited. It is opined that the name of brass
“messing” in many languages comes from the name of Mossinik tribe – pioneers in
producing this alloy. According to Georgian writing sources, zinc alloys and
metal zinc have been known in Georgian from the 11the-12th
centuries. King Vakhtang VI is found to introduce the Arabian-Persian term
“tutia”, which has been used as a borrowed Georgian term of zinc for 3
centuries already. Ref. 22.
Auth.
b14.2.5.2. Producing Ta-Al-B4c
ceramic materials under the impact of air-blast. /B. Godibadze, A. Peikrishvili, E. Chagelishvili, M.Tsiklauri, A.
Dgebuadze/. Mining Journal. – 2014. –
#2(33) – pp.63-68. – geo.; abs.: geo., eng., rus.
The main objective of this work was to study
the possibility of compacting intermetallic Ta-Al-B4C compounds by hot
shock-wave compaction technology; to establish the possibility of formation of
tantalum aluminates intermetallic compounds to near theoretical density with
improved structure and good mechanical properties by combining self-propagating
high temperature synthesis (HTS) and hot-shock wave compaction (HSWC)
technologies. It was established, that for formation flawless composition
materials by HSWC compaction temperature should not exceed temperature of SHS,
9400C. Investigated are the structural and mechanical properties of
tantalum-aluminum-boron carbide intermetallic materials. Fig. 8, Tab. 8.
Auth.
b14.2.5.3. Georgian enamel – the
present and the future. /G. Gaprindashvili, S. Sanadze, M. Kekelidze/. Ceramics. – 2014. – #1(31). – pp. 37-41. – geo.; abs: rus,
geo., eng.
The present state of artistic enamels and pigments for painting in
Georgia is considered. At present in the Eparchy of Alaverdi a plant for
production of these materials in a centralized way is under construction. Fig. 1, Ref. 9.
Auth.
b14.2.5.4.
Coating of duralumin surface by black, wear-resistant layer. /V. Gharibashvili, V. Metreveli, Z. Mirijanashvili, Z. Jabua, I.
Kupreishvili/. Science and Technologies. – 2014.
– #1(715). – pp. 79-83. – geo.; abs.: geo., eng., rus.
The blackening of the AlZn6MgCu aluminum alloy was carried out by the
anodizing and colouring technique. The samples, which were hard anodized in
sulfuric acid solution (<50C) and coloured by black aniline dye
were found to have the best protective properties against wear and fading. Fig.
3, Tab. 2, Ref. 8.
Auth.
b14.2.5.5. Preparation of erbium
monotelluride films, and their optical and electrical properties. /Z. Jabua, I. Tabatadze, A. Gigineishvili/. Science and Technologies. – 2014. – #1(715). – pp.
84-90. – geo.; abs.: geo., eng., rus.
For the first time a technology of preparation of thin crystalline ErTe
films by vacuum-thermal evaporation from two independent sources of components
was developed. Thin films had a cubic crystalline structure with lattice
parameters a=6,03Å. The absorption spectra of prepared films at 300 K were
obtained. The resistance, Hall constant and thermoelectric power of the films
were measured in the temperature range of 100-500 K as function of temperature.
It is shown by the electro-physical properties ErTe films are a metal. Fig. 8, Ref. 9.
Auth.
b14.2.5.6. Prospects of
application of Georgian natural zeolites as building material admixtures /R. Skhvitaridze, V.
Tsitsishvili, B. Keshelava, G. Tsintskaladze/. Science and Technologies. – 2014. – #1(715). – pp. 98-102. – geo.; abs.:
geo., eng., rus.
There is examined the chemical composition of Georgian natural zeolites
– analcime, phillipsite, mordenite, laumontite, clinoptilolite - established
their identity and containment of zeolite phases. It is shown that the
introduction of zeolites into the cement compositions as admixtures leads to
the improvement of the cement quality. In this respect, zeolite - clinoptilolite was found the most
effective. Fig. 1, Tab. 3, Ref. 5.
Auth.
b14.2.5.7. Silk production development history in Georgia. /N. Chkhaidze, N.
Makhviladze, L. Lursmanashvili, T. Chubinishvili/. Science and Technologies. – 2014. – #1(715). –
pp. 120-126. – geo.; abs.: geo., eng., rus.
The history of silk production
in Georgia from ancient times
to the present day is given. Mulberry tree leaves have been used as natural feed of silkworms in the Caucasus from ancient times. Therefore,
the secret of getting silk fibre has been were known in Georgia from those
times. In the oldest Georgian literary work “Martyrdom of Shushanik” (5th
c. A.D.) the existence of silk in Georgia is evidenced. In the next centuries
the silk production in Georgia became one of the main industries. The produced
silk products were used both in the country as well as were exported. The raw
silk thread production totalled 400 tonnes per annum in the 1960s and the rate
was kept up to 90s. In the early 90s the silk production was ceased due to the
known reasons of the collapse of the Soviet Union. The restoration of silk
production in Georgia should become one of the priorities of Georgia’s economy
development. Tab. 1, Ref. 11.
Auth.
b14.2.5.8. Electrophysical properties of tulium monosulfide thin
films. /M.
Teteloshvili, Z. Jabua, A. Gigineishvili/. Science and Technologies. – 2014. – #2(716). – pp. 61-64. – geo.; abs.: geo.,
eng., rus.
The dependence of
electrophysical parameters of TmS thin films from on sizes of their constituent
particles is considered. It is shown that the reduction of the sizes of
particles below 55 nanometers leads to a dramatic concentration of electrons in
the film, which, in turn, reduces the temperature coefficient of resistance. Fig. 5, Ref. 1.
Auth.
b14.2.5.9.
Stabilizers for filled PVC. /N.
Kheladze, G. Chiradze/. Bulletin of Akaki Tsereteli State University. –
2014. – #2(4). – pp. 115-124. – geo.; abs.: geo., eng.
The paper presents a
study
of thermo-oxidative destruction
of polyvinyl-chloride composites obtained using local mineral
fillers (teshenite, basalt,
white and pink
eklari) and the ways of its increase.
It is estimated that the maximum increase of thermal stability
occurs at (3.0:3.0) ratio application of stearate Сa and PbSiO mixture of stabilizers. Tab. 2, Fig. 1, Ref. 3.
Auth.
b14.2.6.1. Object-oriented
approach in the solution of problems of medical diagnostics. /N. Jaliabova/. Proceedings of the A.
Eliashvili Institute of Control Systems. – 2014. – #18. – pp. 247-251. – rus.;
abs.: geo., eng., rus.
The
concept of creation of the
intellectual system structure of diagnostics by using the
object-oriented approach is offered in the work.
The use
of the methodology of object-oriented structuring allows uniting the process of
object decomposition and a method of representation as logical and physical, as
well as static and dynamic models of the designed system. In the process of
finding the solution to the problems of medical diagnostics, the often raised
question is not whether this object belongs to a class, but to what degree it
can be carried to this class. To do this, there is used the methods of fuzzy
classification, based on the concept of class as a diffuse (fuzzy) set of
objects for which the transition from non-membership of a given class to
supplies gradually, and not jump wise. Ref. 2.
Auth.
b14.2.6.2.
Controlled
local hyperthermia for therapy of malignancies. /Z.
Kovziridze, G. Menteshashvili,
P.
Khorava, Kh. Bluashvili/. Ceramics. – 2014. –
#1(31). – pp. 16-27. – geo.; abs:
rus, geo., eng.
On
the basis of an experimental material the anticancer mono-therapeutic effect of
hyperthermia and its adjuvant action in poly chemotherapeutic treatment was
presented by the use of a device created by us – “Lezi”. (
Auth.
b2.7 Environmental
engineering
b14.2.7.1. Modeling of the
structure of Georgian power grid. /M. Gudiashvili, S. Lomidze/. Transactions of Technical University of Georgia.
– 2014. – #4(494). – pp. 9-13. – geo.; res.: geo., eng., rus.
The development of the structure of the
Georgian power grid is a multi-criteria task, which can be solved by building a
mathematical model. According to the calculation, it is recommended to
construct during the prospective period of 2015-20 years 85 MW capacity small
hydro-power plants, 1610 MW capacity middle and large hydro-power plants with
regulating reservoir, 1250 MW capacity wind farms and 230 MW capacity natural
gas-fired heat power station. They will ensure meeting the country’s demand of
electricity, considering the country's economic, environmental and territorial
distribution of power capacities. Tab. 2, Ref. 2.
Auth.
b14.2.7.2. Definition of thermal
equivalent of fuel calorific value measurement equipment. /K. Chkhikvadze/. Transactions of Technical University of Georgia.
– 2014. – #4(494). – pp. 19-22. – geo.; res.: geo., eng., rus.
The working principle of solid and liquid
fuel calorific value measurement equipment –XRY-1C. is discussed The thermal
equivalent of the calorimeter is defined, which is equal to 13947 j/K with the
standard error of 0.08%. For calibration it is used exemplary substance –
STU-1, created on the basis of benzoic acid brand STANCHEM, which purity,
according to main substance, is 99.24% and calorific value is equal to 26.437
j/g ±0.78%. Fig. 2, Ref. 2.
Auth.
b14.2.7.3. Profile analysis of
deviated wells based on directional survey data. /G. Gadjiev/. Transactions of Technical University of Georgia.
– 2014. – #4(494). – pp. 23-27. – rus.; res.: geo., eng., rus.
The drift of survey data of directionally
drilled wells, which is used to assess the well bore profile for the purpose of
studying the effect of wellbore profile on technical parameters of exploitation
of wells is analyzed. Indicators, such as the inclination angle from vertical α, azimuth angle φ,
the well deviation angle from vertical ℓ are also analyzed. The
relationship between amax and ℓ is
established. The model is obtained based on this relationship, and it has high correlation
coefficient 0.80 and the lowest dispersion. Parameters of the maximum deviation
angle and deviation angle at the zone of running in the hole the pump equipment
are analyzed based on normal distribution law. Also changes in azimuth angle
and intensity of well bore curvature in deviated wells are evaluated to ensure
normal landing job of a pumping unit. Fig. 7, Ref. 9.
Auth.
b14.2.7.4. 60-year experience in flight design and practical application of heat
pump systems in Georgia. /N. Mirianashvili, O. Vezirishvili, K. Vezirishvili-Nozadze, T. Megrelidze, N. Gdzelishvili, V. Khatashvili, V. Bakhtadze/. Proceedings of the A.
Eliashvili Institute of Control Systems. – 2014. – #18. – pp. 116-120. – geo.; abs.: geo., eng., rus.
The paper analyzes
the current level of use of heat pump installations in Georgia and
presents the important results achieved in this area. On the basis of several
years’ theoretical and experimental studies, there are recommended
refrigerants, the application of which is effective for heat
pump in terms of the thermodynamics and for environmental
reasons. The wide usage of heat pump for heating and cooling will enable the
optimal development of the fuel and energy complex of Georgia and save fossil
fuel consumption by 27-36%. All this will enable to
improve the economic state of the country and increase the society’s level of
the well-being. Tab. 1, Fig. 2,
Ref. 10.
Auth.
b14.2.7.5. Problems of heating of public schools in Georgian regions and the ways of their solution. /Kh. Sichinava, G.
Arabidze, T. Jishkariani/. Proceedings of the A. Eliashvili Institute of
Control Systems. – 2014. – #18. – pp. 97-104.
– geo.; abs.: geo., eng., rus.
Firewood, that needs a considerable amount of
financing, is used by Georgian regional schools for heating purposes. The
article demonstrates that this type of heating is completely ineffective. To
solve the problem, it is important to efficiently use the energy potential of
firewood, to improve the combustion process and the technical condition of the
public school buildings. Tab. 1, Fig. 4,
Ref. 4.
Auth.
b14.2.7.6. Hydropower as guarantee for power independence of Georgia. /R. Arveladze, T. Kereselidze/. Proceedings of the A. Eliashvili Institute
of Control Systems. – 2014. – #18. – pp. 83-89. – geo.; abs.:
geo., eng., rus.
Georgia today does
not have sufficient resources to meet the energy balance. Against the
background of increasing demand for energy resources, such situation is hardly to
change in the near or distant future. The role of hydroelectric power plants in
meeting the country's power needs is extremely important, although, even under
conditions of their complete utilization, the problem will still remain. The
development of a cost-effective and environmentally acceptable energy potential
of rivers should be done very rapidly. To ensure the complete satisfaction of
future demand for electricity, the following activities should be carried out:
the construction of a regulating power plant, enabling to arrange a
hydroelectric complexes; the import of basic power instead of export of peak
energy; the winter-spring energy exchange with concerned states; the
introduction of wind, solar and own coal into the energy balance; the import of
electricity or the construction of thermal power plants running on imported
gas; in addition to the thermal power plants running on imported gas, the
adoption and use of hydrogen would be reasonable, the resources of which in
Georgia are practically unlimited. Tab. 2,
Fig. 1, Ref. 6.
Auth.
b14.2.7.7. Safe distances during
blasting operations and storage of explosives. /A. Bezhanishvili, N. Kukuladze, N. Bochorichvili, M. Gogrichiani/. Mining Journal. – 2014. – #2(33) – pp.78-83. – geo.; abs.: geo., eng., rus.
The methods of calculation of
safe distances for people, buildings and devices during blasting operations and
storage of explosives are considered. in particular these concern: blasting works
in an open locality and under water, special blasting works, upon tunneling, on
the objects located on land surface, as well as in in coal seams dangerous in
terms of rock burst; in mines dangerous by outburst and explosion of gas and
dust. The design formula for calculating a safe seismic is given. Tab. 2, Ref. 1.
Auth.
b14.2.7.8. On the effectiveness of some automobile fuel admixtures. /T. Natriashvili, V. Margvelashvili, R. Demetrashvili/. Science and Technologies. – 2014. – #1(715). – pp. 52-57. – geo.; abs.: geo., eng., rus.
The effect of admixtures intended for automobile fuels supplied by two
different sources on the operation of the internal combustion engine is
considered. Tests of the diesel- and petrol-run automobiles carried out on a
special testing stand have shown that the technical and economic as well as
ecological indices of the engines working on fuels with the considered
admixtures actually do not differ from the indices of the engines working on
the fuel without admixtures. Fig. 5.
Auth.
b14.2.7.9. Choice of a
compatibility criterion for lubricating materials. /S. Iashvili/. Science and Technologies. – 2014. – #1(715). – pp. 58-62.
– geo.; abs.: geo., eng., rus.
The problems of choice and calculation of
lubricating materials of friction units of machines are considered. It is shown
that the proper operation and reliable exploitation of the heavily loaded
details of friction are mainly dependent on the ability of lubricating
materials to divide the ground surfaces of the lubricating layer and carry out
the effective extraction of energy. The criterion of continuity of the
lubricating layer - critical temperature of surface of friction, is determined.
The calculation formulas for such temperatures upon application of both
ordinary and modified lubricants are given. Fig. 1, Ref. 8.
Auth.
b14.2.7.10. Application of powder
metallurgy in mining industry. /E. Chagelishvili, A. Peikrishvili, T. Pirtskhalava, M. Tsiklauri, B. Godibadze, A. Dgebuadze/. Science and Technologies. – 2014. – #2(716). – pp. 71-76. – geo.; abs.: geo.,
eng., rus.
The results of research conducted by
G.Tsulukidze Mining Institute, in accordance with the principles of the
restructuring of the coal industry in Georgia are given. For the projected mine
of Tkibuli-Shaori deposits it is recommended to apply the developed by the
institute promising reinforcement technology of cutting tools. The formation of
a transient zone between the cutting material and steel basis provides a
decrease in stresses arising during the cutting process of rocks. On the other
hand, the diamond inclusions provide an increase in hardness and cutting
characteristics of cutting tools. The pressing scheme using Al-B4C explosives,
which is intended for producing composite multilayer cylindrical containers for
operation in an aggressive environment, is considered. Fig. 2, Ref. 9.
Auth.
b2.8 Environmental
biotechnology
b14.2.8.1. Opportunities
of fulvic acids allocation from the ground and their further use. /L. Tatiashvili, N. Tserodze, M. Stefanishvili, R. Uridia, I. Mikadze/. Proceedings of
Georgian National Academy of Sciences. – Chemical Series. – 2014. – vol. 40.
– #1. – pp. 90-93. – geo.; abs.: geo., eng., rus.
Works are carried out with the purpose of different
types of fulvic acids allocation from the ground and peat. Optimal conditions
are chosen for obtaining maximum yield from the compounds mentioned above.
Extract consistency is researched and new cleaning methods are developed. This
gives an opportunity to use liquid fertilizers rationally on the bases of
fulvic acids. Fig. 2, Ref. 19.
Auth.
b14.2.9.1. Microwave
in environmental technologies of processing of mining, metallurgical and
polymeric waste. /A.
Chirakadze, Z. Buachidze, M. Wireman, W. Toscano, N. Kavlashvili, G.
Kervalishvili, L. Gurchumelia, A. Gigineishvili, Z. Gasitashvili, T. Chichua,
D. Bibiluri, L. Sharikadze/. Proceedings of the A. Eliashvili Institute of
Control Systems. – 2014. – #18. – pp. 157-160.
– eng.; abs.: geo., eng., rus.
Recent discoveries by Georgian scientists and
scientific institutions in the field of microwave enhanced processing of mining
and metallurgical, polymeric, agricultural, municipal, medical, radioactive
waste are described. These advances can form a scientific and technological
basis for Georgia to move toward an increased economic and social development,
environmental safety and security, establish a “Green Economics” and a
Knowledge-Based Society and achieve sustainable development. Ref. 9.
Auth.
b14.2.9.2. The effect of nanostructured silver on
biologically active substances and microbiological processes of dry red wine. /N.
Ebelashvili, L. Shubladze, E. Salia, N. Gagelidze, N. Bibiluri/. Bulletin of the Georgian National Academy of Sciences
.– 2014. – vol. 8. – #1. – pp. 94-101. – eng.; abs: eng., geo.
In the present study we investigated the
effect of various doses of nanostructured silver on the content of polyphenols,
organic acids, main conditional indices, lactic acid bacteria and acetic acid
bacteria in biotechnological processes of making dry red wines. Research
material was prepared from the red grape variety “Saperavi”. Sulfur dioxide –
Kadifit, 50 mg/l concentration and various doses of nanostructured silver (0.2;
0.3; 0.4; 0.5; 0.6; 0.7; 0.8 mg/l) were used during the first year of making
red wine material for different biotechnological stages: 1) processing of
destemmed grape pulp prior to alcoholic fermentation; 2) after malolactic fermentation;
3) at the second and 4) third racking off the lees. Malolactic fermentation of
the wine material was conducted after termination of alcoholic fermentation and
racking off the yeast lees using lacto bacteria of the strain “Extraflore” of
Oenococcus oeni as starters. Content of catechins, phenolcarbonic acids,
flavanols and organic acids was investigated by means of the HPLC analysis. The
main conditional indices were determined using standard international methods.
Efficiency of application of nanostructured silver in the wine samples infested
with lactic acid bacteria and acetic acid bacteria was evaluated.
Nanostructured silver was found in biotechnological processes of making dry red
wines to have the effect similar to that of sulfur dioxide. The optimum doses
of using nanostructured silver 0.4 mg/l - prior to alcoholic fermentation for
the processing of grape pulp; 0.6 mg/l – in the processes of the second and
third racking off the lees, for the oxidation of biologically active substances
and inhibition of growth of lactic- and acetic acid bacteria were identified.
Fig. 3, Tab. 4, Ref. 12.
Auth.
b14.2.9.3. Higher basidial fungi
isolated from different zones of Georgia – producers of lignocellulosic enzymes. /N.
Tsiklauri, R. Khvedelidze, N. Zakariashvili, T. Aleksidze, M. Bakradze-Guruli,
E. Kvesitadze/.
Bulletin of
the Georgian National Academy of Sciences. – 2014. – vol. 8. – #1.– pp. 102-109.
– eng.; abs: eng., geo.
Great interest in basidiomycetes for targeted
technological treatment of agro-industrial plant substrates is conditioned by
their ability to produce lignocellulosic enzymes. The samples of wood-degrading
basidiomycetes were collected from different taxonomic niches of Georgia to
study biochemistry and physiology of wood-degrading basidiomycetes. 36 strains
were obtained as pure cultures and 29 ones were identified. Producers of
lignocellulosic enzymes were revealed among the test fungi under solid-state
and submerged cultivation conditions. Pleurous ostreatus GV12, Pleurous
ostreatus GK10 and Fomes.sp. KA20 were found to be the best producers of
cellulosic enzymes using orange peel, wheat straw and wheat bran as substrates,
and Ganoderma sp. GM 04 – the best producer of laccase during cultivation on
orange peel waste. The influence of lignocellulose on accumulation of the
enzymes laccase, xylanase and filter paper assay was studied.Tab. 3, Fig.3, Ref. 25.
Auth.
b14.2.9.4. Chemical composition and functional role of
oil extracted from seeds of Saperavi grape variety (Vitis vinifera L.). /T. Mchedluri, D. Margalitashvili, N. Aleksidze/. Bulletin of the Georgian
National Academy of Sciences .– 2014. – vol. 8. – #1.– pp. 110-113.
– eng.; abs: eng., geo.
Chemical composition of oil extracted from the seeds of Saperavi grape variety, in
particular, the quantitative content of fatty acids, biogenic amines and amino
acids and their influence on the physiological activity of white Wistar rats
were investigated. Constituents of grape seed oil were separated using the
method of high-pressure liquid chromatography (WATTERS, USA) on Nova-Pak column
C18 (100 mm, 83.2 mm) and determined on a fluorescent detector (at 270 nm).
Effects of extracted solutions on emotional state of adult Wistar rats were
tested in special experiments and evaluated using Irvin’s scale. Saturated and
unsaturated fatty acids (lauric, myristic, palmitic, stearic, oleic, linolenic
and arachidonic acids), biogenic amines (serotonin, dopamine, noradrenaline,
adrenaline) and amino acids (aspartic and glutamic acids, asparagine, phenylalanine,
tyrosine, threonine, tryptophane, leucine, methionine, proline, alanine,
glycine) were found to improve functional state of white rats and, as a result,
to alleviate aggressive behaviour. Application of grape seed oil in medical
practice for curative purposes seems to be very prospective. Tab. 3, Ref. 12.
Auth.
b14.2.10.1. Decoder of digital television signal
К1879ХБ1Я. /M. Surguladze/. Proceedings of the A.
Eliashvili Institute of Control Systems. – 2014. – #18. – pp. 220-223. – geo.; abs.: geo., eng., rus.
The application possibility of in the field
of construction of multi-function HDTV receiver as well as many other
electronic devices for control and encryption by the example of the decoder
К1879ХБ1Я (90 nanometric technology) is shown. Tab. 1,
Fig. 1, Ref. 1.
Auth.
b14.2.10.2. Artificial intelligence methods for
developing nanosensorial systems of biochemical analysis of blood. /M. Khachidze, D. Khachidze, N. Khachidze/. Proceedings of the A. Eliashvili Institute of Control Systems. – 2014. –
#18. – pp. 42-46. – geo.; abs.: geo., eng., rus.
The application of the analytical heuristics
method for developing nanosensorial systems of biochemical analysis of blood is
discussed. The procedure for selecting nanosensors for sensorial system of
blood biochemical analysis (for specific disease) is considered. Also
considered is the performance of knowledge base filler “disease concepts” for
system which supports the physician’s decision. This system will give the
physicians an opportunity to diagnose correctly on the basis of the automatic
data analysis received from nanosensorial system. Ref. 6.
Auth.
b14.2.10.3. Use of nanoreinforcement in concrete technology. /R. Skhvitaridze, B.
Keshelava, I. Giorgadze, Sh. Verulava/. Science and Technologies. – 2014. – #2(716). – pp. 65-70. – geo.; abs.: geo., eng., rus.
An innovation is the execution of a
three-dimensional dispersive reinforcement at a nanolevel, implying the self-reinforcement
process with the inclusion into concrete of a zeolitic fiber and needle-shaped
fiber nanosize crystals. As a result, the technology of producing monolithic
concrete resistant to different impacts is developed. Fig. 7, Ref. 3.
Auth.
b14.2.10.4. The
innovative concrete nanotechnology in Georgia. /R. Skhvitaridze, B. Keshelava, I. Giorgadze, G. Tsintskaladze, Sh. Verulava/. Nano Studies. – 2014. – #9. – pp.
5-8. – eng.
The cement
is produced by inclusion of zeolite tuff therein. Before inclusion into the
cement, the mixture additive is subjected to thermal treatment at 100–700oC.
The obtained data testified the positive influence of the active mineral
additives on thermal treatment of cement and concrete strength. The active
mineral additives thermally treated and saturated by sulfur dioxides at 7000C
were studied by XRD. Interesting results were obtained by studying the
physical-mechanical properties of cement based on Portland cement with
thermally treated mineral additives. Upon inclusion of the thermally treated
mineral additive – zeolite tuff Al2O3*2SiO2
– in the cement mixture, the additives and clinker minerals
reacted at the nano-level to produce ettringite 3CaO*Al2O3*3CaSO4*32
H2O, and create preconditions for forming the clusters of
natrolite and so-called zeoettringite, probably, with the chemical formula Na2O*2Al2O3*3SiO2*
6CaO*3SO3*34H2O, which increases activity,
compressive and flexural strength of the concrete. Fig. 4, Ref. 3.
Auth.
b14.2.10.5. Sensitivity and
low-frequency noises of gas sensors made of a nanoscale composite material. /R. Hovhannisyan, H. Khondkaryan, M. Aleksanyan, F. Gasparyan, V.
Arakelyan, V. Aroutiounian/. Nano Studies. –
2014. – #9. – pp. 21-28. – eng.
Thin film gas sensors based on nanocomposite In2O3*Ga2O3*SnO2(70:20:100) have been
manufactured by the high-frequency magnetron sputtering method. The
technological cycle of sensor fabrication processes is described. Sensitivity
of the prepared sensors at the temperature of working body 250oС
and low-frequency noises within the 1–300Hz range were investigated. The
response of sensors to vapors of ethanol and acetone was investigated using
resistive and noise methods. It is shown that the value of the sensitivity
measured by the noise method exceeds the value of sensitivity measured by the
resistive method. Sensors show appreciable sensitivity to the ethanol vapors
already at working body temperature 150oC. Sensors can be used for
the detection of low concentrations of ethanol vapors. The monotonous increase
in the sensitivity of these sensors with increase in the ethanol and acetone
vapors content allows applying nanosensors also for fast determination of gases
concentration in air. Fig. 7, Tab.2, Ref. 12.
Auth.
b14.2.10.6. Nanotimber - innovative construction material of the 21st
century. /T.
Khmelidze, D. Nikabadze, M. Nikoladze/. Nano Studies. – 2014. – #9. – pp.
29-32. – eng.
Since the ancient times, humans have used
timber to make implements, combat equipment, living houses, fortification
buildings, etc. Timber was, is and always will be the most wanted ecologically
clean material in the construction industry. Despite all the good properties
which timber has, like lightness, high strength to density ratio, texture,
easiness to obtain, nice color gamma, etc., the timber and constructions made
from it have some negative properties: burn-ability, low bio endurance,
inclination to rotting, etc. These negative properties are lowering the carrying
capacity of the timber. Mostly these are the reasons why man uses other
materials to construct their buildings. Timber of the coniferous trees is more
used in constructions then the timber of deciduous trees, because of its low
technical indicators. The nanotechnologies, which give a chance of deep
treatment of the timber to produce new construction materials, are discussed.
The use of nanotimber resolves many problems. Fig. 12, Ref. 4.
Auth.
b14.2.10.7. Rare, ultrasmall,
and radioactive nanoparticles. /B. Kharisov, O. Kharissova/. Nano Studies. –
2014. – #9. – pp. 33-48. – eng.
When the nanotechnology area began to develop
intensively as an independent field in the frontiers of physics, chemistry,
materials chemistry and physics, medicine, biology, and other disciplines two
decades ago, such terms as “nanoparticle”, “nanopowder”, “nanotube”,
“nanoplate”, and other related shape-like terms had rapidly become very common.
For instance, a simple search using SciFinder
results hundreds thousands of articles with keywords “nanoparticle” or
“nanotube”. At the same time, during the last years, efforts of researchers
have led to reports of enormous number of the nanostructure types above and the
discovery of more rare species, such as “nanodumbbells”, “nanoflowers”,
“nanorices”, “nanolines”, “nanotowers”, “nanoshuttles”, “nanobowlings”,
“nanowheels”, “nanofans”, “nanopencils”, “nanotrees”, “nanoarrows”,
“nanonails”, “nanobottles”, or “nanovolcanoes”, among many others. The problem
how to name a discovered rare nanoform is commonly resolved according to
imagination of researchers. Since any novel nanoform/nanostructure could
theoretically get useful, unexpected and unpredictable applications, each new
achievement, reproducible or not, is welcome due to an extreme importance of
nanotechnology at this moment and in future. Without a good understanding of
the reasons for shape formation, approaches to the synthesis of nanostructures
can be hard to carry out. According to the available literature, no any
universal generalization of rare and common nanostructures is observed in
available literature. Several existing classifications are related with
dimensionality of the nanostructure itself and their components (for instance,
0D clusters and particles, 1D nanotubes and nanowires, 2D nanoplates and
layers, 3D core/shell nanoparticles or self-assembled massives, intermediate
dimensional nanostructures as fractals or dendrimers) or the classification
based on the triad symmetry group-shell composition-structural formula of the shell
(here nanostructures are divided in branches, classes, and subclasses
determined by the symmetry group of a shell and the sets of the quantum numbers
of a structure). There is offered for discussion by the nanotechnological
community a non-formal classification, which is not directly related with
dimensionality and chemical composition of nanostructure-forming compound or
composite and it is based mainly on the less-common nanostructures. The
discussion is focused to the examination of less-common nanostructures (i.e., published mainly in the range
of 1–100 reports) corresponding to the shapes above. Such
structures possess unusual shapes and high surface area, which make them very
useful for catalytic, medical, electronic and many other applications. In
addition, certain attention is paid to the ultrasmall nanoparticles (size
<10nm) and those containing radioactive elements. Fig. 14, Tab.1, Ref. 7.
Auth.
b14.2.10.8. Recent advance in electrophoretic deposition for
nanotechnologial applications. /G. Gunkaya, H. Kurama/. Nano Studies. – 2014.
– #9. – pp. 49-64. – eng.
Nanotechnology is
a multidisciplinary area of applied science and engineering that deals with the
utilization of unique physical, chemical and biological
properties of nanoscale substances in fundamentally new and useful ways.
Although the researches on nanoscale is back to the
centuries, the study of biological systems and the engineering of many
materials such as colloidal dispersions, metallic quantum dots, and catalysts
can be given as a common previous areas performed in nanometer regime,
the application of nanotechnology for design and
production industries is relatively new. Recent advance on the image, engineer
and manipulate system in the nanometer scale leads to production and uses of
nanoparticles or nanosurfaces hence it has becoming more and more important
topic in the whole world. Several techniques can be concerning the manufacture
of nanosized materials, however, in recent years, the electrophoretic deposition (EPD) has been recognized as a most growing and
promising technique for the manufacturing of nanotechnology based coating
materials due to the high versatility of its use
with different materials and the cost-effectiveness of the process. The fundamental aspects of electrophoretic deposition, mechanism, affecting
factors and applications in various areas including coatings, nanoscale
assembly, micro patterned thin films, advance and fiber reinforced ceramics,
glasses, laminated, graded or hybrid materials, etc. is overviewed. A
special attention has also given to performed researches aimed to utilization
of boron and boron compounds in EPD processes to increase the final product
properties. Boron is a material, which can show high
corrosion resistance, high hardness, high refractory properties and strong
bonding properties with different substrates. Furthermore, the high ionization
energies means that stability at low voltages make it a potential material for
electrophoretic deposition. Fig. 9, Ref. 71.
Auth.
b14.2.10.9. Influence of production conditions on the structural
state of boron crystals. /D.
Gabunia, O. Tsagareishvili, L. Chkhartishvili/. Nano Studies. – 2014. – #9. – pp.
65-70. – rus.
Nanoscale structure provides a unique opportunity
to obtain materials with improved characteristics. In this respect, boron
attracts an increasing attention. Taking into account the low specific weight
and possibility to form nanoscale structure, boron-containing materials and
coatings can be successfully used in the electronic, nuclear and aerospace
engineering. They also can be utilized in medicine and for protection of the
service personnel working with neutron sources. Basic data on the preparation
of nanocrystalline (previously they were called as “ultra-dispersive”) boron
powders and the results of their characterization have been summarized. This
work deals with the nanocrystalline particles of boron and boron-based
materials in dependence on the producing conditions: mechanical and high-voltage
electric discharge grindings; chemical and electrical arc synthesis; heat
treatment of amorphous boron. The prospect of using unique properties of boron
in modern technology should encourage the design of novel boron-based
nanocrystalline materials. Ref. 2.
Auth.
b14.2.10.10. Application of structural nanomaterials in petroleum
industry. /N.
Nabhani/. Nano Studies. – 2014. – #9. – pp. 71-82. – eng.
Nanotechnology is a rapidly growing
technology with considerable potential applications and benefits, to effect
revolutionary changes in several aspects of the oil and gas industry. While
tangible benefits realized in oil and gas industry, the area of construction to
the oil industry has been slow to embrace the new technology. The construction
sector might accommodate broad applications of nanotechnology and nanomaterials
in several areas of the oil and gas industry, such as exploration, drilling,
production and enhanced oil recovery. For example, lighter, stronger and more
long lasting structure; low maintenance coating; better properties of
cementitious material and steel alloys; construction related smart sensors for
monitoring of the structural integrity. In short, there are numerous areas in
which nanotechnology can contribute to more efficient, less expensive and more
environmentally sound technologies. In this paper, a broad overview of
potential application of various nanotechnology developments in the
construction oil and gas field is discussed. The potential opportunities and
challenges that face future trends of nanotechnology application in this field
are also discussed. Fig. 1, Tab.2, Ref. 60.
Auth.
b14.2.10.11. An alternative method for obtaining nanosize tubes,
fibers, magnetic clusters. /L. Rukhadze, L. Chkhartishvili, O.
Tsagareishvili/. Nano Studies. – 2014. –
#9. – pp. 83-86. – eng.
Carbon nanotubes, nanofibers, and
magnetic clusters doped with ferromagnetic metals are obtained by the thermal
dissociation of organic hydrocarbons at low-oxygen partial pressure condition.
Depending on amount or density of hydrocarbons, velocity of the pyrolysis
product within a rector and substrate surface conditions, carbon nanomaterials
of various geometric forms and sizes can be obtained (e.g., it is possible the
vertical growth of nanofibers with diameter from 20–30mm and length from 20mm up to several cm). Besides, the
mentioned method includes the obtaining of pure metals in nanocrystalline form
from minerals of ferromagnetic elements, and pure hydrogen from hydrocarbons, as
well purification of the gaseous hydrogen. The cheap precursors, simply
controllable technological process, as well as simple apparatus used make it
possible to obtain diversity of low-cost carbon-based nanomaterials. Fig. 4, Ref. 2.
Auth.
b14.2.10.12. The effect of
electrohydraulic discharge for high dispersive magnetic nanofluid synthesis. /V. Mikelashvili, J.
Markhulia, Sh. Kekutia, R.Tatarashvili/. Nano Studies. – 2014. – #9. – pp. 87-92. – eng.
Experimental studies have shown the
effectiveness of electrohydraulic processing on the high dispersive magnetite
nanofluid synthesis. The concentration enhancement of magnetite nanoparticles
was caused by an instant increase of pressure and other physical phenomena
influence, which accompanied during electrohydraulic effect. The effective use
of this effect closely related to the control of some physical parameters. The
recorded hysteresis loops shows that the particles are superparamagnetic at
room temperature, which is characteristic of a soft ferromagnetic material such
as magnetite. Fig. 4, Ref. 12.
Auth.
b14.2.10.13. Nanosensor for thermoelectric single-photon detector. /A. Kuzanyan/. Nano Studies. – 2014. – #9. – pp. 93-102. – eng.
The results of computer simulation of kinetic processes in the
thermoelectric detector sensor after photon absorption are presented. Different
geometries of the thermoelectric single-photon detector with sensor size, which
decreases from microns to nanometers, are considered. The time dependence of
the electric potential appearing on the sensor is calculated. It is determined
the optimal dimensions of the thermoelectric single-photon detector sensor and
of the absorber to achieve gigahertz count rates for 100eV photons
registration. Fig. 5, Tab.2, Ref. 31.
Auth.
b14.2.10.14. English–German–Russian–Georgian electronic dictionary
(glossary) in nanochemistry, nanophysics and nanotechnology. /Ts. Ramishvili, V. Tsitsishvili/. Nano Studies. – 2014. – #9. – pp. 103-106. – eng.
Nanoscience and nanotechnology are interdisciplinary
branches that mandatorily require a creation of united term base. This is
communication language for specialists of various branches (physicists,
chemists, biologists, technicians, material scientists and others) who create
nanoscience and nanotechnology.Besides, notions and
terms corresponding to international standards will cause their uniform
understanding and allow us to get rid of false, ambiguous interpretations. This
language is created in advanced countries and we have to make it understandable
for Georgians using adequate terms in our native language. Creation of Georgian
electronic dictionary in nanochemistry, nanophysics and nanotechnology is
timely. Nanoscience is being developed of a high rate, and the electronic
format of dictionary provides possibility of its fast update. Electronic
dictionary will have one subject and different linguistic directions,
particularly in special, nanoscience (nanochemistry, nanophysics) and
nanotechnology directions; multilingual, translational: English–German–Russian–Georgian,
illustrated and with explanations in Georgian. This dictionary will be a mass
consumer product. It will have a lexicographical, reference and especially
educational value. Ref. 7.
Auth.
b14.2.10.15.
Modern theories of homeopathic nanopharmacology. /M.
Chikava, T. Tsintsadze,
Kh. Mishelashvili,
N. Sulashvili/. Nano Studies. – 2014. – #9. – pp.107-110. – eng.
The most efficient medications used in
medicine affect the tissue receptors. Supposedly, there are special receptors in
an organism, so called homeoreceptors, supporting the action of the homeopathic
preparations. At present, the view of the homeopathy stimulating the
immunobiological forces of a body is widely recognized. P.V.Simonov established that subminimal
doses of substances cause retention evidenced by the clearly seen protective
properties. The author called this action preventive. Hahnemann was the first
to pay particular attention to the regular dilutions and put forward the idea
of drug potentiation. Some authors give a hypothesis of water becoming coherent
as a result of interaction between the water dipole and irradiation of a
diluted molecule and acquiring the property to transfer the specific
information to the cell receptor, like the laser does. The receptor molecules
are forced to move between the bilipid layers and resonate with specific
frequencies to cause a signal transfer. In recent years, they tried to explain
the effects of homeopathic drugs by using a famous Arndt–Schultz law. However,
this law is not universal. If considering the literary data, the issue as to
whether the given law is effective with high dilutions is unclear, as such
dilutions contain no molecules of the initial substance. There is a theory
linking the mechanism of action of homeopathic drugs to the effect of
contamination. Free radicals are formed in a contaminated solution resulting in
the pharmacological effect. Didier Grand George was one of the first to try to
explain the mechanisms of action of a homeopathic drug by means of neurophysiology.
In his opinion, the central nervous system functions with the scales of
homeopathy. A nerve impulse causes the changes
in the state of a cell membrane and liberation of the homeopathic doses of
neurotransmitters in the synaptic gap. Ref. 3.
Auth.
b14.2.10.16. Electrical, optical and structural properties of
titaniumdioxide dielectric films formed by DC magnetron sputtering. /A. Bibilashvili, Z. Kushitashvili, G. Skhiladze/. Nano Studies. – 2014. – #9. – pp.111-114. – eng.
DC Magnetron sputtering technic has been used
to receive thin titanium dioxide films onto p-type silicon substrate. The
substrate temperature was kept at 250^oC during deposition. By Spectroscopic
Ellipsometer was calculated the thickness of TiO2 and refractive
index, which were respectively 85nm and 2.25. Good capacitance–voltage
characteristics were observed with dielectric constant of 35 using Keithly
Instruments Semiconductor Parameter Analyzer. The crystal structure was shown
to be nanocrystaline by X-ray diffraction. Fig.3, Ref. 9.
Auth.
b14.2.10.17. The magnetization due to activities of magnetic particles
in magnetic fluids. /K.Kotetishvili,
G.Chikhladze/. Nano Studies. – 2014. – #9. – pp.115-118. – eng.
The magnetization due to activities of magnetic
particles in magnetic fluids is studied theoretically. Ref. 3.
Ed.
b14.2.10.18. Structural features
of the iron–oxygen nanoparticles formed when the rotation-corrosion
dispergation method is applied. /O. Lavrynenko, Y. Bolbukh/. Nano Studies. – 2014.
– #9. – pp.127-148. – eng.
The usage of the rotation-corrosion dispersion method permits to form
the different nanosized iron oxyhydroxides and its oxides as well as iron–oxygen metastable forms. The structural features of such particles were
studied applying X-ray diffraction, TEM and SEM images and Fourier transform infrared spectroscopy. While SEM and TEM images permit to show the morphology of the
particles and X-ray diffraction points to the main phase and the product of
their phase transformation, the FTIR study explains the way of the particles
formation due to the analysis of the structural elements and admixtures
containing in the main mineral phase. The structure of the iron–oxygen nanoparticles obtained when the RCD-method was applied differs
from similar particles formed under other physical-chemical conditions, for
example, under co-precipitation. Fig.15, Ref. 37.
Auth.
b14.2.10.19. Radioactive waste management in Georgia. /G. Nabakhtiani, L.
Chkhartishvili, A. Gigineishvili, K. Gorgadze/. Nano Studies. – 2014. – #9. –
pp.149-154. – eng.
Georgia takes active steps for establishment
of Radioactive Waste Management System (RWMS) in the country. Generally
speaking, RWMS should contain four major elements: legal basement,
administrative structure, infrastructure for handling with radioactive waste,
and financial system. Only some parts of above-mentioned elements are exist in
Georgia now. RWMS should meet nine basic principles defined by the
International Atomic Energy Agency (IAEA).Based on these it is possible to
define more detailed principles. The following main routes for radioactive
waste generation in Georgia can be considered: demolition of large facilities
(such as nuclear reactor), renovation of the disposal site, generation of new
waste due developing of industry and medical application of radioactive
sources, and generation of secondary radioactive waste. Besides of all Disused
Radioactive Sources (DSRS) and historical waste should be also considered.
Whole process for handling with radioactive waste can be divided into three
main phases: establishment of national system for radioactive waste management,
predisposal activity, and disposing. The main task is establishment of
Radioactive Waste Management Agency (RWMA), which on behalf of state will
operate all radioactive waste management facilities. Functions of RWMA also
cover handling with DSRS on all steps and decontamination activity. RWMA should
meet all requirements set by IAEA.Tab.1, Ref. 5.
Auth.
b14.2.10.20. Method of standard deviation for analysis of
hydrogeodynamic parameter. /A. Gevorgyan, A. Khangaldyan, S. Mavrodiev, M. Adibekyan,
G. Melikadze, A. Sborshchikovi, G. Kobzev, T. Jimsheladze/. Nano Studies. –
2014. – #9. – pp.155-162.
– eng.
The method of standard deviation for analysis of hydrodynamic
parameter is studied. For that purpose, the hydrogeodynamic parameters of
several earthquakes in Armenia and Georgia following the earthquakes in South
Caucasusare investigated and for a comparative analysis the hydrogeodynamic
parameter of the networks of Armenia and Georgia is used. The result of the
monitoring of water level variation parameter indicated a direct connection
between deformation processes to strong earthquakes. Fig. 9, Ref. 9.
Auth.
b14.2.10.21. Mobility of Cr(VI) by Spirulina
platensis and Arthrobacter
species. /E.
Gelagutashvili, E. Ginturi, A. Rcheulishvili/. Nano Studies. – 2014. – #9. – pp.163-166. – eng.
The uptake of Cr(VI) by Arthrobacter species (Arthrobacter
globiformis 151B and Arthrobacter
oxidas 61B) and Spirulina platensis were studied by the
simultaneous application of dialysis and atomic absorption analysis. A
significant difference between the binding constants for Cr(VI) – Arthrobacter oxidas and Cr(VI) – Arthrobacter globiformis is observed.
The comparative Freundlich biosorption characteristics Cr(VI) Arthrobacter species of living and dry
cells show that capacity in both cases is nearly the same. Dry cells have
larger biosorption constant for both species than living cells. Fig. 2, Tab.1, Ref. 16.
Auth.
b14.2.10.22. Disinfection of drinking water
from the effects of anthropogenic and natural disasters by nanotechnology. /D. Eristavi, N. Bibiluri, Sh. Andguladze, A. Gogishvili, M. Gugeshidze, E.
Matsaberidze, Z. Matsaberidze/. Nano Studies. – 2014. – #9. – pp.167-168. – rus.
Designing and manufacturing of colloidal
silver device with the use of nanotechnologies is considered. By means of it the
water solution of colloidal silver with various concentrations will be received
and used for necessary purposes. Ref. 5.
Auth.
b14.2.10.23. Modernization of the vacuum unit of type VU–1A to
obtain multilayered periodic optical coatings. /Z. Berishvili,
I. Kordzakhia, D. Zardiashvili, G. Abramishvili, I. Avaliani, D. Shalamberidze, I. Ivanidze/. Nano Studies. – 2014. – #9. – pp.169-176. – geo.
The study is devoted to the construction and modernization
of the vacuum plant of
type VU–1A and the creation of modern
experimental and technological coating lines. As part of the work under the dome of
the vacuum apparatus two sets of units of a planar magnetron sputtering were
installed; on top of the dome vacuum unit the quadrupole masspectometer of type
RGA200has been installed; the gas system was designed, constructed and
installed; electrical units were produced by continuous and pulsed voltage and
connected to a magnetron sputtering by the high voltage switch (RFDC “Plasma Switch”).
Geometric distribution of parts under the dome, obtained by means of 3D design,
characterized as compact and enables a high capacity to form high-quality
antireflective layers. On the upgraded vacuum plant of type VU–1A, the optimal technology for forming antireflective
layers developed with a view to its use in research, inthemanufactureofindustrialdesignsand, inthefuture, in a
smallproduction. Fig.3, Ref. 4.
Auth.
b14.2.10.24. Formation of titanium alloys 3D nanostructures. /K. Gorgadze, T. Berikashvili,
G. Nabakhtiani, T. Berberashvili, Sh. Khizanishvili/. Nano Studies. – 2014. –
#9. – pp.177-180. – eng.
Titanium alloys are characterized by high
Shape Memory Effect (SME) and Super Elasticity (SE). They also have good
theremoelastic properties. Focused on these properties Ti–Ni alloy can be
assigned as a good material for using in medical application. Same time there
are some problems such as extraction of “free” Nickel which could be cause of
allergic reaction for medical patients, therefore creation of new materials
having appropriate characteristics for human tissue and remaining high
thermoelastic property, SME and SE is very essential. Especial attention should
be paid to formation of nanostructures and alloy property defined by this structure.
The given article summarizes great activity for experimental investigations
conducted for different Titanium alloys to find good “replacement” for Nickel.
Finally two Ti alloys were fixed Ti–33Nb–7Zr and Ti–26Nb–4Ta–7Zr, which have
comparably good characteristics to be used for medical application. Fig. 4, Ref. 2.
Auth.
b2.11 Other engineering sciences and technologies
b14.2.11.1. Apipuri – bread enriched
with amino acids, vitamins and minerals. /K. Chakhunashvili,
Sh. Yusufov, N. Jobava, N. Badriashvili, N. Topuridze,
G. Chakhunashvili, Z. Shakarashvili/. Social, Ecological & Clinical
Pediatrics. – 2013. – #16-11-10. – pp. 82-84. – geo.; abs.: geo., eng.
Bread is has the biggest consumer base in
Georgia. According to the studies, only 24.9% of bread samples were
fortified enough to correspond to daily standard and decrease the chance
of micronutrient deficiencies. Apipuri, however, is made by totally
new technology which enriches bread with amino acids, vitamins and
minerals. Cheap and daily product, affordable for everyone “Apipuri” –
will decrease the chance of disease developed because of micronutrient
deficiencies. Tab. 1.
Auth.
b14.2.11.2. Main aspects of
Georgian National Food Policy. /T. Darsania, D. Zarnadze, Ir. Zarnadze, G.
Chakhunashvili/. Social, Ecological & Clinical Pediatrics. – 2013. –
#16-11-10. – pp. 94-96. – geo.; abs.: geo., eng.
By the end of 20th century and start of 21st
century various worldwide activities improved health indexes,
such as: in the US fatal outcomes during cardiovascular management
decreased by 20%, In Finland 50% decrease of mortality by such diseases.
The goal of the study was to study complexity of Georgian national food
policy. The data analysis show: The study of daily ration
showed: lack of products in daily ration such as meat, vegetables and
fish. Ration for older people who are on pension is monotonous and
is of low nutritional value; Majority of populations does not have
fruit and meat in daily ration. All above said enables we to say that
this work is of quite an importance and we can conclude that further
studies should be performed for evaluating public healthcare.
Ref. 16.
Auth.
b3.
MEDICAL AND HEALTH SCIENCES
b14.3.1.1. Galectins as new
therapeutic targets for galactose-containing polysaccharides. /A.
Klyosov/. Bulletin of the Georgian National Academy of Science.– 2014. – vol.
8. – #1.– pp. 5-17. – eng.; abs: eng., geo.
The Galectin protein family includes 15
members that are characterized by galactose binding domains and are widely
expressed in diverse cell types. Galectins are found in multiple intracellular
compartments and are secreted into the extracellular space. There has been an
explosion in information on these fascinating proteins in pathological states,
particularly inflammation, fibrosis, and cancer. This Review summarizes
attempts to cover the key areas of galectin-dependent disease and discusses the
approaches to developing galectin blockers for treatment. The time is right for
major efforts to advance galectin-based therapies into multiple human diseases.
Fig. 3, Tab.1 Ref. 67.
Auth.
b14.3.1.2. Genetic
aspects of male infertility. /V. Grabar/. Georgian Medical
News. – 2014. – #4(229). – pp. 21-25. – rus.; abs.:
geo., eng., rus.
We examined 118 men with infertility.
Among them we identified phenotypic syndromes associated with infertility in 4
and chromosomal abnormalities in 16. Further molecular genetic study of 98
infertile men found that microdeletions in AZFc-locus had 3, pathological AR
allele had 2, CFTR gene mutation had 4 of them. In 37 infertile men an
increased DNA fragmentation index (>20%) was found. Fig. 4, Ref. 12.
Auth.
b14.3.1.3. Effect of
gene polymorphism of ppar-γ2 regulatory proteins on the metabolic syndrome
in children with nonalcoholic fatty liver disease and obesity. /T. Kryuchko, I. Kaidashev, O. Pilipenko, V.
Ostapenko, I. Kolenko/. Georgian Medical News. – 2014. – #4(229). – pp. 66-73. –
rus.; abs.: geo., eng., rus.
The aim of this study was to
investigate the influence of single nucleotide polymorphism Pro12Ala of
PPARγ2 gene in phenotypical manifestations, carbohydrate and lipid
metabolism, blood pressure (BP) and tumor necrosis factor alpha (TNF-α) in
children with exogenous constitutional obesity (ECO) and nonalcoholic fatty
liver disease (NAFLD). 67 children aged from 7 to 17 years were examined; among
them 34 patients were diagnosed with NAFLD and 33 children with ECO. The
algorithm of examination included assessment of anthropometric parameters,
blood lipid profile, glucose indicators and immunoreactive insulin (IRI) on an
empty stomach, the calculation of the HOMA-IR index, genetic methods of
examination. The study of Pro12Ala polymorphism of PPARγ2 gene showed that
patients with NAFLD demonstrated the highest percentage in the frequency of the
“wild genotype” Pro/Pro (88.2%) and significantly lower prevalence rate in
frequency of allele Ala (11.8%). The presence of the polymorphic allele Ala was
associated with lower levels of IRI, HOMA-IR index, a significant reduction of
virtually all components of lipid metabolism, systolic blood pressure and
pro-inflammatory cytokine TNF-α. Children with genotype X/Ala have greater
body weight and higher BMI as compared with homozygous carriers of Pro allele.
The detected changes allow us to recommend the use of genetic screening to
identify single nucleotide polymorphism Pro12Ala of PPARγ2 gene in obese
children in order to determine the degree of risk of metabolic disorders
development and implement the preventive measures in a timely manner. Tab. 2, Ref. 17.
Auth.
b14.3.1.4. Carcinogenesis – a new point of view. /L. Gevorkyan, K. Gambashidze/. Georgian Medical
News. – 2014. – #4(229). – pp. 73-80. – eng.; abs.:
geo., eng., rus.
The presented article suggests a novel
hypothesis of carcinogenesis, where the key moment for all types (biological,
physical, chemical) of carcinogenesis has been discussed. For confirmation of
the hypothesis thorough theoretical analysis of the mechanisms of malignant
transformation of cells after influence of any type of carcinogens and results
of experiments have been presented. The hypothesis highlights are formulated as
follows: 1) Covalent bond disorders between S+-methionine and
Fe3+ atoms in cytochrome; 2) Electron transport chain blockade with
certain ligand after its penetration in cytochrome pocket with further
formation of 6th coordination bond between ligand and Fe atom (in
one case increase in mitochondrial pH precede-, and in other, it follows
electron transport chain blockade in cytochromes); 3) Fe3+ reduction
up to Fe2+ leading to blockade of aerobic glycolysis; 4) Decrease in
enzyme (Е1-TDP, oxidases etc.) activity due to
mitochondrial pH alterations; 5) Production of S-adenosylmethionine
owing to lipoic acid amide leading to accumulation of homocysteine in cytoplasm
with further penetration in cell nucleus producing DNA mutations; 6) Fe2+
wash-out from cytochrome and its deposition in ferritin. Fig. 4, Ref. 3.
Auth.
b14.3.1.5. Experimental basis and comparison of clinical use of radio frequency
energy argon plasma coagulation, adhesions preparation «intercoat» complex and
rehabilitation after laparoscopic treatment of patients with polycystic ovary
and tubal-peritoneal infertility. /N.
Kozub, M. Sokol/. Georgian Medical News. – 2014. – #4(229). – pp. 80-88. –
rus.; abs.: geo., eng., rus.
Aim of this study was to evaluate
the efficiency of the use of radio wave energy and argon plasma surgery, use of
«Intercoat» for the prevention of adhesions and use of rehabilitation complex
(L-arginine, electrical stimulation of the fallopian tubes) in the treatment of
patients with PCOS and tubal-peritoneal infertility. Experimental studies on 56
female rats of Wistar and clinical studies of 90 patients with PCOS and
tubal-peritoneal infertility were undergone. Use of argon plasma coagulation
for ovarian hemostasis characterized by the smallest damaging effect.
Application adhesions barrier «Intercoat» prevents the development of adhesions
II, III, IV degree. Use of argon plasma coagulation and ligature tuboplasty 2.1
times increases recovery of reproductive function in women with PCOS. Developed
method of intraoperative and postoperative management reduces 2 times the
number of patients who develop subsequent tubal pregnancy. Tab. 4, Fig. 2, Ref.
29.
Auth.
b14.3.1.6. Preliminary phytochemical and biological evaluation of Daphne
glomerata extracts. /B.
Tabidze, G. Moshiashvili, N. Tabatadze, J. Aneli, V. Mshvildadze/. Georgian Medical
News. – 2014. – #4(229). – pp. 88-91. – eng.; abs.:
geo., eng., rus.
The article reports on the
phytochemical and biological potentials of leaves and stems of Daphne glomerata Lam. (Fam. Thymelaeaceae). The study indicated that
crude extracts from the leaves and stems of the plant have high biological
activity. Cytotoxicity was assessed using resazurinon an automated 96-well
Fluoroskan Ascent F1_ plate reader (Labsystems) using excitation and emission
wavelengths of 530 nm and 590 nm, respectively. High cytotoxic activity
(<1,563 µg/ml) of both extracts toward lung carcinoma cell lines was
elucidated. The specificity of extracts to WS-1 human fibroblast cell lines was
observed. For the first time, the profiles of compounds with terpenic and
phenolic nature were described in Daphne glomerata leaves and stems MeOH
extracts by TLC and (HPLC-DAD-MS) techniques. Tab. 1, Fig. 2, Ref. 10.
Auth.
b14.3.1.7. Analysis
of Perilla nankinensis
Decne essential oil using gas chromatography coupled with time-of-flight
mass spectrometry. /N. Shashiashvili, M. Jokhadze, P.
Tushurashvili, A. Bakuridze, D. Berashvili/. Georgian Medical
News. – 2014. – #4(229). – pp. 92-96. – eng.; abs.:
geo., eng., rus.
Perilla is the genus of
herbaceous plants of Lamiaceae family.
The essential oil of Perilla is believed to be essential part of the
herb. It was claimed to have anti-inflammatory, anti-hyperlipidemia,
antioxidative and antimicrobial activities. Apart from pharmaceutical and
nutrition purposes, it is an edible plant frequently used as a fresh vegetable.
It was also applied to produce perfume and cosmetics. Due to the importance of
the essential oil from the P. nanakinensis and the lack of detailed studies of them, our work aimed
investigation of contents of essential compositions by GC- TOF/MS method. The
materials of the study were the aerial parts of P. nankinesis collected at full flowering stage, Guria
Region, Georgia. A qualitative analysis of the individual compounds in P. nankinensis essential oil
performed by gas chromatography (GC) coupled with time-of-flight mass
spectrometer (TOF/MS) for the identification of the resolved peaks. 28
components, which accounted for 77,7% of the oil, were identified. The main
components of this essential oil were 1,3,6,10-Dodecatetraene,
3,7,11-trimethyl-, (Z,E)- (α-Farnesene) (34.3%), Caryophyllene oxide
(10.2%), 1,6-Octadien-3-ol, 3,7-dimethyl- (linalool) (10.2%). Essential oil
also contained humulene (3.9%),caryophyllene (1.9%), methyl salicilate (1.15%),
2-hexanoylfuran (1.0%), gernacrene (1.1%). Based on the results of our
experimental data and literature reviews, Perilla essential oil can represent
special interest and can be used as an important natural substance for
obtaining medicinal and preventive products with the several biological
activities. Tab. 1, Fig. 2, Ref. 12.
Auth.
b14.3.1.8. Familial
Mediterranean fever in Georgia. /K.
Pagava, B. Rauscher, I. Korinteli, D. Shonvadze, G. Kriegshauser, Ch.
Oberkanins/. Georgian Medical News. – 2014. – #5(230). – pp. 79-82. – eng.; abs.: geo., eng., rus.
Familial Mediterranean Fever
(FMF) is a hereditary autoinflammatory disorder caused by mutations in the MEFV
gene. Carrier rates are known to be particularly high among Sephardic Jews,
Turks, Armenians and Arab populations. Our literature survey regarding FMF and
MEFV mutations in Georgia revealed a lack of existing studies. We applied
multiplex PCR and reverse-hybridization teststrips (FMF StripAssay) to
simultaneously analyze twelve common MEFV mutations in DNA samples from dried
blood on filter cards, which had been obtained from 202 unselected newborns at
various hospitals in Tbilisi, Georgia. We found 30 samples to be heterozygous
and one to be compound heterozygous or carrier of a complex allele (two mutations
in cis). The carrier rate of MEFV mutations (15.3%) was remarkable. The most
frequently observed variants were E148Q (15x), M680I G/C (5x) and M694V (4x).
Five other MEFV mutations were found at lower prevalence (V726A, A744S, R761H:
2x each; P369S, F479L: 1x each). Based on these new findings, the awareness for
FMF and the availability of appropriate testing should be further promoted in
Georgia. Tab. 1, Fig. 3, Ref. 22.
Auth.
b14.3.1.9. Role of the
bacterial vaccine Solco-Urovac® in treatment and prevention of recurrent
urinary tract infections of bacterial origin. /D. Kochiashvili, A. Khuskivadze, G. Kochiashvili,
G. Koberidze, V. Kvakhajelidze/. Georgian Medical News. – 2014. – #6(231). – pp. 11-16. –
eng.; abs.: geo., eng., rus.
Urinary Tract Infections (UTI)
represent a serious medical problem with considerably high rate of morbidity.
Recurrent episodes of urinary tract infection (rUTI) may commonly develop in
the way of relapse or reinfection. For patients, rUTI is always associated with
costs, discomfort and decreased quality of life. Standard treatment of rUTI is
through antibiotics and usually such treatment is required repeatedly. Repeat
course of antibiotics leads to increase of resistance of uropathogenic strains.
According to the European Association of Urology, “the present state of
microbial resistance development is alarming”. Our post-marketing trial was
designed to demonstrate the substantial effect of the bacterial vaccine Solco-Urovac®
both with independent administration and in conjunction with standard
antibacterial medication within therapy and prevention of rUTI. Total of 115
patients (men and non-pregnant women) were enrolled in our open-label
post-marketing trial. Each patient had more than one year history of rUTI and
in the past had already taken appropriate course of standard therapy. The trial
group included 50 patients: 32 men, 18 women (average age ± 32.5). 32 patients
(men) of the trial group received vaccination with Solco-Urovac® together
with the standard antibacterial medication. According to bacteriologic tests,
in 62% cases infection was caused by Escherichia coli, and in 38% cases
by Morganella morganii, Proteus mirabilis, Klebsiella
pneumoniae, Enterococcus faecalis. 18 patients within the trial
group were women with no recurrence episode at the start and during the trial
period. Each woman was involved as the intercourse partner of the respective
man within the trial group. The women received only vaccination with
Solco-Urovac®. 65 patients of the control group had more than one
year history of rUTI and had been treated earlier, too. Patients of the control
group received appropriate antibacterial medication without Solco-Urovac®. After
therapy and follow-up examination, results in the both groups were classified,
also in consideration of the pathogen-specified subgroups, and then summarized
and compared respectively. During the follow-up period no case of rUTI was
noticed in women. In total, analysis of the medical records of 50 patients of
the trial group demonstrated no case of rUTI in 46 patients during the
follow-up period. Altogether, the rate of improvement of symptoms was as
follows: the trial group – 92%, the control group – 74%. Through comparison with
the past medical histories of patients, the higher rate of improvement and
longer absence of rUTI episodes after treatment were certainly associated with
the effect of Solco-Urovac®. The results of our post-marketing trial
allow recommending Solco-Urovac® for appropriate reference within
the Georgian National Guideline on Urologic Infections. Tab. 4, Ref. 9.
Auth.
b14.3.1.10. Polymorphism
of gene ІL-8 (А-251Т) in patients with acute pancreatitis. /V. Chantsev, V. Leonov/. Georgian Medical
News. – 2014. – #6(231). – pp. 35-38. – rus.; abs.:
geo., eng., rus.
The research aims to investigate
the IL-8 А-251Т (rs 4073) gene polymorphism in patients with acute
pancreatitis. The frequency of allelic variants of cytokine gene in 100 patients
was determined. Genotype А/Т was found in 47.0% of cases (47
patients) of acute pancreatitis, T/T alleles – in 37% of cases (37 patients),
A/A alleles in 16% of cases (16 patients). In 73.3% of non-operated patients
with destructive forms of acute pancreatitis the reliable (р<0,05)
increase of heterozygous carriers of genotype А/Т were detected. In
patients with edematous form of acute pancreatitis frequency of А/Т
was detected in 42.2% of cases, in control group frequency of А/Т
was detected in 46% of cases, the possible association between genotype
А/Т and the destruction of the pancreas was determined. Tab. 1,
Ref. 12.
Auth.
b14.3.1.11. The
association of some genetic factors with pulmonary tuberculosis in Georgian and
Azeri ethno groups. /R. Khukhunaishvili, S. Tskvitinidze, M.
Nagervadze, L. Akhvlediani, M. Koridze/. Georgian Medical
News. – 2014. – #6(231). – pp. 45-49. – eng.; abs.: geo., eng., rus.
Pulmonary Tuberculosis (TB) is
still one of the major public health problems. Over the last half decade the
significant problem is an increased ratio of drug-resistant TB cases. TB is as
well the most significant infectious disease in the country of Georgia.
Pulmonary tuberculosis is assessed as a complex infectious disease affected by
both, environmental and genetic factors. Present study was undertaken to find
out the correlation between pulmonary tuberculosis and erythrocyte blood groups
antigens determinant alleles (ABO - r, p, q; Rh D+, Rh D- and MN - p, q)
in two different, Georgian and Azeri, ethno groups. Immune-serological methods,
direct reaction of universal monoclonal antibodies were used. Materials
processed by biostatistician methods. The study had shown different correlation
of pulmonary tuberculosis to erythrocyte blood groups determinant alleles in
Georgian and Azeri ethno groups. In Georgian ethno group pulmonary TB
correlates with ABO-r and p, Rh-D, +’ and MN-p alleles,
whether ABO-q, Rh-D,-’ and MN-p in Azeri ethno group. Tab. 1,
Ref. 12.
Auth.
b14.3.1.12. The
possible use of V. parahaemolyticus –
specific bacteriophages for prevention and therapy of infections caused by V. parahaemolyticus. /A. Tskhvediani, T. Khukhunashvili, T. Eliashvili, G.
Tsertsvadze, N. Gachechiladze, M. Tediashvili/. Georgian Medical
News. – 2014. – #6(231). – pp. 82-88. – eng.; abs.: geo., eng., rus.
Vibrio parahaemolyticus is the
most common halophilic Vibrio species causing serious gastroenteritis in
humans. The main source of infection is consumption of undercooked or raw seafood
or exposure to contaminated water. The monitoring conducted in 2006-2008
demonstrated that warm, subtropical climate and low- to moderate salinity of
water in the Black Sea coastal zone provides a favorable environment for growth
and spread of V. parahaemolyticus bacteria. Antibiotics are commonly
applied for control V.parahaemolyticus infections in humans. However,
with the growing problem with bacterial antibiotic-resistance search for
alternative biological anti-infectives, such as bacteriophages, becomes more
actual. The aim of the presented work was characterization of V.parahamolyticus–
specific bacteriophages in relation with their possible use for treatment and
prevention of food and waterborne gastroenteritis in humans infected with V.parahaemolyticus.
69 bacteriophages specific to V.parahaemolyticus were isolated from
different water sources and 5 of them were characterized according to their
virion morphology, host-range, temperature and pH dependence. Stability of
phages in different media and solutions, also susceptibility to action of a
number of protolithic enzymes was studied as well. Obtained results showed that
studied bacteriophages can be used for preparation of phage mixture as a
potential therapeutic preparation against V.parahaemolyticus associated
infections. Tab. 3, Fig. 3, Ref. 13.
Auth.
b14.3.1.13. Chemical
composition and microstructural peculiarities of overground and underground
vegetative organs of field restharrow (ononis arvensis l.). /M. Sichinava, K. Mchedlidze, M. Churadze, M.
Alania, J. Aneli/. Georgian Medical News. – 2014. – #6(231). – pp. 88-94. – rus.; abs.: geo., eng., rus.
The paper presents the results of
the study of anatomy and chemical composition of Field Restharrow (Ononis
arvensis L.). The existence of triterpene alcohol α-onocerin
and isoflavons in the overground organs of the plant is established by chemical
analysis. Oxycumarines – scopoletin and scopolin are isolated and identified.
Morphological characterization of the whole plant is given. Anatomy of the
vegetative organs of the species is examined. Among the main microstructural
characteristics multilayer integumentary tissues, active periderm and
sclerenchyma cells were specified in roots; and complex radial rays and structural
units of wood, located radially, were observed in the central cylinder. Shoots
are characterized with intensive pubescence. Mechanical tissues of different
structures exist in the parenchime of crust and central cylinder of shoots.
Vessels with spiral and spiro-annular thickened walls are located in the
libriforms of wood. Leaves of Ononis arvensis are bifacial, mesophile is
of dorsiventral structure; central conductive bunch is complex-collateral.
Basal cells of upper and lower epidermis belong to of bent-walled type, where
paracytal and anisocytal cells of stomatal apparatus are scattered chaotically.
Fig. 4, Ref. 10.
Auth.
b14.3.1.14. Clinical-electroneuromyographic
and immunologic aspects of myasthenia gravis with anti-musk antibodies. /N. Kvirkvelia, R. Shakarishvili/. Georgian Medical
News. – 2014. – #7-8(232-233). – pp. 42-47. – rus.; abs.: geo., eng., rus.
Myasthenia gravis (MG) is a
neuromuscular autoimmune disorder caused by autoaggression directed to
different antigenic goals of peripheral neuromotor apparatus. Approximately 80%
of patients have detectable serum antibodies against acetylcholine receptors
(ACHR). About 10-15% of the MG patients do not have ACHR – antibodies. This
form is called seronegative (SN) MG. IN 35% of SN patients antibodies against
muscle – specific fyrozine kinase (MUSK) is clearly observed. According to
modern data, SN MG patients are resistant against traditional pathogenetic
therapy of MG. In order to develop the strategy of timely and adequate treatment
of SN MUSK positive MG, we decided to build up differential diagnostic
criterions for this form of MG. For this purpose we analyzed clinical –
electroneuromyographic (ENMG), immunologic and pharmacological data of 9 SN
MUSK positive MG patients. The specific clinical patterns for SN positive MG
were not revealed. The analogical clinic – ENMG and pharmacological signs were
observed in seropositive MG. Accordingly, antibodies do not determine the
peculiarity of this disease. Therefore, the revelation of the antibodies has
not only diagnostic value; it also defines the expediency of pathogenetic
therapy of MG. Ref. 21.
Auth.
b14.3.1.15. Mortality
and its predictors among highly active antiretroviral therapy naive HIV-infected
individuals: data from prospective cohort study in Ukraine. /D. Zhyvytsa/. Georgian Medical
News. – 2014. – #7-8(232-233). – pp. 69-74. – eng.; abs.: geo., eng., rus.
There is little information from
Ukraine about the effect of highly active antiretroviral therapy (HAART) on
survival of HIV-infected patients. Our objective was to identify predictors of
mortality in HIV-infected patients initiating HAART at the Zaporizhzhya AIDS
Center, Ukraine. Prospective cohort study of HIV-infected patients from January
2005 to December 2008 in a ZaporizhzhyaAIDSCenter, and were tracked for 60
months after start HAART. Unvaried and multivariate analysis and constructed
Kaplan-Meier curves to assess predictors. To identify predictors of mortality
were used to build a regression Cox proportional hazards model. Two hundred and
seventy two patients were studied (mean age 34 years, 42% female, median CD4
count 120 cell/μL). In 60 months of HAART 36 patients died. The
probability of survival was 87%. In the univariate analysis, mortality was
strongly associated with male gender (HR 6,28; 95% CI 2,22-17,78), IDU route of
HIV transmission (HR 2,90; 95% CI 1,32-6,36), WHO clinical stage 4 (HR 3,45 95%
CI 1,7-7,0). Mortality was also strongly associated with anemia (HR 2,24 95% CI
1,02-4,92) and HBsAgseropositivity (HR 6,26 95% CI 3,01-13,02). In the
multivariate analysis independent factors associated with mortality were WHO
clinical stage 4 (HR 2,66 95% CI 1,26-5,58) and HBsAgseropositivity (HR 4,35
95% CI 2,05-9,23). HAART significantly increased probability of survival and
reduced the risk of death for HIV-infected patients in Ukraine. Simple clinical
and laboratory data independently predict mortality and allow for risk
stratification in HIV-infected patients in Ukraine. Tab. 2, Ref. 21.
Auth.
b14.3.1.16. The role
of nitric oxide in the pathogenesis and severity of psoriasis. /M. Matoshvili, A. Katsitadze, T. Sanikidze, D.
Tophuria, A. Richetta, S. D’Epiro/. Georgian Medical News. – 2014. – #9(234). – pp. 61-64. – eng.; abs.: geo., eng., rus.
The aim of our study was to
investigate the possible role of nitrogen reactive species in pathogenesis of
psoriasis. A total of 187individuals were included in this study, out of these
84 were patients suffering from psoriasis and 103 were healthy subjects, served
as a control. Patients with psoriasis were graded according to the Psoriasis
Area Severity Index (PASI), presenting at the time of blood collection. After
obtaining prior consent, about 2 ml of random blood was collected for
estimation blood free nitric oxide (NO) content by Electron Paramagnetic
Resonance (EPR) Spectroscopic method. For detection of NO in blood the
spin–trap (diethilditiocarbamate (DETC) (Sigma) was used. In blood samples of
patients with psoriasis nitrosilated hemoglobin (HbNO) complexes and
alterations of free spin-trapped NO EPR signal intensity and were detected.
Free NO content in blood decreased with the increasing severity of the
psoriasis. It may be concluded that under oxidative stress conditions during
psoriasis the decrease level of free nitric oxide in the patient’s blood may
contribute to a violation of the vasomotor activity of subcutaneous
capillaries, impairment of skin blood supply, development of hypoxia,
exacerbation of oxidative stress, alteration of immune balance, spreading of
skin infection and exacerbation of the severity of psoriasis. Use of
NO-containing creams will contribute to a partial recovery of disturbed
functions and remission of the disease. Tab. 1,
Ref. 16.
Auth.
b14.3.1.17. Outcomes
of treatment of chemotherapy drugs of different manufacturers tuberculosis of
patients with multiple drug resistance. /N.
Tabriz, B. Ospanova, J. Nurtazina, J. Mutayhan, K. Tabriz/. Georgian Medical
News. – 2014. – #9(234). – pp. 64-70. – rus.; abs.: geo., eng., rus.
The
article is devoted to studying the effectiveness of treatment of tuberculosis
(TB) patients with multidrug-resistant TB drugs 2 number of different
manufacturers. To assess the effectiveness of treatment of second-line drugs
were taken to study two groups of patients: Group 1 - 164 patients who received
anti-TB drugs from the Global Fund and Group 2 174 patients who received
anti-TB drugs for the national program. Comparative evaluation showed high
efficiency second-line drugs from the Global Fund, as evidenced by the high
level of 95,8 % abacillation in a short time in this patient group. Tab. 6,
Ref. 10.
Auth.
b14.3.1.18. Various purposes of using
immunomodulators in modern cardiology, children and adolescents. /G. Chakhunashvili, N. Jobava/. Pediatric Cardiology. – 2014. – #8. – pp.11-17. – geo.; abs.: geo., eng.
Continuous
adaptive changes are the basis of survival for human organism. The
work discussed and points out the importance of immunomodulators during
treating, managing, preventing cardiologic problems in children
and adolescent. Tab. 1, Ref. 4.
Auth.
b14.3.1.19. Osteogenesis imperfecta.
/M. Chalisuri, M. Chipashvili/. Pediatric Cardiology.
– 2014. – #8. – pp. 77. – geo.; abs.: geo., eng.
This is a congenital disease of connective
tissue, which is characterized by frequent fractures, deformation of skeletal
system and functional restrictions. The article includes interesting details
for clinicians and not only. Ref. 1.
Auth.
b14.3.1.20. The development of
desomorphine extraction methods from biological liquids. /L
Adeishvili-Andguladze, M. Jokhadze, R. Makharadze, T. Kirvalidze, K. Bukhnikashvili/. Tbilisi State Medical University Collection of
Scientific Works. – 2013. – #47. – pp. 7-9. – geo.; abs.: geo., eng.
The results of chemical-toxicological
analysis are greatly dependent of the methods of isolation and an incorrect
approach could lead to the loss of a substance of interest. That is why we
consider the development of Desomorphine isolation method as a relevant topic.
The goal of this study was the development of the method of isolation
Desomorphine from biological liquids. Two methods, liquid-liquid extraction and
solid phase extraction (SPE) were developed. We have experimentally studied the
effect of Desomorphine extraction on the isolation and concluded that the best
extragent for Desomorphine is a chlorophorm-isopropanol (9 : 1) mixture with
pH-9. And for the SPE we have used the Vacuum manifold - Supelco, with
silicagel C-18 solid phase and dichlormethaneisopropanol- ammonia (72 : 20 : 2)
mixture as a solvent. Tab. 1, Ref. 6.
Auth.
b14.3.1.21. A rare case of
the outer trans-hepatic fistula of the appendix. /L. Akhmeteli, L. Saginashvili/. Tbilisi State Medical University Collection
of Scientific Works. – 2013. – #47. – pp. 18-19. – geo.; abs.: geo., eng.
Appendicular fistula is a rare type of the
intestinal fistula. At the same time, it represents a rare complication of the
acute appendicitis. The appendicular fistula could develop in the case of the
non-treated appendicitis, when there is a spontaneous opening of the inflamed
appendix in the surrounding organs or the wall of the abdomen. In most of the
cases, it is very difficult to establish the connection between the fistula and
the appendix. The article presents the rare case of the external transhepatic
fistula of the appendix, in which the final diagnosis was made just
intraoperatively. The patient was 34 years old male, admitted to our clinic
after 4 month from ultrasound guided transcutaneal liver abscess drainage, when
even after the disappearance of the abscess cavity, the prolonged excretion of
the stinky discharge was observed. According to fistulography, the contrast
injected via the drainage passed to the colon, but the colonoscopy couldn’t
reveal the inner hole of the fistula in the colon. During the surgery, it was
found that the reason of the stated pathology is the disintegrated appendix,
which adhered to the visceral surface of the liver. After analyzing the stated
case, it became obvious that on one hand it was due to atypical location of
appendix and on another hand, not diagnosed appendicitis resulted
periappendicular abscess, which due to its location was infiltrated and drained
into liver. After the liver abscess drainage, the trans-hepatic fistula of the
appendix was formed. Ref. 5.
Auth.
b14.3.1.22. New aspects of tolerance to nitrates. /N. Gongadze, N.
Gorgaslidze, T. Makharadze, M. Mirziashvili, D. Abulashvili/. Tbilisi State Medical
University Collection of Scientific Works. – 2013. – #47. – pp. 43-44. – eng.;
abs.: geo., eng.
In last years it has been suggested the
development oftolerance and endothelial dysfunction in long-term
nitratestherapy, that implicits the diminution of anti-ischemic and
vasodilating effects of this group of drugs. Some authors indicate that such
tolerance to nitrates is associated with reduction of their antiplatelet
activity and with decreasing production of vasodilating prostaglandin-prostacyclin,
while other investigators indicate about preserved cardio protective effect of
nitrates despite the hemodynamic alteration produced by this group of drugs.
Nitrates tolerance includes increased level of plasma renin activity and
angiotensin II, elevation of aldosterone and vasopressin as well as
catecholamines. It is also very important the generation of superoxide ion and
peroxynitrite formation in vasculature along with tolerance to nitrates leads
to. In addition, in the development of tolerance to nitrates reduction of CGRP
production is also involved. In last decade it was established the
participation of ATP-sensitive K+ channels in nitrates tolerance, which
inhibition may cause the desensitization to nitrates and the loss of their anti-ischemic
effect. Ref. 14.
Auth
b14.3.1.23. Progesterone -
regulator of immune response in Jurkat cells. /A. Gokhelashvili, L.
Jashi, N. Gogebashvili, T. Mchedlishvili, N. Intskirveli, T. Sanikidze/. Tbilisi State Medical University Collection of
Scientific Works. – 2013. – #47. – pp. 44-46. – geo.; abs.: geo., eng.
Progesterone is
important hormone for the maintenance of pregnancy. During physiological
pregnancy level of progesterone in blood is 4-6 times higher than in the blood
of nonpregnant women. The aim of our study was determination of the role of
progesterone in the regulation of immune response of T lymphocytes. It was
established that the PHA-activated Jurkat cells intensify IL-2 and decrease
IL-10 secretion. Under influence of progesterone on intact Jurkat cells and
IL-10-IL-2-expressionlevels did not change significantly compared to the
control level. Influence of progesterone on PHA-activated Jurkat cells induces
intensification of IL-2 expression and didn’t change intensity of IL-10
expression statistically significantly in comparison with the initial
parameters. Therefore it was found that under influence of progesterone on
intact Jurkat cells IL-2/IL-10 cytokines balance does not changed, whereas in
the PHA- activated Jurkat cytokines profile inclined toward cytoprotective
(IL-2/IL-10 ratio was reduced from 2.56 to 1.53). Our study results
confirm that progesterone plays an important role in the regulation of the
immune homeostasis in the mother’s body and maintenance of the pregnancy. Tab. 1, Ref. 9.
Auth.
b14.3.1.24. Study of Beshumi clay for using it as excipient in soft pharmaceutical products.
/N. Gumberidze, A. Gaprindashvili, T. Masiukovichi, N. Alavidze, A.
Bakuridze/. Tbilisi
State Medical University Collection of Scientific Works. – 2013. – #47. – pp.
46-48. – geo.; abs.: geo., eng.
Nowadays the world pharmaceutical market
is represented by the synthetic as well as the natural medicinal products.In
the modern world there is going on the active search of
the biologically active compounds. Unfortunately, such tendency is not observed
towards the excipients. At the same time, it should be noted that in some
pharmaceutical products their amount is larger than that of the active
ingredient, e.g. in soft pharmaceutical products the average amount of
excipients varies between 75-99%.For the purpose to use as the excipient in
soft pharmaceuticalproducts great attention deserves the mineral raw materials,
especially – clays. The aim of our research was to study Beshumi clay for its use
as an excipient in soft pharmaceutical products. On the basis of the conducted
experimental studies, the following canbe concluded: by using a modern
instrumental method, it is found that Beshumi clay contains in large amounts
sulphur and zinc, which are biologically valuable components for the treatment
of various skin diseases;Beshumi clay has the optimal physical-chemical and
technological characteristics and can be used as the base in soft
pharmaceutical products; Teimurovi paste prepared on the base of Beshumi clay
meets the requirements of the pharmacopoeia; as a result of the
bio-pharmaceutical research in comparative aspect, it is ascertained, that the
Teimurovi paste made of Beshumi clay after a short period of time releases
larger amounts of the biologically active compounds than the one made of Askana
clay. Tab. 2, Ref. 5.
Auth.
b14.3.1.25. Peculiarities of
treatment and outcome of patients with cerebral stroke in multiprofile
hospitals. /I. Verulashvili, D. Kakabadze, M. Akubardia/. Tbilisi State Medical
University Collection of Scientific Works. – 2013. – #47. – pp. 59-61. – geo.;
abs.: geo., eng.
A comparative
analysis of therapeutic results of patients with an acute stage of cerebral
stroke treated in 2010-2011 both in a TSM University Hospital (158 patients;
mean age 56.3±7.5) and in an emergency neurological clinic (169 patients; mean
age 53.83±6.1) was carried out. The obtained data prove the fact that a medical
aid to cerebral stroke patients, rendered in a hospital with stroke unit, has
apparent advantages: therapy is accompanied by a good regress of a neurologic
deficit (correspondingly 76% to 28%) and somatic complications (correspondingly
7% to 2.5%). Lethality (correspondingly 3.2 to 5.8 lethal events per 100
patients), disability and self-care incapability of a patient are greatly
decreased at the end of the third month of the disease onset in patients
treated in stroke unit. An advantage of stroke units is that specialized care
can be given to a broad spectrum of patients regardless of the interval after
stroke or severity of neurological impairments. Ref. 4.
Auth.
b14.3.1.26. Caroli disease – the
rare surgical pathology (case report). /G. Tomadze, M. Mizandari, A. Megreladze,
G. Azmaiparashvili, G. Danelia/.Tbilisi
State Medical University Collection of Scientific Works. – 2013. – #47. – pp.
72-75. – geo.; abs.: geo., eng.
Caroli
disease is a rare inherited disorder characterized by dilatation of the intrahepatic
bile ducts. There are two types of Caroli disease, the most common being the
simple, where the bile ducts are widened by ectasia. The second, more complex,
cause is commonly known as Caroli Syndrome. This complex form is also linked
with portal hypertension and congenital hepatic fibrosis. Caroli disease is
also associated with liver failure and polycystic kidney disease. The disease
affects about 1 in 1,000,000 people, with more reported cases of Caroli
syndrome than of Caroli disease. The cause appears to be genetic; Females are
more prone to Caroli disease than males. The first symptoms typically include
fever, intermittent abdominal pain, and hepatomegaly. Occasionally jaundice
occurs. Patients with Caroli disease are 100 times more at risk for
cholangiocarcinoma than the general population. Morbidity is common and is
caused by complications of cholangitis, sepsis, choledocholithiasis, and
cholangiocarcinoma. Portal hypertension may be present, resulting in other
conditions including splenomegaly, hematemesis and melena. The treatment
depends on clinical features and the location of the biliary abnormality. When
the disease is localized to one hepatic lobe, hepatectomy relieves symptoms and
appears to remove the risk of malignancy. Antibiotics are used to treat the
inflammation of the bile duct, and ursodeoxycholic acid - for hepatolithiasis.
In diffuse cases of Caroli disease, treatment options include conservative or
endoscopic therapy, internal biliary bypass procedures and liver transplantation
in carefully selected cases. The aim of the article is to present our clinical
case of Caroli disease, which was diagnosed and managed using noninvasive and
mini-invasive methods of diagnosis and treatments. 67 years old male admitted
in our clinic complaining abdominal pain in epigastric area, jaundice. Lab
results revealed elevation of AST, ALT, Bilirubin. Ultrasound revealed enlarged
liver with cystic structures in it. Echinococosis was excluded via serology. CT
and MRI diagnosed Caroli disease (showed enlarged intrahepatic bile ducts due
to ectasia and tubular dilation of the bile ducts). Cysts where drained using
ultrasound control. Passability of CBD was restored using balloon dilatator.
Presented case is interesting because of its rarity showing usage of
non-invasive or mini-invasive methods in the diagnose and management of the
disease. Fig. 3, Ref. 29.
Auth.
b14.3.1.27. Cervical epithelium
reaction in reproductive age females under hypothyroidism. /Z. Topuria, M.
Beruchashvili, L. Gogiashvili, Z. Tsagareli, M. Dgebuadze/. Tbilisi State Medical University Collection
of Scientific Works. – 2013. – #47. – pp. 75-77. – eng.; abs.: geo., eng.
The
purpose of the investigation was to examine the morphological manifestations of
hypothyreosis in the reproductive age women cervical mucosa. With clinically
verified hypothyroisis in 1524 cases, 538 patients had a different variants of
endocervical pathology, accounting for two major research groups: I - (n = 259)
operated by colloidal goiter treated by L-thyroxin during last 3 years, II - (
n = 279) with similar diagnosis, without replacement therapy within last 3
years. Therapeutic and diagnostic scrapings from cervix, as well as parallel
samples of the operative removal thyroid gland (TG), after staining with
hematoxylin and eosin and picrofuchsin by van Gieson were studied
morphologically. The different variants of the cervical mucosa reaction from
simple hyperplasia in treated group to adenomyosis with stratification of
epithelium, and the tendency of sclerosis and atrophy in the group not
receiving L-thyroxin were revealed. In all compared cases Spearmen correlation
coefficient had high level of relevance (0,00003). We believe that the cervix
changes are the consequence of the decrease of sensitivity to estrogen under
the low level of T3 and T4 and increase TSH in plasma. Molecular atypia of
endocervical cells clearly demonstrates cross-combination of two leading
hormonal systems. Ref. 8.
Auth.
b14.3.1.28. Pharmacological load tests. /A. Isakadze/. Tbilisi State Medical University Collection
of Scientific Works. – 2013. – #47. – pp. 78-80. – geo.; abs.: geo., eng.
With
the aim of diagnosing heart ischemic disease, conducting of physical tests has
the decisive role. If due to the various reasons the implementation of physical
tests is unavailable, the tests with pharmacological load are conducted. The
load with Dipyridamol causes the dilatation of unaltered coronary arteries and
the inter coronary stealing phenomenon is developed. Load with adenosine dilates
coronaries and increases segments perfusion provided by it. Uneven blood supply
provokes ischemia. Load with synthetic catecholamine Dobutamin also provokes
ischemia, 10-36% of patients develop arrhythmias during tests. The use of
special (GenESA) system is essential at the time of load with agonist of
b-adrenoreceptors Arbutamin. Tab. 1, Ref. 21.
Auth.
b14.3.1.29. Role of epigenetic
factors and cancer. /K. Kankava, T. Tkemaladze/. Tbilisi State Medical
University Collection of Scientific Works. – 2013. – #47. – pp. 82-87. – geo.;
abs.: geo., eng.
Epigenetics has
gained increasing popularity in modern science. The hereditary factors,
independent from DNA-sequences are being studied in normal cells and in various
pathologic disorders. Due to cancer being an acute and largely not defeated
problem in medicine nowadays, the detailed analysis of epigenetic factor
involvement in cancerous processes and seeking of new ways for early
identification and treatment of cancer is being performed. DNA-methylation and
histone modification are best studied epigenetic modifications. Influence of
these factors has already been identified as a trigger or
aggressiveness-determining factor for some types of cancer. Epigenetic effect,
in contrast to change in DNA-sequence, is reversible and, because of this,
tumors, conditioned by these factors should be more manageable. This review
provides an insight into the identified mechanisms of action for epigenetic
factors in cancer cells, ways of intervention and future perspectives for
development of this field. Ref. 57.
Auth.
b14.3.1.30. Thymus cell
specificity of gnotobionts in regard to age. /B. Kochlamazashvili, L.
Gogiashvili, Z. Tsagareli, K. Jandieri/. Tbilisi State Medical University Collection
of Scientific Works. – 2013. – #47. – pp. 94-96. – geo.; abs.: geo., eng.
Immunomorphologic
study with morphomerty of cytoarchitecture of thymus of regular (conventional)
and germfree (gnotobionts) rats of different age have been carried out. The results
of the investigation revealed undeveloped lymphoid tissue of gnotobiont’s
thymus in comparison with thymus of conventional rats despite of proportional
decrease of antigenic load. Limphopoietic potential of thymus of gnoto26 bionts
in accordance with the microbial status of the body is limited, irrespective to
the age. Concerning to the age-related changes, must be said, that aging of
gnotobiont and conventional rats, basically have identical orientation, and
hence, they depend not on environmental influence, but genetically determined
peculiarities of internal regulative mechanisms, which take place during the
ontogenesis. Tab.1, Ref.5.
Auth.
b14.3.1.31. Research of
polyphenol compounds in Populus tremula
buds. /J. Kuchukhidze, M. Jokhadze, T. Murtazashvili/. Tbilisi State Medical University Collection
of Scientific Works. – 2013. – #47. – pp. 102-103. – geo.; abs.: geo., eng.
A
qualitative-quantitative analysis of flavonoids of the buds of popular Populus tremula growing in Georgia
through liquid chromatographic method was carried out. As a result of the
experiment, the optimal conditions of the chromatography: the gradient mode of
the moving phase, the stationary phase and the detection wavelength in the
ultraviolet region were estimated; It was found that the leaves of Populus tremula contained the following
flavonoids and phenolic acids (mg/g):chrisine (8.73), pinocembrine (7.52),
pinostrobine (7.38), galangine (4.26), apigenine (3.15), caffeic acis (3.72),
salicylic acid (3.39), benzoic acid (3.1), cinnamic acid 2.89), ferulic acid
(1.54). Thus, Georgian Populus tremula
is rich in flavonoid units and represents an interesting object for further and
deeper scientific study. Tab.1, Fig. 1, Ref. 8.
Auth.
b14.3.1.32. Morphological and
microstructural features of the purple flower garlic (Allium rotundum l.). /M. Maisashvili, J.
Kuchukhidze, D. Chincharadze, L. Zardiashvili, A. Bozhadze/. Tbilisi State Medical University Collection
of Scientific Works. – 2013. – #47. – pp. 111-113. – geo.; abs.: geo., eng.
Allium rotundum L. (Alliaceae) is broadly distributed
throughout the whole territory of Georgia. It is easily cultivated and can
supply a raw material base on an industrial scale. We preciously isolated and
characterized the main active principles, steroidal sapogenines and saponines,
phenolic compounds such as flavonoids and coumarines, carotinoids and amino
acids. Saponins have different pharmacological activity: antimicrobial,
antifungal, antioxidant and cytotoxic. For the raw material of Allium a methodological
description of its microscopic features was elaborated: for the leaf, the stem,
the flower and the bulb. The knowledge of their features is crucial for the
determination of the raw materials authenticity. Fig. 2, Ref. 8.
Auth.
b14.3.1.33. Rare case of
hyper-adhesive mechanical ileus of intestine (case report). /A.
Megreladze, G. Tomadze, G. Azmaiparashvili, A. Gvazava, M. Goletiani/. Tbilisi State Medical University Collection
of Scientific Works. – 2013. – #47. – pp. 115-117. – geo.; abs.: geo., eng.
Nowadays at least
20% of the patients, who apply to general surgery services complaining from
acute abdomen, are due to intestinal obstructions. The rate of developing
intraabdominal adhesion after an abdominal operation is between 67% and 93%.
This ratio is higher in gynecologic and pelvic operations. The intestinal
obstruction rate in the patients who had intraabdominal operation is between
0.3 and 10.7%. Adhesions are thought to be the cause of around 30-41% of all
intestinal obstruction. For small-bowel obstruction, the proportion rises to
65-75%. We present a very rare case of small bowel obstruction with extremely
strong hyperadhesive process, which made impossible to eliminate all adhessions
and split bowels. 24 years old male was admitted in the clinic with ileus. Year
ago he was operated because of peptic ulcer perforation and peritonitis. Three
months after operation he was reoperated because of mechanical ileus due to
adhesions and 10 days after – reoperation again for ileus. Small bowel looked
like “turtle-shell” what made impossible to identify borders between bowels.
Ileostome had been performed. In postoperative period during eight months the
patient received hormonotherapy, antiadhesive treatment and finally last
reconstructive operation - entero-enteroanastomosis. Discharged on 7th
postoperative day. This is a seldom seen case, which shows very rare
hyperadhesive ileus, when sinechiolysis was impossible and patient was operated
in 2 stages. Ref. 10.
Auth.
b14.3.1.34. Review of the chemical toxicological methods of analysis
of some antipsychotic drugs of second generation. /K. Sivsivadze, T. Murtazashvili, M. Jokhadze, R. Makharadze, N.
Imnadze/.Tbilisi
State Medical University Collection of Scientific Works. – 2013. – #47. – pp.
128-131. – geo.; abs.: geo., eng.
In recent years the pharmaceutical market has
been enriched with a number of new antipsychotic drugs. In the list of such
agents are risperidon, olanzapine and clozapine. The number of its medical and
nonmedical utilization significantly increased; respectively raised the
quantity of intoxications caused by the antipsychotic drugs. Many scientists of
various countries are working to elaborate the methods of qualitative and
quantitative analysis for determination of risperidon, olanzapine and clozapine
in drugs or in biological material. The main subject of the research is
individual and simultaneous determination of above-mentioned agents and
validation of these methods. The bibliography shows variety of these methods–
spectral, electrochemical and chromatographic. Antipsychotic polypharmacy is
well established in schizophrenia therapy. Due to importance of this subject it
is essential to deep study of the bibliographic data. Development and
amelioration of the chemical-pharmaceutical methods of analysis of
above-mentioned agents are still open for scientific discussions. The present
review serves to elaborate the respective background to establish the new,
sensitive and reproductive methods of analysis in the narcological - toxicological
practice of Georgia. Fig. 1, Ref. 15.
Auth.
b14.3.1.35. Cardiotonic steroids in saltsensitive arterial
hypertension in Georgia. /G. Simonia, I. Andronikashvili, I. Pantsulaia, N. Kantaria, N.
Basishvili/. Tbilisi
State Medical University Collection of Scientific Works. – 2013. – #47. – pp.
131-133. – geo.; abs.: geo., eng.
The overall goal of our study was to
elucidate the role of endogenous ouabain (EO) and marinobufagenin (MBG) in the
development of salt-sensitivity and salt-sensitive hypertension in Georgian
patients. The objectives of the study were typing of normotensive and
hypertensive subjects by salt-sensitivity test, and detection of circulating
levels of EO and MBG in salt-resistant and salt-sensitive normotensive subjects
during low and high salt diet; Salt sensitivity (when difference between MAP
exceeded 3 mm Hg) was detected in 12 (54,5%) of normotensive subjects and in 32
(64%) of hypertensive patients. In salt-sensitive hypertensives plasma levels
of both MBG and EO significantly exceeded those of salt-resistant patients. Conclusions: High incidence of
salt-sensitivity and prevalence of salt-sensitive hypertension associated with
high sodium intake has been detected in Georgian normotensive and hypertensive
subjects. Development of salt-sensitivity and salt-sensitive hypertension might
be due to increased production of marinobufagenin and endogenous digoxin – so
called cardiotonic steroids. Tab. 1, Ref. 7.
Auth.
b14.3.1.36.
Aspects of zinc deficiency worldwide and in Georgia. /Sh. Tukvadze, R. Kverenchkhiladze, R. Kvanchakhadze/. Tbilisi State Medical University Collection
of Scientific Works. – 2013. – #47. – pp. 133-134. – geo.; abs.: geo., eng.
Zinc deficiency is one of the most prevalent risk factors for
nutrient-related diseases. Young children as well as pregnant women are at highest
risk of zinc deficiency. Populations in the developing countries consume
limited animal products (excellent source of many trace elements) and plants or
cereal meals high in inhibitors and are generally at increased risk of
deficiency. FAO national food balance data and WHO, 2004 estimate that zinc
deficiency affects one third of the world population (about 2 billion people).
Currently national prevalence estimates of zinc deficiency based on direct
measures are lacking for most countries. The most popular method for assessing
the risk of population zinc deficiency includes assessment of dietary intakes
of zinc. Each year the Food and Agriculture Organization (FAO) of the United
Nations publishes national food balance sheets (FBS) which currently provide
data on 95 food commodities available for human consumption in 176 countries.
This can be used as an ecological indicator of the risk of inadequate zinc
intake in population. Using these assumptions, it appears that nearly 47.3% of
population in Georgia is at risk of zinc deficiency. Tab. 1, Ref. 5.
Auth.
b14.3.2.1. Influence of laser and some drugs on the intima of the
aorta and erythrocytes in experimental atherosclerosis. /T.Tavkhelidze/.
Modern Issues of Medicine and Management. – 2014. – #1. – pp. 13-23. – geo.; abs.:
geo., eng., rus.
Researches of many authors have shown that in
the development of atherosclerotic process in walls of arteries, the important
role plays the condition of their capillaries (so-called vaza vazorum) and
rheological properties of blood. Last is defined, somewhat, by reds blood cell.
Normal reds blood cell (normocytes) has the form of a biconcave disk. Such reds
blood cell gives to blood peculiar rheological qualities. Such reds blood cell
have an optimum electric charge, so-called a zeta-potential because of what
reds blood cell push away each other and do not stick together. They also make
a start and from vessel walls. Normocytes have ability of deformation because
of what can easily climb through in the capillaries which gleam have
cross-section section less than their diameter, that in the conditions of norm
an everyday occurrence. At infringement of an exchange of lipoproteins of low
density, the quantity of normocytes decreases. Instead of them there are the
modified reds blood cell which majority abilities to be deformed do not
possess, and their membranes have lowered a zeta-potential. The modified, not
possessing abilities be deformed cannot to climb through reds blood cell in the
capillaries which gleam have cross-section section less than their diameter,
and fall of the zeta-potential of membranes of red blood cages cause
aggregation of reds blood cell because of what fluidity of blood worsens, its
viscosity increases, that also leads to blood-groove deterioration
microcirculation channels of a wall of an artery (vaza vazorum). All it causes
metabolism deterioration in a vessel wall that along with other factors,
promotes accumulation of lipidic inclusions and occurrence of atheromas.
Studying of morphological changes in an aorta and morph-functional changes of
reds blood cell in dynamics of an experimental atherosclerosis and at
influences of various possibilities was the purpose of our research. For this
purpose, we against an experimental atherosclerosis used preparations (aspirin,
trental), and also the low-intensity helium-neon red laser. Researches have
shown, that, both aspirin and trental, and an irradiation of blood helium - the
neon laser, and especially their complex application causes situation
improvement in an aorta intim. Tab. 4, Fig. 5, Ref.
12.
Auth.
b14.3.2.2. Pancreatoduodenectomy as classic and pylorus-preserving
variant: Single center experience. /M.
Kiladze, A. Antadze, G. Chiqobava, G. Kherodinashvili, M. Chubinidze/.Georgian Medical
News. – 2014. – #4(229). – pp. 7-10. – eng.; abs.:
geo., eng., rus.
The experience of
pancreatoduodenectomy for pancreatic head and ampullary tumors is presented and
discussed. Out of 7 cases of pancreatoduodenectomy 3 were performed as classic
Whipple procedure and 4 as modified pylorus-preserving variant (PPPD). Two
cases of mild pancreatic and biliary leak were observed and one patient
developed abdominal wall dehiscence after the surgical site infection. There
was no operative mortality and overall postoperative morbidity rate was 42.8%.
It is concluded that “end-to-end” pancreaticojejunostomy with stent placement
and the PPPD variant are the most optimal and preferred operative procedures in
the pancreatoduodenectomy cases. Ref. 26.
Auth.
b14.3.2.3. The effectiveness of orthopedic treatment
using immunomodulator polyoxidonium in patients with type II diabetes. /E. Mamporia/. Modern Issues of
Medicine and Management. – 2014. – #1. – pp. 31-37. – geo.; abs.: geo., eng., rus.
The immunomodulator
Polyoxidonium is proposed for use in orthopaedic dentistry, by which the
correction and stabilization of local and general immunity is done, which
improves the clinical and morphological picture of the oral cavity. The
orthopaedic treatment efficiency increases by using of Polyoxidonium.
Auth.
b14.3.2.4. Calcium hydroxyapatite,
biological active regenerations made on its basis and the role of them in
therapeutic dentistry. /Kh. Tvildiani/. Modern Issues of
Medicine and Management. – 2014. – #1. – pp. 38-43. – geo.; abs.: geo., eng., rus.
The
resorption of pathological areas in bone tissue and stimulation of the
osteogenesis of these areas within a short period of time, as a result of
periodontitis and parodontiti still remain a topical problem and the subject of
discussion in therapeutic dentistry. During the clinic research and
experiments, as well as analysis of long-term results, it became clear that the
use of calcium hydroxyapatite and osteoplastic stuff, made on its basis, have a
major advantage over the methods of traditional medicine. As studies have
shown, the use of bio-regenerations for teeth preparation and working on them
are much more useful. Ref. 5.
Auth.
b14.3.2.5. Risk assessment of
adhesion of microbes dentures with bases made of polypropylene and acrylic
plastics. /M. Jervalidze, I. Taboridze, L. Aladashvili/. Modern Issues of
Medicine and Management. – 2014. – #1. – pp. 44-51.
– geo.; abs.: geo., eng., rus.
Under observation were 55 patients – the contingent of
the dental clinic “Leader-Dent” aged 45 to 55 with bases made of polypropylene.
The control group consisted of 50 patients of the same age with the bases of
acrylic plastic. Biopsy specimens were taken in a month after using dentures. A
comparative analysis of microbial oral cavity in the patients with removable
dentures made on the basis of polypropylene and acrylic plastics showed that
adhesion of oral bacteria depended on the base material; dentures with the
bases of acrylic plastics had a high risk of microbe colonization compared with
the dentures with the bases made of polypropylene: F. periodonticum (RR = 2,25,
95% CI: 1,81-2,80); A.Israelii (RR = 2,22, 95% CI: 1,79-2,76); P.gingivalis (RR
= 2.12, 95% CI: 1,73-2,60); S.salivarius (RR = 1,76, 95% CI: 1,19-2,62);
S.epidermidis (RR = 1,74, 95% CI: 1,20-2,51);); lactobacilus SPP. (RR = 1,57,
95% CI: 1,06-2,30); S.piogenus (RR = 1,56, 95% CI: 1,05-2,30. The use denture
bases of polypropylene provide a significantly lower level of colonization with
microorganisms than the acrylic plastic. Tab. 2, Ref. 10
Auth.
b14.3.2.6. Topical
diagnostics of traumatic condylar injuries and alloplastic reconstruction of
temporomandibular joint heads. /Z.
Gvenetadze, T. Danelia, G. Nemsadze, G. Gvenetadze/. Georgian Medical
News. – 2014. – #4(229). – pp. 10-15. – eng.; abs.: geo., eng., rus.
Condylar fractures have an
important place in facial traumatic injuries. Classification of condylar
fractures according to clinical-anatomic picture is common in clinical
practice. According to this classification there are: 1) fractures of
mandibular joint head, aka intraarticular fractures, 2) condylar neck fractures
or high extra articular fractures, 3) condylar base fractures. Radiographic
imaging plays important role in diagnosing condylar fractures along with
knowledge of clinical symptoms. We used computer tomography imaging in our
clinical practice. Three-dimensional imaging of computer tomography gives exact
information about location of condylar fractures, impact of fractured
fragments, and displacement of condylar head from articular fossa. This method
is mostly important for the cases which are hard to diagnose (fractures of
mandibular joint head, aka intraarticular fractures). For this group of
patients surgical treatment is necessary with the method of arthroplasty. We
have observed 5 patients with bilateral, fragmented, high condylar fractures.
In all cases the surgery was performed on both sides with bone cement and
titanium mini-plates. Long-term effects of the treatment included observation
from 6 months to 2 years. In all cases anatomic and functional results were
good. Shape of the mandible is restored, opening of mouth 3-3.5 cm, absence of
malocclusion. Fig. 13, Ref. 6.
Auth.
b14.3.2.7. Early
activation of heart-operated patients as a tool for optimization of
cardio-surgery treatment (review). /M.
Nachkepia, V. Akhaladze, A. Kopaliani, K. Beselia, V.Simonidze/. Georgian Medical
News. – 2014. – #4(229). – pp. 15-20. – rus.; abs.:
geo., eng., rus.
Lately foreign countries have
widely introduced the tactic of early activation of cardio-surgery patients.
The necessary components of this methodical approach are early finishing of
post-operation artificial respiration and extubation of trachea, shortening of
time spending in intensive therapy to 1 day and discharge from the hospital in
5 days. As a result of reducing the hospitalization period, the treatment costs
are significantly reduced. The goal of this research is to analyze the methods
of anesthesia that allow early extubation and activation after cardio-surgery
interventions. The data of protocols of anesthesia and post-operation periods
for 270 patients were studied. It was concluded that the applied methods of
anesthesia ensure adequate protection from the operation stress and allow
reducing the time of post-operation artificial respiration and early activation
of patients without reducing the level of their safety. It was also proved that
the application of any type of anaesthetics does not affect the rate of
post-operation activation. The conducted research proves the advisability of
wide introduction of the proposed tactics. Tab. 2, Ref. 28.
Auth.
b14.3.2.8. Autoimmune
mechanisms toward type I collagen during parodontitis. /L. Jashi, N. Gogebashvili/. Georgian Medical
News. – 2014. – #4(229). – pp. 26-28. – rus.; abs.:
geo., eng., rus.
The article presents original
data about autoimmune mechanisms according to the severity of the process
during the chronic generalized parodontitis. The medical examination of 179
patients with different forms of parodontitis demonstrated that during
parodontitis the synthesis and re-synthesis of type I collagen is negatively
affected and as a result, type I collagen concentration in the blood serum
raises. In addition, the selection of antigen reactive lymphocytes increases
toward type I collagen, which in turn boosts their quantity in blood and also
stimulates the creation of auto-antibodies toward type I collagen. This is
reflected by the increased quantity of auto-antibodies in the blood serum. The
intensity of these processes amplifies as the parodontitis inflammation becomes
more severe. These results demonstrate that the autoimmune process develops
toward type I collagen during parodontitis and its intensity reflects the
severity of the pathological processes in parodontitis. Ref. 9.
Auth.
b14.3.2.9. Prevention of complications developed as result
of prosthesis with fixed dentures in hypertensive patients. /S. Gordienko/. Georgian Medical
News. – 2014. – #4(229). – pp. 29-32. – rus.; abs.:
geo., eng., rus.
The author, on the basis of clinical and laboratory methods, justifies
that the use of locally made dental cream “Solcoseryl-Denta” helps in persons
suffering from arterial hypertension increase the speed of recovery of normal
epithelial layer of the cells of the mucous membranes of the oral cavity, and,
consequently, prevents the development of complications in prosthesis. Tab. 3,
Ref. 11.
Auth.
b14.3.2.10. Correction
of endothelial dysfunction in patients with essential hypertension and type 2
diabetes. /A. Shalimova/. Georgian Medical
News. – 2014. – #4(229). – pp. 33-40. – rus.; abs.:
geo., eng., rus.
Presence of comorbidity in
patients – that is essential hypertension and type 2 diabetes is associated
with early progression of target organs affection and cardiovascular complications.
Hyperinsulinemia and insulin resistance are some of the factors that determine
the frequency of cardiovascular complications in type 2 diabetes. According to
some authors, endothelial dysfunction is a link between insulin resistance and
cardiovascular diseases. To investigate severity of endothelial dysfunction in
patients with essential hypertension and type 2 diabetes and its correction by
using a complex treatment α-lipoic acid we have examined 84 patients with
essential hypertension stage II and type 2 diabetes in a moderate condition
before and after 6 months treatment. The patients were divided into two groups:
the first one consisted of the patients who received only basic therapy, and
the other one consisted of those patients who in addition to basic therapy
received also α-lipoic acid in tablets at a dose of 600 mg/day. After the
investigation it was discovered that changes in the vascular wall in patients
with essential hypertension and type 2 diabetes are characterized by increase
of intima-media thickness and pulse wave velocity in the carotid arteries and
abdominal aorta, decrease of endothelium-dependent vasodilation degree and
increase of the levels of proinflammatory cytokines. Under the influence of the
mentioned complex therapy in these patients it was found some improvement of
metabolic homeostasis and correction of endothelial dysfunction. The effect on
the structural and functional state of great vessels and proinflammatory
cytokines, gained due to additional prescription of α-lipoic acid to the
patients with essential hypertension and type 2 diabetes, was more considerable
that the one which was shown in the group of patients who received only
standard therapy. Tab. 7, Ref. 38.
Auth.
b14.3.2.11. 12Ala
polymorphism of receptor gene, which activates proliferation by peroxisome
γ2, determines severity of bronchial asthma course associated with
coronary heart disease. /O. Byelan, O.
Shlykova, T. Mamontova, L. Vesnina, I. Kaidashev/. Georgian Medical
News. – 2014. – #4(229). – pp. 40-47. – rus.; abs.:
geo., eng., rus.
The aim of the research was to
detect the role of PPAR-γ2 gene Pro12Ala polymorphism in the
development of bronchial asthma (BA) in combination with coronary heart disease
(CHD). BA patients in combination with coronary artery disease were examined in
terms of anthropometric measurements, lung function, cycle ergometry, ECG,
blood pressure, and endothelium-independent vasodilatation. The alleles of
PPAR-γ2 genepolymorphic region were determined; the
high-sensitivity C-reactive protein (hs-CRP) and the adhesion molecules sVCAM-1
and sICAM-1 in the blood were detected; the biochemical blood analysis was
performed. It was found that patients with Ala allele in homo-and heterozygous
state, as opposed to patients with Pro allele in homozygous variant, reveal a
significantly higher incidence of first grade arterial hypertension and mild
persistent BA; lower rates of heart rate were recorded; significantly higher
levels of parameters characterizing the systemic inflammation (white blood cell
count and hsCRP) and lower rates of adhesion molecules of sICAM-1 level, total
cholesterol, total and indirect bilirubin were detected. Ala allele carriers in
homo- and heterozygous state in patients with BA in combination with CHD is associated
with the risk of overweight, mild persistent asthma and angina I FC. Thus, the
carrier state of 12Ala allele of PPAR-γ2 gene Pro12Ala polymorphism may be
associated with a higher risk of developing BA against the background of CHD.
Tab. 3, Ref. 13.
Auth.
b14.3.2.12. Quality of life of patients with
chronic hepatitis C at different degrees of expression of mixed
cryoglobulinemia. /Y. Ryabokon/. Georgian Medical
News. – 2014. – #4(229). – pp. 48-52. – rus.; abs.:
geo., eng., rus.
The article investigates the
quality of life of 305 patients with chronic hepatitis C. It was revealed that
in the absence of mixed cryoglobulinemia but in the presence of its biochemical
signs the effect of physical conditions and emotional state on role functioning
don't differ from those of the healthy people. However indicators of social
functioning, self-rating of mental health and the general state of health are
decreased. Increase of the quantitative maintenance of the mixed cryoglobulins
in blood serum of patients with chronic hepatitis C leads to clinical
manifestations of the HCV-related cryoglobulinemia syndrome accompanied by the
decrease of self-assessment of health by patients due to the deterioration of
influence of a physical conditions and emotional state on role functioning.
Tab. 2, Ref. 18.
Auth.
b14.3.2.13. Optimization
of long-term hypolipidemia treatment of patients with myocardial infarction in
combination with non-alcoholic steatohepatitis. /I. Skrypnyk, T. Dubrovinskaya, E. Ohanisyan/. Georgian Medical
News. – 2014. – #4(229). – pp. 53-58. – rus.; abs.:
geo., eng., rus.
In a comparative aspect, the
dynamics of indices of lipidogram, functional state of liver and level of
C-reactive of protein have been analyzed in 79 patients with myocardial
infarction in combination with non-alcoholic steatohepatitis, who received a
9-months treatment by rosuvastatin of 20 mg, atorvastatin of 80 mg, as well as
rosuvastatin of 10 mg, atorvastatin of 40 mg in combination with
ursodeoxycholic acid (UDCA). The obtained results show the equivalent of
hypolipidemia effectiveness of all investigated courses of statinotherapy with
the benefit of rosuvastatin of 20 mg in increase of level of HDL cholesterol
and combined statinotherapy with UDCA in decrease of level of triglycerides. It
was confirmed the significant advantages of combined statinotherapy with UDCA
as for the influence on functional state of liver and CRP level, and advantages
of rosuvastatin of 10 mg in combination with UDCA. Thus, the combination of
rosuvastatin of 10 mg with UDCA should be preferable in the treatment of
patients with myocardial infarction in combination with non-alcoholic
steatohepatitis from the positions of the effectiveness and safety. Besides,
taking into account positive correlation between the CRP level in blood and
activity of transaminases in the dynamics of observation it can be concluded
that high activity of transaminases is the prognostic marker of the severity
and procession of polymorbid pathology – myocardial infarction in combination
with non-alcoholic steatohepatitis. Tab. 1, Ref. 17.
Auth.
b14.3.2.14. Early
repolarization as a risk factor of atrial fibrillation. /Z. Matoshvili, Sh. Petriashvili, A. Archvadze, I.
Azaladze/.Georgian Medical News. – 2014. – #4(229). – pp. 59-61. – eng.; abs.: geo., eng., rus.
Early repolarization pattern is a
common ECG pattern characterized by J-point and ST segment elevation in 2 or
more contiguous leads. There are some opinions that early repolarization may be
associated with some kind of arrhythmias (including life-threatening
arrhythmias) Aim of this study was to declare correlation between early
repolarization and atrial fibrillation. In this study participated patients
(19-68 years old) with early repolarization and without exclusion criteria.
Monitoring was made by helping 24h ambulatory ECG monitoring. Variables are
expressed as mean ± SD, The analysis was performed using Student’s t test,
statistical tests were two-tailed, and a p value < 0.05 was considered
statistically significant. We compared rate of atrial fibrillation in patients
with early repolarization to rate of atrial fibrillation in general population;
The comparison of this two data shows that rate of atrial fibrillation in
patients with early repolarization is significant higher than rate of atrial
fibrillation in general population (7,3 fold higher; 14,6% Vs 2%). So, early
repolarization may be considered as independent risk factor of atrial
fibrilallation. This is principally new and very important information. Tab. 1,
Ref. 15.
Auth.
b14.3.2.15. Influence
of risk-factors in infants on the peculiarities of cognitive development. /M. Bezrukikh, E. Parcalis, E. Loginova/. Georgian Medical
News. – 2014. – #5(230). – pp. 7-17. – rus.; abs.:
geo., eng., rus.
The importance of risk-factors
during the early development of children on the development of cognitive
difficulties in pre-schoolers and school children are reviewed. The
effectiveness of comprehensive diagnostic of main reasons of disorders of
cognitive development is shown. The importance of complex medical, pedagogical,
psycho-physiological and neuropsychological treatment of cognitive disabilities
in children is demonstrated as well. Fig. 3, Ref. 32.
Auth.
b14.3.2.16. Some
features of development and course of bronchial asthma in children in
Azerbaijan. /H. Gabulov/. Georgian Medical
News. – 2014. – #5(230). – pp. 17-24. – rus.; abs.:
geo., eng., rus.
According to the international
«ISAAC» program, we studied the peculiarities of bronchial asthma in children
at the age of 13-14 years in various climatic and geographic regions of
Azerbaijan. At the first stage of investigation, 14693 eighth-class pupils of
high school from four different regions were surveyed: region I (n=4979) – an
industrial city, placed in a semi-desert area; region II (n=3010) – rural
areas, located in a semi-desert climatic zone; region III (n=3133) – areas,
located in a subtropical climatic zone; region IV (n=3571) – an ecologically
clean mountainous region, located along southern slopes of the Greater
Caucasian ridge. At the second stage of the investigation allergological,
clinical-functional examinations were carried out in children with symptoms of
allergic diseases. It was established that prevalence of BA was reliably more
frequent in the industrial city (4,6%) than in other three, especially rural
areas. In subtropical climatic area 2,8%, in rural semi-desert area – 2,5%, in
mountainous region – 1,8% of examined children were suffering from BA. Study of
the clinical course of diseases in children with allergic diseases and their
allergic status revealed that structure and expressiveness of sensitization to
domestic, pollen, fungous and food allergens depends on residing area. Tab. 4, Ref.
11.
Auth.
b14.3.2.17. Clinical
analysis of 102 cases of Epstein-Barr virus infections in Chinese children. /F. Jiao, X. Yan, K.Yan, Y. Chen, K. Liu/. Georgian Medical
News. – 2014. – #5(230). – pp. 35-38. – eng.; abs.:
geo., eng., rus.
The purpose of this study is to
investigate the clinical manifestations and disease severity, to evaluate the
recent trend of clinical manifestations and differences in the clinical and
laboratory findings of EBV-associated IM (infectious mononucleosis) according
to the age of children. We retrospectively collected cases on hospitalized
patients a majority of 7 years old with characteristic symptoms of IM and
serologically diagnosed EBV-associated IM at Shaanxi Provincial
Peoples University Hospital in Xi’an from Apr,
2012 to Oct, 2013. All their medical records were reviewed and analyzed. For
each patient, clinical, laboratory data and outcome were collected
retrospectively and compared to previous studies to evaluate the differences
between the clinical and laboratory findings of patients of different ages. The
clinical manifestations in children with EB virus infection varied. There were
60 (58.8%) cases of children with infectious mononucleosis, 26 (25.49%) cases
of Epstein-barr virus infection,16 cases of the atypical EB virus infection,
accounting for 15.67%. 78% children were under 7 years of age, 12% were 7 to 14
years of age. There are differences in the symptoms and signs among the
different age groups. The clinical manifestations in children with EB virus infection
involved multiple systems and produced harm is heavier and should be paid
attention to during the treatment. The disease continues to occur mostly in
children under 10 years of age. When compared to previous Chinese studies about
15 years ago, the age distribution was similar and the incidence of
hepato-splenomegaly was lower in our study. Ref. 13.
Auth.
b14.3.2.18. Fuzzy
approaches in pediatrics. /T. Kiseliova, K.
Pagava/. Georgian Medical News. – 2014. – #5(230). – pp. 38-46. – eng.; abs.: geo., eng., rus.
In this paper we present a review
of applications of fuzzy methods in children and adolescence health care. Based
on the several examples, available from journal papers, conference proceedings
and book chapters we have concentrate us on problems in the pediatrics that
have been or can be solved with the help of fuzzy methodology. The paper is
organized as follows. In section I we consider the general considerations about
fuzzy logic and medicine. Section II considers the basics of fuzzy sets and fuzzy
logic, the main methodological approaches for medical practical applications.
Section III describes problems and the way of their solving using fuzzy
approaches in pediatrics. Conclusions summarize the review in Section IV. Fig.
4, Ref. 39.
Auth.
b14.3.2.19. Tactics
of surgical treatment at traumatic injuries of maxillo-zygomatic–orbital
complex and the lower edge of the orbit. /Z.
Gvenetadze, G. Lagvilava, G. Toradze, I. Devidze, G. Gvenetadze/. Georgian Medical
News. – 2014. – #6(231). – pp. 7-11. – eng.; abs.:
geo., eng., rus.
The
maxilla-facial traumatic injuries, zygomatic – orbital complex and orbit lower
edge injuries are characterized by dislocation of bone fragments, causing not
only the anatomo-functional disorders but well-expressed deformity/ abnormality
of the patient. 28 patients with traumatic fractures of zygomatic – alveolar
complex and orbit lower edge have been studied and got surgical treatment by
the authors. At admission to the hospitals, all the patients were the subjects
to a classic comprehensive / complex examination including a Spiral Computed
Tomography, with 3D reconstruction (three-dimensional) (in 3 projections). All
the patients underwent surgical treatment under endotracheal anesthesia that
included osteosynthesis of zygomatic bone body and arch and plasty of orbit
lower edge. Osteosynthesis of zygomatic bone body and arch was conducted with
titanium plates and screws (hanging zygomatic arch by steel wires), restoration
of bony wall was carried out by prosthesis of titanium (net) plate made
individually (auto-graft, taken from calvaria bone was used for restoration of
orbit lower edge defect in 2 cases). According to the study materials no
complications of transplanted grafts like purulency, removal reaction, or
dislocation were observed. The obtained data have proved over again, that
endoprothesis made of medical titasnium are effective for treatment of the
patients with middle third facial traumatic injuries. Fig. 9, Ref. 9.
Auth.
b14.3.2.20. Laparoscopic
surgery of Hiatal hernia and gastro-esophageal reflux disease. /D. Elgandashvili, M. Kiladze/. Georgian Medical
News. – 2014. – #6(231). – pp. 17-20. – eng.; abs.:
geo., eng., rus.
About 10% (per cent) of world
population have Hiatal hernia and gastro-esophageal reflux diseases of
different forms. From this amount of people 1/5 need required surgical
treatment. The goal of the thesis is to show the results and effectiveness of
laparoscopic surgical treatment of this disease. In 2005-2013. at out clinics (Thoracoabdominal
clinic and Caraps Medline) had been performed 145 laparoscopic fundoplications.
Were used as Nissen Method with its modifications (Floppy Nissen, Classic
Nissen and Nissen Rosset), as well as „Toupet“ and „Dor“ methods of
fundoplication. From 145 cases were 84 – female, 61 – male. Age ranged from 24
to 76. From performed 145 operations in 97 cases was done Floppy Nissen
Fundoplication, 23 cases – Nissen-Rosset modification, 5 cases – Classic
Nissen. Toupet method Partial Fundoplication was done in 17 cases and anterior
Fundopexia - Dor method – was done in 3 cases. Using various methods of
laparoscopic fundoplication, due to the analysis of our results, the perfect
positive result was achieved in 93.2% (per cent). Tab. 2, Ref. 10.
Auth.
b14.3.2.21. The
severity of menopausal symptoms and cardiovascular risk in women. /A. Isayeva, M. Vovchenko/. Georgian Medical
News. – 2014. – #6(231). – pp. 21-26. – rus.; abs.:
geo., eng., rus.
Menopause is a crucial time in
the life of any women. Perhaps the severity of menopausal symptoms defines
further state of female health. The aim of the study is to assess changes of
cardiovascular system during perimenopause and the connection between this
changes and severity of menopausal symptoms. The data of 155 premenopausal
women without coronary heart disease were analyzed. To assess women hormonal
state follicle stimulating hormone was measured. The severity of menopausal
symptoms was evaluated with the help of Kupperman questionnaire form in Uvarova
modification. All women were divided into two groups according to follicle
stimulating hormone. Women with follicle stimulating hormone higher 30 MU/l
were classified as postmenopausal. It was shown that groups of pre – and
post-menopausal women significantly differ in age, progesterone, follicle
stimulating hormone level, and SCORE. The severity of menopausal symptoms was
the same in studied groups. Regression analysis revealed that severity of
menopausal symptoms depended on systolic blood pressure, follicle stimulating
hormone level, progesterone level. The link between cardiovascular risk (SCORE)
and follicle stimulating hormone, NO2, ApoА1, and severity of menopausal
symptoms was found. Tab. 3, Fig. 1, Ref. 20.
Auth.
b14.3.2.22. State of
integral remodeling parameters of target organs in patients with essential
hypertension and obesity. /M. Kochueva, V.
Sukhonos, A. Shalimova, V. Psareva, N. Kirichenko/. Georgian Medical
News. – 2014. – #6(231). – pp. 26-30. – eng.; abs.:
geo., eng., rus.
Arterial hypertension combined
with obesity is a very common form of comorbid disease in most countries all
over the world. The combination of these diseases is characterized by mutual
burdening of remodelling processes in important target organs, what greatly
increases the risk of cardiovascular complications and death. The mechanisms of
injury progression to vital organs in essential hypertension (EH) and obesity
have some common features. The most important risk factors of target organs
damage are hemodynamic and neurohumoral: inflammatory, effectors of the renin-
angiotensin-aldosterone system, insulin resistance and others. Polyethiologic
remodelling, lack of knowledge concerning violations in structural and
functional status of important target organs and mechanisms of the interactions
of their progression with this comorbidity require further study of these
issues. The objective of the study was the comparative study of the state of
integral indicators of structural and functional state of the heart, blood
vessels and liver in patients with EH second stage with normal body weight and
with concomitant obesity I and II degrees. This study found that the presence
of obesity I and II in patients with EH stage II is associated with the
concentric type of left ventricular hypertrophy, saved by its ejection fraction
and impaired diastolic filling processes. For the patients with EH in the early
stages of obesity the following characteristics are quite typical: considerable
increase of intima media thickness in the carotid arteries, increasing the
stiffness in the main arteries and liver parenchyma, impaired of the functional
state of endothelial. Tab. 2, Ref. 20.
Auth.
b14.3.2.23. Apelin
activity in patients with essential hypertension accompanied prediabetes and type
2 diabetes mellitus. /G. Demydenko/. Georgian Medical
News. – 2014. – #6(231). – pp. 30-34. – rus.; abs.:
geo., eng., rus.
Apelin’s activity corresponding
to pronunciation of carbohydrate disorders was studied in 136 patients with
essential hypertension. General clinical and laboratory investigations were
used. In 40 (34,46%) patients with essential
hypertension comorbid type 2 diabetes was revealed, in 37 (31,92%) patients –
pre diabetes. Significant increasing of apelin levels were estimated in the whole
group of hypertensive patients with marked expression in patients with comorbid
type 2 diabetes. Significant correlations of apelin with components of
carbohydrate pool dedicate that apelin takes part in the development of
gluco-metabolic disorders in essential hypertension. Tab 1, Fig 1, Ref. 10.
Auth.
b14.3.2.24. Features
of the humoral immune response in patients with chronic hepatitis C,
spontaneous clearance of hepatitis C virus and false-positive reactions of
anti-HCV. /N. Zhandarova/. Georgian Medical
News. – 2014. – #6(231). – pp. 38-41. – rus.; abs.: geo., eng., rus.
Among the patients residing in
the territory of Ukraine false-positive reaction of anti-HCV was determined in 5.4%
of anti-HCVpositive patients with low frequency of antibodies and low
reactivity of sera to a structural viral protein or nonstructural viral
proteins (by SIA or RIBA). Cases of spontaneous clearance of hepatitis C virus
(HCV) were detected in 16.1% of anti-HCV positive patients and based on the
detection of antibodies to the core-protein and one or several of nonstructural
viral proteins on condition negativation of RNA-HCV twice with an interval of
6-12 months. Chronic hepatitis C with the presence of specific RNA-HCV in blood
serum was confirmed in 83.9% of patients. The group of examinees with
spontaneous clearance of HCV was characterized by low humoral immune response
compared to chronic persistent infection. Tab. 2, Fig. 2, Ref. 7.
Auth.
b14.3.2.25. Monocyte
chemo attractant protein-1 in patients with chronic heart failure of different
functional class with type 2 diabetes. /P.
Kravchun, A. Narizhna, N. Ryndina/. Georgian Medical News. – 2014. – #6(231). – pp. 42-45. – eng.; abs.: geo., eng., rus.
The aim of the study was to
assess the dynamics of monocyte chemo attractant protein-1 in patients with
chronic heart failure of different functional classes depending on the presence
or absence of concomitant type 2 diabetes. 95 patients with chronic heart
failure II - III FC were examined due to coronary heart disease who were
treated at the cardiological department of the Kharkiv City Clinical Hospital
№ 27 (mean age 65,13±8,66 years). The first group included 52 patients with
CHF with type 2 diabetes, the second - 43 CHF patients without type 2 diabetes.
Research was excluded patients with acute coronary syndrome, acute myocardial
infarction. 71 patients of patients had II NYHA FC, 24 patients - III FC. Among
the patients of first group 40 patients were diagnosed in CHF FC II, 12 - III
FC. In II group 31 patients were with CHF class II, 12 patients – with III FC.
Concentration of proinflammatory cytokine interleukin-1β and fibrosis
factor monocyte chemoattractant protein-1 were determined by ELISA
(enzyme-linked immunosorbent assay). In patients with chronic heart failure in
presence or absence of type 2 diabetes increase in the profibrotic parameter
monocyte chemoattractant protein-1 and proinflammatory cytokine interleukin-1β
were increasing in parallel with NYHA FC increasing. Presence of type 2
diabetes negatively affects the work of cytokines and markers of fibrosis, as
evidenced by higher levels of interleukin-1β and monocyte chemoattractant
protein-1, compared with patients without diabetes in the presence of the same
NYHA FC of chronic heart failure. Tab. 2, Ref. 9.
Auth.
b14.3.2.26. The
analysis of changes in bioelectrical activity of the muscles of the upper
extremities in patients with traumatic deformation of the cervical spine. /A. Barysh, Y. Doluda, N. Isaeva/. Georgian Medical
News. – 2014. – #6(231). – pp. 49-54. – rus.; abs.: geo., eng., rus.
The analysis of changes in
bioelectrical activity of the muscles of the upper extremities was conducted
with the help of electromyography in 37 patients with traumatic deformation of
the cervical spine in order to identify its dependence on the nature of the
initial damage, the amount of deformation and the terms of its existence. It
was revealed that in the instrumental evaluation of patients with uncomplicated
traumatic deformation of the cervical spine in 33.3 % of cases determined
subclinical signs of neurological disorders in the form of changes in the
bioelectric activity of the muscles of the upper extremities, most often in the
DF and CF types. Frequency of manifestation of peripheral neurologic symptoms
is possible with all types of traumatic deformation equally. Violation of
bioelectric activity of the muscles of the upper extremities may occur at any
value of the angular deformation in the sagittal plane and at different terms
of its existence. Tab. 3, Fig. 3, Ref. 14.
Auth.
b14.3.2.27. The
vitamin D sufficiency in children with recurrent bronchitis. /A. Vertegel, L. Ovcharenko/. Georgian Medical
News. – 2014. – #6(231). – pp. 55-59. – rus.; abs.: geo., eng., rus.
Currently in the world there is
no consensus on the provision of sufficient vitamin D and its optimum serum
levels of both healthy children and patients with various pathological
conditions. The objective: investigation of vitamin D sufficiency in children
with recurrent bronchitis (RB), living in Zaporozhye, by examining of 25(OH)D
and parathormone serum level. The study involved 120 children aged 4 to 10
years, divided into 2 groups (60 children each): 1) children, occasionally ill
with acute respiratory infections, 2) children with RB. Investigation of serum
25(OH)D was conducted between November and February. Decrease of vitamin D3
below 30 ng/ml in serum was observed in 85% (р<0,05) patients with RB
(insufficiency), below 20 ng/ml – in 15% (deficit). The children aged 4-10
years with RB, who living in Zaporozhye, have decrease of serum 25(OH)D that
characterizes their vitamin D3 supply as insufficient. Tab. 3, Ref.
29.
Auth.
b14.3.2.28. Etiology
as a predictor of morbidity after Convulsive Status Epilepticus in children. /T. Shatirishvili, N. Tatishvili, G. Lomidze, T.
Kipiani/. Georgian Medical News. – 2014. – #6(231). – pp. 60-63. – eng.; abs.: geo., eng., rus.
CSE is the most common childhood
neurological emergency in developed countries, which can lead to neuro
cognitive sequel and death with different hazards and outcome. The majority of
authors ‘agreed that etiology is the main determinant of morbidity, but
different studies reported different etiology groups as predictors of the poor
outcome. Present study was conducted to evaluate predictive value of etiology
in post CSE morbidity. Prospective, hospital-based study was performed in
Tbilisi. Patients, aged from one month to18 years with CSE, admitted to the
emergency department of M. Iashvili Children’s Central Hospital from March 2007
to March 2012 were included. The short-term outcome of CSE was evaluated after
30 days from admission and it was classified into three categories: unchanged
neurologic status, neurological consequences (new neurologic deficit compared
to the condition before CSE), and lethal outcome. 48 children aged one month-
18 years were analyzed. In our study acute symptomatic, remote symptomatic and
progressive encephalopathy were associated with higher morbidity. Progressive
encephalopathy is the most frequent etiology group which led to develop new
neurological sequel after CSE and long duration of CSE. According to our data
we conclude that children with idiopathic or febrile CSE have a favorable
outcome. While acute symptomatic etiology group mostly was associated and
statistical significant association were found with progressive encephalopathy
and development morbidity after CSE. According to our data we conclude that
children with idiopathic or febrile CSE have a favorable outcome. While
progressive encephalopathy lead to develop morbidity after CSE. Fig. 1, Ref. 8.
Auth.
b14.3.2.29. Effect of
treatment of Convulsive Status Epilepticus on outcome in children. /T. Shatirishvili, N. Tatishvili, G. Lomidze, T.
Kipiani/. Georgian Medical News. – 2014. – #6(231). – pp. 63-67. – eng.; abs.: geo., eng., rus.
Convulsive Status Epilepticus
(CSE) is most common neurological emergency in childhood. Condition has been defined
as a convulsion lasting at least 30 min or recurrent convulsions occurring over
a 30-min period without recovery of consciousness. It is generally accepted
that early intervention for terminating seizures is beneficial for outcome. The
aim of our study was to evaluate influences of pre-hospital and hospital
treatment strategies on the outcome of CSE. Our prospective, hospital-based
study was performed in Tbilisi and included 48 Patients with CSE, admitted to
the emergency department of M. Iashvili Children’s Central Hospital from March
2007 to March 2012. The cases were reviewed according to pre-hospital and
hospital treatment strategies and outcome. “North Central London Epilepsy
Network for Children & Young People” Guideline -“The Management of Convulsive
Status Epilepticus” was adapted for the Georgian reality. Our study identified
statistically significant increase of incidence of artificial ventilation in
patients receiving more than one dose of BZD in pre hospital as in hospital
setting; additionally we found a statistically strong relationship between
timely initiation of treatment and appropriate pre-hospital treatment with a
short duration of CSE. From our data the number of doses of benzodiazepine and
a long period before admission are the main determinants of seizure
prolongation. Lack of standardized pre hospital treatment of pediatric CSE had
statistically significant negative influence on outcome of CSE. Fig. 2, Ref. 9.
Auth.
b14.3.2.30. Isolation
of dentin tissue by using a new liner biodentine at management of simulated
experimental caries. /M. Ustiashvili, M. Mamaladze, L.
Sanodze, G. Labuchidze/. Georgian Medical News. – 2014. – #6(231). – pp. 67-72. – eng.; abs.: geo., eng., rus.
The aim of our study was the use
of different types of isolation systems in the treatment of experimentally
simulated dental caries that will allow to present additional comparative
characteristic for morphological responses of the pulp. For realization of this
purpose, 3 systems have been selected: Ultra Blend (Ultradent), Biodentine
(Septodont) and adhesive system Prime&Bond NT (Dentsply). The study was
conducted at the laboratory of Alexander Natishvili Institute of Morphology.
For this experiment, 12 male, 6 months of age rabbits were selected. There were
created 3 experimental groups, each of which included 4 rabbits. Restoration of
the teeth in experimental rabbits with Biodentine revealed sufficient physical
properties enabling the operator most comfortably conduct his/her clinical
activities: kneading, bringing into caries cavity, condensing and filling
dental defect. Isolation of dentin by Biodentine doesn’t contradict and/or
reduce application of adhesive systems, which is also important for teeth
restorations. Biodentine has optimal working time (final curing 10-12 minutes)
enabling the operator to conduct maximal formation of material at the bottom of
caries cavity. Fig. 5, Ref. 34.
Auth.
b14.3.2.31. The
morphological features of the uterine body adenocarcinoma. /N. Japaridze, L. Chakvetadze, I. Jikia/. Georgian Medical
News. – 2014. – #6(231). – pp. 72-77. – rus.; abs.: geo., eng., rus.
The authors studied the
morphological features of uterine adenocarcinoma using immunohistochemical
methods. The endometrial tissue was studied resulting from surgery – hysterectomy
with oophorectomy in 103 patients aged 45-76 years with a clinical diagnosis of
endometrial cancer. To exclude false-positive and false-negative results, we
carry out same investigation on 12 patients with morphological diagnosis
easy-glandular hyperplasia of the endometrium. The results showed that the
endometrioid adenocarcinomas exhibit the high and moderate expression of
estrogen and progesterone receptors and low rate of the proliferation marker
Ki-67. For serous-paapillary and enocarcionoma of the uterine body the negative
ER-PR-receptor over expression phenotype and proliferation marker Ki-67 super
expression are characteristic. The results showed that in a simple-glandular
endometrial hyperplasia is determined a moderate expression of estrogen and
progesterone receptors, as for the Ki-67 proliferation marker an expression was
found only in the single arrears with an average of 5-8% of findings Based at
this study it may be concluded that the use of immunohistochemical studies
particularly a detection of negative estrogen and progesterone receptor
phenotype and high expression of the proliferation marker Ki-67 is an
additional differential diagnostic criterion for the diagnosis of serous
papillary adenocarcinoma of the uterine body that will ensure adequate
therapeutic approach to patients suffering from this disorder. Given the fact
that serous papillary carcinoma of the endometrium is the most common neoplasm
of the rarer forms of endometrial cancer with an extremely peculiar aggressive course
a surgical treatment as in ovarian cancer is recommended for this pathology,
including a hysterectomy with bilateral oophorectomy, lymphadenectomy,
omentektomy, cytological examination of the abdomen and biopsy of suspicious
areas of the abdominal cavity, with adjuvant treatment including chemotherapy
and radiation therapy. The absence of estrogen and progesterone receptors on
serous-papillary adenocarcinoma of the uterine body justifies the
inadvisability of hormone therapy in these patients. Since the patients with
serous-papillary adenocarcinoma of the uterine body need a larger volume
surgical treatment the patients with еndometrioid adenocarcinoma of the
uterine body. We consider that this morphological type of uterine cancer should
be diagnosed preoperatively. Fig. 2, Ref. 10.
Auth.
b14.3.2.32. Influence
of radiation on survivability, behavior and neurochemical correlates of rats. /M. Nikolaishvili, G. Iordanishvili, К.
Chichinadze, G. Jikia, S. Zenaishvili/. Georgian Medical
News. – 2014. – #6(231). – pp. 77-82. – rus.; abs.: geo., eng., rus.
The aim of the work was to study
the dependence of individual radio sensitivity of white and black rats on
radiation. The rats under study were derived from a cross between black and
white rats and called Ratus-Georgia. Comparative radio sensitivity of white
(Wistar) and black rats was studied at a total exposure with sublethal and
lethal doses (5, 7 and 9 Gy). Cumulative survival functions of rats, a spectrum
of changes in some ethological parameters and content of serotonin and
catecholamines in their brain structures were given as criteria of
radiosensitivity. Survival rate of black and white rats is connected with
changes in the composition and distribution of biogenic amines in the various
brain structures, as well as with a decrease of locomotor and
orienting-exploratory activity, on the one hand, and with increase of
emotionality, stereotyped activity, and passive defensive behavior of the rats,
on another. Regression coefficients of dependence of survival functions on
irradiation doses of black rats were rather higher than those of white rats
after irradiation with doses in 5, 7 and 9 Gy. A change in the intensity of
mortality with changes in radiation dose per unit depends on the synthesis of
serotonin and on the number of sulfhydryl groups, deficiency of which is one of
the important factors for white rats. Results of the study allow us to suppose
that changes in the radiation sensitivity of rats after irradiation with
sublethal and lethal doses are caused by consequences of radiation damage and
by activation of the serotonergic system at the process of restitution after
radiation injury. On the other hand, a higher radiation sensitivity of white
rats in comparison with that of black rats is caused by low content of
serotonin, thiols, melanin and other biologically active substances which are
endogenous radio protectors defining individual radio resistance. Tab. 3, Fig.
1, Ref. 13.
Auth.
b14.3.2.33. Current
issues, problems and prospects of tension-free hernioplasty (review). /M. Gogoladze, T. Chkhikvadze, M. Kiladze, D. Jikia/. Georgian Medical
News. – 2014. – #7-8(232-233). – pp. 7-12. – rus.; abs.: geo., eng., rus.
The present study discusses modern
methods of the tension free hernioplastics, the complications associated with
them and technical difficulties, up-to-date views and the perspectives of the
issue development in terms of avoiding infectious complications, positioning of
implants and their fixation. Hernia is one of the widespread surgical
pathologies as it is found in 4% of the population and its share among the
inpatient surgical diseases is about 18-30%. Consequently annually up to 20-21
mln hernioplasties are carried out worldwide. Despite of many years of
experience in the field of hernia surgical treatment there still exist many
unsolved problems such as safe closure of defects of abdominal cavity wall. Up
to 200 methods of hernioplastics, various implantations and application of synthetic
materials refer to lack of the optimal surgical strategy. In modern herniology
priorities are given to tension free plastics. The merge of the synthetic
implants and “tension free hernioplastics concepts enabled sharp reduction of
the side effects list, making it possible to perform successful surgeries in
that contingent whose treatment by the method of tissue-plasty was related with
high risk of lethality. Large-scale introduction of tension free hernioplastics
caused intensification of the associated problems such as migration, dissection
and shortening of the net. Ref. 14.
Auth.
b14.3.2.34. Urinary IL-33
and galectin-3 increase in patients with interstitial cystitis/bladder pain
syndrome (review). /G.
Kochiashvili, D. Kochiashvili/. Georgian Medical
News. – 2014. – #7-8(232-233). – pp. 12-15. – eng.; abs.: geo., eng., rus.
Interstitial cystitis/bladder
pain syndrome (IC/BPS) is an enigmatic chronic disorder characterized by vague
bladder pain of variable severity accompanied by urinary symptoms. The
pathogenesis and etiology of IC/BPS remain incompletely defined. However, there
is an emerging consensus about the central role of epithelial dysfunction,
bladder sensory nerve up-regulation, and mast cell activation in the genesis of
IC/BPS. Accumulating evidences have suggested that tissue damage is recognized
at the cell level via receptor-mediated detection of intracellular proteins
(so-called alarmins) released by the necrotic cells. Among these proteins
IL-33, galectin-3 (Gal-3) and advanced glycation end products (AGE), may have
an important role because they can be participated as cellular components that
stimulate the immune system. We determined IL-33, Gal-3, and AGE in 24-hour
urine specimens from patients with IC/BPS and healthy subjects. Study
participants included 43 woman with IC/BPS and 29 female volunteers. Urinary
IL-33, EGF and Gal-3 levels were measured using an enzyme-linked immunosorbent
assay, whereas the content of AGE was quantified by natural AGE-specific
fluorescence (Ex. 370 nm, Em. 440 nm). Urinary IL-33, and Gal-3 levels were
normalized by urinary creatinine (Cr) levels and compared among subgroups. We
have found that the levels of IL-33 and Gal-3 were significantly increased in
IC/BPS. The level of the IL-33 in the urine of healthy women was equal to 0.32,
while the level of IL-33 in IC/BPS patients increases up to 0.58 (p<0.05).
Further, the amounts of urine Gal-3 were also elevated in IC/BPS compared to
healthy subjects (0.16 versus 0.07; p>0.01) and AGE-specific fluorescence in
urine was increased up to 140% in IC/BPS patients. These data suggest on the
participation of IL-33, Gal-3 and AGE in the pathogenesis of IC/BPS. Tab. 1,
Fig. 1, Ref. 9.
Auth.
b14.3.2.35. The
prevalence of dental caries among adult population of different regions of
Georgia. /L. Tsitaishvili, M. Margvelashvili, M.
Kalandadze, V. Margvelashvili/. Georgian Medical News. – 2014. – #7-8(232-233). – pp. 21-28. – eng.; abs.: geo., eng., rus.
The aim of the study was to
determine the prevalence and intensity of dental caries in adult population of
Georgia according to their regional distribution. The survey was carried out by
pathfinder survey, based on cluster-stratified method derived by WHO. 2370
adults including 1289 women and 1081 men distributed in 4 age groups: I - 20-34
years, II - 35-44, III - 45-64, IV - 65+ years, the residents of the city, town
and village in 9 regions of Georgia and the capital Tbilisi were examined. The
assessment of dental status and oral hygiene was based on WHO-'s recommendation.
(WHO 1997 ‘Oral Health Assessment Form’) Examination was done under good
natural light using a mouth mirror and an explorer. Questionnaires comprised
questions for revealing the following risk-factors: social status and family
income, existence of common diseases, people’s attitude towards oral hygiene
(tooth brushing, using dental floss) accessibility and acceptability of dental
service, sugar consumption rate, tobacco use, consumption of dairy products.
The study revealed the high prevalence of dental caries in Georgia’s adult
population (96-100%) Caries intensity and severity was seen as the highest in
Mtskheta- Mtianeti - 13.26±5.97, Guria - 12.79±8.92, Samtskhe-Javakheti -
12.62±8.44, Shida Qartli - 12.03±7.22 and Achara - 12.23±7.89 regions, relatively
lower in Tbilisi - 11.64±7.8; Qvemo Qartli - 10.96±7.07; Imereti - 10.79±7.63
Samegrelo - 10.54±7.95 and in Kakheti - 9.86±7.02. By the mean number of caries
decayed teeth Mckheta-Mtianeti - 4.26±3.51, Samckhe-Javakheti - 3.52±3.51 and
Imereti - 3.05±3.1 were distinguished. The mean number of caries missing teeth
was noted to be highest in Guria - 5.49±7.42, Samckhe-Javakheti - 5.31±6.97 and
Achara - 5.32±6.73. Mckheta-Mtianeti - 2.62±3.05, Shida Qartli - 2.39±2.8 and
Tbilisi - 2.28±2.09 were the leading regions by the mean number of filled
teeth, the lowest value of filled teeth variable was seen in Imereti -
0.67±1.39. In behavioral factors (unsatisfactory oral hygiene and less
acceptability of dental service due to low medical educational background) play
substantial role in occurrence and prevalence of dental caries among adult
population of Georgia in all regions, though the financial problem seems to be
a considerable contributor in caries prevalence. Reliable statistical data
obtained in the study allowed to conclude that in spite of small differences in
prevalence in different regions of Georgia dental caries is very widespread
throughout the country (96-100%). It represents a major problem in Georgia and
needs serious attention and preventive measures to be carried out to enhance
peoples’ referral to dental service and improve medical educational background
of the population. Tab. 2, Ref. 17.
Auth.
b14.3.2.36. Anatomical
and morphological peculiarities of maxillary first molars in Georgian population. /N. Chipashvili, E. Beshkenadze/. Georgian Medical
News. – 2014. – #7-8(232-233). – pp. 28-33. – rus.; abs.: geo., eng., rus.
Maxillary first molars due to the
complexity of the root canal morphology are the object of constant interest.
The present work investigates anatomical and morphological peculiarities of
maxillary first molars in the Georgian population. A study on 440 maxillary
first molars was conducted. The subjects were divided into three groups. The
first group consisted of 156 extracted maxillary first molars (ex vivo study).
The second group consisted of 243 endodontically treated teeth (in vivo study).
The third – control group. Cone beam computed tomography (CBCT) was used to
investigate 41 teeth. The investigation showed that inconsistencies exist in
the results of ex vivo and in vivo studies. In vivo study showed less 4 canals,
than ex vivo study. That’s why for the credibility of the results we examined
the results of ex vivo study. The results showed (ex-vivo study) that 70.5% of
the examined teeth had high probability of 4 canals existence. The occurrence
of MB-2 canals of the maxillary first molar of Georgian population was in full
accordance with the results of other authors. Tab. 2, Ref. 18.
Auth.
b14.3.2.37. Comprehensive
evaluation of new diagnostic criteria for progression of essential hypertension
stage II. /I. Plesh, L. Haidych, S. Riaboy/.Georgian Medical
News. – 2014. – #7-8(232-233). – pp. 47-51. – rus.; abs.: geo., eng., rus.
The aim of the study was to
improve the diagnosis of essential hypertension (EH) stage II in patients with
different circadian blood pressure profile through a comprehensive analysis of
various parts of hemodynamics. The diagnostic capabilities of
compression-decompression test by using of original method
angio-tensio-rheo-baro-graphy (ATRBG), which is based on volume-impedance
dependence of forearm tissue’s hyperemia, peculiarities of the changes of
microcirculation of the nail bed and central venous pressure (CVP) have been
studied in 92 patients with EH stage II depending on the circadian rhythm of
blood pressure. The results of using ATRBG may indicate that the arterial
hypertension is combined with venous one in the majority of patients with EH
stage II. We have discovered the inverse relationship between the increasing of
CVP level and the decreasing of density of functional capillaries in the
patients with low (non-dipper) and negative (night-picker) circadian index of
arterial pressure that can be proposed as new diagnostic criteria of progression
of EH. Tab. 1, Fig. 2, Ref. 7.
Auth.
b14.3.2.38. The role
of TLR-2, TLR-3, TLR-4 genes polymorphism of grippe. /G. Dubinskaya, N. Pryimenko, I. Kaidashev, V.
Pohilko, K. Chub/. Georgian Medical News. – 2014. – #7-8(232-233). – pp. 51-55. – rus.; abs.: geo., eng., rus.
Distribution and prognostic value
of Arg753Gln TLR-2, Leu412Рhe TLR-3, Asp299Gly TLR-4 genes polymorphism
in case of grippe have been studied in the present article. The examination has
comprised 112 patients with grippe including 63 cases with uncomplicated course
and 49 cases with grippe-associated pneumonia. The population control group has
included 90 scarcely healthy persons to study Arg753Gln TLR-2 gene polymorphism
and 80 ones to study Leu412Phe TLR-3 gene polymorphism. The conducted
researches results have shown reliably higher frequency of heterozygous
genotype Asp/Gly TLR-4 in patients with grippe (12,69%) and grippe-associated
pneumonia (14,28%) compared with population control (3,33%). The frequency of
homozygous genotype Phe/Phe TLR-3 in patients with grippe-associated pneumonia
(18,37%) has exceeded the indices of patients with uncomplicated grippe (4,76%,
р=0,02) and healthy persons (5,00%, р=0,03). Mutant genotypes
combinations TLR-2, TLR-3, TLR-4 have been determined barely in patients with
grippe and grippe-associated pneumonia with the frequency 11,11%-14,28%. It has
been established that there is the increased risk of grippe development for
persons with Asp/Gly TLR-4 genotype and TLR-2, TLR-3, TLR-4 mutant genotypes combinations;
there is the increased risk of grippe-associated pneumonia for patients with
mutant homozygous genotype Phe/Phe TLR-3. Tab. 2, Ref. 14.
Auth.
b14.3.2.39. Role of
montelukast in treatment of mild and severe forms of asthma. /E. Ekaladze, I. Pkhakadze, N. Alavidze, K. Jugeli/.
Georgian Medical News. – 2014. – #7-8(232-233). – pp. 56-60. – eng.; abs.: geo., eng., rus.
The aim of the study was to
evaluate the effect of Montelukast - leukotriene inhibitor in longitudinal
treatment of mild and severe forms of asthma. The research was conducted at LTD
Kutaisi Nazarishvili Regional center of Family Medicine. Retrospect analysis of
187 patients histories were carried out. Patients histories were grouped
according to the severity of the disease, method of treatment (monotherapy with
inhaled glycocorticoid and inhaled glycocorticoid combined with leucotriene
inhibitor) in different age groups. The results of measurements of lung
function - especially spirometry (FEV1 - Forced Expiratory Volume1 sec and PEF-
Peak Expiratory Flow) were studied. Descriptive statistics methods were used to
characterize each variable. Our results indicate on positive role of
montelukast – leukotrien inhibitor in the treatment of severe and mild forms of
asthma. Tab. 4, Ref. 11.
Auth.
b14.3.2.40. Alterations
of redox-status during psoriasis. /M.
Matoshvili, A. Katsitadze, T. Sanikidze, D. Tophuria, A. Richetta, S. D’Epiro/.
Georgian Medical News. – 2014. – #7-8(232-233). – pp. 60-64. – eng.; abs.: geo., eng., rus.
The skin is constantly exposed to
oxidative stress induced by reactive oxygen species (ROS) that are generated
both from endogenous neutrophils and external pro-oxidant stimuli. The present
study was planned to investigate the possible involvement of free radical
oxidation in psoriatic patients. Study was carried out in the Department of
Dermatology and Venereology in Tbilisi State Medical University. A total of 60
individuals were included in this study, out of these 40 were patients
suffering from psoriasis and 20 were healthy subjects (a control). Psoriasis
patients were further graded according to the Psoriasis Area Severity Index
(PASI); in patients’ blood redox-status superoxide (O2−)
and lipoperoxide (LOO.) free radicals, free Mn2+-ions and
(ceruloplasmin/Fe3+-transferrin) system antioxidant activity were
estimated by Electron Paramagnetic Resonance (EPR) method and activity of
catalase (CAT) and superoxide dismutase (SOD) were determined by
spectrophotometry. In the blood of patients with psoriasis, the EPR signal
intensities of oxidized form ceruloplasmin (Cp) increased and ferrum-transport
protein, Fe3+-transferrin (Fe3+-Tr) decreased in
comparison to the same parameters of healthy persons. Activity of blood
catalase increased and activity of blood SOD decreased with increasing severity
of psoriasis. EPR signals of low-molecular Mn2+-containing complexes
and lipoperoxide (LOO.) free radicals were detected. The obtained
data indicate the alteration of blood redox-balance during psoriasis; the
intensity of impairment of redox balance correlates with severity of psoriasis.
Tab. 2, Ref. 9.
.
b14.3.2.41. Influence
of ippotherapy on primary constipation. /M.
Sherozia, Kh. Saganelidze, G. Beradze/. Georgian Medical
News. – 2014. – #7-8(232-233). – pp. 78-81. – rus.; abs.: geo., eng., rus.
Effective treatment of primary
constipation remains one of problematic issues. The disease may be represented
individually in the form of functional constipation, and in most of cases it is
observed in the form of irritable bowel syndrome or it is conjugated with other
functional disorders of bowels. Treatment with combined preparations and means
of pluripotential orientation are more and more acknowledged. Ippotherapy is
distinguished with its complex action. Aim of the research was to determine
influence of the given natural method on dynamics of primary constipation. The
research had been held among eleven patients, nine of whom were women and two
men. In five cases functional constipation was diagnosed, in six cases - irritable
bowel syndrome. Seven patients have been treated with ippotherapy from the very
beginning and four of them underwent this treatment after one month of
pharmacotherapy. Ippotherapy lasted within five weeks. On a general basis three
sessions were held in a week, and after pharmacotherapy – two sessions. Before
the beginning of the course of treatment and after its completion patients
filled in questionnaires of self-appraisal. Subjective estimation of the
dynamics of symptoms was handled in accordance with the method of nonparametric
statistics – appraisal criteria had been calculated. All of the examined people
have mentioned improvement of health condition after ippotherapy; nine of them
have mentioned significant improvement. According to the accurate statistics
result of the impact of ippotherapy on all four manifestations of constipation
– intervals between defecations have been reduced to the norm, contractions
during defecation have reduced, and excrements were of normal consistence and
configuration, the sense of fatigue has disappeared. In the case of irritated
bowel syndrome according to accurate statistics the episodes with abdominal
pains and abdominal swelling have reduced. Iippotherapy was less effective in
treatment of postprandial distress syndrome and practically ineffective in case
of heartburn. It is important to note that in no cases of ippotherapy no
complication of any syndrome or occurrence of new symptoms was revealed. In the
process of treatment no procedural discomfort had been observed. Received data
confirm manifested positive influence of ippotherapy on the course of
functional disorders of bowels, which in case of availability should be
considered at the determination of the strategy of management of the given
disease. Ref. 11.
Auth.
b14.3.2.42. Prevention
of peritoneal desiccation in acute adhesive intestinal obstruction. /B. Slonetsky, O. Dovzhenko, I. Verbitskiy, M.
Maksimenko, V. Kocubenko/. Georgian Medical News. – 2014. – #7-8(232-233). – pp. 103-107. – rus.; abs.: geo., eng., rus.
The research study was carried
out on 30 white Wistar rats, which were divided into three groups. In the first
group the effect of carboxyperitoneum on visceral peritoneum during a two hour
period at a pressure of 9-10 mm Hg and after 20 minutes its further fractional
replacement during 10 seconds was examined. In the second group, the study was
carried out after modeling 12-hours acute adhesive intestinal obstruction. To
the third group at the beginning was given a single injection of fourcomponent
mixture (carboxyperitoneum gel carboxymetiltcellulose novocaine and antibiotic)
into the abdominal cavity. In the first group under the condition of tension
carboxyperitoneum after a day of use there were signs of desiccations of
visceral peritoneum. The increase of lipid peroxidation products and decrease
of antioxidant enzymes were also observed. In the second group of animals these
processes were exacerbated by acute adhesive intestinal obstruction. In the
third group intraabdominal use of four components disperse mixture reduced the
negative organic and functional changes in visceral peritoneum and improved its
protective properties. Tab. 2, Fig. 1, Ref. 10.
Auth.
b14.3.2.43. Correlating
the length of internal carotid artery stenosis to the technique of
endarterectomy and anesthesia used. /J. Partsakhashvili,
N. Rtveliashvili, O. Philishvili, R. Kurdadze, J. Ukkat/. Georgian Medical
News. – 2014. – #9(234). – pp. 7-11. – eng.; abs.: geo., eng., rus.
A consensus correlating the
length of the internal carotid artery stenosis (short vs. long) to the
preferred Endarterectomy (Conventional Vs. Eversion) and type of anesthesia
(General Vs. cervical blockade) implemented has not yet been met. In a
collaboration study between two hospitals in Germany and Georgia, 215 patients
were analyzed and stratified into 3 groups according to length of stenosis,
surgical technique and type of anesthesia used. In this series, for eversion
endarterectomy with cervical blockade, non-neurological complications commenced
at 1.78%. For conventional endarterectomy performed under general anesthesia,
patients with a short stenosis had no postoperative complications whatsoever,
whereas the incidence rate for various neurological deficits was 2.7% for long
stenosis. In case of short stenosis of the internal carotid artery, eversion
endarterectomy with cervical block seems to be an optimal choice. Whereas for
long stenosis, conventional endarterectomy under general anesthesia is a more
suitable option. Tab. 1, Ref. 26.
Auth.
b14.3.2.44. Improvement
of surgical treatment of echinococcosis. /D.
Kalieva, E. Turgunov, M. Tusupbekova, N. Abatov, Z. Saduova/. Georgian Medical
News. – 2014. – #9(234). – pp. 11-19. – rus.; abs.: geo., eng., rus.
A hydatid disease is a serious
public health problem in Kazakhstan. Surgical treatment is the main treatment
of hepatic echinococcosis. Considering high rate of recurrence of the disease
the search for new methods of surgical treatment remains relevant. The aim of
the study was to improve the efficiency and safety of surgical treatment of
hepatic echinococcosis; to develop a new physical method for cleaning residual
cyst cavity. Experimental and clinical investigation of IED effects on hydadtid
cyst embryonic element was studied. In order to monitor the effectiveness of
developed method the morphological study of histological material was done. It
is experimentally proved that the optimal mode of impact of IED on germinal
elements of hydatid cysts at which their complete destruction, is the exposure
120 seconds by 200 ml of liquid or 0,6 seconds per 1 ml volume. The method of
cleaning of residual cavity with IED was developed. By this method for the
years 2007-2013, 25 patients were operated on, of which there were 13 (52,0%)
men, 12 (48,0%) women. The mean age was 37,8±0,8. Single cysts observed in 16
(64.0 %) cases, multiple in 9 (36.0%). Primary cysts were observed in 20
(80.0%) cases, recurrent 5 (20.0%). Size up to 10 cm cyst verified in 8 (32.0%)
cases , from 10cm to 20 cm in 15 (60.0 %) cases , 20 cm or more - 2 ( 8.0%). To
localize the left lobe of the liver was struck in 24.0% of cases, the right to
76.0%. The cysts were located in the right lobe of the liver in 76,0%, left lobe
in 24,0%. Echinococcectomy was performed in 22 (53.0%) patients, resection-2
(12.0%), pericystectomy-1 (6.0%). Average estimated blood loss was 320.6 ml.
Blood transfusion was performed in only 1 (4.0%) patients. Postoperative
complications in the form of left-hand reactive pleuritis were marked in 3
(12.0%) cases. Average period of hospitalization amounted to 12,8±2,2 bed-days.
Echinococcectomy supplemented by cleaning of the residual cavity impulse
electric discharge may be an alternative to radical methods of surgical
treatment of hepatic echinococcosis, due to the fact that IED has a destructive
effect against Echinococcus germinal elements, simple to use, safe. Tab. 1,
Fig. 13, Ref. 12.
Auth.
b14.3.2.45. Investigation
of functional activity human dental pulp stem cells at acute and chronic
pulpitis. /M. Ustiashvili, D. Kordzaia, M.
Mamaladze, M. Jangavadze, L. Sanodze/. Georgian Medical
News. – 2014. – #9(234). – pp. 19-24. – eng.; abs.:
geo., eng., rus.
It is already recognized that
together with the other connective tissues organ-specific progenic stem cells
are also found in postnatal dental pulp. This group of undifferentiated cells
is only 1% of total cell population of the pulp. The aim of the study was the
identification of stem cells in human dental pulp, detection of their
localization and assessment of functional activity during inflammation process
and/or at norm. The obtained results showed that at acute pulpitis the pulp
stroma is hypocellular in comparison with the norm but cells proliferative
activity is low. CD 133 and NCAM (CD 56) positive stem cells were found in
perivascularl space of the pulp stroma and in Hohle layer. At process
prolongation and transition to the chronic phase pulp stroma is hypercellular,
the cells with large, rounded or oval-shaped nuclei with clear chromatin appear
together with fibroblasts. They are distributed as about entire thickness of
the stroma as especially Hohle layer. In such cells higher proliferative
activity (Ki67 expression) was observed. The cells in the mentioned
proliferation phase are intensively marked by CD133, the rate of which is high
in Hohle layer and along it. A large number of NCAM (CD 56) positive cells
appear in pulp stroma. Conclusions. During pulpitis an involvement of stem
cells into the process of reparative dentinogenesis should be conducted
stepwise. In acute cases of the disease, stem cell perivascularl mobilization
and proliferation and its migration to Hohle layer occur in response to
irritation /stimulation. Chronification of the process leads not only to the
migration of stem cells to the periphery of the pulp but also s their
«maturation» (increase of NCAM expression in the stem cells), which causes an
increase the number of dentin producing active odontoblasts and initiation of reparative
dentinogenesis. Fig. 2, Ref. 13.
Auth.
b14.3.2.46. The
prevalence of periodontal diseases among adult population in Georgia. /L. Tsitaishvili, M. Margvelashvili, M. Kalandadze,
V. Margvelashvili/. Georgian Medical News. – 2014. – #9(234). – pp. 25-32. – eng.; abs.: geo., eng., rus.
The present research was
conducted to estimate the prevalence of periodontal diseases in the adult
population of Georgia, to study the peculiarity of their distribution within
population in different regions of the country. The survey was carried out
based on cluster- stratified method derived by WHO. 2370 adults including 1289
women and 1081 men distributed in 4 age groups: I - 20-34, II - 35-44, III -
45-64, IV - 65+ the residents of the city, town and village in 9 regions of
Georgia and the capital Tbilisi were examined. The assessment of periodontal
status and oral hygiene was based on WHO-’s recommendation. (WHO 1997 ‘Oral
Health Assessment Form’) Examination was done under good natural light using a
mouth mirror and a periodontal index (CPI) probe for measurements of
periodontal pockets depth. Questionnaires comprised questions for revealing the
following risk factors: social status and family income, existence of common
diseases, people’s attitude towards oral hygiene(tooth brushing, using dental
floss, mouth rinsing) acceptability of dental service, sugar consumption rate,
tobacco use, consumption of dairy products. The reliable statistical data
received from the study relieved high prevalence of periodontal diseases in all
regions: in Achara - 71.7, Mtskheta-Mtianeti - 70.8%, Imereti - 64.9%, Kvemo
Kartli - 61.6%, Tbilisi - 61.8% and Shida Kartli - 60.5%, Guria - 55.9%,
Samtskhe-Javakheti - 56.0%, Kakheti - 59.1%, Samegrelo - 55.2%. Despite the
variability of risk factors high prevalence of inflammatory periodontal
diseases in regions of Georgia was related to more extent to the low
educational medical background, less dental acceptability due to not very
positive attitude towards dental service and oral hygiene skills though
financial problems also played substantial role. The study confirmed that
periodontal diseases represent an actual problem in Georgia and need caring out
serious preventive measures to enhance peoples’ referral to dental service and
improve medical educational background of the population. Tab. 6, Ref. 34.
Auth.
b14.3.2.47. Clinical
efficacy of autologous mesenclyme multipotential stem cells transplantation in
the liver cirrhosis and portal hypertension treatment. /B. Agaev, R. Agaev, A. Popandopoulo, R. Jafarli/. Georgian Medical
News. – 2014. – #9(234). – pp. 39-45. – rus.; abs.: geo., eng., rus.
In 14 patients with cirrhosis and
portal hypertention autologous mesenclyme multipotential stem cells (AMMSC)
transplanation was performed in portal vein (I group, n=7) and common trunk of
the hepatic artery (II group, n=6). Duration of pathological processes since
diagnosis is 1-8 years (3,7±2,4 years). The initial severity was evaluated by a
set of child-Pugh score: Class A – 6 (42.9%), Class B – 8 (57.1%). Cell
cultures indentation and characteristics consistent with International Society
of cell technology guidance (ISCT) since 2006. The treatment results and
patients survival were determined in period 2 month – 5 years according
Kaplan-Meir survival curve analysis. Morphology of liver bioptats also was
performed. It was shown that AMMSC transplantation generally positively effects
on the morpho-functional dynamics and basic hepatic syndromes. Aterial perivascular
zone is the most optimal for transplantation in terms of migration, engraftment
and differentiation of cells in comparison with portal field, as evidenced by
the transition of some patients from class B to class A by child-Pugh score.
Tab. 1, Fig. 1, Ref. 12.
Auth.
b14.3.2.48. Changes
of focal and brainstem neurologic signs in patients with traumatic brain injury
and their dependence on the -675 4g/5g polymorphism in the PAI-1 gene. /O. Potapov, O. Kmyta/. Georgian Medical
News. – 2014. – #9(234). – pp. 45-51. – rus.; abs.: geo., eng., rus.
Regressive course of neurological
signs and symptoms is an important factor of evaluating the clinical course and
treatment efficacy of traumatic brain injury. This article presents changes
evaluation of focal and brainstem symptoms in 200 patients with traumatic brain
injury, and determines the association between these changes and the -675 4G/5G
polymorphism in the PAI-1 gene. We have found a connection between 4G/4G and
4G/5G genotypes for the studied polymorphism and the changes of focal and
brainstem symptoms in patients with traumatic brain injury. Thus, we have
demonstrated that the clinical course of traumatic brain injury is influenced
by the -675 4G/5G polymorphism in the PAI-1 gene. Tab. 4, Ref. 13.
Auth.
b14.3.2.49. Evaluation
of peripheric blood in patients with different forms of hypothyreosis and iron
deficient anemia. /Z. Tauesheva, D. Tayzhanova, Z.
Guseinova, A. Toleuova, Zh. Beysenbekova/. Georgian Medical
News. – 2014. – #9(234). – pp. 51-55. – rus.; abs.: geo., eng., rus.
The aim of the research was to
estimate peripheric blood in patients with iron deficiency anemia and different
forms of hypothyreosis. 192 patients with diagnosis of iron deficiency anemia
and different forms of hypothyreosis were investigated. Among investigated
patients 34 (22.9%) were men and 158 (87.5%) – women. The patients’ age varied
from 21 to 77 years old. Patients were divided into 3 groups: group I –
patients with subclinical hypothyreosis; group I A – patients with isolated
subclinical hypothyreosis; group I B - patients with subclinical hypothyreosis
in combination with iron deficiency condition. Group II A – patients with
isolated primary hypothyreosis; group II B – patients with primary
hypothyreosis in combination with iron deficiency. According to the results the
different degree of blood formation disturbances were detected in the study
groups: tissue iron deficiency; light, moderate and heavy degrees of anemia,
and the etiology of risk factors of anemic syndrome in the study groups were
determined. It was found that the insufficiency of thyroid hormones determined
the insufficiency of the formed elements of blood. The iron deficient anemia
with deficit of iron- containing enzymes in tissue led to decreased secretion of
thyroid hormone from the thyroid gland and hypothyreosis. Fig. 1, Ref. 10.
Auth.
b14.3.2.50. Magistral
and intravenal blood flow in type 2 diabetes mellitus patients with kidney
lesions. /D. Amirkhanova, L. Turgunova, E.
Laryushina, A. Alina/. Georgian Medical News. – 2014. – #9(234). – pp. 56-60. – rus.; abs.: geo., eng., rus.
The study was conducted to
investigate the main and intravenal blood flow in type 2 diabetes mellitus
patients with kidney lesions. Renal blood flow was estimated by Doppler
ultrasonography at the level of the magistral and intravenal arteries with
assessment of speed and resistive indexes in 20 patients with pre-clinical
stage of diabetic nephropathy, 45 with chronic pyelonephritis and diabetes
mellitus. The control group consisted of 20 healthy individuals. Increase of
intrarenous blood flow, against the background of increased vascular resistance
in the magistral trunk and segmental renal artery was indicated in diabetic
nephropathy. Decline of the main intrarenous blood flow to the level of the
interlobar arteries on the background of increased renal vascular resistance
was marked in patients with chronic pyelonephritis and type 2 diabetes
mellitus. Renal hemodynamics disorders in patients with various kidney lesions
and with type 2 diabetes mellitus were established. Tab. 2, Ref. 7.
Auth.
b14.3.2.51. Clinical
pathogenetic role of neurohumoral regulation in the build up of vegetative
dysfunction in patients with purulent meningitis. /D. Zadiraka, E. Ryabokon/. Georgian Medical
News. – 2014. – #9(234). – pp. 79-84. – rus.; abs.: geo., eng., rus.
The article presents information
obtained during the examination of 60 patients with purulent meningitis. It is
shown that in patients with purulent meningitis in the acute period of the
disease objective clinical signs of autonomic dysfunction detected only 23.3%
of the predominance general intoxication and cerebral syndromes, accompanied by
a decrease in the power spectra of all studied heart rate variability in the presence
of autonomic dysfunction aside vagotonia in together with elevated levels of
adrenocorticotropic hormone and low serum growth hormone levels. Starting from
the 2 week of illness clinical signs of autonomic dysfunction detected in 95.0%
of patients with purulent meningitis of recourse against the backdrop general
intoxication manifestations and cerebral syndromes and combined with a
progressive decrease in the power spectrum of humoral influences and
quantitative content of growth hormone in the blood serum. In the recovery
period of purulent meningitis in most patients (72.7%) persistence of symptoms
of autonomic dysfunction is combined with low power core spectra of heart rate
variability, parasimpatikotonia and endocrine imbalance. Tab. 2, Ref. 25.
Auth.
b14.3.2.52. The
effectiveness of combined treatment of the children with congenital radial and
ulna club hand. /I. Harbuzniak/.Georgian Medical
News. – 2014. – #9(234). – pp. 94-99. – rus.; abs.: geo., eng., rus.
The purpose of the investigation
is the analysis of the treatment results of the children with congenital club
hand. The study was based on the treatment results of 35 patients with
congenital club hand. All of them have anomaly of the hand. The patients are
divided into 2 groups. The first group includes 13 patients who had surgical
treatment: centralization or radialization of the wrist, distraction
lengthening of the forearm and the correction of the ulna. The second group
includes 22 patients who had the combination surgery of the forearm and the
hand. The best functional treatment results have the patients of the second
group who had the combination surgery of the forearm and the hand. Tab. 5, Fig.
6, Ref. 14.
Auth.
b14.3.2.53. Immediate
and long-term effects of posthypoxic myocardial ischemia in newborns. /S. Кabiyeva, А. Sandybayev, N.
Аbildina, B. Koshkarbayeva, Y. Korneeva/. Georgian Medical
News. – 2014. – #9(234). – pp. 100-105. – rus.; abs.: geo., eng., rus.
The aim of the research was to
study heart adaptation to hypoxia in infants in the early neonatal period and
the dynamics of their development catamnesis of 294 infants who underwent
hypoxia in the perinatal period was examined. Strain index is used as a
prognostic criterion of cardiovascular disorders, which characterizes the activity
index of independent contour and coefficient of myoglobin. Intensity of
cardiovascular disorders in infants in the early neonatal period depended on
the length and severity of hypoxia. Follow-up data revealed various outcomes
posthypoxic myocardial ischemia. In most cases, there is a benign outcome in
recovery, but in 37% of cases developed posthypoxic cardiomyopathy. Long-term
consequences of posthypoxic myocardial more pronounced in severe cardiomyopathy
in 16.7% posthypoxic cardiomyopathy transformed into dilated cardiomyopathy,
accompanied by life-threatening arrhythmias and heart failure. The immediate
forecast and remote consequence of posthypoxic myocardial ischemia depends on
the degree of hypoxic myocardial injury, timely adjuvant therapy. Tab. 2, Ref.
42.
Auth.
b14.3.2.54. Assessing
the impact of risk factors and polymorphisms GST genes on the development of
bronchopulmonary dysplasia in premature infants. /E. Kovalоva, V. Pohilko, Z. Rossokha, N.
Horovenko, Y. Goncharova/. Georgian Medical News. – 2014. – #9(234). – pp. 105-112. – rus.; abs.: geo., eng., rus.
An increasing incidence of
bronchopulmonary dysplasia (BPD) in premature infants has been reported in
recent years. In the present study we analyzed the risk factors for BPD. It was
revealed that the most significant factors are the low gestational age and
birth weight, as well as prolonged use of mechanical ventilation and late
neonatal infection. Polymorphism of studied genes and various combinations of
polymorphic variants did not affect the risk of BPD developing. The influence
of genetic polymorphisms on the duration of mechanical ventilation, the
occurrence of late neonatal infection. For proper evaluation of the
contribution of genetic polymorphism is necessary to conduct a preliminary
analysis of all possible clinical and laboratory parameters to identify strong
independent predictors and then analyze the indirect effects of genetic
factors. Further research and development of new approaches to ventilation mode
in preterm infants, based on the genetic polymorphism, will create a set of
preventive measures and reduce the incidence of BPD. Tab 2, Fig. 1, Ref. 16.
Auth.
b14.3.2.55. Infants'
complementary feeding and factors influencing its timing. /N. Kavlashvili, M. Kherkheulidze, E. Kandelaki, I.
Chkhaidze/. Georgian Medical News. – 2014. – #9(234). – pp. 112-116. – eng.; abs.: geo., eng., rus.
The aim of our study was to
detect factors that influence timing and adequacy of complementary feeding (CF)
practices in Georgian families. The study was conducted at M. Iashvili Central
Children’s Hospital Child Developmental Center in 2013-2014 year. The data was
collected from 389 mothers of infants’ age ranging from six months to one year.
Results of the study show that CF was started in time only in 30.2%, In 18.1%
it was CF was introduced too early (<4 month), in 27.3 early (4-6 month) and
in 11% - late. 13.4% of children haven’t started CF at all. Most of mothers
received information about CF and semi-solid and solid food used for CF from
pediatricians and family-doctors. Timing of complementary feeding was related
to maternal age, young mothers started CF too early, early or late. In urban
areas early CF was significantly high (51.1%) than in rural (29.7%) areas
(P<0,05). Proportionally employed mothers and students also started CF
earlier (51.4%) than housewives (33%) (P<0.01). Mothers who had 2 and more
child introduced CF timely compared to those who had the first child
(P<0.01). Our research study showed that educated women started
complementary feeding of their infants at appropriate ages as compared to those
who were uneducated (P<0.001) among women who introduced CF in time most
were educated (91%). The data from the study shows that many infants are
beginning complementary feeding earlier than WHO recommends (6 month). Findings
from our study revealed that maternal knowledge, age, education level was
directly related with timing of CF. Promotion of strong community based
education and support to ensure optimal infant and young child feeding is
recommended. Tab. 2, Fig. 3, Ref. 19.
Auth.
b14.3.2.56. Unknown
bile ductuli accompanying hepatic vein tributaries (experimental study). /D. Kordzaia, M. Jangavadze/. Georgian Medical News. – 2014. – #9(234). – pp. 121-129. – eng.; abs.: geo., eng., rus.
Studying Ductular reaction (DR)
at early stages after common bile duct ligation (CBDL) in rats we revealed some
ductular profiles (DPs) of unusual location - accompanying different caliber
tributaries of hepatic veins (THV) including central and sub-lobular venules.
We investigated the essence and genesis of these atypically located ductuli. 28
Wistar Rat livers were studied histologically and immuno-histochemically in
norm and after 6, 12 and 24 hours of CBDL. Biliary system of part of the
animals was preliminary injected by Indian Ink. After CBDL the number of DPs
including the ones accompanying large and small THV was increased. The
diameters of DPs found immediately at central and sublobular veins were varying
from 5 to 15 mµ and of DPs located in the adventitia of the large THV are
varying from 10 to 30 mµ. The cell of these DPs were CK19, CK7 and OV6
positive, but Ki-67 negative, what confirms their belonging to cholangiocytes
but denies their proliferative genesis. In the sites of crossing of different
size portal tracts (PT) and THV with integration of their connective tissue
sheaths were revealed some biliary ducts/ductules dislocated from PT towards
the THV and situated within their adventitia. The Indian Ink injected via CBD
was found in both - portal and perivenous DPs as well as in bile canaliculi,
what confirms their inter-continuity. The biliary ductules dislocated from PT
toward THV may accompany hepatic venous pathways reversely up to central
venules. These finest ductuli having spare function are likely to communicate
with bile canaliculi. Tab. 2, Fig. 4, Ref. 34.
Auth.
b14.3.2.57. Local
treatment of purulent-necrotic complications of diabetic foot syndrome. /V.
Feoktistov, K. Shakeyev, S. Akhmetova, M. Zhanassova, M. Berkut/. Georgian Medical
News. – 2014. – #10(235). – pp. 7-11. – rus.; abs.: geo., eng., rus.
Diabetic foot syndrome is the
most frequent and severe complication of diabetes. At present, problem has not
been fully resolved, which may lead to the development of more effective ways
of correction of purulent complications. The study investigates the efficacy of
Hydrogel bandage (Miramistin) combined with physiotherapeutic methods in the
treatment of purulent-necrotic lesions of foot. Eighty-three patients with
purulent-necrotic lesions of foot were treated at the Clinic of Surgical
Diseases №1. The proposed method of treatment demonstrated a greater
efficacy than currently available treatments: better cleaning of wounds,
reduction of the severity of intoxication and pain, decrease of the duration of
inpatient treatment from 28-30 days to 18-19. Hydrogel bandage (Miramistin) is
the most efficient drug in prevention and treatment of purulent and infectious
complications. Tab. 1, Fig. 4, Ref. 10.
Auth.
b14.3.2.58. Expression
of epidermal growth factor receptor and concentrations of epidermal growth
factor and melatonin in endometrial carcinoma. /N. Dznelashvili, D. Kasradze, A. Tavartkiladze/. Georgian Medical
News. – 2014. – #10(235). – pp. 17-24. – rus.; abs.: geo., eng., rus.
The aim of the research was to
study the Epidermal Growth Factor Receptor (EGFR) expression, measure Epidermal
Growth Factor (EGF) and melatonin concentrations in patients with endometrial
carcinomas. In order to reveal EGFR expression, immunohistochemical examination
of morphologic material (tumor of the uterine body, histopathological
diagnosis: endometrial carcinoma) from 21 patients was performed. The EGF blood
plasma levels were measured using the method of high performance liquid
chromatography (HPLC).The blood serum levels of melatonin were measured by the
method of immunoferment analysis ELISA(IBL International reagent). The
resultant numerical data were processed statistically using the computer
program SPSS-12-ANOVA. A statistical analysis was also performed using the
system IBM SPSS Statistics, version 20. The investigation revealed: 1. In
endometrial adenocarcinomas (high-grade, low-grade) the expression of EGFR is
detected in 100%. 2. In endometrial adenocarcinomas a relatively weak positive
correlation between EGFR expression and melatonin blood serum levels is
observed. With that, there is a negative correlation between the blood levels
of EGF and melatonin. 3. The average index of EGF blood plasma level in simple
endometrial hyperplasia (atypia-free) is significantly lower than that of the
patients with endometrial adenocarcinoma, while in complex endometrial
hyperplasia (atypia-free) the average index of EGF blood plasma level is
slightly lower than in endometrial carcinoma. With low-grade endometrial
carcinomas, the average index of EGF blood plasma level is higher compared to
that of the patients with high-grade endometrial adenocarcinomas. 4. The
average level of blood plasma melatonin in patients with simple/complex endometrial
hyperplasia (atypia-free) is significantly higher than in high-grade
endometrial adenocarcinoma. 5. In endometrial adenocarcinoma (high-grade,
low-grade),a drastic increase in average levels of blood plasma EGF is observed
with a correspondingly sharp lowering in average blood serum melatonin levels.
6. Under about equal conditions (strong expression of EGFR in the timorous
tissue and sharp/extremely sharp decrease in the levels of
anti-proliferative/anti-neoplastic melatonin in blood serum) high values of
proliferative EGF content in blood plasma are indicative of poor diagnosis. Tab. 1, Ref. 29.
Auth.
b14.3.2.59. Periodontal
disease in children with diabetes mellitus type 1. /S. Tuleutaeva, Z. Ashirbekova, D. Manapova, S. Almurat,
V. Kharchenko/. Georgian Medical News. – 2014. – #10(235). – pp. 25-29. – rus.; abs.: geo., eng., rus.
The aim of the article was to
study the occurrence of periodontal diseases in children with type I diabetes
mellitus. The examination of 78 children revealed periodontal diseases in 40
children with type I diabetes. OHI-S, CPITN, PMA indices were determined.
Pathological changes in periodontal tissues were revealed in 100% of cases. The
following were identified: gingival hemorrhage (100%), over - and
under-gingival dental tartar (100%), inflammation of gingival papilla (87.5%)
marginal (80%) and alveolar gingiva (55%). Spread of periodontal disease among
children with I type diabetes is characterized as high and is equal to 100%.
Degree of periodontal sickness is evaluated as average and is M=2.28; SD=0.47
according to CPITN index. Treatment and preventive measures should be carried
out taking into account major somatic disease. Tab. 1, Fig. 2, Ref. 4.
Auth.
b14.3.2.60. Efficiency
of interlamellar refractive tunnel keratoplasty in myopia and astigmatism
correction. /Y. Shusterov/. Georgian Medical
News. – 2014. – #10(235). – pp. 29-36. – rus.; abs.: geo., eng., rus.
Correction of high degree myopia,
anisometropia and astigmatism continues to remain one of actual problems of
ophthalmology. The purpose of the present work - the analysis of results of
application of refractive interlamellar tunnel keratoplasty variants. We
develop 6 updatings tunnel keratoplasty. In total in clinic 310 operations from
which in 158 cases as a transfer material used a donor cornea, in 63 cases –
brephocornea (a fruit cornea) and in 89 cases – hydrogel synthetic implant,
modified in low-temperature to gas-discharge plasma are spent. From the
specified number of operative interventions, on 86 eyes of operation tunnel
keratoplasty have been spent at those patients by whom earlier it has been
given up in carrying out eximerlaser corrections, in connection with presence
of a “thin”, “flat” and “convex” cornea. Maximum refractive effect fell first
two weeks after operation. Definitive stabilization of a refraction occurred on
2-3 month, thus regress of the reached effect made an order of 10-12 %. It is
reached refractive effect from 5.5 to 20.0 D. Under correction in some cases
made to 3.5 D that spoke very high myopia (more than 20.0 D) degrees. It has
been noticed, that refractive effect of operations with ecsplants was above (on
the average on 10 %), than at use of a donor cornea, at identical cross-section
section of used transfer materials. It spoke that the synthetic material,
unlike a donor cornea, kept the form. In all patients a substantial increase in
visual acuities was found, and in 75 % it was equal or exceeded visual acuity
before operation with the greatest possible correction. Thus, clinical
approbation has proved that the variants of tunnel keratoplasty are effective
ways of high myopia, anisometropia and astigmatism correction. Updating in
gaseous plasma is presented as a perspective way of improvement of
biocompatibility of synthetic materials. Fig. 3, Ref. 28.
Auth.
b14.3.2.61. Effect of
estrogen receptor gene ESR1 polymorphism on development of premenstrual
syndrome. /L. Pakharenko/. Georgian Medical
News. – 2014. – #10(235). – pp. 37-41. – eng.; abs.: geo., eng., rus.
To identify risks of development
of any disease is a priority of modern medicine. The aim of this study was to
investigate the frequency of polymorphic variants of A-351G gene estrogen
receptor ESR1 in patients with various forms of PMS. Molecular genetic analysis
of ESR1 gene polymorphism in 50 women with PMS (25 women of them had edematous
form of disease, 25 - neuropsychical, 25 – mild, 25 - severe form) was carried
out. 25 women without diagnosis of PMS were examined as controls. The study
A-351G polymorphism estrogen gene ESR1 showed no statistically significant
differences in the frequency of distribution of genotypes and alleles between
women with PMS and without this pathology. However, the frequency of GG
genotype in women with severe PMS was significantly higher in 8.0 times
compared with healthy women (χ2=4.87, p=0.03) and in women with
edematous form of PMS – in 7.0 times (χ2=3.72, p=0.05). Thus, a
polymorphic variant of A-351G gene ESR1 estrogen can be considered as a marker
of PMS. Pathological variant GG genotype was significantly associated with the
presence of edematous and severe forms of the disease. Tab. 3, Fig. 1, Ref. 12.
Auth.
b14.3.2.62. A rarely
seen case among retroperitoneal mass lesions: paraganglioma. /Ç. Yildirim, Ö. Yüksel, A. Ürkmez, N. Özbay, A.
Verit/. Georgian Medical News. – 2014. – #10(235). – pp. 41-44. – eng.; abs.: geo., eng., rus.
Pheochromocytomas are rarely seen
cathecolamine-secreting neuroendocrine tumors. Diagnosis, treatment, and
prognosis of this rarely seen condition have been discussed. In this study, a
retroperitoneal paraganglioma with a diameter of 27 mm was detected in a
29-years old nephrectomized male patient. In our case, in reevaluations
performed after definitive establishment of the diagnosis, any abnormal
radiological signs suggesting a metastatic lesion were not detected. During the
postoperative period the patient was referred to the clinics of endocrinology,
and oncology for medical follow-up. In the differential diagnosis of
retroperitoneal mass lesions, pheochromocytoma/paraganglioma should not be
forgotten. Besides, for malignant tumors chemoradiotherapy, and for benign
functional tumors medical treatment should be applied. Fig. 2, Ref. 9.
Auth.
b14.3.2.63. Peculiarities
of cytokine status in patients with vitiligo and stress in anamnesis. /N.V. Tsiskarishvili, A. Katsitadze, N.I.
Tsiskarishvili, L. Chitanava/. Georgian Medical News. – 2014. – #10(235). – pp. 45-48. – rus.; abs.: geo., eng., rus.
The aim of our study was to
investigate the content of some proinflammatory cytokines (IL-2, IL-6) in the
serum of patients with vitiligo and stress in anamnesis. Cytokine levels in
serum were measured in 50 patients with vitiligo (20 men and 30 women aged from
18 to 65 years old.) All the patients were divided according to anamnesis (27
patients with stress in anamnesis and 23 patients, where the onset of the
disease was not preceded by stress). Patients of both groups were similar in
terms of shape (according to T. Fitzpatrick classification) and in terms of the
dermatosis stages. Concomitant autoimmune or inflamatory diseases of the skin
in our vitiligo patients were not observed. The cytokines in the blood serum of
vitiligo patients were determined by ELISA using the corresponding monoclonal
antibodies. Student’s t-test was used for evaluation of statistical
significance of received results (p<0.05 was considered as a statistically
significant). Content of IL-2 in the serum of patients with vitiligo, in which
stress was not preceded dermatosis, was significantly higher than that in
healthy individuals (25.5±7.6 vs. 10.5±3.6 pg/ml, p<0.05). But the same
parameter in patients with stress in anamnesis was significantly lower than
those in healthy individuals (3.5±1.5 vs 10.5±3.6 pg/l, p<0.05). Changes in
the content of IL-6 in the serum of vitiligo patients was a similar to changes
in IL-2 content, and the most significant this indicator was in patients with
generalized and progressive stage of the disease. Data on increased
concentrations of IL-6 agree with the majority of studies conducted earlier.
For a complete analysis of our results on the reduction of the cytokines (IL-2,
IL-6) content in patients with a stress in anamnesis, that will allow to
identify the most effective ways to treat patients with this pathology
(including their cytokine status), further research is necessary. Tab.2, Ref.
10.
Auth.
b14.3.2.64. Modern
tendencies in co-morbid conditions. /K.
Ischeykin, M. Potyazhenko, N. Lyulka, N. Sokolyuk, G. Khaymenova/. Georgian Medical
News. – 2014. – #10(235). – pp. 49-53. – rus.; abs.: geo., eng., rus.
The present manuscript reviews
frequency of the concomitance of Ischemic Heart Disease (IHD) with Chronic
Obstructive Pulmonary Disease (COPD). The conclusion has been drawn, that quite
a large group of patients (25.9%) suffers from pulmonary pathology concomitant
with disorders of cardio-coronary system. 97 patients (84 male and 13 female)
with concomitant IHD and COPD (steady cardiac angina FK II st.) have been
admitted with acute pulmonary condition, and examined at the Department of
Pulmonology at N.V. Sklifosovskiy Regional Teaching Hospital in Poltava. The
patients were divided into 2 groups: patients in Group I (n=51) were receiving
the basic therapy, according to the case management protocol for this type of
disorders (β2-agonists, anticholinergic drugs, methylxantines, inhaler
glucocorticoids, phosphodiesterase-4 inhibitors). Patients in the Group II
(n=46), in addition to the basic protocol treatment were prescribed 4.2%
L-Arginine (Tivortin) venous infusion therapy (100 ml QD for 6 days) with
consequent change onto PO administration of 5-10 ml of the solution TID for 4
weeks. As a result, positive dynamics of regressing of clinical signs of COPD
was apparent in both Groups after 10-12 days of the treatment. Clinical
parameters, pulmonary, cardiac and indurance functions in patients of the Group
II, who in addition to the basic treatment, were receiving L-Arginine were much
better improved (p>0.05) than in Group I. The conducted study has allowed us
to draw a conclusion, that including L-Arginine in the treatment protocol of
COPD with concomitant IHD improves cardiohaemodynamics and allows for the
better efficacy of respiratory pathology therapy. Addition of L-Arginine
(Tivortin, «Yuriya-Farm», Kiev) to the complex therapy of COPD with concomitant
IHD results in statistically significant improvement of clinical and
instrumental test results, due to the drug's intihypoxic, antiagregational,
membrane-stabilizing, antioxydant and vasodilating effect. Tab. 2, Ref. 8.
Auth.
b14.3.2.65. Role of
redox- and hormonal metabolism in the mechanisms of skin aging. /K. Berianidze, A. Katsitadze, N. Jalaghania, T.
Sanikidze/. Georgian Medical News. – 2014. – #10(235). – pp. 54-57. – rus.; abs.: geo., eng., rus.
The aim of the study was to
investigate the role of redox balance in the pathogenesis of skin aging in menopausal
women. 30 menopausal women aged 40 to 55 years and 30 reproductive women aged
25 to 35 years were studied. Qualitative assessment of the skin (moisture, fat,
elasticity) was performed; in the venous blood hormonal metabolism indicators:
estradiole - E, testosterone - T, follicle stimulating hormone - FSH and redox
parameters - oxygen and lipid free radical content (EPR method), antioxidant
enzymes (catalase, superoxide dismutase (SOD) and glutationreducrase (GR))
activity (spectroscopic method) were studied. According results of the study,
in menopausal women statistically significant loss of skin elasticity and
increase the number of pores was revealed in comparison to the reproductive
women. These changes occur against the background of statistically significant
increase of the blood testosterone and FSH content; estradiol in women
menopausal period has tendency to decrease. Redox indicators of blood did not
differ statistically significant in women of reproductive and menopausal
period, although there was a tendency to increase the activity of catalase and
GR in menopausal women period, indicating on the intensification of oxidative
processes in this age group. Statistically significant negative correlation
between blood estradiole content and SOD’s activity (r=-0.413, p=0.0017) and
positive correlation between blood estradiole content and GR activity (r=0.565,
p=0.002) was revealed. Decrease in the estradiol concentration and disbalance
in redox-system in the women’s blood correlats with the rate of pigmented spots
growth and decrease of the skin moisture. It is concluded that in mechanisms of
skin aging of menopausal women estrogen-depending alterations in redox-balance
places important role. Tab. 3, Ref. 14.
Auth.
b14.3.2.66. Pain as the main rheumatic problem ways of managing acute
pain and syndromes associated with it. /G.
Chakhunashvili, D. Rekhviashvili, K. Matcharashvili, N. Jobava, K.
Chakhunashvili, D. Chakhunashvili/. Pediatric Cardiology. – 2014. – #8. – pp. 35-50. – geo.; abs.: geo., eng.
Good knowledge of cardio-rheumatology also
involves knowledge of managing pain, most importantly pain in the knees. The
wide spectrum of pain types needs according knowledge of general principle of
how to manage various diseases in cardio rheumatologic field.Tab. 6, Ref. 43.
Auth.
b14.3.2.67. Anthropologic
hemodynamic principle for diagnosing cardiac failure. /G. Belkania, L. Dilenian, I. Gvinjilia, E.
Mathiashvili, S. Jaiani, A. Bagrii, L. Pukhalskaia/ Pediatric Cardiology. –
2014. – #8. –
pp.61-67. – rus.; abs.: geo., eng.
The main
principle is to identify blood flow in lying and standing positions. This gives
a wider diagnosing range.Fig. 4, Ref. 17.
Auth.
b14.3.2.68. Tubulopathies and
richets-like diseases in children. /G. Chitaia, D. Kvirkvelia, M. Tsanava, B. Zenaishvili, T. Abuladze, T.
Gachechiladze/. Pediatric Cardiology. – 2014. – #8. – pp. 78-81.– geo.; abs.:
geo., eng.
Pathologies with renal tubular dysfunction
refer to rare diseases, diagnoses of which are complicated because
of the late onset of symptoms as well as their challenging interpretation.
The early diagnosis of the syndromes with renal tubular dysfunction
could prevent hard, even life threatening complications of the diseases.
Polyuria, polydipsia, dehydration, growth retardation, seizures,
arrhythmias, persistent metabolic acidosis, hypokalemia, hypocalcemia,
hypophosphatemia are the symptoms the generalists and pediatricians
should be careful about. In this report we reviewed the most frequently
confronted types of tubulopathies such as Fanconi’s syndrome, hereditary
hypophosphatemic rickets, vitamin D resistant rickets, hypomagnesemia.
Tab. 4, Ref. 30.
Auth.
b14.3.2.69. Phimosis in children. /I. Burdjanadze, D. Kvirkvelia, G. Chitaia/. Pediatric Cardiology. – 2014. – #8. –
pp. 81-83. – geo.; abs.: geo., eng.
The definition of phimosisis given; the
significance of foreskin and smegma, phimosis in age categories as
well as the causes of pathologic phimosis and its management are
considered. Fig. 6, Ref. 3.
Auth.
b14.3.2.70. Kinesiotherapy in little children. /I. Dolidze/.
Pediatric Cardiology. – 2014. – #8. – pp. 92-94. – geo.; abs.: geo., eng.
Scientific research states that since
the birth kinesiotherapy is proven to be beneficial. Children who
underwent the therapy easily learnt how to sit, crawl, stand and walk. It
is also found to positively affect mental development of the child.
The article discusses various benefits and aspects of kineziotherapy.
Ref. 11.
Auth.
b14.3.2.71. Use
of plasma rays at purulent-septic complicacions in critical care medicine. /B. Tsutskiridze, S. Jaiani, N. Kvitsiani, D.
Chakhunashvili, G. Chakhunashvili, G. Tsutskiridze/. Critical Care & Catastrophe Medicine. Materials of
Int. Symp. – 2014. – #13-14. – pp. 46-48.
– eng.; abs.: eng., geo.
One of the leading problems in the modern
medicine, regarding critical care conditions, is prevention and treatment of
purulent-septic complications, including nonhealing bedsores. Estimating the
results of various realizations of concepts for preventing the mentioned
pathology developed after damaged extremities, taking into account the
experience acquired over past decades, it can be suggested that the leading
prophylactic principle was and still remains to be the primary surgical
treatment (1, 5, and 8). It also needs to be mentioned that presently, a lot of
other various ways and methods are being used for preventing and treating
purulent-septic pathologies. But the results of the treatment, in regards of
maintaining high level efficiency against purulent-septic and other
complications, still require further improvements (3, 7, and 9). The use of
high temperature impact methods has shown its effectiveness and is known for a
long time. However, each of these methods, together with positive properties,
has their own drawbacks (6). Over the past years, the use of plasma rays for
treating purulent-septic complications and Decubital received wider importance.
This method is thought to be a significant breakthrough in physical methods of
impact on biological tissues, providing fast hemostasis, coagulation, sealing
and reliable sterilization of damaged wounds (2, 4). Ref. 9.
Auth.
b14.3.2.72. Hyperfibrinogenemia and its role during
inflammation. /N.
Muradashvili, T. Jariashvili, S. Tyagi, D. Lominadze/. Critical Care & Catastrophe
Medicine. Materials of Int. Symp. – 2014. – #13-14. – pp. 49-56. – eng.; abs.: eng., geo.
Fibrinogen (Fg) is one of the biomarkers of inflammation and a high
risk factor for many vascular disorders. It is involved in various
physiological processes such as blood coagulation, platelet thrombogenesis,
erythrocyte aggregation, and cell-cell interactions. High level of Fg in blood
exacerbates circulatory complications during inflammatory diseases such as
hypertension, diabetes, stroke, traumatic brain injury and other cardiovascular
or cerebrovascular disorders. Enhanced blood content of Fg alters vascular
reactivity and compromises endothelial cell layer integrity resulting in
leakage of plasma substances from blood stream to interstitium. The purpose of
this review is to demonstrate and discuss the effects of Fg causing a
cerebrovascular leakage of blood plasma proteins and to offer possible
mechanisms for this effect, which could enhance microcirculatory complications
during inflammatory cerebrovascular disorders accompanied by an increased blood
content of Fg. Fig. 1, Ref. 25.
Auth.
b14.3.2.73. New opportunities for correction of water and
electrolyte homeostasis disordersin critical conditions. /O. Galushko/. Critical Care & Catastrophe Medicine. Materials of Int. Symp. – 2014. – #13-14. –
pp. 57-64. – eng.; abs.: eng.,
geo.
Water-electrolyte imbalance occurs in 66.78%
of patients in critical condition. We examined 60 patients who were treated in
the General ICU of the Municipal Institution "Kyiv Regional Clinical
Hospital", aged between 18 and 60 years. Patients were divided into two
groups: 1st group included patients with severe concomitant injury and 2nd-3rd
degree traumatic shock (n=30), in which a standard intensive therapy (IT) has
been supplemented with Rheosorbilact at dose of 8-10 ml/kg of body weight, with
a parallel correction of detectable hypomagnesemia and hypophosphatemia; 2nd
group included patients with concomitant injury and 2nd-3rd degree traumatic
shock (n=30) that undergone the standard intensive therapy. Application of
polyionic multicomponent, sorbitol-based solutions leads to rapid stabilization
of hemodynamic parameters, it is not accompanied by disruption of homeostasis,
and promotes the elimination of аcid-base imbalance. Treatment with
solutions based on sorbitol is well tolerated and is not accompanied by the
development of complications associated with the use of colloidal solutions or
classical crystalloid.Tab.3, Ref. 15.
Auth.
b14.3.2.74. Calcium homeostasis in diabetic patients with critical conditions. /A. Kistauri, M. Jibladze, An. Kistauri, D.Gabunia/. Critical Care & Catastrophe Medicine. Materials of Int. Symp. –
2014. – #13-14. – pp. 65-68. – eng.; abs.: eng., geo.
68% of diabetic patients present impaired
calcium homeostasis, regardless of type of diabetes, age and sex. Mainly
hypocalcemia is present. Diabetes mellitus is characterized by the deficit of
calcium retention, as a result of activation of renal calciuretic function.
Management of critical clinical condition caused by diabetic ketoacidosis
requires thorough monitoring of calcemia and calciuria and its dynamic
correction. Fig. 3, Tab.2, Ref. 5.
Auth.
b14.3.2.75. Brain electrical activity manifestation in Orthodox Christian patients
during praying. /M. Metreveli, Z. Kheladze, Zv. Kheladze/. Critical Care & Catastrophe Medicine. Materials of Int. Symp. – 2014. – #13-14. –
pp. 69-71. – eng.; abs.: eng.,
geo.
That in praying people (monks, priests)
depression of α rhythm is revealed well (regeneration is performed fast);
Β rhythm does not disappear 20%. In pagans (29%) - amplitude of α
rhythm was highest, in 28% - densed, high amplitude waves egzaltatic and
disorganized, in 21% depression of α rhythm is revealed badly, in 27% -
β disappeared. Also it was found that in 39 patients slow waves were
revealed, in 41 - some spiky pattern appeared, in 17 - fast waveform
disrhytmia. The research found that Orthodox praying influences the
bioelectrical activity of the cortex and has correlation with vegeto nervous system. Tab.2, Ref. 4.
Auth.
b14.3.2.76. Life science’s nanotechnological approach in pathogenesis of
post-aggressive reactions of human organism and critical conditions. /M. Danielov/. Critical Care
& Catastrophe Medicine. Materials of Int. Symp. –
2014. – #13-14. – pp. 72-81. – eng.; abs.: eng., geo.
There is no real new medicine in treatment of
patients not only in critical conditions, but we can observe overall stagnation
in new drug development (we are not talking about number of new drugs on the
market, but about their real efficacy). Such stagnation is based on luck of new
technology in life science industries. There are several objective reasons for
this, but the facts speak for themselves. Presented technological approach
allows assembling specific compositions of biologically active substances
composing [NANO-COMPLEXES™] of
nano-quantities (10-9) of naturally existing in Human Organism bioactive
substances. These bioactive substances are stabilized and incorporated into
a specially developed NuCell-Direct™ delivery system by means of
nanotechnological process. Bioactive NANO-COMPLEXES™ targeting pathogenetical
factor of specific disease / dysfunction / pathology, allows: enhancing
adaptation mechanisms to the post-aggressive reaction of the organism and
critical conditions, restoring self-healing processes of the organism; repairing the genetically determined chain of
biological information transfer. All the
above-mentioned advances can be achieved by moving from the singular
biologically active substance [singular drugs] to the technology allowing
assembling from endogenous bioactive substances targeted to the pathogeneses
multicomponent bioactive systems [NANO-COMPLEXES™]. Fig. 6.
Auth.
b14.3.2.77. Dopamine quantity study in critical patients. /N. Barnabishvili, E. Ivanidze, Z. Kheladze, Zv. Kheladze/. Critical Care & Catastrophe Medicine. Materials of Int. Symp. – 2014. – #13-14. –
pp. 82-87. – eng.; abs.: eng.,
geo.
Dopamine is a neurotransmitter that is produced
in the human and animal brain. Dopamine plays an important role in ensuring the
cognitive function. Dopaminergic transmissions are necessary to switch
attention from cognitive to other actions. The goal of the study was to define
the quantity of dopamine in critical patients. The studies have revealed that
dopamine concentration in critical patients is higher. Especially high
concentration of dopamine in the blood was received from those patients who
were on dopamine infusion. The concentration was also high in their liquor. The
concentration of dopamine was high in children notwithstanding their health
state that is in conformity with the references’ data.Tab.5, Ref. 5.
Auth.
b14.3.2.78. Analysis of critical pneumonia multicenter
studies under the auspices of the European Society of Intensive Care Medicine
conducted in Critical Medicine Institute of Georgia. /Z. Kheladze, Zv. Kheladze, N. Ramishvili, T. Qurcikidze/. Critical Care &
Catastrophe Medicine. Materials of Int. Symp. – 2014. – #13-14. – pp. 88-91. – eng.; abs.: eng.,
geo.
European Society of Intensive Care Medicine
and Yasser Sakr – Jena University conducted multicenter study of Severe Acute
Respiratory Infection – SARI in 2013, the leading critical medicine clinics
from different countries participated in this study too. Fig. 4, Ref. 1.
Auth.
b14.3.2.79. Characteristics of surgical treatment of “diabetic foot” in elder age
patients in critical condition. /S. Didia, A. Kistauri, S. Jaiani, R.
Eliger, J. Petashvili, L. Ajamova/. Critical Care &
Catastrophe Medicine. Materials of Int. Symp. – 2014. – #13-14. – pp. 92-95. – eng.; abs.: eng.,
geo.
Analysis of 65 elder patients in critical
condition cleared out that quality of treatment of patients with diabetic foot
is being developing, during surgery operation, done is stages. In this view of
point, at the first stage they remove life-threatening, point of intoxication,
leaving stump open. Next stage, formation of stump is done after liquidation of
endotoxic shock. Fig. 1, Tab. 2.
Auth.
b14.3.2.80. Remote control systems for Critical Care
Medicine – reality and perspectives. /Zv. Kheladze, Z. Kheladze, I. Strelnikov, I. Nasri/. Critical Care &
Catastrophe Medicine. Materials of Int. Symp. – 2014. – #13-14. – pp. 96-99. – eng.; abs.: eng.,
geo.
Information about management of treatment
process form far distance was announced several years ago by Critical Care
Medicine Institute (Z. khelade, Zv. kheladze and other 2011, 2012, 2013). The
system consists of video cameras and since the united to it personal computers
that are connected to the internet. By the system can be conducted permanent
control on patient treatment process. Fig. 1, Ref. 5.
Auth.
b14.3.2.81. Study of personality characteristics in
critical patients. /N. Ramishvili, N. Taboridze, S. Makharashvili, T. Kajaia, Z. Kheladze, Zv. Kheladze, T.K. Kaavanger, S. Shivananda/. Critical Care &
Catastrophe Medicine. Materials of Int. Symp. – 2014. – #13-14. – pp. 100-104. – eng.; abs.: eng.,
geo.
Most of the patients in first group turned
out to be pragmatic. The most rare destiny number in second group was 4. (This
person has analytic mind and original thinking. Usually this the number of
genius people with independent character). The most common destiny digit was 7
(This person has supreme love, he is philosophical and mystic. The main aim of
this person’s life is religion, universal love and kindness). Fig. 6, Ref. 1.
Auth.
b14.3.2.82. Bone marrow electro stimulation shall become a standard treatment for
critical patients. /Z. Kheladze, Zv. Kheladze, E. Kartsivadze, N. Kajaia/. Critical Care &
Catastrophe Medicine. Materials of Int. Symp. – 2014. – #13-14. – pp. 105-110. – eng.; abs.: eng.,
geo.
Is analyzed the results of bone marrow
electro stimulation use in Critical Care Medicine Institute, namely is
significantly reduced the liquidation period of critical condition, patients
death mortality rate and cost of treatment, also is observed complication
reduce while treating. The results indicate on the necessity of bone marrow
processing by electrical impulses in the standard care of Critical Care
Medicine. Fig. 5, Tab.2, Ref. 1.
Auth.
b14.3.2.83. Peculiarities of Surgical treatment of intracerebral hemorrhage. /T. Kerdzevadze, G. Gegia, Q. Kerdzevadze, T. Abramov, Zv. Kheladze/. Critical Care & Catastrophe Medicine. Materials of Int. Symp. – 2014. – #13-14. –
pp. 111-112. – eng.; abs.: eng.,
geo.
Surgical treatment of patients that have
intracerebral hematoma is better to be conducted after lasting 24 hour form
disease outbreak. Operation is better to be made by using traditional “open”
method and patients have to be under hypotension and sedation regime as goal. Ref. 2.
Auth.
.
b14.3.2.84. EEG changes in critical patients. /M. Khaburdzania, Z. Kheladze, Zv. Kheladze, N. Kajaia, D. Kazaishvili/. Critical Care & Catastrophe Medicine. Materials of Int. Symp. – 2014. – #13-14. –
pp. 115-118. – eng.; abs.: eng.,
geo.
Coma is the most common disorder of the
consciousness caused by a severe damage of the brain which is reported in 3-4%
of patients at resuscitation and intensive therapy departments. In spite of
wide capability of modern methods of visualization EEG still holds the leading
position in estimation of brain functional state as well as in diagnostic
confirmation of a vegetative state, the terminal state and the death of brain.
Despite the vast data accumulated in scientific literature about EEG in coma it
is not fully defined and studies in this direction are being continued all over
the world. In the presented study we made an effort to estimate the EEG
patterns of coma of different etiology in Georgian population. By registration
of bioelectric brain activity a localization of motor and sensorial sphere
pathological process, changeability of behavioral reactions, and the level of
consciousness is defined. EEG allows us to evaluate thalamus-cortical disorders
of patients in coma state which is impossible clinically. According to EEG
patterns the process and result of the disease or brain death can be stated. Fig. 3, Ref. 8.
Auth.
b14.3.2.85. Memory and intelligence
assessment in critical patients. /Z. Kheladze, G. Chkhartishvili, E. Bibiluri, Zv. Kheladze/. Critical Care & Catastrophe Medicine. Materials of Int. Symp. – 2014. – #13-14. –
pp. 119-123. – eng.; abs.: eng.,
geo.
100 critical patients have been researched,
60 men, 40 women. The patients were divided into the groups of higher education
and secondary education. The research was carried out in a dynamic process,
during the critical condition and after the liquidation of critical condition.
30 employees of clinic were in control group. The study shows that memory
changes during critical condition have are obvious for short-term memory.
Memory changes are more obvious for patients with secondary education and after
liquidation of critical condition both short-term and long-term memories are
improved. Intellectual abilities are also lowered during critical conditions
and the level of lowering depends on the education of patient. Fig. 5, Tab. 4, Ref. 2.
Auth.
b14.3.2.86. Influence of music on EEG of critical patients. /N. Nikabadze, Z. Kheladze, Zv. Kheladze, D. Kalandia/. Critical Care & Catastrophe Medicine. Materials of Int. Symp. – 2014. – #13-14. –
pp. 124-127. – eng.; abs.: eng.,
geo.
Electroactivity of brain is better outlined
when the same music are being listened by patients that are in unconscious
condition and by the working personal with these changes are better presented
in right hemisphere. Fig. 2, Ref. 3.
Auth.
b14.3.2.87. Lymphoma in emergency surgery (case report). /G. Azmaiparashvili,
G. Tomadze, A. Megreladze/. Tbilisi State Medical University Collection of Scientific
Works. – 2013. – #47. – pp. 9-11 – geo.; abs.: geo., eng.
Lymphoma of stomach, small and large bowel is
rare disease in emergency surgery. We described two cases of stomach, small and
large bowel lymphomas. Clinically and intraoperatively they look very much like
as stomach cancer. In case of complicated lymphoma with bleeding operative
treatment is advisable in addition to endoscopic biopsy and histology of
specimen. Immunohistochemical staining is widely used in the diagnosis of
lymphoma. In case of histology confirming of, final diagnosis is made after
imunohistochemical assessment and consultation of oncologist is mandatory to
select adequate treatment: chemotherapy, and/or radiotherapy and/or
immunotherapy, and/or bone morrow transplantation. Two presenting cases are
interesting because of its rarity in emergency surgery. Fig. 1, Ref. 5.
Auth.
b14.3.2.88. Treatment/management of juvenile strokes. /G. Arveladze, N.
Geladze, T. Sanikidze, N. Khachapuridze, N. Kapanadze, S. Bakhtadze/. Tbilisi State Medical University Collection
of Scientific Works. – 2013. – #47. – pp. 11-18. – geo.; abs.: geo., eng.
Over the past 10 years, significant increase
in the rate of cerebro-vascular pathologies and among them juvenile 6 strokes
has been observed. According to the scientists working on this problem, the
results of pediatric strokes are always difficult, both for the patient and
parents. According to G. Aicardi (2009) the main reasons for development of
arterial occlusion and strokes at juvenile age are as follows: heart diseases,
vascular dysplasias, inflammatory vascular diseases, destructions of connective
tissue, hematologic diseases, metabolic disturbances, infectious diseases,
tumors, trauma, toxic disturbances, etc. The most frequent causes of pediatric
stroke are metabolic mitochondrial diseases. Main biochemical indicators of
mitochondrial pathology are lactic acidosis, elevated levels of lactic and
pyruvic acids in blood and liquor, which are also acidic. According to the
above, the aim of our study was to identify lactic acidosis and mitochondrial
insufficiency, detection of disorders in cell energy metabolism and acid base
balance for a variety of neurological syndromes and diseases in children and
adolescents to develop the algorithms for specific treatment. Clinical
observations and paraclinical studies in 11 patients (children from 0 to 3
year) with acute disorder of cerebral blood circulation revealed hypoglycemia,
significant increase lactate and pyruvate in blood, mitochondrial deficiency
(reduction ph MTT test parameters rate), as well as imbalances of the blood
redyx system, ehich revealed in decrease of the antioxidant enzymes (Superoxide
Dismutase, Catalase) activity. These disorders are associated with ischemia and
oxidative stress and are manifested especially during with MELAS syndrome.
Revealed lactic acidosis and mitochondrial insufficiency help us to make a
correct diagnosis and develop the algorithms for specific treatment. Detection
MELAS syndrome in one case indicated to need of evaluation of mitochondrial
activity in this group. Ref. 32.
Auth.
b14.3.2.89. Role of redox-system of
blood in the mechanisms of skin aging in menopausal women. /K. Berianidze, A. Katsitadze, I. Datunashvili, M. Matoshvili/. Tbilisi State Medical
University Collection of Scientific Works. – 2013. – #47. – pp. 27-29. – geo.;
abs.: geo., eng.
The aim of the study was investigation of the
role of redox balance in the pathogenesis of the skin aging in menopausal
women. Menopausal women of age 40-55 years (15 women) were studied. Qualitative
assessment of the skin (moisture, fat, elasticity was performed in the venous
blood hormonal metabolism indicators (estradiol (E), testosterone (T), follicle
stimulating hormone (FSH)) and redox parameters (oxygen and lipid free radical
content (EPR method), antioxidant enzymes (catalase, superoxide dismutase (SOD)
and glutathionreductase (GR)) activity (spectroscopic method))were studied.
Statistically significant negative correlation between blood estradiol content
and SOD’s activity (r = - 0.413, p=0.0017) and positive correlation between
blood estradiol content and GR activity (r = 0.565, p = 0.002) was revealed.
Decrease in the estradiol concentration therefore, disbalance in antioxidant
system in the women’s blood correlates with the rate of growth of pigmented
spots decrease of the skin moisture. It is concluded that in mechanisms of skin
aging of menopausal women estrogen-depending alterations in redox-balance
places important role. Tab. 2, Ref. 7.
Auth.
b14.3.2.90. Role of
redox-imbalance in the pathogenesis of hypertension in menopausal women. /M. Buleishvili, l. Ratiani, N. Lobzhanidze, T. Sanikidze/. Tbilisi State Medical
University Collection of Scientific Works. – 2013. – #47. – pp. 29-31. – geo.;
abs.: geo., eng.
The aim of the
research was determination role of redox imbalance in the pathogenesis of
hypertension in menopausal women. The menopausal women with (30 women) and
without hypertension (30 women) were investigated. Exclusion criteria from the
study were cystic ovarectomy, viral hepatitis, kidney disease, tobacco use,
frequent consumption of coffee, alcohol and other addictions. Genetic
predispose to the hypertension (data of anamnesis) and body mass index were
defined in women; blood content (by ELISA method), redox - balance (pro -
(lipoperoxides (LOO) content) and antioxidant (catalase, superoxide dismutase
(SOD) and glutathione reductase (GR) activity) were investigated. The study
revealed a statistically significant negative correlation between severity of
the hypertension and blood estradiol content (r =-0.4531, p = 0016). In the
blood of postmenopausal women with hypertension lipoperoxide (LOO)EPR signal
revealed, blood catalase activity increased by50%, GR activity decreased by
38%, while the SOD activity didn’t significantly changed in comparison to the
control parameters (in menopausal women without hypertension).It was concluded
that the redox imbalance plays important role in pathogenesis of hypertension
in menopausal women. Tab. 2, Ref. 11.
Auth.
b14.3.2.91. The sleep apnea in neonates and children and
the treatment strategy. /N. Geladze, N. Khachapuridze,
S. Bakhtadze, N. Kapanadze/. Tbilisi State Medical University Collection of Scientific
Works. – 2013. – #47. – pp. 32-38. – geo.; abs.: geo., eng.
The normal sleep
with sufficient duration and architectony provides the complete implementation
of various functions of brain including cognitive. The contribution of sleep in
the plasticity of brain, in neural ontogenesis, in the synthesis of CNS
proteins, in consolidation of memory and fulfilling of immune function is
enormous. Mildly expressed sleep disorders can be revealed in 19.8% of
children, moderately and severe forms - in 13.8%.The most frequent forms of
sleep disturbances are microarousals at night (18.1%), problems in falling
asleep (9.7%), daytime drowsiness (9.1%). In this paper, we have reviewed sleep
apnea - one of the most frequent and severe forms of sleep disorder in neonates
and children, which passes with respiratory disturbances. The prolonged
(lasting for months or years) obstructive sleep apnea results in several
physiological impairments including growth retardation, cognitive and
behavioral problems (aggression, inattentiveness, hyperactivity, low academic
achievement), which in turn cause the worsening of quality of life, also
developing of enuresis, the cardiorespiratory insufficiency (cor pulmonalis,
hypertension) and even seizures. The primary neonatal sleep apnea is one of the
most frequent and sometimes life-threatening conditions. It often can be
accompanied with autonomic disorders like bradycardia, cyanosis or pallor,
rarely can occur epileptic seizures and psychomotor retardation of different
severity. Sometimes the outcome can be fatal. Thus, it is clear that timely
recognition and adequate diagnostic and treatment approaches are crucial. This
process includes the detailed interviewing of mother or other caregiver. The
correct management is important not only for physical development of child but
also for normal cognitive functioning. Tab. 2, Ref. 58.
Auth.
b14.3.2.92. Clinical outcome of cerebral venous
thrombosis. /I. Verulashvili, M. Beraia, A. Jvarsheishvili/. Tbilisi State Medical
University Collection of Scientific Works. – 2013. – #47. – pp. 61-63. – eng.;
abs.: geo., eng.
Cerebral venous thrombosis (CVT) 35-50
years ago was considered as a rare disease with a
poor outcome: mortality rate was ranging from 30% to
50%. This concept has been revised during the last decade. The goal of the
study was to evaluate the clinical outcome in 55 consecutive patients with CVT
admitted over a 7-year period [2005-2011] and to determine predictors of death
and dependence. We included all consecutive patients admitted over a 7-year
period [2005-2011] at neurology and neurosurgery units of Tbilisi State Medical
University’s hospital and Research Institute of Clinical Medicine, which met
criteria for CVT. The studied population consisted of 55 patients (42 women and
13 men), with a medium age of 43 years (range: 26-68). In our study, despite
inclusion of patients from the intensive care department, mortality at the
acute stage was only of 7.3%, which is similar or lower than in most previous
studies. The decreased mortality rates over the last 30 years are the
consequence of the development of brain MRI (allowing an early diagnosis of
benign cases of CVT, which may have remained undiagnosed before the era of MRI)
and early anticoagulation therapy. Ref. 8.
Auth.
b14.3.2.93. Diagnostic significance of procalcitonin in
children with urinary tract infections of different level severity. /B. Zenaishvili, G. Chitaia, N. Manjavidze/. Tbilisi State Medical
University Collection of Scientific Works. – 2013. – #47. – pp. 67-69. – geo.;
abs.: geo., eng.
Renal
involvement has always been the main diagnostic objective in children with
febrile urinary tract infections. If more studies confirm the correlation
between procalcitonin, renal involvement during urinary infections and scar
formation, we will finally have a noninvasive tool that can identify children
at risk of complications and in need of a close follow-up as early as their
first episode of febrile urinary tract infection. This parameter is correlated
with the severity of renal involvement at the time of diagnosis of febrile UTI
and also with the risk of permanent scarring. Therefore, PCT measurements could
be a valuable tool for the treatment of children with febrile UTIs. Serum PCT
levels may be a sensitive and specific measure for early diagnosis of acute
pyelonephritis and determination of the severity of renal parenchymal
involvement. Tab. 3, Ref. 21.
Auth.
b14.3.2.94. Possibilities of correction of lipid profile
during essential hypertension and diabetes type 2 patients. /R. Tabukashvili, V.
Kapetivadze, K. Tchaava, N. Gegeshidze, Z. Maglapheridze/. Tbilisi State Medical University Collection
of Scientific Works. – 2013. – #47. – pp. 70-71. – geo.; abs.: geo., eng.
Objective: Studying efficiency and safety of Prestarium
in treatment of the patients with essential hypertension and diabetes type 2. Methods: 55 patients (55±3.5 year old)
with essential hypertension (systolic pressure >140 mmHg, diastolic pressure
>90mmHg) and diabetes type 2 were studied. Control of efficiency and safety
of Prestarium included main clinical methods, hemodynamic levels, indicators of
lipid profile and HbA1c. RESULTS: After
3 month normalization of systolic pressure by 21%, diastolic pressure by 17.1%,
and considerable improvement of lipid profile were found. Conclusion: Prestarium is an effective
medicine in treatment of patients with essential hypertension and diabetes type
2; at the same time, it improves lipid profile. Tab. 2, Ref. 6.
Auth.
b14.3.2.95. Using cupral threads in the complex treatment
of periodontal disease. /M. Iverieli, N. Abashidze, Kh.
Gogishvili, L. Jashi, N. Gogebashvili/. Tbilisi
State Medical University Collection of Scientific Works. – 2013. – #47. – pp.
77-78. – geo.; abs.: geo., eng.
Aim
of our research was evaluation of the cupral threads efficiency in the
treatment of periodontal disease. For this purpose 35-55 year-old 42 patient
were observed – 22 (52%±0,09%) woman and 20 (48%±0,09%) men. The efficiency of
provided research was evaluated by clinical indices - hygiene (HI), gingival
(GHI) and periodontal indices; on the basis of received results we conclude
that cupral threads are very effective to use. In addition to efficiency, the
placement of the thread in the periodontal pocket is technically very easy and
cost-effective. Thus. we recommend the usage of cupral threads in the treatment
of periodontal disease. Ref. 3.
Auth.
b14.3.2.96. Relationship between motor skills and body
mass index (BMI) in 3-to-6 year-old children. /E. Kandelaki, N. Kavlashvili, M. Kherkheulidze, I. Chkhaidze/. Tbilisi State Medical
University Collection of Scientific Works. – 2013. – #47. – pp. 80-82. – geo.;
abs.: geo., eng.
Purpose
of this study was to investigate the relationships between movement skills and
body mass index (BMI) of the 3-to-6 year-old children. We used observational
study design to answer the study questions. Five Movement Skills of 340
children were assessed: balance on feet, horizontal jump, overhand throw,
drawing the figure and cube test) .BMI was calculated from the height(m) and
weight (kg) [weight/ height2] for each participant. Raw scores of the
participants’ fundamental movement skills were correlated with BMI in all
subjects. Similarly, significant negative correlations were found between the
raw scores of the gross motor skills and BMI in overweight and obese children;
whereas correlations were not found between fine motor skills and BMI. The
hypothesis of a motor deficit in obese children is rather interesting and must
therefore be addressed further, especially in fine motor skills. Tab. 2, Ref.
9.
Auth.
b14.3.2.97. Spitz Nevus-dermatoscopic characteristics and
diagnosis of pathomorphology. /A. Katsitadze, N.
Kiladze, T. Sulaia, N. Korsantia, Z. Bendeliani, A. Chirinashvili/. Tbilisi State Medical University Collection
of Scientific Works. – 2013. – #47. – pp. 87-88. – geo.; abs.: geo., eng.
In recent decades,
the use of dermatoscopy in clinical practice has led to significant changes in
the diagnostic of melanocytic neoplasmas of the skin. Dermatoscopy makes
possible to evaluate a number of morphological structures, gives the valuable
information for their assessment, and makes the differentiation more reliable.
The aim of our investigation was to study the specific dermatoscopic criteria
for Spitz nevus and their correlation with dermatopathologic data. In all
examined cases we described the characteristic peculiarities of dermatoscopic
pattern and found a satisfactory conformity between dermatoscopic and
histological data, which proves that dermatoscopy is a reliable and trustworthy
method of diagnostics. Ref. 4.
Auth.
b14.3.2.98. Comparison of stabilization
of dental appliances for the edentulous mandible for the functional moulds
obtained by means of different techniques. /S.
Kraveishvili, N. Shonia, N. Sakvarelidze/. Tbilisi State Medical University Collection
of Scientific Works. – 2013. – #47. – pp. 96-98. – geo.; abs.: geo., eng.
Degree of fixation
of the dental appliances depends on the anatomic-physiological characteristics
of the denture fixation area. Hence, improvement of making of the techniques
for making moulds of the edentulous mandible still is the significant issue.
Goal of our research was comparison of individual moulding spoons for two
different techniques in prothetic dentistry and determining significance of
them for the purpose of improvement of the final outcomes. The study showed
that the application of anatomic retention with formation of the edges of
individual moulding spoons significantly improves stabilization of the
prostheses and number of adjustments in the process of prostheses fitting. Tab.
1, Ref. 5.
Auth.
14.3.2.99. Plastic surgery in the head and neck
reconstruction of oncologic patients. /I. Kuzanov, K.
Mardaleishvili, A. Kuzanov, Z. Dabrundashvili, G. Kuzanov, G. Ioseliani, M.
Machavariani, V. Javakhishvili, G. Baratashvili/. Tbilisi State Medical University Collection
of Scientific Works. – 2013. – #47. – pp. 98-101. – geo.; abs.: geo., eng.
After excision of
extensive tumors, reconstruction of lost tissue without use of a microsurgical
technique does not allow restoring in full function and esthetics of the face.
Often biomechanics of food intake is broken. In individual cases, the nasal and
oral cavities are open, which leads to the swallowing, speech and breathing
function disorders. Such patients often become associal and are compelled to
hide not only from a society, but also from the members of own family. The
development of microsurgery and the use of flap surgery gave us the possibility
to cover such big and compound defects with healthy, not irradiated tissues.
Free and rotated flaps can stimulate reparation and revascularization process
in reconstructed regions and can less the period of rehabilitation of patients
with head and neck cancer. Since 1985, under the guidance of K. Mardaleishvili
and I. Kuzanov, two teams (oncologic and plastic surgeons) started
collaboration in the treatment of oncologic patients with the head and neck
tumors. We performed more 47 one stage and delayed reconstructions with the use
of free or rotated flaps. Thus, the teamwork of oncologic and plastic surgeons
and plastic surgeons allows achieving good functional and aesthetic results in
the treatment of oncologic patients with the head and neck tumors. Fig. 15,
Ref. 11.
Auth.
b14.3.2.100. Treatment of choledocal cysts. /N. Lomidze, Z. Manizhashvili/. Tbilisi State Medical University Collection
of Scientific Works. – 2013. – #47. – pp. 107-109. – geo.; abs.: geo., eng.
Cystic dilatations
of the extra hepatic biliary tree are one of the rarest congenital
malformations of the biliary tract. 60% of cases are diagnosed during 3 month
to 10 years of age. Biliary cysts are four times more often found in females
than in males. Since 2001, 3 patients with choledochal cyst type I (according
to Todani classification) have diagnosed and treated at the University Central
Clinic (age of female patients were 8,16,17 years). All the patients had
similar history. Symptoms included pain, jaundice and tumor in the right upper
quadrant. Total bilirubin was elevated in all cases. Ultrasound, CT and MRI
revealed significant enlargement of choledochal cysts. Diagnoses of choledochal
cyst type I (according to Todani classification) were confirmed in all cases.
Surgical treatment involved resection of choledochal cyst , cholecystectomy,
formation of hepato-jejuno anastomosis and enteroentero anastomosis with
Roux-en Y method. Early and late complications after surgical treatment were
not observed. Surgical excision of the cyst with the formation of a rouxen-Y
anastomosis to the biliary duct is recommended rather than formation of
cystoenteroanastomosis. Ref. 15.
Auth.
b14.3.2.101. Delayed diagnosis of
genital tuberculosis (case report). /G. Lortkipanidze,
L. Vashakidze, M. Nonikashvili, T. Mamaladze/. Tbilisi State Medical University
Collection of Scientific Works. – 2013. – #47. – pp. 109-111. – geo.; abs.:
geo., eng.
Georgia is a high
tuberculosis (TB) burden country. In addition to pulmonary TB, extra-pulmonary
TB cases are also presented in the country, genital TB being one of the types.
Diagnosis of genital TB is challenging due to lack of specific symptoms and
signs and low yield of instrumental investigations in identifying the causing
agent. A female patient (medical record No. 392) was diagnosed to have an
ovarian cancer after undergoing MRI, CT and micro-laparatomy. Three courses of
chemotherapy in combination with total surgery including hysterectomy, adnexal
and omentum resection were conducted. The morphological study of the resection
materials identified diagnosis of TB salpingo-oophoritis. During the
differential diagnosis of female genital diseases, tuberculosis should be
considered as a potential cause and consultation with a TB specialist with
relevant investigations should take place. Ref. 5.
Auth.
b14.3.2.102. Modification of determination of central
occlusion and method of fixation. /S. Mgebrishvili,
V. Gurbanov, I. Barbakadze/. Tbilisi State Medical University Collection of Scientific
Works. – 2013. – #47. – pp. 120-121. – geo.; abs.: geo., eng.
Central occlusion
is the functional position of lower jaw, from where all chewing movements begin
and end. The definition of central occlusion and its precise transfer to the
articulator is the basis for making movable dental prosthesis. We have
developed a method of central occlusion definition by applying the first layer
of the mass of silicone imprint. In comparison with the current method of
definition of central occlusion, the method proposed by us includes lots of
advantages, namely: 1) image of antagonist teeth is more exactly shown that
enables us to place models in the position of central occlusion without any
inaccuracy, 2) after hardening silicone becomes harder mass compared with the
softened wax that is later deformed. This feature of silicone enables application
even at the time of having higher ambient temperature, 3) enables anew
conduction of procedure till reaching desirable result without changing the
mold of wax, 4) it is possible to separate models easily from each other
without breaking plaster teeth, 5) procedure may be conducted easily by
facilitating doctor’s work. Fig. 2, Ref. 3.
Auth.
b14.3.2.103. Chronic viral hepatitis in Georgia. /I. Mchedlishvili, D.
Gelovani, R. Chochishvili, T. Mchedlishvili/. Tbilisi State Medical University
Collection of Scientific Works. – 2013. – #47. – pp. 121-123. – geo.; abs.:
geo., eng.
The investigation
of different types of hepatitis in Georgia revealed that during 2001-2011 the
incidence rate of acute hepatitis (hepatitis A, hepatitis B, hepatitis C) had
decreased significantly throughout the country as well as in Tbilisi. On the
other hand, morbidity of chronic hepatitis B and C had increased. In 2011 the
incidence of acute hepatitis A 33.4-times decreased in comparison with 2001,
while incidence of hepatitis B and C reduced 3.2-times and 4.7-times
accordingly. However, the incidence of chronic hepatitis B and C increased
13-times and 8.6-times correspondingly. The incidence rate of chronic hepatitis
B was 32 per 100 000 population in 2011. Recently, chronic hepatitis has high
prevalence in Georgia than in other countries of Europe. These infections
seriously affect public health in the country. Tab.2, Ref. 7.
Auth.
b14.3.2.104. Prevalence of
allergic rhinitis in children’s population – Adjara Region. /N. Katamadze, N. Adamia, L. Jorjoliani, N. Manjavidze, I.
Ubiria/. Tbilisi State Medical University Collection
of Scientific Works. – 2013. – #47. – pp. 135-137. – geo.; abs.: geo., eng.
Alergic rhinitis is a widely distributed
disease in children population. The goal of the study was estimation of
prevalence of allergic rhinitis under subtropical climate conditions in the
children population of Adjara region, Batumi. Study materials and methods:
Active detection of allergic rhinitis symptoms through study of prevalence was
conducted based on a single epidemiological study. For this purpose a
questionnaire, as well as an expanded, study-specialized map of allergic
rhinitis were developed;. We appropriated diagnostic-test criteria of allergic
rhinitis by ARIA (2008-2010 ) and selected a representative study cohort. The
studied population included 1237 children of Batumi population from 4 to 15
years (511 girls and 726 boys). The study cohort was distributed according to
age in two groups: the first group included 4-9 year-old children and the
second group - 10-15 year-old children. According to the survey, during 12
month the recurrence episodes of sneezing, especially in first part of day,
were detected in 9.8% of the study population and 52,8% of them were children from
group I and 47.2% from group II. Nasal itching was observed in 15.5% of cases,
45.4% of group II children and 54.6% of group I children. Rhinorrhea was
observed in 14.5% of cases, mainly in children from group II (69.8%). 13.9% of
respondents had nasal obstruction. Positive results frequency was high in
children from group I (57.1%). The mentioned symptoms in 4.5% of cases were
accompanied with lacrimation and eye itching. The prevalence of allergic
rhinitis symptoms in Adjara region was significantly high in boys compared with
girls (p<0.05). According to the results, in the study cohort, the allergic
rhinitis was diagnosed in 15.3% cases. Late diagnostics of allergic rhinitis
and hypo diagnostics are still a problem. Conclusion: According to the epidemiological
study of allergic rhinitis in children population of Batumi, prevalence of
allergic rhinitis was 15.3%, in 4.5% of cases being accompanying with
conjunctivitis. Based on a combination of surveys, the clinical and specific
allergic diagnostic peculiarities in 56.7% of cases intermittent (56,7%) and
persistent (43.3%) allergic rhinitis was established with moderate (47.8%) and
mild (52.2%) progress. The epidemiological study showed high frequency of hypo
diagnostics. Tab. 4, Ref. 10.
Auth.
b14.3.2.105.
Factors influencing the timing of
infant’s complementary feeding. /N. Kavlashvili, M. Kherkheulidze, E. Kandelaki, I. Chkhaidze/. Tbilisi State Medical
University Collection of Scientific Works. – 2013. – #47. – pp. 140-143. –
eng.; abs.: geo., eng.
The aim of the present study was to find out
factors influencing the timing and adequacy of complementary feeding practices.
The study was conducted at M. Iashvili Central Children’s Hospital Child
developmental Center in 2013 year. The data was collected from 389 mothers of
infants’ age ranging from six months to one year. A one-page questionnaire as a
survey instrument was designed. Demographic variables were age, sex of the
infant, mother’s age, occupation of parents and residential area Women’s knowledge
of optimal child feeding practices and socio-cultural influences of child
feeding were also included in the questionnaire. Data entry and analysis was
done using SPSS statistical program. Completely filled questionnaires were
received from 358 mothers. Results of the study show that CF was started in
time only in 30,2%. In 18,1% it was introduced too early (<4 month), in 27,3
early (4-6 month) and in 11% - late (after 7 month). 13.4% of children haven’t
stared CF at all. Results of the study show that most interviewed women lived
in urban area (73.3%), most of them has high school/university education
(65.1%), 51.7% of them were employed. 24.3% of infants came from single-child
families, 75.6% from families with two or more children. Timing of complementary
feeding was related to maternal age, young mothers started CF either too early
or late. In rural areas early CF was significantly high than in urban areas
(P<0,05). Proportionally employed mothers and students also started CF
earlier than housewives (P<0.01). Mothers who had 2 and more child
introduced CF timely compared to those who had the first child (P<0.01).
Most of mothers received information about semi-solid and solid food used for
CF from pediatricians and family-doctors. From 98 cases when CF was started at
4-6 month, in 59% it was recommended by doctor. Our research study showed that
educated women started complementary feeding of their infants at appropriate
ages. 39 The data from the current study shows that many infants are beginning complementary
feeding earlier than WHO recommends (6 month). Findings from our study showed
that maternal knowledge, age, education level was directly related with timing
of CF. Promotion of strong community based education and support to ensure
optimal infant and young child feeding is recommended. Tab. 2, Ref. 18.
Auth.
b14.3.2.106. Rotaviral infection in children. /I. Shalamberidze, T. Jokhtaberidze, M. Khotchava/. Tbilisi State Medical University Collection
of Scientific Works. – 2013. – #47. – pp. 143-145. – geo.; abs.: geo., eng.
The research was conducted in Children’s
Infectious Diseases Hospital. For the diagnosis of rotaviral infection a quick
test RIDA®Quick Rotavirus/Adenovirus Combi was performed. In total, 54 patients
with diarrhea upon admission were assessed. Among them 74.06% were positive to
rotaviral infection. Some of the patients had mix-infections (5.56%). The
majority of the patients were males – 34 (63%), and 20 (37%) - were females.
Most of the patients had persistent vomiting, which complicated with oral
rehydration and required intravenous infusions of saline solution (Ringer
Lactated solution, NaCl – 0.9%, Ringer solution). According to the research in
Children’s Infectious Diseases Hospital rotaviral infection is the leading
cause of diarrhea in children and is one of the main reasons of admission to
Hospital. The diseases in most cases are convoyed with moderate dehydration,
and a severe dehydration with hypovolemic shock is rare. All received data is
reflecting also literature overviews. Tab. 1, Fig. 7, Ref. 5.
Auth.
b14.3.2.107. Modern methods for treatment of vitiligo /N.V. Tsiskarishvili, A. Katsitadze, L.
Chitanava, N.I. Tsiskarishvili/. Tbilisi State Medical University Collection
of Scientific Works. – 2013. – #47. – pp. 151-155. – geo.; abs.: geo., eng.
The paper presents a review of modern methods
for treatment of vitiligo and the mechanisms of their action. The existence of
different forms of vitiligo creates the need for individual selection of
therapy for each patient. Each therapeutic model should be applied sufficient
period of time, since the initiation of repigmentation may be very slow.
Effective therapy has to be continued up to complete repigmentation.
Non-surgical treatments involve the use of certain topical and oral
preparations (topical and oral corticosteroids, calcineurin inhibitors, topical
analogs of vitamin D3, topical L-phenylalanine, antioxidants, stimulants of
mitochondrial activity in combination with natural sunlight and oral Helins).
In case of unsuccessful aforementioned conservative therapy, phototherapy
(monotherapy or in combination with topical treatment) is recommended.
Monochromatic excimer laser phototherapy (monotherapy or in combination with
topical corticosteroids or calcineurin inhibitors) may be used as a reserve
therapy in patients with unsuccessful phototherapy (UVB, UVA). Surgical
procedures can be used in case of ineffective conservative therapy. The correct
choice of techniques to suit the individual characteristics of the patient and the
surgeon’s skills can provide excellent cosmetic results. Special depigmentation
methods can be used for treatment of Generalized / universal vitiligo taking
into account their irreversible effects. At all stages of treatment we have to
remember that vitiligo is chronic condition that dramatically affects the
psychological aspects of the patient’s life. Camouflage techniques may provide
a temporary cosmetic effect, and psychotherapy can help patients overcome
psychological aspects of the disease. Ref. 39.
Auth.
b14.3.2.108. Influence of the
intestinal lavage with mineral water “Nabeghlavi” on the external secretion of
liver. /I.
Chabashvili, N. Saakashvili/. Tbilisi State Medical University Collection of
Scientific Works. – 2013. – #47. – pp. 155-157. – geo.; abs.: geo., eng.
80 patients with chronic cholecystitis were
observed. They took mineral water “Nabeghlavi” and utilized the same water for
intestinal lavage. As a result, because intestinal lavage leads to the
inactivation of toxic substances and better depletion, which prevents the liver
from getting toxic substances, the double effect was achieved. High efficiency
of the mineral water “Nabeghlavi” is associated with the stimulation of hepatic
blood flow, elimination of cholestasis, reduction of inflammation and
improvement of the chemical composition of bile. The mineral water “Nabeghlavi”
contributes to the development of intestinal nonpathogenic microflora, which is
impossible to reach by medications. Ref. 4.
Auth.
b14.3.2.109. Rehabilitation of patients with acalculous
chronic cholecystitis with low-mineralized water “Sakharbedio”. /I. Chabashvili, N.
Saakashvili/. Tbilisi State Medical University Collection of Scientific Works.
– 2013. – #47. – pp. 157-158. – geo.; abs.: geo., eng.
Chronic diseases of digestive system are
considered as diseases of the century. We used the less studied mineral water
“Sakharbedio” in patients with biliary system disorders. “Sakharbedio” is the
law-mineralized water from the resort Menji. 70 patients with calculus chronic
cholecystitis were investigated. They were taking 3,5ml/kg of the mineral water
“Sakharbedio” three times per day during 24 days. At the same time the patients
were adhered to dietary food according to the conditions of gastric secretion.
Mineral water “Sakharbedio” improves liver function, urination, positively
influences motor and concentration functions of the gallbladder. Investigation
of the features of “Sakharbedio” revealed significant detoxification and
spasmolytic effects of this mineral water and its extremely attractive
properties – “Sakharbedio” is ecologically safe, effective, low-cost natural
factor without side effects. Ref. 4.
Auth.
b14.3.2.110. Evaluating the state of the
morphological parameters of root and canals of maxillary
incisors and canines in Georgian population. /N. Chipashvili, E.
Beshkenadze/. Tbilisi State Medical University Collection of Scientific Works.
– 2013. – #47. – pp. 158-161. – geo.; abs.: geo., eng.
One of the main reasons that cause the failure
of endodontic treatment is the lack of knowledge of the complex anatomy of
tooth cavity. Numerous researchers have laid the foundation for anatomical and
morphological peculiarities of root system of the tooth, their classification
and nomenclature indices. This study is devoted to the investigation of
anatomomorphological peculiarities of maxillary anterior teeth (incisors and
canines) in Georgian population. The purpose of the work was to study the
anatomo-morphological data of teeth among Georgian population, to establish the
average statistical indices of tooth length, the peculiarities of “canal
system” and to make a correlation between the obtained results with the
international statistical indices. Tab. 2, Ref. 9.
Auth.
b14.3.2.111. Factors affecting
child development and behavior. /M. Kherkheulidze, N. Kavlashvili, I.
Chkhaidze, E. Kandelaki/. Tbilisi
State Medical University Collection of Scientific Works. – 2013. – #47. – pp.
165-168. – eng.; abs.: geo., eng.
The aim of the study was to assess early
child development and identify biological as well as social risk factors that
affect development. MATERIALS AND METHODS -The case-control study was conducted
at M.Iashvili Central Children’s Hospital Child developmental Center during
2013 year. We assessed 2449 0-6 years old child admitted during the 2013 year
for developmental and school readiness assessment. The full ante and postnatal
as well as family history was collected, patients were assessed for physical
and global development by special tools. In problematic cases child were
assessed by neurologists, psychologists, ophthalmologists and hearing screening
was conducted. RESULTS From the studied children 53,3% were boys and 46,7%
girls (n=1143), 12,3% were under 1 year old, 21,2 from one to 3 year, 46,7%
from 3- to and 21,2% from 5 to 6 years. 5,8% of studied population was
premature. Most frequent neonatal problems most were: RDS that occurs in 8%,
hyperbilirubinemia 2.1%, infections 2.0%, congenital anomalies 0.5%. From the
family anamnesis most frequent were endocrine disorders (19.9% and allergic
diseases 14.4% (n=352). From the family social problems most frequently were
met economical shortages 55.6 45%. The results of the physical development show
prevalence of the high weight for age (5.1%), while low weight and height for
age were met in 1.5% and low weight for age 1.2% of cases. Among developmental
and behavioral disorders emotional disorders were met in 8.2%, behavioral and
emotional disorders 4.8% expressive language delay 2.2%, autistic spectrum
disorders 1.6%. The study revealed significant correlation between the mother
education level and child development (P<0.0001). The incidence of autistic
spectrum disorders is significantly higher in boys then in girls (P<0.0001).
Economical shortage influence child development and behavioral problems. The
frequency of developmental and behavioral disorders is significantly higher in
premature infants and in children with neonatal problems that need
resuscitation. CONCLUSION The biological (prematurity, neonatal problems) as
well as social factors (economical shortage, low maternal education) influence
child development increasing developmental and behavioral problems in early
years. Tab. 2, Fig. 1, Ref. 21.
Auth.
b14.3.2.112. Spontaneous and
specific modulation peculiarities of T-lymphocytes’ adhesive receptors during
parodontitis. /L. Jashi, M. Iverieli, N. Abashidze, N.
Gogebashvili, Kh. Gogishvili/. Tbilisi State Medical University Collection of Scientific
Works. – 2013. – #47. – pp. 170-172. – geo.; abs.: geo., eng.
The article studies
the spontaneous and specific modification peculiarities of adhesive receptors
of leukocytes during parodontitis. We have determined that during parodontitis,
the spontaneous activity of T-lymphocytes’ adhesive receptors increases
depending on the process generalization. Unlike T-lymphocytes, the activation
of neutrophils’ adhesive receptors’ synthesis is insignificantly reflected and
does not depend on the degree of the development of pathological process. The
specific sensitization of the adhesive receptors of T-lymphocytes was more
often revealed towards bacterial lipopolysaccharides versus liver
lipopolysaccharides. The modulation of the adhesive function of T-lymphocytes
using adhesive activity regulators, such as Prostaglandini (PE2), recombinant a2 interferon (r2INF), and Type I Collagen cause conflicting effects. The
intensity of the effects is triggered by the strong pathological process in
Parodontitis. More often Prostaglandin E2 results in inhibition of adhesive
receptors of T-cells, while recombinant a2 interferon and Type I Collagen lead to the
stimulation of the receptors. Ref.11.
Auth.
b14.3.2.113. Using antioxidants, the kallikrein kinin system and lipid peroxidation inhibitors in the
thrombolytic therapy of acute myocardial infarction. /M. Jibladze, A.
Kistauri/. Tbilisi
State Medical University Collection of Scientific Works. – 2013. – #47. – pp.
172-177. – geo.; abs.: geo., eng.
104 patients with acute myocardial infarction (AMI) and 44 controls
were studied to assess the efficacy of thrombolytic therapy (TLT) in patients
with AMI using antioxidants and kallikrein kinin system (KKS) and fat
peroxidation (LPO) inhibitors. Findings: 1. Using antioxidants and KKS and LPO
inhibitors improves the course of AMI, significantly reduces the level of
ischemia, and decreases the hospitalization period, number of complications and
lethal outcomes. 2. Pathogenesis of favorable effect of using KKS and LPO
inhibitors in the treatment of myocardial infarction includes the improvement
of re-oxygenation stress, blood rheology and fermentation, coronary blood
circulation and myocardial electrophysiological function. 3. Favorable effect
of TLT using antioxidants, KKS and LPO inhibitors is linked to avoiding
complications of reperfusion. Tab. 4, Fig. 4, Ref. 13.
Auth.
b14.3.2.114. The role of multiplanar computed tomography in the diagnostics of tumors of the neck.
/F. Todua, K. Mardaleishvili,
L. Gzirishvili, D. Miminoshvili, G. Tsivtsivadze, R. Kharadze/. Clinical
Oncology. – 2014. – #2. – pp. 16-23. – geo.; abs.: eng.
MDSCT-Angiography is an effective, highly informative
method in the diagnosis of neck tumors that enables us to assess the changes
around the tumor, also walls of large vessels and evaluate intra and
peritumoral vascularization of tumors. The MDSCT-Angiography plays very
important role in planning the treatment tactics. Fig. 8, Ref. 17.
Auth.
b14.3.2.115. Methodological principles to improve results of treatment for rectal
cancer. /B. Mosidze, D. Lomidze, G. Kevlishvili/. Clinical Oncology. – 2014. – #2. – pp. 24-31. – geo.; abs.: eng.
Treatment
of rectal cancer must be complex and include radical surgery, chemotherapy and
radiotherapy. Such treatment gives significant improvement of distant
results (20%), where 20% = 100%! The correctly conducted combined treatment
increases the number of organ-saving interventions, and makes possible
reconstruction and restoration operations, improves quality of life, increases
the number of socially rehabilitated patients. Preoperative radiation therapy
in combination with mesorectumectomy gives the best result in case of rectal
malignancies. New technologies significantly expand boundaries of radical
influence on tumor, preserve the function of damaged organ and improve quality
of life of people with cancer. Tab. 3, Ref. 9.
Auth.
b14.3.2.116. Management of thyroid
differentiated carcinoma therapy (University
Clinic of Nuclear Medicine of the Vienna General Hospital). /N. Shengelia-de Lange/. Clinical Oncology. – 2014. – #2. – pp. 42-47. – geo.; abs.: eng.
Thyroid
disorders are widespread; a large proportion of the world’s population is in
need for treatment. Nuclear medicine is a well-used discipline for the
diagnostic and treatment of various cancers and disorders, in particular those
of the thyroid gland. Since the 1950, Iodine 131 radiation therapy is used
successfully in patients with both benign and malign abnormalities in the
thyroid. Ablation therapy with use of I-131 capsules is a well-established
method for the treatment of differentiated thyroid cancer; when given after a
total thyroidectomy, the patients’ prognosis is evidently better. This article describes
the long time experiences of the University Clinic of Nuclear Medicine of the
Vienna General Hospital (AKH), which treats more than 500 patients annually in
its safeguarded inpatient ward. Fig. 3, Ref. 7.
Auth.
b14.3.2.117. Efficiency of treatment with Bolnisi mineral water in the
case of some pathologies of alimentary organs. /L. Burchuladze/.
Modern aspects of medical rehabilitation, prevention and healthy lifestyle.
Int. Symp. – Sairme. 9-13 Oct. – 2014. – pp. 23-28.
– geo.; abs.: eng., geo.
92 patients with gastiritis chronica and cholecystitis
chronica were kept under observation. They were given the Bolnisi mineral
water taking into account a secretory function of stomach. The analysis of
findings made clear that after treatment with the Bolnisi mineral water, the
secretory functions of stomach were regulated, the functional state of the
liver, biliary tract and bile composition were improved. Tab. 3.
Auth.
b14.3.2.118. Effect of complex medical rehabilitation by physical
factors on patients with spondyloarthritis ankylopoetica. /I. Tarkhan-Mouravi,
M. Tabidze, I. Malazonia, E. Khelashvili/. Modern aspects of medical
rehabilitation, prevention and healthy lifestyle. Int. Symp. – Sairme. 9-13
Oct. – 2014. – pp. 36-39. – geo.; abs.: eng., geo.
It is
found that complex medical rehabilitation using electromagnetic field of
millimeter waves, thermal baths of sulphide water, massage of spine and the
affected joints and muscles, causes in patients with spondiloarthritis
ankylopetica weakening, until disappearance, of inflammatory and destructive
processes in the spine and in the affected joints and muscles, as demonstrated
by reduction in the blood serum of C-reactive protein, haptoglobin, seromucoids
and alkaline phosphatase; and reduction, down to the norm, of the erythrocyte
sedimentation rate. Weakening, until the disappearance, of inflammatory and
destructive processes in the specified structural formations entailed the
improvement of movement in the spine and joints, and index increase of the spine,
which was accompanied by the improvement of radiographic indicators (expansion
of the intervertebral and sacroiliac joint gaps and alignment of the articular
surfaces of affected joints), increase in working capacity and reduction, until
disappearance, of pain in the spine and in the affected joints and muscles.
Ref. 3.
Auth.
b14.3.2.119. The effectiveness of a complex treatment with Borjomi
mineral water in the patients with diabetes mellitus. /N. Malania/. Modern
aspects of medical rehabilitation, prevention and healthy lifestyle. Int. Symp.
– Sairme. 9-13 Oct. – 2014. – pp. 40-44. – geo.; abs.: eng., geo.
Total of 171 patients with diabetes of light
and middle severity were examined. In some of the patients accompanying
diseases were noticed, such as heart-blood-vessels and the system of digestion.
The patients were examined before and after medical treatment together with
subjective and objective data, carbohydrate and lipid metabolism. Methodology
of the medical treatment included: medical nourishment, taking Borjomi mineral
water, in case of need taking medicines for lowering diabetes, medical
gymnastics, and passive climate-therapeutics. Pursuant to the treatment the
following was established: subjective and objective data have been
significantly improved, normalization of carbohydrate and lipid metabolism took
place in the patients; as at Borjomi resort, so beyond it, number of the
anti-diabetes medicines taken by the patients had been reduced, or they were
completely removed. Ref. 6.
Auth.
b14.3.2.120. Effect of medical rehabilitation of patients with
bronchial asthma using aloe and silver electrophoresis. /I. Tarkhan-Mouravi,
K. Saganelidze, N. Gurgenidze/. Modern aspects of medical rehabilitation,
prevention and healthy lifestyle. Int. Symp. – Sairme. 9-13 Oct. – 2014. – pp.
141-144. – geo.; abs.: eng., geo.
It is found that medical rehabilitation of
patients with bronchial asthma using aloe and silver electrophoreses causes
weakening, until disappearance of the organism sensitization and of inflammatory
process in the bronchi; strengthening of the cellular link of immunity;
improvement of immunological indices, respiratory function and clinical status.
The indicated positive changes decreased with aggravation of the disease.
Auth.
b14.3.2.121. Effect of medical
rehabilitation on patients with
traumas of peripheral nerve trunks of the extremities (TPNTE) with the complex use of electrostimulation and Akhtala therapeutic mud. /N. Saakashvili, I. Tarkhan-Mouravi, N. Kakulia, N. Jakobia, I. Kvinikadze,
N. Kvinikadze/. Modern
aspects of medical rehabilitation, prevention and healthy lifestyle. Int. Symp.
– Sairme. 9-13 Oct. – 2014. – pp. 167-169. – geo.; abs.: eng.,
geo.
It has been established that the above-said medical rehabilitation with the
complex use of electrostimulation and Akhtala
therapeutic mud evokes a weakening of inflammatory process (up to the
disappearance) in the focus of damage of peripheral nerve trunks of the
extremities in the patients with TPNTE of the extremities, which has a
normalizing action on the functions of the central and peripheral nervous
systems. The weakening of the
inflammatory process (up to the disappearance) evokes an enhancement of
cellular link of immunity in the focus of damage of peripheral nerve trunks
extremities and immunobiological reactivity in the patients with TPNTE of the
extremities, the recovery of regulatory function of T-lymphocytes; has a
normalizing effect on non-specific resistance of the organism and the indices
of humоral immunity, improves
the neuromyographic, rheovasographic and clinical data. These positive shifts
were more pronounced at neurapraxia of peripheral nerve trunks of the
extremities. The indicated rehabilitation had a positive effect on all the
investigated patients.
Auth.
b14.3.3.1. The role of sanology in modern medicine. /I. Dolidze/. Modern Issues of Medicine and Management. – 2014. – #1. –
pp. 24-30. – geo.; abs.: geo. eng. rus.
The work considers the
problems of development of perspective direction – sanology (medicine of
health). Researches in this direction are not conducted in Georgia. This work
is topical and promotes the development of health criteria and implementation
of healthy life style in population. Ref. 9.
Auth.
b14.3.3.2. Efficiency investment for health security of people
working in harmful conditions. /M. Lomsadze-Kutchava/. Modern Issues of
Medicine and Management. – 2014. – #1. – pp. 52-60. –
geo.; abs.: geo. eng. rus.
In this paper, we
analyse the effectiveness of investments made to ensure the health safety of
people working in hazardous conditions. The article discusses the factors that
adversely affect the health of people, such as loud noise, polluted
environment, electromagnetic field, etc. The paper discusses the efficiency of
investments made in the mentioned problems and economic aspects of the
activities to be implemented. It also provides recommendations and recipes for
improving health in hazardous conditions. Tab. 5, Ref. 6
Auth.
b14.3.3.3. Managerial
innovations and ways to improve the quality of service in the primary health
care. /T. Chakhunashvili, L. Chakhunashvili/. Modern Issues of
Medicine and Management. – 2014. – #1. – pp. 61-70. –
geo.; abs.: geo. eng. rus.
The article deals with the importance of
familiarization with the progressive international experience accumulated in
the sphere of primary health care and the level of satisfaction of local
population with the services provided in this health care sector. It found out
that the available level of medical services in the country fails to meet
international standards, which adversely affects the medical service efficiency
and quality. It is noted that special attention should be paid to the
evaluation of outcome, because the outcome is exactly what reflects the main
goal of medical service – to provide a patient with appropriate medical
service. The study results are given. Tab. 1, Fig.
2, Ref. 20.
Auth.
b14.3.3.4. Problems of
organization of healthcare system management and medical service. /E. Motsonelidze, R. Kutateladze/. Modern Issues of Medicine and Management. –
2014. – #1. – pp. 71-80. – geo.; abs.: geo. eng. rus.
A healthcare system management model is proposed, as
well as the options of organization of medical service and an innovative model
of physicians' activity. Tab. 1, Fig. 3, Ref. 7.
Auth.
b14.3.3.5. The importance of
marketing in healthcare system. /D.
Pirtskalava, I. Tsurtsumia/. Modern Issues of Medicine and Management. – 2014. – #1. –
pp. 88-92. – geo.; abs.: geo. eng. rus.
The role of marketing in the healthcare system is
discussed in connection with the regulation of demand for medical service under
conditions of the state healthcare programs’ implementation. The influence of
marketing on such type of relations and the possibilities of achieving success
are considered. Ref. 5.
Auth.
b14.3.3.6. Evaluation
of state opioid substitution treatment program in Georgia. /G. Piralishvili, D.
Pirtskalava, M. Chavchanidze,
I. Gamkrelidze, N. Nikolaishvili/. Georgian Medical News. – 2014. – #4(229). – pp. 62-66. –
eng.; abs.: geo., eng., rus.
The aim of the research was
evaluation of the results of the state opioid substitution programs by means of
methadone and buprenorphine/naloxoneam in Georgia and the optimization of the
routine measurement instrument. A detailed analysis of the conducted survey and
results (statistics) of the treatment of different categories of patients is
given, with the discussion of positive and negative effects. Tab. 2, Ref. 9.
Auth.
b14.3.3.7. Reflection
of tolerance to alcohol in the structure of the sleep-wakefulness cycle. /M. Gogichadze, M. Nemsadze, N. Lortkipanidze, E.
Khachaturov, N. Oniani/. Georgian Medical News. – 2014. – #10(235). – pp. 87-92. – eng.; abs.: geo., eng., rus.
The purpose of the present work
was to study the effects of tolerance to ethanol on the sleep-wakefulness cycle
(SWC) structure. Experiments were carried out in chronic conditions on the adult
cats (n=5). The following methods were used: the stereotaxic - for implanting
electrodes; polysomnographic - for EEG registration of the SWC structure.
Alcoholisation (0.2-2.5 g/kg 25% ethanol solution) was conducted by
intraperitoneal injections that lasted for two weeks. The obtained results were
processed statistically and significance of the changes was determined by the
Student t-test. Low single doses of ethanol (0.2 - 0.5 g/kg) did not induce any
significant changes in the structure of the SWC. While using doses of 0.6 g/kg
it was noted only increasing of the latent period of the onset of sleep.
However, the structure of the SWC recovered within 1-2 hours after injection.
Increasing the dose to 1 g/kg caused severe intoxication. This was reflected in
a behavioral (anxiety, tremor, vocalizations) and autonomic (vomiting and
frequent urination) signs. Against the background of restless behavioral
wakefulness synchronization of the characteristic of light slow-wave sleep
developed. The volume of deep slow-wave sleep was statistically significantly
decreased and the latent period of the onset of paradoxical sleep was
increased. The structure of sleep was fragmented, due to frequent awakenings.
For the fifth-eighth day of alcoholization the structure of the SWC restored,
behavioral and vegetative signs of intoxication disappeared, which must
indicate the development of tolerance to this dose of ethanol. The obtained
results signify that development of tolerance to ethanol can be reflected in
the alteration of the structure of SWC. Alcoholization disturbs the subtle
mechanisms of the sleep due to destruction of brain homeostasis. Fig. 3, Ref.
14.
Auth.
b14.3.3.8. Cannabis:
a controversial 21st-century drug of antiquity. /D. Greydanus, M. Holt/. Georgian Medical
News. – 2014. – #5(230). – pp. 24-30. – eng.; abs.:
geo., eng., rus.
Cannabis consumption has been
popular for thousands of years and its historical use is noted in many parts of
the world, including ancient China, India, and the Middle East. It is currently
the most popular illicit drug in the world, being utilized as a medicinal
plant, and many parts of the world are legalizing its consumption. This article
considers various aspects of cannabis use, including its prevalence, history,
co-morbid drug abuse, designer cannabinoids, psychiatric adverse effects,
medical adverse effects, and management options. The youth of the world should
be comprehensively taught that cannabis is neither safe nor benign. Prevention
with comprehensive drug education is the best plan for our youth since
management of chronic or heavy cannabis consumption is difficult and fraught
with failure if cessation is the goal. Caveat
emptor! Tab. 2, Ref. 42.
Auth.
b14.3.3.9. Final height, target
height and the community. /M. Hermanussen, C. Aßmann, D.
Groth, K. Staub/. Georgian Medical News. – 2014. – #5(230). – pp. 30-34. –
eng.; abs.: geo., eng., rus.
Height varies with age, and it varies with
historic time. Final height is determined by endocrine parameters and genetics,
by nutrition and health, by environmental factors, by birth weight, early
growth, BMI, and developmental tempo. European populations of the 19th
century were short, but their shortness did not result from growth impairment
at all ages. In those days, shortness was mainly due to a significantly blunted
adolescent growth spurt. New modeling approaches suggest an independent
regulation of adolescent growth and final height: the target for growth and final height appears to be set by the community. In
order to test this hypothesis, we formed a geographic network of Switzerland
consisting of 169 nodes (district capitals) and 335 connecting edges (roads),
and investigated military conscript data obtained between 2004 and 2009.
Average height of Swiss military conscripts was 178.2 cm (SD 6.5 cm). But
conscripts from first order neighboring districts were more similar in height
than expected. Short stature districts have short, tall stature districts have
tall neighbors. We found significant height correlations between 1st
(r=0.58), 2nd (r=0.64), 3rd (r=0.45) and even 4th
order neighbors (r=0.42). It appears that tall stature communities generate
tall people, short stature communities generate short people, and migrants
orientate towards the new height target of their host population (community
effect on growth). Fig. 6, Ref. 18.
Auth.
b14.3.3.10. The
health of adolescents around a world in transition. /P. Michaud, A. Ambresin/. Georgian Medical
News. – 2014. – #5(230). – pp. 54-59. – eng.; abs.:
geo., eng., rus.
For several years, the health of
adolescents has been on the agenda of ministers, decision makers and health
professionals. Around the world, while there has been a steady decrease of the
death rates among young children, this is not the case for young people. This
is mainly linked with the fact that mortality and morbidity during this period
of life is largely linked with non-communicable diseases and conditions,
including deaths from injuries, suicide, homicides and drug abuse. Unplanned
pregnancies, illegal abortions, newly acquired HIV infections are also
situations that have short and long term consequences. This paper reviews the
epidemiological data pertaining to adolescent health and disease. It proposes
evidence-informed avenues as how to address these issues in the field of health
care (e.g. adolescent friendly services) and of prevention and health
promotion. It also stresses the importance of creating safe environments for
the development and well-being of young people and thus, of an
interdisciplinary and inter sectorial approach to their complex health problems
and challenges. Ref. 28.
Auth.
b14.3.3.11. Medical-social
peculiarities of health state of schoolchildren in Ukraine. /S. Nyankovsky, M. Iatsula, O. Senkevich, I.
Pasichnuk/. Georgian Medical News. – 2014. – #5(230). – pp. 60-65. – rus.; abs.: geo., eng., rus.
The article considers the results
of surveys on school children’s health in Lvov region in the years 2002 and
2012. The basic risk factors for functional disorders, school disadaptation
syndrome, and neurotic reactions are presented as well as the age prevalence of
basic complaints. Among the factors that contribute to the decline of child’s
health level an important role belongs to the educational loading. It causes
fast development of disadaptation syndrome with the neurotic reactions in
different degree of expressiveness. The complex estimation of the children’s
health state and introduction of new technologies of revitalizing give an
opportunity to prevent the increase of functional disorders and organic
pathology in schoolchildren. Ref. 14.
Auth.
b14.3.3.12. Childhood
vasculitis hospitalizations in Spain, 1997-2011. /A. Villaverde-Hueso, V. Lonso, A. Morales-Piga, M.
Hens-Pérez, I. Abaitua, M. Posada-de-la-Paz/. Georgian Medical
News. – 2014. – #5(230). – pp. 65-72. – eng.; abs.:
geo., eng., rus.
The aim of this study is to
describe the childhood vasculitis hospital burden in Spain (1997-2011),
considering type of disease, hospitalization rates and time trends. Data were
obtained from the National Discharges Basic Minimum Data Set (National Patient
Data Base). Inpatient events of children younger than 15 years of age were
analyzed. Principal diagnosis of vasculitis were selected according Ninth
Revision of the International Classification of Diseases: Takayasu arteritis,
Polyarteritis nodosa, Kawasaki disease, Wegener`s granulomatosis, Churg-Strauss
syndrome, and Henoch-Schönlein purpura. A total of 14518 children
hospitalizations related to vasculitis were identified in Spain from 1997 to
2011. The average hospitalization rate for children was 13.33±1.71 per 100,000.
Henoch-Schönlein purpura and Kawasaki disease were the most common type of
vasculitis, hospitalization rates were 11.00 and 3.97 per 100,000 children,
respectively. Other vasculitis hospitalizations are much rare in childhood.
Average length of stay was 6.04 days and estimated cost per inpatient hospital
care was 2,847€. Hospital case fatality rate was 0.05% for overall vasculitis.
In conclusion, epidemiological data of childhood vasculitis are useful both to
health decision-making and to identify research priorities. Tab. 2, Fig. 2,
Ref. 33.
Auth.
b14.3.3.13. Some
personal views on pediatrics and not only. /K.
Pagava/. Georgian Medical News. – 2014. – #5(230). – pp. 82-86. – eng.; abs.: geo., eng., rus.
The paper presents the author’s
personal views on youth education, medical education, child and adolescent
physiology, some other common medical and pediatric issues. The role of the
physician as an educator of the child is underlined. The pediatrician must be
the main advisor to the society, school and family in the matter of youth
education, contribute to their optimal self-realization. The importance of
moral values, gender peculiarities and cultural codes are emphasized. The
imprinting of cultural codes should be considered as a biological basis of
patriotism. The effectiveness of the implementation of healthy life style is
discussed. The opinion regarding the protection of youth from potentially
negative effects on their development and behavior is expressed. It would be
purposeful to give more consideration to the fundamental research, particularly
to the problem of age-related morphological and functional peculiarities of the
growing organism in the conditions of norm and pathology. One should have in
mind the importance of research of the combination of harmful factors for the
organism. The elaboration of empathic and optimistic attitudes should be considered
as the very important goals of medical education. The differential usage of
clinical guidelines is discussed. It is mentioned the purposefulness of more
wide application of fuzzy logic approaches in medicine. The items of rare
diseases, individualized medicine, alternative medicine and bacteriophage
therapy are discussed as well. Ref. 12.
Auth.
b14.3.3.14. Dietary
fiber’s benefit for gallstone disease prevention during rapid weight loss in
obese patients. /G. Sulaberidze, M. Okujava, K. Liluashvili,
M. Tughushi, S. Bezarashvili/. Georgian Medical News. – 2014. – #6(231). – pp. 95-99. – eng.; abs.: geo., eng., rus.
The aim of the present study was
to compare the effects of very low calorie diets – protein rich and dietary
fiber-rich food based – on gallstones formation during rapid weight loss. 68
patients were involved into the study. The body weight index in all cases
exceeded normal value and equaled to 35±4.7 kg/m2. For weight correction purposes during 5 weeks
the patients in first group were kept on a 520-800 kcal diet of “Margi” food
products prepared according to our technology, and in the second group - on a
protein rich diet of the same calorie content. The body weight and changes in
the gall-bladder wall and content were assessed by sonography before starting
the diet, after three weeks from the commencement of the diet and upon its
completion. The measurement of the body weight after completion of the 5 week
diet revealed decrease by 10.9±1.5kg in the first group and by 11.2±1.1kg in
the second group. Sonography disclosed growth in the amount of biliary sludge
in 3 cases in the first group and in 9 cases in the second group. The
statistical analyses of results indicate successful and nearly equal reduction
of body weight by means of dietary fiber rich and protein rich diet, but high
fiber consumption showed statistically significant benefits for prevention of
biliary slug accumulation. The study showed that, in the respect to weight
loss, diets based on fiber rich and protein rich food are equal, but fiber rich
diet has considerable privilege in prevention of gallstone disease. Our
findings support the presence of known association between increased dietary
fiber consumption and reduction of gallstone formation. Obesity and rapid
weight loss are risk factors for development of gallstones. Taking in account
the beneficial effect of dietary fiber, the food rich in this nutrient,
particularly low-calorie fiber-rich food “Margi”, can be recommended for rapid
weight loss in obese patients. Tab. 2, Ref. 15.
Auth.
b14.3.3.15. Antimullerian
hormone in cases of different reproductive pathologies. /L. Barbakadze, J. Kristasashvili/. Georgian Medical
News. – 2014. – #7-8(232-233). – pp. 16-21. – eng.; abs.: geo., eng., rus.
The aim of this study was to
define the importance of determination of AMH during different reproductive
pathologies and to identify the correlations between the tests currently used
in ovarian reserve assessment (AMH, FSH, AFC) in different age groups of
infertile woman. Study population consisted of 153 women. In 41 women with
different reproductive pathologies we evaluate the values of AMH. 112 women
with infertility were divided into the three age groups: group I <35 years
(n=39); group II 35-40 years (n=31); and group III >40 years (n=42). AMH,
FSH and AFC were determined on days 2-3 of menstrual cycle. We evaluated the
AMH values during different reproductive pathologies (n=41) and found that: in
cases of gonadal dysgenesis and ootesticular disorders AMH levels are
decreased. In cases of POI AMH levels were extremely low. Normal levels of AMH
were detected in cases of Hyperprolactinemia and Hypogonadotropic hypogonadism.
In patients with PCOS AMH levels were increased. The correlation analysis
between ovarian reserve tests was performed in 112 infertile women. Generally,
age is in a significant high negative correlation with AMH level (rs=-0.67,
p<0.0001) and AFC (rs=-0.55, p<0.0001), and in positive
correlation with FSH (rs=0.38, p<0.0001). AMH negatively
correlates with FSH (rs=-0.48, p<0.0001) and positively with AFC
(r=0.71, p=0.0001). There is a moderate negative relation between FSH and AFC
(r=-0.41, p=0.0001) and moderate positive relation between age and FSH (rs=0.38,
p<0.0001).The correlation analysis performed in separate groups showed that
AMH and AFC in all three study groups correlates positively and are
statistically significant (r=0.57, p<0.0001; r=0.69, p<0.0001; r=0.47,
p<0.002 respectively). Whereas statistically significant correlation between
FSH and AMH detected only in the first and second age groups (r=-0.41,
p<0.02; r=-0.55, p<0.0001 respectively). Statistically significant
correlation between FSH and AFC revealed only in the third age group (r=-0.42,
p<0.006), as well as between age and AFC only in first age group (r=-0.35,
p<0.03). Nowadays, among used ovarian reserve assessment tests AMH should be
considered to be more reliable, than FSH. Serum AMH level is in strongly
positive correlation with AFC. Using of AMH measurement in combination with AFC
may improve the evaluation of ovarian reserve. Determination of AMH also may be
of diagnostic value in cases of different reproductive pathologies. Tab. 2,
Fig. 1, Ref. 18.
Auth.
b14.3.3.16. Prevalence
and intensity of dentition defects and secondary deformations in the population
of 15-40 age groups. /S. Kraveishvili, N.
Shonia, Z. Sakvarelidze, N. Sakvarelidze/. Georgian Medical
News. – 2014. – #7-8(232-233). – pp. 38-42. – eng.; abs.: geo., eng., rus.
Partial secondary adentia
together with caries and parodont diseases is among the most widespread
diseases of dentofacial system, correlated, in addition, to the number of lost
teeth, with the age. Result in speech and chewing functions’ disorders, change
of face shape, esthetic and psychosocial inferiority, pathologies of digestive
and other systems, formation of the chronic infection areas, changes of
reactivity etc.,. Improvement of the methods of prevention and treatment of the
above diseases is one of the most significant problems in the dentistry.
Effectiveness of dental assistance organization and planning is based on the
epidemiological studies. In Georgia, epidemiological studies were conducted in
the populations of various age groups in previous years though, according to
our data, no studies of dentition defects and deformations were conducted in
the recent decades. Goal of our research was study of prevalence and severity
of dentition defects and deformations, regarding sizes of existing defects,
their localization, causes and types of deformation in different age groups,
for development of specialized dentistry assistance plans and prevention
programs. We have studied 147 patients of ages between 15 and 40 years. We have
developed special questionnaire. Researches showed that in the studied age
group (15-40), 62% (96 patients), i.e. more than half of studied 147 patients
had secondary adentia. Most of them had the defects in the buccal teeth area.
112 of studied 147 patients required orthopedic treatment but only 18 (16%) of
them have visited the clinic for this purpose while 94 (83.9%) of them were
unaware about need of prothetic assistance. Regarding significance of the
mentioned problem, the obtained results show the need of timely orthopedic
intervention for the purpose of prevention of further complications. As a
result, a specialized dental assistance plan and prevention measures’ program
has been developed to prevent further complications. Tab. 1, Fig. 4, Ref. 11.
Auth.
b14.3.3.17. Development
and application of the information and communication technologies in quality
standards of health care management for patients with arterial hypertension. /V. Smііanov, O. Smiianova, S.
Tarasenko/. Georgian Medical News. – 2014. – #7-8(232-233). – pp. 65-68. – eng.; abs.: geo., eng., rus.
Mobile health technologies
improve the quality of health care service. The information and communication
technology is developed and applied to remind patients with arterial
hypertension to follow medical recommendations. The feedback system from
general practitioners was developed (the reminder system for patients sending
the feedbacks). It helped to supervise follow-up patients online. Suggested
system provides for forming the database for summarized analysis of online survey
of the patients, who receive medical care at health care institution, to take
managerial decisions concerning the improvements of medical services quality.
Evaluation of efficiency of the applied technology assured that the number of
patients, who checked regularly his/her arterial pressure, increased by 31.00%.
The number of patients, who visited doctors for preventive purpose two or more
times during given year, rose by 18.24%. The number of patients with target
pressure grew by 24.51% and composed 38.55±4.26%. Fig. 1, Ref. 8.
Auth.
b14.3.3.18. Development
of a training programme in disability assessment methodology based on
international classification of functioning, disability and health (ICF) for
psychiatric disability claims in Georgia. /V.
De Boer, M. Danelia, D. Zurabashvili, L. Chigladze/. Georgian Medical
News. – 2014. – #7-8(232-233). – pp. 74-77. – eng.; abs.: geo., eng., rus.
The new concept for social
integration of people with disabilities pointed at the need to develop
disability assessment methodology with the subsequent validation, based on
modern approaches that conceptualize disability as arising from the interaction
of a person’s functional status with the physical, cultural and policy
environments, therefore focusing on an individual’s functional abilities. The
academy of Swiss insurance medicine, ASIM, worked together with Georgian
representatives to develop the principles of functional assessment and provide
a method of applying these principles. As instrument for output specification
the Mini ICF APP was selected, translated and back translated from German to
Georgian. A training course of one day was conducted after which psychiatrists
tested the approach in 5 cases each and suggested minor modifications of
interpretation. After this they each performed 40 assessments with the new
methodology. Doing the assessments with the new procedure was appreciated by
all participants and provoked no problems. Being asked to fill out the Mini ICF
form in a systematic fashion makes the reports more objective and transparent.
The shift to a functional approach in evaluation of disability for work is
practicable with the methodology ASIM has developed for this purpose and this
fits with the present legislation. This approach could be used in other fields
than psychiatry as well. Ref. 9.
Auth.
b14.3.3.19. Bartonella
henselae infection–cat-scratch disease in children (case report). /M.
Kvezereli-Kopadze, A. Kvezereli-Kopadze, Z. Mtvarelidze, Sh. Tsintskaladze/. Georgian Medical
News. – 2014. – #7-8(232-233). – pp. 82-86. – rus.; abs.: geo., eng., rus.
This study was designed to
investigate the 11 year-old patient with cat scratch disease. The diagnosis of
this infection was based on detailed history, physical examination and para-clinical
data analyses. In case of cat-scratch disease (because it is rare diagnosis), a
different approach is required to every specific occasion. A series of
investigations (most informative is intrinsic factor antibody - IFA) should be
conducted to determine the cat-scratch disease from the various reasons of the
lymphocytic leukaemoid reaction. Tab. 1, Ref. 9.
Auth.
b14.3.3.20. Helicobacter
and hepatobiliary diseases: conceptual view and review of the literature. /S. Kandelaki, D. Kordzaia/. Georgian Medical
News. – 2014. – #7-8(232-233). – pp. 92-98. – eng.; abs.: geo., eng., rus.
The authors conducted an analysis
of multiple data concerning the possible role of Helicobacterias in
pathogenesis of different hepato-biliary disorders in clinical as well as in
experimental settings. Two pathways of Helicobacterias penetration into
hepato-biliary system – “translocation” and “ascending way” - are discussed.
Selection of “control group” in both – clinical and experimental studies – is
identified as one of crucial problems. It is concluded, that there is a need
for further clinical and experimental studies to determine the participation of
different Helicobacterias in the initiation/pathogenesis of the hepatobiliary
system. It is important to develop reliable experimental model, where only
Helicobacterias cause the pathology of liver and bile tract and where the
selection of “adequate control group” is possible. For the identification of
helicobacter strains inhuman (where the problem of “adequate control group”
selection will always remain), it is greatly important to conduct the complex
study of multiple data of histological (immunohistochemical, fluorescence,
etc.), cultural and molecular investigations of helicobacter species with
subsequent phylogenetic analyses in different hepatobiliary diseases. Ref. 76.
Auth.
b14.3.3.21. Apolipoprotein
B/apolipoprotein A-I ratio in relation to the metabolic syndrome, its
components, total cholesterol and low-density lipoprotein cholesterol in the
population of Georgia. /Z. Makaridze, E.
Giorgadze, K. Asatiani/. Georgian Medical News. – 2014. – #9(234). – pp. 32-39. – eng.; abs.: geo., eng., rus.
The study was designed to assess
the association of ApolipoproteinB/ApolipoproteinA-I (ApoB/ApoA-I) ratio with
metabolic syndrome, its components, total cholesterol (TC) and low-density
lipoprotein cholesterol (LDL-C) in the population of Georgia. The subjects were
1522 Georgians of Caucasian origin aged 18-80 (653 women and 869 men) without
diabetes mellitus. The subjects were divided into two groups. High ApoB/ApoA-I
ratio group was defined as gender-specific upper quartile (≥ 0.88 for
women and ≥ 1.0 for men) and low ApoB/ApoA-I ratio group as the remaining
three quartiles (< 0.88 for women and < 1.0 for men). ApoB/ApoA-I ratio
was significantly higher in patients with vs. without MetS (p <.0001). Mean
values of ApoB/ApoA-I ratio significantly increased as the numbers of MetS
components increased (p<.0001 in both sexes). After adjustment for age and
gender, ApoB/ApoA-I ratio was associated significantly with MetS as definition
(OR=1.86), IR as definition (OR=9.83), LDL-C (OR=1.99), systolic pressure
(OR=3.31), diastolic pressure (OR=1.64), fasting glucose (OR=2.46),
triglycerides (OR=2.52), high-density lipoprotein cholesterol (OR=7.08) (all
p<0.05). Tab. 4, Fig. 1, Ref. 35.
Auth.
b14.3.3.22. Clinical
and epidemiological peculiarities of hemorrhagic colitis complicated by
hemolytic-uremic syndrome. /E. Pachkoria, E.
Vashakidze, T. Megrelishvili, L. Tevzadze/. Georgian Medical
News. – 2014. – #9(234). – pp. 70-73. – eng.; abs.: geo., eng., rus.
The aim of the research:
identification of etiological structure of acute diarrheas and hemorrhagic
colitis in Georgia, manifestation of clinical peculiarities and predictors of
hemorrhagic colitis complicated by HUS ( Hemolytic-Uremic syndrome). In
2011-2013 we studied 274 hospitalized patients at the Center of Infectious
Diseases, AIDS and Clinical Immunology (160 hemorrhagic colitis and 114
non-bloody diarrheas). Causative agents of hemorrhagic colitis (160 patients)
were determined in 110 (69%) cases; etiology of the non-bloody diarrhea (114
patients) was established in 46 (40%) cases. Enteronterohaemorrhagic E. coli
(EHEC) strains are major causes of hemorrhagic colitis. For the confirmation of
STEC infection by the bacteriological investigation some significant additional
methods were used: serologic examination of feces on shiga- toxin molecular
markers by ImmunoCard STAT and PCR methods. Thus, these above mentioned investigations
contribute to diagnosis STEC infection at the early stage of the disease. Based
on our findings we were able to reveal predictors of complications of
hemorrhagic colitis by HUS. They include: Delayed hospitalization, rural
residents, premorbid background, onset of the disease with low-grade fever
accompanied with abdominal cramps, manifestation of bloody diarrhea on the
2-3-rd days of the disease, frequent bowl movement (>20 times a day),
development of oliguria and edema on the following days, leucocytosis in
hemogram, elevation of LDH, creatinine and urea, hypoalbuminemia and
development of ascites. Tab. 1, Ref. 9.
Auth.
b14.3.3.23. Comparative
evaluation of clinical effectiveness of treatment of giardiasis. /G. Muldaeva, R. Begaydarova, E. Polyakova, Y.
Yukhnevich, Sh. Kaliyeva /. Georgian Medical News. – 2014. – #9(234). – pp. 74-78. – rus.; abs.: geo., eng., rus.
Giardia is the most common causes
of protozoan diarrhea that leads to significant morbidity and mortality worldwide.
The purpose of this study was to determine the clinical efficiency of different
scheme of therapy giardiasis with new original plant preparation “Sausalin”
(Kazakhstan). We conducted open clinical trial with participation of 93
patients with giardiasis. According the method of treatment the patients were
divided into three groups. Group I – Sausalin at the dose 300 mg/day; group II
– Metronidazole at 750 mg/ day; group III – combination of Sausalin 300 mg/day
and Metronidazole 750 mg/ day. The treatment was conducted during 10 days. The
protozoal clearance rate and clinical symptoms were assessed. There were no
significant differences in the efficiency of treatments in group I and group
II. The protozoal clearance rate was 68% in group I (Sausalin); in group II –
42,1% (metronidazole). In group III – 83.2% (combination therapy)
(р=0.001; 95% CI 54.6-89.7). There was no negative effect on clinical and
biochemical blood analysis. We detected statistically significant differences
in the dynamics of clinical symptoms (defecation disorders, dyspepsia,
abdominal pain, and asthenia) of giardiasis in a group of patients receiving
Sausalin. The scheme with new drug Sausalin can be used as alternative
treatment of Giardiasis. Moreover, the use of the Sausalin is improved the
clinical symptoms and safety of therapy. Tab. 1, Fig. 3, Ref. 6.
Auth.
b14.3.3.24. Development
of sexuality and motivational aspects of sexual behavior in men with
obsessive-compulsive disorders. /L. Gerasimenko/. Georgian Medical News. – 2014. – #9(234). – pp. 85-88. – rus.; abs.: geo., eng., rus.
Sexual behavior and formation of
sexuality in men with obsessive-compulsive disorder is one of the pressing
issues in contemporary medicine. Obsessive-compulsive disorder is characterized
by the development of intrusive thoughts, memories, movements and actions, as
well as a variety of pathological fears (phobias). Increase in the number of
patients with this pathology in modern clinical practice of neurotic disorders,
the young age of the patients and as a result violation of interpersonal,
communicational and sexual nature is quite apparent. The study involved 35 men
aged 23 to 47 years with clinical signs of OCD. We determined the severity of
obsessive-compulsive symptoms using the Yale-Brown scale. We established the
presence of a mild degree of disorder in 34.3% of cases; in 48.6% of cases
disorder of moderate severity was diagnosed; remaining 17.1% were assessed
subclinical condition of OCD at the applicable scale. The system of motivational
maintenance of sexual behavior in men with obsessive-compulsive disorders is
investigated. Motives of sexual behavior of the investigated men with the
pathology are determined. The presented research in men with OCD has
established multidimensionality and complexity of motivational ensuring of
sexual behavior. Tab. 1, Ref. 14.
Auth.
b14.3.3.25. Peculiarities
of sexual development and reproductive function in young women with childhood
onset weight problems. /N. Chikvaidze, J.
Kristesashvili, M. Gegechkori/. Georgian Medical News. – 2014. – #10(235). – pp. 11-16. – eng.; abs.: geo., eng., rus.
The risks of reproductive
problems are higher in underweight and overweight or obese women, especially in
case of rapid weight gain or loss. But evidence is inconsistent especially in
relation to the effect of age of body weight changes. The aim of the study was
detection of peculiarities of sexual development and reproductive function in
underweight and overweight/obese females with childhood thinness or childhood
obesity.103 young females (48 – with low BMI, 55 – with high BMI) with
different reproductive problems were examined prospectively. In all
investigated patients full clinical examination was held, including body mass
index (BMI), type of body fat distribution (waist-to-hip ratio), age of body
weight changes, assessment of hirsutism, acne, stretch marks and
hyperpigmentation, menstrual disturbances and fertility problems were recorded
and gynecological ultrasound was performed. There was no difference established
according to the age of menarche and types of menstrual disturbances between
the groups of low BMI and high BMI females (p>.05). The correlation was
established between the onset of menstrual disruption and progression of
changes in body mass (R=.448, p=.005). Hirsutism, stretch marks and acantosis
nigricans (hyperpigmentation) were exhibited significantly more frequently in
the patients with high BMI (p<.05), whilst distribution of acne was almost
the same in the study groups (p>.05). 74.5% of overweight and obese patients
had upper body fat distribution (waist-to-hip ratio > 0.8), whilst
underweight patients had mostly equal (66.7%) or lower body fat distribution
(31.3%) (p=.000). Polycystic ovarian syndrome (PCOS) and metabolic syndrome
(MS) was the most frequent in overweight and obese patients, whilst
non-classical congenital adrenal hyperplasia (NCAH) and ovarian dysfunction
prevailed in the underweight females (p<.05). Infertility was mostly
observed in patients with high BMI (p<.05). In conclusion, the peculiarities
of sexual development and menstrual function in young females with childhood
thinness and obesity are related to their reproductive disorders, childhood BMI
and progression of BMI changes. Tab. 4, Fig. 1, Ref. 25.
Auth.
b14.3.3.26. Experience
of practical application of the method of expert assessment in the study of
quality of life. /Zh. Kalmatayeva, E. Bekbotayev, A.
Skakov, M. Brimzhanova, A. Omarova/. Georgian Medical News. – 2014. – #10(235). – pp. 58-62. – rus.; abs.: geo., eng., rus.
The article investigates the
experience of practical implementation of expert assessment method for the
evaluation of life quality of preschool children with different disabilities.
The trial is carried out in four stages and two anonymous surveys. Based on the
evaluation the most important eight problems are selected by experts. Seven
problems related to social assistance of children with chronic disabilities and
one problem related to availability of occupational therapy. It is recommended
to use the results of expert evaluation in integrated development and
establishment of standards of medical and social rehabilitation of patients.
Tab.2, Ref. 10.
Auth.
b14.3.3.27. Evaluation
and implementation of quality standards to ensure relevant medical care in the
system of military medical services of Armenia. /R. Khachatryan/. Georgian Medical
News. – 2014. – #10(235). – pp. 82-87. – eng.; abs.: geo., eng., rus.
It was the goal of this review to
determine if the MHS of Armenia meets benchmarks for health care quality; to
provide military medical officials with relevant information to create an
adequate environment for all the quality improvement initiatives being
undertaken at the medical care level; to design and implement effective
interventions to make informed strategic choices and promote quality and a
culture of safety in. Documents addressing the quality of care in the MHS of
Armenia were reviewed. Ref. 20.
Auth.
b14.3.3.28. Medical examination results after involving “Apipuri” in ration. /G. Chakhunashvili, N. Badriashvili, M.
Topuridze, N. Jobava, K. Chakhunashvili, I. Kalandia, Z. Pkhaladze, D.
Chakhunashvili/. Pediatric Cardiology. – 2014. – #8. – pp.11-17. – geo.; abs.: geo., eng.
Assessing functional
tests of basketball players under heavy load and involving “Apipuri” in the food ration to assess its
effects Method: Research involves 100 basketball players of 12-18 age and
assessing functional tests before and after adding “Apipuri” to the ration. The research has
not been finished yet. Basketballers subjectively underline increasing of their stamina.
However, no objective results were found
to back those results yet. Multiple sportsmen have BBB and Ventricular
Hypertrophies, none of which has yet been improved. Tab. 1, Ref. 21.
Auth.
b14.3.3.29. On some peculiarities of Dipylidium
caninum. /D. Tskhomelidze, N. Onashvili,
A. Abashidze/. Pediatric Cardiology. – 2014. – #8. – pp. 74. – geo.; abs.: geo., eng.
Dipyidium
caninum
is a common parasite of dogs, cats and humans, especially children,
all over the world. The adult tapeworm lives in the small intestine of
the definitive host, where gravid proglottides separate from the strobila
and proglottides are capable of moving on the substance or be passed
wite feces. Eggs and capsules are ingested by larvae of fleas belonging
do the genera Pulex end Ctenocephalides or by the dog louse Trichodeqtes
canis. When the infected arthropod is ingested by a suitable definitive
host, the cisticerkoid is liberated in the small intestine and develops
to sexual maturing in about 20 days. Most human infections are in children
younger than 8 years old, with a high percentage falling in the under 6
month age group. Transmission to humans usually results from accidental
ingestion of ingested fleas or lice or from allowing dogs and cats to
lick the mouths of children immediately after the pet has bitten and
infected arthropod. Fig. 1, Ref. 4.
Auth.
b14.3.3.30. The use of Clovate ointment in the complex
treatment of contact allergic chelitis. /N. Abashidze, M. Iverieli, M. Borjadze,
Kh. Gogishvili, L. Jashi/. Tbilisi State Medical
University Collection of Scientific Works. – 2013. – #47. – pp. 3-4. – geo.;
abs.: geo., eng.
The
aim of our research was to develop an effective treatment scheme for Contact
allergic cheilitis. To achieve the aim of our research we examined and treated
18-50 years old 24 patients, of whom 19 (79.2±1.1%) were women and 6 (20.8±1.1%)
- men. The patients were divided into two groups. Each group included 12-12
person. In the I group we added the application of “Clovate” ointment. Studies
of our examination showed that the patients of the I group have been improved
on the second or third day. Patients did not noted itch, feel of tension, and
pain when opening the mouth widely; size of lips became close to the norm.
Thus, it is recommended to use the ointment “Clovate” for the treatment of
contact allergic cheilitis. Ref. 6.
Auth.
b14.3.3.31. Food allergy
epidemiology in children’s population. /N. Adamia, I. Chkhaidze, I. Ubiria, K. Barabadze, D. Khachapuridze, N.
Katamadze/. Tbilisi
State Medical University Collection of Scientific Works. – 2013. – #47. – pp.
4-7. – geo.; abs.: geo., eng.
Share of food allergies is quite high in the
general structure of allergy morbidity (varies between 0.1% and 7%). Allergy
diseases comprise global problem of public health care system. Goal of the work: foal of our work is
study of prevalence of food allergies and risk factors in children’s population
in selected populations of Tbilisi, Batumi and Kutaisi-Tskaltubo. Materials and methods: studied
population includes 2655 children (2010-2013) from 1-month to 14-year age. 1359
of them were girls and 1296 – boys (I group: children from 1 month to 6 years
and II group – from 6 years to 14 years). At the first stage of epidemiological
study, screening of 2665 children was conducted by means of the initial
questionnaire filled in directly at a time of interviewing of the parents.
Identification of the factors of causal significance was provided based on
anamnesis data, comparison of general serum and specific IgE and in vivo
allergologic diagnostics (prick-tests). Obtained data were statistically processes
by means of SPSS/V12.5 software (Statistical Package for Social Sciences). Results: Epidemiological studies
showed that prevalence of food allergies in children’s population (7.5% -
Tbilisi; 6.2% - Kutaisi-Tskaltubo; 4.3% - Adjara) was 18.04%. Average total
IgE, in both cases, was 3-5 times higher than normal value and no statistically
reliable difference between the groups was found (p>0.05). Only 3.9 of
children with food allergies had IgE within normal limits. High frequency of
late diagnostics was established (p<0.001). Conclusion: Thus, according to the obtained data, share of the
manageable risk factors is high and this could provide basis for development of
targeted and effective prevention measures for the children’s population. Food
allergy is complex and versatile process requiring further study. Tab. 1, Ref.
22.
Auth.
b14.3.3.32. Hygienic
characteristic of the main risk factors of health of employees of the chemical
industry of Georgia. /L. Bakradze, R. Kverenchkhiladze, M. Tsimakuridze,
G. Kverenchkhiladze, S. Nozadze/. Tbilisi State Medical University Collection
of Scientific Works. – 2013. – #47. – pp. 24-27. – geo.; abs.: geo., eng.
Working conditions in leading branches of the
chemical industry of Georgia – production of arsenic and its preparations,
cyanic sodium and nitrate fertilizer - for identification of the main risk
factors of workers, health, establishments of the reasons of their formation
and definition of priorities of preventive measures are studied. Considerable
pollution of the air environment of the studied enterprises by harmful
chemicals is revealed. The reason of the revealed circumstance in producing of
arsenic and its preparations is the uncontinued technological cycles;
Otherwise, despite a continuity of technological cycles in the technology of
cyanic sodium and nitrate fertilizer production, pollution of air environment
by toxic compounds is caused by insufficient tightness of the production
hardware, insufficient efficiency of absorbing ventilation, and other industrial
and non-industrial factors. Ref. 9.
Auth.
b14.3.3.33. Acute hepatitis due
to measles. /T. Gegeshidze, E. Vashakidze, M. Kvitashvili/. Tbilisi State Medical
University Collection of Scientific Works. – 2013. – #47. – pp. 31-32. – geo.;
abs.: geo., eng.
We retrospectively
collected the characteristics of patients with serologically confirmed measles
during an epidemic in Georgia in 2013. Liver involvement with elevated
transaminase levels was found in 60% of the patients, 23% of patients had
clinically established jaundice. Hepatitis commonly occurs in severe form of
disease and it may manifest clinically as jaundice, but long-term follow-up
shows a clear tendency to complete resolution of the liver damage. Hepatitis
should be regarded as a usual symptom rather than a complication of measles
infection in adults. Ref. 8.
Auth.
b14.3.3.34. Optimization of treating open-wound surgical infections of the head and neck area using
bacteriophages. /G. Gvasalia, N. Khotenashvili,
T. Danelia, G. Merabishvili/. Tbilisi State Medical University Collection of Scientific
Works. – 2013. – #47. – pp. 38-41. – geo.; abs.: geo., eng.
For the purpose of
assessment of the treatment and prevention efficiency of the maxillofacial area
open-wound surgical infections, 235 patients were researched during 4 years.
Among them 185 had “new” casual not-suppurated, 50 patients- suppurated wounds.
The bacteriologic research has shown that the overwhelming majority of
bacteria, segregated from the “new” wounds during the first 6 hours, further
play a significant role in the development of wound infection. The open wounds
suppuration in the maxillofacial area is developed in 12.4% of cases, the wound
infection is caused by S. aureus,
Streptococcus spp, E coli, Proteus spp and Klebsiella. Phago-prophylaxis of the wound infection decreases the
suppuration frequency down to 3.4%; the suppurated wounds’ phagotherapy surely
improves the microbiological and clinical parameters of the wound regeneration
process on average by 5.2+0.3 days, and decreases the regeneration time or the
secondary wound closure period. Ref. 4.
Auth.
b14.3.3.35. Health reform and
public health in Georgia. /N. Gokieli, Sh. Zarnadze, I.
Zarnadze, D. Kitovani, L. Lomtadze/. Tbilisi State Medical University Collection
of Scientific Works. – 2013. – #47. – pp. 41-43. – geo.; abs.: geo., eng.
Public health
services aim to protect or improve health. Resources should be used for
interventions, the efficiency of which is proved and it should be implemented
in accordance with the national or local priorities. The main services of
public health are: epidemiological surveillance and control of the health
status of the population, prevention and control of communicable and
non-communicable diseases, identifying, preventing and controlling
environmental hazards and other dangers to health diseases; promoting and
enabling healthy life styles; conducting a review/study to justify benefits of
interventions among population and estimate their coverage by the private
companies; revising and developing evidence-based screening and preventive
health examinations; recommending and elaborating models for reimbursing PHC
providers for health promotion, screening and disease prevention services. Ref.
8.
Auth.
b14.3.3.36. Hygiene assessment of actual nutrition among
different psychologic types. /T.
Darsania, B. Kurashvili, Sh. Zarnadze, I. Zarnadze/. Tbilisi State Medical University Collection
of Scientific Works. – 2013. – #47. – pp. 49-51. – geo.; abs.: geo., eng.
Foodstuffs are
utilized not only as the remedy of hungerm satisfaction, but as a means of
problem prevention and solving. The objective of the research/study was to find
out how psychological disorders/malfunctioning influenced factual nutrition. The
study was conducted throughout Georgia. Identification of eating behavior
psychological types was carried out according to the questionnaires of Academic
Department of Psychiatry, St.Georges Hospital Medical School modified by us. We
studied different types of eating human behavior (rational, emotional,
eccentric, external, limited/scanty), their food allowance/ration and foods’
chemical content. All the cases of eating disorder indicated redundant energy
intake. The highest eating energy value was recorded among external types. In
case of emotional types redundancy reached 14.7%. Redundant energy intakes were
more frequently manifested among emotional types of women. Fig. 2, Ref. 4.
Auth.
b14.3.3.37. Assessment of foodstuff consumption frequency
rate by population of Georgia. /T.
Darsania, B. Kurashvili, Sh. Zarnadze, I. Zarnadze/. Tbilisi State Medical University Collection
of Scientific Works. – 2013. – #47. – pp. 51-53. – geo.; abs.: geo., eng.
Improvement of
population’s health is significantly associated with adequacy of foodstuff and
eating behavior. The objective of the presented research/study was assessment
of foodstuff consumption frequency. The study was conducted throughout Georgia.
We considered adequacy of consumed foodstuffs with the recommended magnitudes.
We also studied the respondents’ opinion about the amount of consumed
foodstuffs and whether they intended to increase or decrease consumption of
foodstuffs of the indicated group in case of improvement of their financial
condition. The outcome of the research/study enables us to conclude that
besides demographic, social and economic factors macro-structure of foodstuffs’
consumption of population influences food preferences that make conditional
consumption of excessive energy intake, non-balanced animal-proteins,
inadequate intake of vitamins, micro elements and abundant consumption of fatty
acids and cholesterol. Tab. 2, Ref. 4.
Auth.
b14.3.3.38. Severe leptospirosis
in Georgia. /E. Vashakidze, T. Megrelishvili, T. Gegeshidze, M.
Kvitashvili/. Tbilisi
State Medical University Collection of Scientific Works. – 2013. – #47. – pp.
58-59. – eng.; abs.: geo., eng.
Leptospirosis is a
zoonotic disease of a worldwide distribution. Frequent circulating serotypes of
Leptospira intterogansas an etiological agent in Georgia are: L. icterohaemorrhagiae, L. canicola, L. grippotyphosa, L. ballum. In recent years, new serotypes have
been identified: L. mankarso, L. wolffii, and L. autumnalis. Incidence during last 5 years has arisen from 0.63
to 1,32. Overall lethality is 7-14%. This research is aimed at identifying
clinical and epidemiological aspects of severe leptospirosis. Totally 13
patients (11 males, 2 females) were registered, among them 4 cases (31%) were
lethal (3 males, 1 female).Severe leptospirosis is characterized with high
mortality rate in Georgia. Most frequent signs are: fever, jaundice,
herapatomegaly, myalgia, oligo-anuria, elevated creatinin, pneumonia, chills,
cutanoeus and mucosal haemoragies. During recent years new serovars have been
registered in Georgia, which have not been circulating before. Ref. 5.
Auth.
b14.3.3.39. Assessment of actual
nutrition of population of Racha-Lechkhumi Region. /N. Vepkhvadze, N. Tskhovrebadze, M. Khorbaladze, I. Kugoti, I.
Tskhovrebadze/. Tbilisi
State Medical University Collection of Scientific Works. – 2013. – #47. – pp. 63-65.
– geo.; abs.: geo., eng.
Actual nutrition of
population of Racha-Lechkhumi Region (Ambrolauri, Oni, Lentekhi and Tsageri
districts) of Georgia has been studied and adequacy of consumption of main
nutrients has been assessed, the reasons of nutritional deficiency and excess
nutrition have been determined and appropriate recommendations for improving
the quality of nutrition have been developed. Analysis of the results indicates
the disturbance of balancing, consumption of high-calorie foods, deficiency of
vitamins and macroelements. Correction of the above can be done by public
education about healthy lifestyle, particularly with implementation of the
healthy eating principles. Tab. 1, Ref. 6.
Auth.
b14.3.3.40. Georgian Manganeze
Ltd – hygienic characteristic of the air pollution of the working area of
Chiatura mining and processing enterprise. /R. Kverenchkhiladze, A. Chikovani,
M. Kvatadze, M. Arabidze, K. Khvadagiani/. Tbilisi State Medical University Collection
of Scientific Works. – 2013. – #47. – pp. 88-90. – geo.; abs.: geo., eng.
A study of the content
of production dust and hazardous chemicals in the air of the working area of
the mines and processing plants was carried out within the framework of a
comprehensive research of working conditions of the workers of Georgian
Manganese Ltd. - Chiatura Mining and Processing Enterprise. The studies were
held within the framework of the State Occupational Disease Prevention and
Monitoring Program. Elevated concentrations of dust and toxic gases were found
in the air of the working zone. The dust concentrations exceed the MPC in
68.3-100% of cases, and the content of toxic compounds in 76% of cases.
According to these indicators, the working conditions are rated as hazardous,
mainly 3.2. and 3.3. classes. Pollution of working area air with dust and
harmful chemicals (mostly manganese compounds in aerosol) is conditioned by
peculiarities of the technological process. In addition, the reason of high
concentration of these compounds might be obsolete equipment and systems,
insufficient tightness of the hardware, lack or failure of ventilation systems;
and generally, the wrong of organization of the working places. A complex of
preventive and health improvement measures has been developed based on the
research. It includes various recommendations. Ref. 9.
Auth.
b14.3.3.41. Medical health insurance and its
peculiarities in Georgia. /N. Kvizhinadze, S. Korganashvili/. Tbilisi State Medical University Collection
of Scientific Works. – 2013. – #47. – pp. 92-94. – geo.; abs.: geo., eng.
The healthcare
development model is closely associated with a country’s development level,
healthcare policy, and cultural and historic experience. Based on the
healthcare strategy, the funds allocated to it should serve to the introduction
of different principles; in general, the main challenge of the healthcare
system is the effective spending and management of healthcare funds and cases
and control of prices on medical services. Based on the current situational
analysis, it is obvious that the health insurance system has a number of defects:
a) in some countries, insurance authorities have turned into bureaucratic
monopolies, because of which it is unclear whose interests are being protected
by them: patients, medical staff or own employees; b) the average insurance is
more or less than the minimum requirements that are essential for high quality
medical assistance; c) medical facilities are well equipped with modern
equipment which, due to the high cost, I being used only for restricted medical
treatments. Ref. 6.
Auth.
b14.3.3.42. The influence of age, sex and anthropometric
parameters on subsets of lymphocytes in Georgian population. /B. Lasareishvili, N.
Pantsulaia, M. Iobadze, N. Kikodze, I. Pantsulaia, T. Chikovani/. Tbilisi State Medical University Collection
of Scientific Works. – 2013. – #47. – pp. 103-107. – geo.; abs.: geo., eng.
Changes in the
immune system have a crucial role in the process of organism’s ageing. Immune
senescence is closely linked to age-associated diseases, such as chronic
diseases and cancer. Revealing influence of impact factors on immune senescence
has theoretical and practical importance. There are different patterns of
immune senescence under different environmental conditions. Therefore, it is
important to study it in populations that live under different geo-climatic
conditions and belong to different ethnic groups. 250 health volunteers from
Georgia’s population were investigated. We studied the percentage of
lymphocytes subsets in the peripheral blood and evaluated the influence of age,
sex and anthropometric parameters on them. Lymphocytes quantitative data
fluctuated in different periods of age. No significant relation was revealed
between the percentage of lymphocytes’ subsets and anthropometric parameters.
Tab. 2, Fig. 1, Ref. 29.
Auth.
b14.3.3.43. Rotavirus infection in Georgia. /T. Megrelishvili, M. Lashkarashvili, Kh.
Zakhashvili, N. Beridze/. Tbilisi
State Medical University Collection of Scientific Works. – 2013. – #47. – pp.
117-118. – geo.; abs.: geo., eng.
Etiological
structures of acute diarrheas have been studied in children population 0-5 year
of age. 5046 stool samples were taken and in 1482 (29%) cases rotaviruses were
identified (ELISA method). The course of the disease was severe. Children were
hospitalized because of exsiccosis. According to the results, prophylactic
measures were carried out by the way of vaccination. `Rotarix` is the rotavirus
vaccine which protects children from rotaviruses and now it is a part of
Calendar of National Immunization. Tab. 2, Ref. 4.
Auth.
b14.3.3.44. Dynamics of the etiological structure of
vaginites 2012-2013. /E. Mirvelashvili, M. Dzagnidze, E. Kikacheishvili/. Tbilisi State Medical
University Collection of Scientific Works. – 2013. – #47. – pp. 118-119. –
geo.; abs.: geo., eng.
The aim of the
study was to investigate the etiological structure of vaginitis dynamics of
2010-2013. The vaginal flora in 250 females during the vaginitis was
investigated by a bacteriological analysis. By the rate of excretion,
staphylococci were on the first place; T.
vaginalis – on the second, and C.albicans
- on the third. One third of the microorganisms was detected in a form of
monocultures, two-thirds - as associations, the most frequent combinations
among which were: S.epidermidis+ T.vaginalis,
T.vaginalis + C.albicans, T.vaginalis + E.coli. Among the combinations,
vaginitis in a form of mixinfectious etiology caused by the presence of three
or more symbionts was observed. Tab. 2, Ref. 7.
Auth.
b14.3.3.45. Hemolytic-uremic
syndrome (HUS) and amebic dysentery in Georgia (case report). /E. Pachkoria, E. Vashakidze, T. Megrelishvili, L.
Tevzadze/. Tbilisi State Medical
University Collection of Scientific Works. – 2013. – #47. – pp. 124-125. –
geo.; abs.: geo., eng.
The number of
patients with HUS syndrome was significantly increased in 2009-2011.
Comprehensive investigations of the etiological structure of hemorrhagic
colitis and the cases complicated by HUS (bacteriological, immuno-ferment –
ImmunoCard STAT and PCR methods) were performed. The research was conducted in
the Centers of Infectious Diseases and National Center for Disease Control and
Prevention (NCDC). 25 cases of amebic dysentery were revealed in the research
process in summer 2012. The course of the diseases was complicated by HUS in 2
cases. Both patients were female, of 65 and 36 years. One of them was at 14
weeks of pregnancy. The pregnant patient required dialysis and the other - 65
year-old female was under the observation of nephrologists. There was no
lethality. Amebic dysentery in the above cases was confirmed by stool antigen
test (EIA, sensitivity -100%, specifity-94,7%), but by bacteriological analyzes
of stool specimens no enteropathogenic bacteria was isolated, and no Shiga
toxin (stx1, stx2) was identified by the PCR method. It should be noted that
our observation is important in its significance as our patients with HUS
received purposeful investigations to reveal enterohemorrhagic E.coli. According to the literature data
an association between amebic dysentery and HUS has been mentioned, but a cause
and effected relationship has never been confirmed. Ref. 6.
Auth.
b14.3.3.46. Isolation of exstraintestinal pathogenic E.coli from postcholecystectomic samples and their antimicrobial
resistance profile in Georgia. /E. Pachkoria, E. Vashakidze, T.
Megrelishvili, L. Tevzadze/. Tbilisi State Medical University Collection of Scientific
Works. – 2013. – #47. – pp. 125-127. – eng.; abs.: geo., eng.
We have been
studying infections caused by E.coli in
Georgia since 2009. Cases of STEC infection and HUS were represented in our
previous articles. In this article we discuss the involvement of E.coli, especially its high resistant
strains, in the development of the gallbladder diseases. Among isolated enterobacteriaceae
there is a noticeable increased rate of extra intestinal ESBL-producing E.coli. These ESBL-producing E.coli produce an enzyme called
extended-spectrum beta lactamase (ESBL) and are able to resist penicillins and
cephalosporins as well as a number of other classes of antibiotics - making
these infections much more challenging to treat. To evaluate the rate of E.coli in the development of the
exstraintestinal abdominal pathology such as chronic calculous cholecystitis,
bacteriological analyses of 130 postoperative tissue of the gallbladder were
carried out; isolated strains’ antibiotic sensitivity was studied by the Double
Disk method; Currently ESBL strain genome analysis is under way MISEQ –Illumina
Platform). 28 cultures were isolated (22%) among them E.coli was isolated in 9 cases (32%). ESBL-producing E.coli showed
high resistance rate to Penicillins and Cephalosporins and to Ciprofloxacin (2
strains) and imipenem as well (4 strains). It is significant that the existence
of ESBL-producing E.coli strains
indicates to the circulation of high resistant E.coli in Georgia. Nowadays microbial resistance is a growing major
public health issue, and a strong concern for the medical community. Ref. 6.
Auth.
b14.3.3.47. Role of physical
exercise in prevention of diseases: new prospects. /T. Svanishvili, E.
Tataradze, N. Chabashvili, Z. Sopromadze/. Tbilisi State Medical University Collection
of Scientific Works. – 2013. – #47. – pp. 127-128. – geo.; abs.: geo., eng.
Considering the world economic crisis, the
use of low-cost preventive interventions, such as physical activity becomes
necessary. Inclusion of physical activity in everyday lifestyle decreases
pharmaceutical and overall costs of public health care system. In recent years,
a number of scientific works has described the potential of regular physical
exercise in prevention of several types of malignant tumors, along with
cardiovascular and metabolic disorders, which have been traditionally viewed as
targets for physical activity programs. For example, physical exercise can have
a preventive role in the development of breast cancer, by means of influencing
its hormonal and metabolic mechanisms, as well as in the development of colon
cancer. Physical exercise decreases insulin resistance, which supposedly is a
connecting link in pathogenesis of many malignant tumors, including endometrial
cancer. According to the newest investigations, the preventive effect of
physical exercise concerns auto-immune diseases as well, such as diabetes type
1. Therefore, national governments should pay greater attention to the
development of physical activity programs, as an important method of diseases
treatment and prevention. Ref. 11.
Auth.
b14.3.3.48. Health risk assessment of chemicals in some enterprises
of Georgia. /I. Gvineria, V.
Saakadze, M. Juruli, O. Gvaberidze, L. Bakradze/. Tbilisi
State Medical University Collection of Scientific Works. – 2013. – #47. – pp.
138-140. – geo.; abs.: geo., eng.
The effect of chemicals on the health of workers
was assessed in some Georgian enterprises (JSC Zestafoni Ferroalloy Plant and
JSC Tbilisi Electric Locomotive Plant). It was revealed that out of 17
chemicals affecting workers in the Zestafony Ferroalloy Plant, 5.8% belong to I
class of extremely hazardous chemicals, 11.7% belong to II class of highly
hazardous chemicals, 41.1% belong to III class of moderately hazardous
chemicals and 41.1% belong to IV class of slightly hazardous chemicals. In the
JSC Tbilisi Electric Locomotive Plant, out of 32 chemicals, to which workers
are exposed, 6.2% belongs to I class of extremely hazardous chemicals, 31.2%
belong to II class of highly hazardous chemicals, 24.5% belong to III class of
moderately hazardous chemicals, and 37.2% belong to IV class of slightly hazardous
chemicals. A combined exposure to highly toxic chemicals causes high risk to
health of workers, which necessitates the timely taking of preventive hygienic
measures. Tab. 2, Ref. 5.
Auth.
b14.3.3.49. Epidemiologic research among the workers of the JSC
Zestafoni Ferroally Plant. /N.
Chkhaidze, Tatia Todua, M. Turmanauli, Tea Todua, G. Kverenchkhiladze/. Tbilisi State Medical University Collection
of Scientific Works. – 2013. – #47. – pp. 147-149. – geo.; abs.: geo., eng.
In order to reveal the connection between the
reasons of disease and risk factors, epidemiologic research activities have
been held through interviewing method face to face with workers of the JSC
Zestafoni Ferroalloy Plant. In this respect, special questionnaire forms have
been composed. Upon the collection and procession of initial material, various
data have been received, classified in compliance with gander, work experience,
age groups, as well as according to classes of disutility (hygienic working
conditions), family conditions, education, life conditions, and addiction to
alcohol, smoking and drugs. The data received indicate that most of the
respondents basically work in the classes of harmfulness with degree 3.2, 3.3,
3.4 and 4.0 and the influence of these factors might stimulate occupational and
work-related diseases development. Many respondents use alcohol and smoke,
which might serve as additional risk factors among the workers of the JSC
Zestafoni Ferroalloy Plant. Fig. 5, Ref. 7.
Auth.
b14.3.3.50. Health condition of Tbilisi underground workers. /Mar. Tsimakuridze, N. Khunashvili, M. Tsimakuridze, D. Zurashvili, N. Khachapuridze/. Tbilisi State Medical
University Collection of Scientific Works. – 2013. – #47. – pp. 150-151. –
geo.; abs.: geo., eng.
The health status of Tbilisi underground
workers was studied according to age, length of service and professional
peculiarities. Purposeful prevention recreational activities for the workers of
the above-mentioned sector were worked out. The research proved the influence
of environment factors on the employees’ health condition. Particularly, in the
basic group practically healthy persons appeared 4.6 times less compared to the
similar index of control group (t=6. P<0.001). In all age groups of basic professions
and within individuals having long-termed working experience the number of sick
persons significantly exceeded the index of control group of the same age and
same length of service (P<0.05- P<0.001). As a result of separate organs
and systems’ health condition analysis, it has been stated that blood
circulation (SBC) problems, nervous and digestive system diseases are the
leading disorders in underground workers. Risk-factors for development of these
diseases are noise, vibration, psychoemotional strains, compulsory condition of
body and others. Tab. 3, Ref. 10.
Auth.
b14.3.3.51. Main problems of
occupational health and safety in Georgia and the ways of their settlement. /R. Javakhadze, N.
Khatiashvili, Kh. Chigogidze, M. Tsimakuridze/. Tbilisi State Medical University Collection
of Scientific Works. – 2013. – #47. – pp. 168-170. – geo.; abs.: geo., eng.
Occupational diseases cause huge suffering
and loss in the world of work. Technological and social changes, along with
global economic conditions, are aggravating the existing health hazards and
creating new ones. While much progress has been made in addressing the
challenges of occupational diseases, there is an urgent need to strengthen the
capacity for their prevention in national OSH systems. WHO at sixtieth World
Health Assembly (2007) gave recommendations for Member States to establish
appropriate mechanisms and legal frameworks in the sphere of labor medicine at
national level for improving basic occupational health services for primary
prevention of occupational and work-related diseases and injuries. In this
article are given main problems of occupational health and safety in Georgia
and the ways of their decision. Ref. 6.
Auth.
Using 20 male albino rats, a histology study
of stomach, liver and kidney was performed to assess the effect of Khulo
district’s Khikhadziri village mineral
water. 10 rats of experimental group received mineral water for 30 days, rats
of control group drank simply water. Stomach, liver and kidney were
investigated. The specimens were stained with hematoxylin and eozin. Entire
microstructure of stomach, liver and kidneys was intact. The liver lobules are
formed of a polygonal mass of hepatocytes with portal spaces at the periphery and a vein, called the central or centrolobular vein, in the
center. The fundal gastric pits contained the large acidophilic parietal cells
and chief cells, secreting zymogen granules, showing the moderate activation of
gastric secretory function. The cuboidal epithelial cells of convoluted
proximal tubules were flattened. So, the data obtained revealed that 30
day-drinking of mineral water doesn’t lead to a change in macro- and
microstructure of stomach, liver and kidney of rats and the mineral water can
be used in practice. Ref. 3.
Auth.
b14.3.3.53. Determination of
biomechanical criteria of human motions and their significance for assessing
the pathological state. /G. Eliava, P. Kasradze, T. Tsintsadze, L. Topuria, M.
Tabidze/. Modern aspects of medical
rehabilitation, prevention and healthy lifestyle. Int. Symp. – Sairme. 9-13
Oct. – 2014. – pp. 161-165. – eng.; abs.: eng.,
geo.
The determination of the biomechanical parameter
of human body, such as body center of mass or body center of gravity gives us
an opportunity to assess body balance, perfection of body motions. In vertical
position human body center of gravity is located approximately at the level of
second sacral vertebra. In prone position the general body center of mass or
body center of gravity shifts to the head by roughly 1 percent. Amplitude of
vertical oscillations of centre of gravity in healthy female persons at the age
of 19-20 has been determined in our studies. Research results testify that
amplitude of vertical oscillations of general body center of mass is
considerably depended on step length compared with other parameters. The study
of change in amplitude of vertical oscillations of general body center of mass
gives us an opportunity to determine its dynamics also during locomotive organs
diseases when the range of motions is limited, as well as to schedule the ways
of optimization of motor reactions. Ref. 5.
Auth.
b14.3.3.54. Some
questions of formation of a balneological region in the western zone of
Kolkheti Lowland. /N.
Akhvlediani/. Science and Technologies. – 2014. – #1(715). – pp. 103-108. – geo.; abs.: geo., eng., rus.
The questions of regulation of balneology resources,
their rational distribution with a view to create the most favorable conditions
balneotherapy in the balneological region, as well as the area arrangement
through functional zoning are discussed. For a deeper study, a group of balneology resorts and
places located near the towns of Zugdidi and Senaki: Menji, Tsaishi, Bia,
Qvaloni, Khorga, Kulevi, Nokalakevi are considered as an example. Fig. 3, Tab. 1, Ref. 5.
Auth.
b14.3.3.55. Changes in the volume
of nitrate-nitrite concentration in greens upon their chopping. /G. Andriadze, E. Mkhchian,
E. Shengelia, L.Gvasalia/.
Science and Technologies. – 2014. – #1(715). – pp. 109-113. –
geo.; abs.: geo., eng., rus.
By keeping manually chopped greens in the air for 2-3 hours, the process
of accumulation in them of both nitrites and nitrates takes place. This means
that the consumption of these products after this time interval involves major
growth of nitrate-nitrite volume in the human body. Accordingly, the greens
better to consume as soon as they are chopped. Fig.
2, Tab. 3, Ref. 11.
Auth.
b14.3.3.56. Glio-capillar
interaction in the rat offspring’s cerebral hemisphers under prenatal ethanol
intoxication. /R. Chikhladze, N. Ramishvili, Z.
Tsagareli, L. Gogiashvili/. Georgian Medical News. – 2014. – #9(234). – pp. 129-134. – rus.; abs.: geo., eng., rus.
Brain cortex specimens
(hematoxylin-eosin stained) from the newborn rats were analyzed for glial
cells’ morphological identification. Oligodendrocytes, astrocytes and glial index
were tested in 1 and 7 days after birth. Under the prenatal alcoholism in the
first 7 days of life in the animals’ sensomotoric cortex the proliferation of
glial cells, restructurization of the glio-capillary interaction,
dyscirculatory changes affecting all layers of the cortex, including layer V
are principal. It is concluded that the changes (death) of neurocytes are
morphological expressions of the glio-capillary interaction pathology – the
deficiency of the cerebral cortex blood supply and the disorganization of the
blood-brain barrier. Tab. 1, Fig. 5, Ref. 22.
Auth.
b14.3.3.57. Analysis of the
pharmaceutical method ADAPT used in health support programs. /N. Kvizhinadze/. Tbilisi
State Medical University Collection of Scientific Works. – 2013. – #47. – pp.
90-92. – eng.; abs.: geo., eng.
Pharmacists
continue to be among the most trusted and accessible healthcare professionals.
The profession of pharmacy continues to evolve from product-oriented to
patient-centered practice with opportunities emerging for population-based
interventions. In response, pharmacists and student pharmacists are more
involved in public health activities, including service learning and community
outreach projects during introductory and advance practice experiences and extracurricular
programs. According to the analysis of the training carried out at the Arizona
University. It is obvious that the ADAPT instrument provides an application and
resource to address pharmacy educational outcomes and accreditation standards
pertinent to public health. The instrument will be beneficial to pharmacists in
planning, developing, and implementing high-quality, evidence-based,
well-planned pharmacist-directed health promotion programs. As pharmacists and
student pharmacists continue to assume active roles in public health
activities, instruments such as 25 ADAPT are important to ensure high quality
health promotion programs that meet the needs of patients and populations and
maintain compliance with laws and regulations. Healthcare providers and faculty
staff anticipate that the ADAPT instrument will promote and further the
documentation of pharmacists’ contributions to address national health goals
and improve the health of society. Ref. 9.
Auth.
b14.3.4.1. Comparative
evaluation of physical-mechanical properties and surface morphology of the
samples of base self-cured acrylic resin "redont-kolir" polymerized
in the silicone and alginate matrixes. /M.
Bogatyrenko/. Georgian Medical News. – 2014. – #7-8(232-233). – pp. 33-37. – rus.; abs.: geo., eng., rus.
Determination of advantages of
using silicone or alginate impression material as a matrix is decisive for
quality of immediate and transitional dentures manufactured by the direct
method using self-cured acrylic resins. The aim of this study was a comparative
evaluation of physical-mechanical properties and surface morphology of the
samples of base self-cured acrylic resin “Redont-kolir” polymerized in the
silicone and alginate matrix. The samples were polymerized in the C-silicone -
"Zeta plus-putty" ("Zhermack", Italy) and alginate -
"Ypeen" ("Spofa Dental", Czech Republic) matrixes under
different regimes: 1) in the pneumopolymerizer “Averon” at an air pressure of 3
atm., a temperature of 450C for 15 minutes, and 2) polymerization in
water at 450C for 15 minutes. We determined the following physical
and mechanical properties: bending load, toughness, bending stress at break,
hardness by Heppler, conical point of fluidity and water absorption. Electron
microscopy studies of the samples have been conducted on electronic raster
microscope JSM-840 ("Jeol", Japan). As a result of studies, it was
found that the optimum regime of polymerization for acrylate
"Redont-kolir" is in the pneumopolymerizer "Averon" at an
air pressure of 3 atm., a temperature of 450C for 15 minutes. By the
results of studying the surface morphology of the samples we can draw a
conclusion that the use of an alginate impression material as matrix allows to
obtain a qualitatively better surface of denture. But taking into account the
technological properties of the alginate impression materials, namely an
expressed shrinkage, their use for this purpose must be limited by the time
during which the impression matrix remain stable in size, which is specified by
manufacturer’s recommendations. Tab. 2, Ref. 6.
Auth.
b14.3.4.2. Role of transcription
nuclear factor ΚB in mechanisms impairing oxidative metabolism in rats’
brain under chronic hypomelatoninemia. /Y. Frenkel, V.
Cherno/. Georgian Medical News. – 2014. – #7-8(232-233). – pp. 99-102. – rus.; abs.: geo., eng., rus.
The experiment carried out on 20 Wistar male
rats weighing 180-220 g was designed to study the effect of NF-κB
activation on the free radical oxidation and bioenergy processes in the brain
under modeled chronic hypomelatoninemia (animals were exposured to steady
illumination at a dose of 1500 lux for 55 days). It has been shown the
intraperitoneal administration (daily for the last 7 days of steady
illumination) of nuclear factor κB (NF-κB) activation inhibitor II -
JSH-23 (4-methyl-N-(3-phenylpropyl) benzene-1,2-diamine) in a dose of 1 mg/kg
of animal’s body wt is accompanied with a significant reduction in ·О2
production by mitochondria and NADPH oxidase of leukocytes, by the formation of
secondary LPO products, increased activity of superoxide dismutase and
catalase, AO potential, ATP content and energy quotient. It might be concluded
the disturbances resulting in the above mentioned processes in the brain under steady
hypomelatoninemia are of NF-κB-dependent nature. Tab. 2, Ref. 13.
Auth.
b14.3.4.3. Total
polyphenols and antioxidant activity in different species of apples grown in
Georgia. /N. Gogia, M. Gongadze, Z. Bukia, M.
Esaiashvili, I. Chkhikvishvili/. Georgian Medical News. – 2014. – #7-8(232-233). – pp. 107-112. – eng.; abs.: geo., eng., rus.
Many studies have shown that
biologically active components in plant-based foods, particularly phytochemicals,
have important potential to modulate many processes in the development of
diseases, including cancer, cardiovascular disease, diabetes, pulmonary
disorders, Alzheimer’s disease, and other degenerative diseases. The aim of the
our study was to provide an updated understanding and analysis of various apple
sorts growing in Georgia by the compounds with a particular focus on their
potential role(s) in disease risk and general human health. The Various sorts
(Kekhura, Banany, Golden, Starty, Chempion, Aidaridy, Brotsky, Achabety,
Sinapy, Jonagold and Antonovka,) of apples were investigated. The total
phenolic content and antioxidant activity were studied in peel and flesh
extracts and were measured by slightly modified method of Folin-Denis using
Folin-Ciocalteu reagent and - 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical
scavenging method in those varieties of apples. Summarizing our data, we can
conclude that, in accordance with the benefit to human health, the most
prominent varieties of apples - Kekhura. It is rich with phenolic compounds,
and also characterized by high scavenging activity. Also has good features
Antonovka and Achabety. It should be noted that apple peel more helpful than
the flesh, and therefore during consumption peeling of apples is unacceptable
in terms of its usefulness. Tab. 1, Fig. 3, Ref. 14.
Auth.
b14.3.4.4. Study of
the immunomodulatory activity of progesterone in an experimental model of
Jurkat cells. /A. Gokhelashvili, N. Gogebashvili, I.
Datunashvili, N. Bejitashvili, L. Jashi, T. Sanikidze/. Georgian Medical
News. – 2014. – #7-8(232-233). – pp. 112-116. – rus.; abs.: geo., eng., rus.
Progesterone plays an important
role in the regulation of the immune system during pregnancy. We investigated
the influence of progesterone on the activity of T-lymphocytes in a model
system of Jurkat cells. Jurkat cells were stimulated with 50 μg/ml of
phytohemaglutinin A (PHA) at 370C for 5 minutes. Then, PHA was
removed by centrifugation, the cells were washed and cultured for 24 hours
alone or with progesterone (added to the incubation medium of Jurkat cells at a
concentration of 0.07 and 0.7 μl). The effect of progesterone on the level
of apoptosis and expression of cytokines in jointly incubated intact and
PHA-stimulated Jurkat cells. It was revealed that progesteron did not affect
the intensity of apoptosis and cytokine expression in intact, but
dose-dependently promotes intensification of apoptosis (to 88%) and inhibits
the cytotoxic activity of jointly incubated intact and PHA-stimulated Jurkat
cells (ratio of IL-2/IL-10 decreased from 2.56 to 1.53). Tab. 1, Fig. 1, Ref. 12.
Auth.
b14.3.4.5. The possible
effect of variable membrane potential of a cancer cell on different
carcinogenic processes. /G.
Gogichadze, T. Gogichadze, E. Misabishvili, G. Kamkamidze/. Georgian Medical
News. – 2014. – #9(234). – pp. 116-120. – eng.; abs.: geo., eng., rus.
Cancer cells (unlike normal
analogs) have a variable membrane potential on their surface, which depends on the
intensity of metabolism of this type of cells and the environmental hydrogen
index: in the case of low-pH (acid medium) they are known to have either a low
negative or even positive charge, while in the case of high-pH (alkaline
medium) – a relatively high negative charge. In this paper we suggest that the
processes of metastasis, progression and invasion ongoing in a macro organism
can be ascribed to the presence of exactly this variable electric charge in a
cancer cell. Ref. 27.
Auth.
b14.3.4.6. The effect
of peptide bioregulator and cobalt ions on the activity of NORs and
associations of acrocentric chromosomes in lymphocytes of patients with
hypertrophic cardiomyopathy and their relatives. /T. Jokhadze, T. Buadze, M. Gaiozishvili, M. Rogava,
T. Lezhava/. Georgian Medical News. – 2014. – #9(234). – pp. 134-137. – rus.; abs.: geo., eng., rus.
The influence of peptide
bioregulator - Livagen (Lys-Glu-Asp-Ala) separately and combined with cobalt
ions, on the activity of nucleolar organizer regions (NORs) and the frequency
of associations of acrocentric chromosomes in lymphocytes from patients with
hypertrophic cardiomyopathy (HCM) and their relatives have been studied. It is
shown that a combined action of Livagen and cobalt ions increases the frequency
of large-sized scoring 2 NORs in both patients and their relatives. Significant
was also the influence of the studied compounds on the associative activity of
acrocsentric chromosomes that was expressed in a sharp increase of this
indicator in both studied groups. In this case more effective was the action of
Livagen and cobalt ions. As activity of NOR and the frequency of associations
of acrocentric chromosomes are dependent of the quality of acrocentric
chromosome stalk condensation, we conclude that the influence of Livagen and
cobalt ions on the lymphocytes of HCM patients and their relatives leads to the
decondensation of heterochromatinized chromatin. This may be a prerequisite for
release of inactivated genes in the studied groups of individuals as a result
of their condensation. Our data are important because they provide new
information about the protective effect of Livagen and Livagen+Cobalt ions on
the lymphocytes of HCM patients and their relatives and may lead to the
development of a therapeutic treatment. Fig. 3, Ref. 5.
Auth.
b14.3.4.7. The fatty
acid composition of large pumpkin seed oil (Curucbitae
maxima Duch) cultivated in Georgia. /B.
Kikalishvili, D. Zurabashvili, D. Turabelidze, J. Aneli, L. Shanidze/. Georgian Medical
News. – 2014. – #9(234). – pp. 138-141. – rus.; abs.: geo., eng., rus.
The aim of the study was to
identify qualitatively and quantitatively the fatty acid composition of the
seed oil of large pumpkin cultivated in Georgia (Cucurbitae maxima Duch) and evaluate its biological activities. The
evaluation was conducted using a high-performance liquid chromatography method.
Fatty acids ranging from C12:0 to C22:0 were identified in the probe. The oil
composition was identified as follows: 0,2±0,01mg% lauric, 0,3±0,01 mg%
miristic, 9,0±0,7mg% palmitic, 5,5±0,4 mg% stearic, 28,1±1,0 mg% oleic,
40,2±1,9 mg% linolic, 12,1±1,0 mg% linolenic, 2,0±0,2mg% arachinic and 1,2±0,1
mg% begenic acids. The investigation showed that large pumpkin seed oil contains
a range of biologically significant fatty acids, the unique proportion of which
attaches great value to the vegetative material. Tab. 1, Ref. 11.
Auth.
b14.3.4.8. Clinical and
biochemical analysis of ligature-induced periodontitis in rats. /Y. Chumakova, A. Vishnevskaya, A. Kakabadze, L. Karalashvili, Z.
Kakabadze/. Georgian Medical News. – 2014. – #10(235). – pp. 63-69. – rus.; abs.: geo., eng., rus.
The most common experimental model of
periodontitis is a “ligature” model. However, due to the complexity connected
with performing on rats, modification of existing model is proposed, which
differs by fixture of cotton ligature around the central incisor and not around
the second molar. The purpose of research - a comparative evaluation of
“peroxide” and modified by us, “ligature” models of periodontitis in rats. 2
series of experiments on 36 white Wistar rats were conducted. The animals were
divided into two groups: intact rats (control) and rats with a “peroxide” model
of periodontitis, which was reproduced by the addition to the diet of rats
overoxidized sunflower oil (5% by weight of the feed), daily, for 45 days.
“Ligature” model in rats was reproduced by applying a cotton ligature on the
central incisor of the upper jaw for 14 days. Elastase activity, malondialdehyde
content and catalase activity in the gums and in the blood serum was measured
by biochemical methods. The degree of atrophy of the alveolar bone of the
mandible was determined by morphometric method. It is found that in both models
of periodontitis in rats, changes in the periodontal tissues and in the
organism as a whole, is common for periodontal disease in humans. Clinically
apparent inflammation of the periodontal tissues is observed, metabolic
disorders in the gums, change of biochemical parameters in serum and
progressive decline in the alveolar bone are determined. A comparative analysis
of the two models showed that the modified “ligature” model of periodontitis in
rats has several advantages over the “peroxide” model: shorter term of modeling,
more pronounced clinical inflammation of periodontal tissues and faster
resorption of alveolar bone. Tab. 3, Ref. 16.
Auth.
b14.3.4.9. The
effects of grape seed and coriander oil on biochemical parameters of oral fluid
in patients with periodontitis. /M.
Nikolaishvili, M. Gogua, Q. Franchuki, T. Tufinashvili, D. Zurabashvili/. Georgian Medical
News. – 2014. – #10(235). – pp. 69-73. – rus.; abs.: geo., eng., rus.
Among the biochemical changes taking
place in patients with periodontitis 1 and 2, the following take place: the
content of lactate dehydrogenase increases, alkaline phosphatase activity
increases and the activity of amylase deteriorates. Therefore, the probability
of increase in superoxide substances, which causes an increase of pathogenic
bacteria in the oral cavity and severity of periodontitis, can be assumed. The
grape seed and coriander oil is of vegetable origin with antioxidant action.
Their effect on the oral cavity causes a statistically significant increase in
the content of amylase and decrease in the content of alkaline phosphatase and
lactate dehydrogenase, also leading to the normalizing of the oral cavity’s pH.
It should be noted that application of the coriander oil is less effective.
Tab. 3, Ref. 12.
Auth.
b14.3.4.10. Discrepancy
between HCV structural and non-structural genes in Georgian genotype two
patients. /T. Tsertsvadze, M. Karchava, L.
Sharvadze, L. Gatserelia, E. Dolmazashvili/. Georgian Medical
News. – 2014. – #10(235). – pp. 74-78. – eng.; abs.: geo., eng., rus.
Correct identification of
hepatitis C genotypes is an important diagnostic tool, which guarantees further
selection of adequate treatment regimen and correct duration. Ideal approach
for accurate genotyping is amplification of both structural and non-structural
parts of HCV genome. As different methods, which use either one or another
region for HCV genotyping sometimes lead to indeterminate genotype and subtype
results. Therefore, it is of importance to compare HCV genotyping results based
on two different genomic regions. As part of this study, remnant 108 specimens,
with previous history of successful genotype identification by 5’UTR/core
Versant HCV genotyping kit, were retrospectively analyzed. “In house” HCV real
time PCR-based method that amplifies parts of NS5B region was used for this
purpose. Based on our data, genotyping calls were concordant between genotype
one and genotype three specimens group in both regions. However, discrepancy
was evident among genotype 2 group. Of 25 specimens originally typed as
genotype 2 in structural region, only 7 was confirmed in non-structural region,
remaining 18 specimens were typed as 1b. Therefore, the discordance rate
between structural and non-structural regions for genotyping call among
genotype two was 72%. Our data showed highly discordant structural and
non-structural genome for genotype two identification in our specimens. We
propose that this phenomenon might be due to the recombination event between genotype
two and genotype one. Possible circulation of this strain in Georgia stresses
the need for detailed sequencing and phylogenetic analyses of these specimens
in both structural and non-structural parts of HCV genome. Tab. 1, Ref. 15.
Auth.
b14.3.4.11. Epigenetic
regulation of acute inflammatory pain. /E.
Abzianidze, E. Kvaratskhelia, T. Tkemaladze, K. Kankava, G. Gurtskaia, M.
Tsagareli/. Georgian Medical News. – 2014. – #10(235). – pp. 78-81. – eng.; abs.: geo., eng., rus.
Acute pain is associated with
tissue damage, which results in the release of inflammatory mediators. Recent
studies point to the involvement of epigenetic mechanisms (DNA methylation) in
the development of pain. We have found that during acute inflammatory pain
induced by the application of 10% mustard oil on the tongues of rats, levels of
DNMT3a and 3b were elevated markedly (36 and 42 % respectively), whereas the
level of DNMT1 was not changed significantly. Previous injection of Xefocam
with 0.4 mg/kg dose decreased levels of DNMT3a and 3b (25 and 24%
respectively). The level of DNMT1 was not changed significantly compared to the
control group. The findings support the idea that inhibitors of
DNA-methyltransferases could be useful for pain management. Our data suggest
that NSAIDs (alone or in combination with DNMT inhibitors) may be proposed as
possible epigenetic regulatory agents, which may play a role in epigenetic
mechanisms indirectly through altering the activity of inflammatory mediators
involved in pain development. Tab. 1, Fig. 1, Ref. 10.
Auth.
b14.3.4.12. Use of a solution
test to evaluate loratadine generics. /K. Baramidze, T.
Chikviladze, M. Jorjikia, H. Ioramashvili, T. Otarashvili/. Tbilisi State Medical
University Collection of Scientific Works. – 2013. – #47. – pp. 19-21. – geo.;
abs.: geo., eng.
The release of active compound out of four
solid dosage form drugs - loratadine made by different manufacturers registered
in Georgia is examined. It is established that all of the samples comply with
monographs USP 36 NF 31 on test “dissolution“, as from all samples are released
more than 80% loratadine for 60 minutes. The solubility profiles of the study
samples and the reference drug are compared and it is established that samples
2, 4 and 5 are eqequal with the reference drug. As regards sample 3 (the
quotient of similarity – 49.87%, the quitient of difference – 9.07%), the
outcomes of in vitro study are not
satisfactory and thus the establishment of therapeutic equivalence requires
additional in vivo studies. Tab. 2,
Fig. 2, Ref. 8.
Auth.
b14.3.4.13. The study of
ofloxacine in vitro release from solid dosage forms. /K. Baramidze, T. Chikviladze, M. Jorjikia, H. Ioramashvili, T.
Otarashvili/. Tbilisi
State Medical University Collection of Scientific Works. – 2013. – #47. – pp.
22-24. – geo.; abs.: geo., eng.
Examined is the release of active compound
out of four solid dosage form drugs - ofloxacine from different manufacturers
registered in Georgia. It is established that all of the samples comply with
the requirement of monograph USP 36 NF 31 for test “dissolution“, as from all
samples more than 80% ofloxacine in 30 minutes are released. The solubility
profiles of the samples under study are compared to found that the solubility
profile of only two samples (#3 and #4) correspond to the reference and,
therefore, only these two samples equal the referral medicine. As regards the
samples #2 and #5, the in vitro study
data are not satisfactory and thus the therapeutic equivalence establishment
requires additional in vivo studies.
Tab. 3, Fig. 2, Ref. 6.
Auth.
b14.3.4.14. Effect of сochlear
implantation in children with hearing loss on their intellectual ability
assessed by raven’s colored progressive matrice. /T. Devdariani, N. Manjavidze, K. Gogberashvili, Z. Kevanishvili/. Tbilisi State Medical
University Collection of Scientific Works. – 2013. – #47. – pp. 53-56. – geo.;
abs.: geo., eng.
Raven’s Colored
Progressive Matrices (CPM) is a well-accepted and widely used tool for assessing
the general intelligence of young children ages 5-11years. The present study
was designed to estimate the intellectual ability of early age children after
cochlear implantation, effect of implantation on child’s intellectual
development after 6-12 months of intervention. A case-control study was
performed in Tbilisi Inclusive Education Centre for children with hearing loss
and National Centre of Audiology. 25 children from these centers formed group I
as control. Cohort II included 10 deaf children after 6-12 months of cochlear
implantation. Comparison of the study and control groups was performed by
Mann-Whitney’s Nonparametric Test for 2 independent groups. The results
revealed statistically significant difference in intellectual ability between children
from cohorts I and II. Therefore, it has no difference whether the deafness
resulted from CMV infection or other causes. The intellectual ability of
children after cochlear implantation was significantly higher than in children
with hearing loss (P<0.05).The intellectual development of implanted
children after 6-12 months of intervention was not significantly different from
the healthy children data. Fig. 1, Ref. 10.
Auth.
b14.3.4.15. Antioxidant polyphenols
from betula medwedewi growing in Georgia. /L. Zardiashvili, M.
Jokhadze, J. Kuchukhidze, M. Maisashvili, V. Mshvildadze/. Tbilisi State Medical University Collection
of Scientific Works. – 2013. – #47. – pp. 66-67. – eng.; abs.: geo., eng.
The
antioxidant effects in plants are mainly due to the presence of phenolic
compounds such as flavonoids, phenolic acids, tannins and phenolic diterpenes.
Oxidative damage is implicated in most diseases processes. In vitro studies are
able to demonstrate for flavonols and flavones a considerable antioxidative
activity, mainly based on scavenging of oxygen radicals. The antioxidative
potential of different fractions (respective organic fractions of n-hexane,
chloroform and ethyl acetate) of 70% methanol extract of Betula medwedewii was
evaluated using free radical-scavenging activity on DPPH
(1,1-diphenyl-2-picrylhydrazyl ) assays. The methanol extract showed signiûcant
activities in all antioxidant assays and contained a high level of total
phenolic content. It was observed that the level of hydrophilic phenolic
content was higher than that of hydrophobics. Among those organic solvent
fractions, ethyl acetate fraction exhibited signiûcant activities due to the
highest level of total phenolic content and their IC50 values were 0.19 ± 0.02
mg/mL. These activities were superior to those of a commercial natural
antioxidants tested. The chloroform and hexan fractions also exhibited
signiûcant free radical-scavenging activity (IC50 0.63± 0.03 μg/mL and
0.84± 0.04 μg/mL respectively) attributed to the high amount of
hydrophobic phenolics. Tab. 1, Fig. 1, Ref. 5.
Auth.
b14.3.4.16. Modern aspects of pharmaco and ecogenetic diagnostic. /M. Chipashvili, E.
Imnadze, Ts. Gigienishvili/. Tbilisi State Medical University Collection of Scientific
Works. – 2013. – #47. – pp. 161-163. – geo.; abs.: geo., eng.
Human immunogenetical determination is out of question. The
inheriting differences are not researched enough. That is why it is necessary to change
the approach with each case. It is also necessary to run pharmacogenetical
diagnostic in conservative and operative treatment course. As for the food and
its addition genetic control, it requires to refine the methods of appropriate
services and research on the molecular level. Nowadays even the natural food
causes sudden individual reactions that are defined by the individual’s
heredity qualities. Thus, pharmaco- and diet therapy must be based on
molecular-genetic researches. Pathological reactions on food and drugs in
humans are caused by biochemical and metabolic defects. Hereditary defects of
enzyme, receptor, transport and antigen protein system cause not only important
functional defects, but may also be a reason of disability or even death. Thus,
it is important to make patients eco- and pharmacogenetic diagnosis. There are
no resistant forms of diseases – but there is a genetic tolerance towards known
drugs. Ref. 6.
Auth.
b14.3.4.17. Actual
problems of clinical pharmacy in Georgia. /T. Chumburidze, N.
Nemsitsveridze, G. Simonia, N. Aptsiauri, T. Kilasonia/. Tbilisi State Medical University Collection
of Scientific Works. – 2013. – #47. – pp. 163-164. – geo.; abs.: geo., eng.
Establishment of the Institute of clinical
pharmacists in Georgia was the question of long-term discussions but due 44 to
lack of information and inertia of mentality it still has not been implemented.
The study was aiming at better getting acquainted with the issues of clinical
pharmacists in Georgian reality, so we supposed it necessary to carry out a
survey - through questionnaires. Respondents were doctors, pharmacists and
patients. According to the survey results the cooperation between doctors and
pharmacists was supported by nearly 90% of respondents. The respondents cited
doctor’s position as impeding factor for developing cooperation between the
physician and the pharmacist. Unfortunately, majority of respondents believe
that there is no agreement between physicians and pharmacists in respect of
prescribing medicines. According to the responses collaboration between the
physician and pharmacist will have a very positive impact on patient’s
condition. Informing physicians and establishment of the institute of clinical
pharmacist will help eliminate professional misunderstandings implying further improvement
and pharmaceutical education in direction of clinical pharmacy, which will
undoubtedly contribute to preparation of MS candidates specializing in clinical
pharmacy and providing trainings in clinical pharmacy for the pharmacists
working at drugstores/ chemist’s shops. Fig.1, Ref. 6.
Auth.
b14.3.5.1. Induratio penis
plastica and the capability of vaginal penetration in the context of forensic
evaluation. /K. Albrecht, G. Kedia, S. Ückert, L. Hagemeier, M.
Kuczyk, M. Klintschar/. Georgian Medical News. – 2014. – #9(234). – pp. 89-93. – germ.; abs.:
geo., eng., rus.
The so-called induratio penis plastica (IPP), also known as Peyronie Disease or Morbus
Peyronie, is the most common cause for deviation of the male penis. In most
cases, the deviation is directed to the dorsal side. In face of a lawsuit
related to a sexual offence, the opponent might argue that, due to an existing
IPP, he is generally unable to insert his penis into a female’s vagina. The aim
of the present study was to examine the clinical files of thirty (30)
consecutive patients who presented with IPP. Particular attention was given to
the individual degree of penile deviation and the ability of the subjects to
conduct vaginal intercourse. Subjects who had a dorsal penile deviation of 800
to 900, or a lateral deviation of 600, were unable to
commence vaginal coitus. In contrast, three (3) subjects who presented with a
ventral deviation of 300 to 400 had no difficulties in performing
vaginal penetration. The medico legal aspects of these findings are being
discussed. Fig. 1, Ref. 18.
Auth.
b4.1. Agriculture, forestry and fishery
b14.4.1.1. Agrochemical characterization
of the main soil types of Georgia. /T. Urushadze, A.
Tkhelidze, T. Urushadze/. Annals of Agrarian Science. – 2014. – vol. 12. – #4.
– pp. 24-31. – eng.; abs: eng., rus.
On the basis of agrochemical
research of all soil types in Georgia on the 22.5% of the total area of soils
hydrolytic nitrogen is low, on 59,4% of the total area it is low or average.
High content is marked only on 18.0%. Therefore, nitrogenous fertilizers must
be used on almost of all types of soils. Regarding mobile phosphorus, 54.3% of
the total area is marked with low content of this element, low or medium – on
40.9%. Higher than average phosphorus content is observed on 4.8 % of the total
area. Therefore, most types of soils require phosphorus in the amount of
1.0-1.25. Exchangeable potassium content analysis shows that on 0.8% of land
its content is low; the average or low content is observed on 16.0% of land;
27.6% of the total area is distinguished by higher than average content of
exchangeable potassium. High levels of exchange potassium are on 55.6% of the
total area. The soils in the next 4-5 years will not require potash
fertilizers. Light texture soils are poor or very poor in exchangeable
potassium, so without potash fertilizers the harvest will be rather low. Ref.
22.
Auth.
b14.4.1.2. Genetic peculiarities of the
black soils of Georgia. /T. Urushadze, D. Machavariani, T.
Urushadze/. Annals of Agrarian Science. – 2014. – vol. 12. – #2. – pp. 29-34. –
eng.; abs: eng., rus.
Black soils
(so-called plain chernozems) are characterized by sharply-expressed
differentiation, powerful humus horizon, increased compactness, clay texture.
The soil profile usually has the following structure: A-B- BC(BC )-C (Ca). Main
diagnostic indexes are resin-black color of the upper part of profile (usually
with luster shine), carbonate and clay formation of the middle part. These
soils are distributed in hill-plain zone between mountains – in outer and inner
Kakheti, in lower and particularly, in Middle Kartli regions. The basic
elementary soil formation processes of black soil are: humus formation, humus
accumulation, salinization, carbonate formation, sialitization and clay
formation. Tab. 5, Ref. 12.
Auth.
b14.4.1.3. The study of the toxicity
level of soils contaminated with arsenic in Racha and Svaneti. /R.Gigauri,
Sh.Japaridze, T.Gogiberidze, N. Khavtasi/. Annals of Agrarian Science. – 2014.
– vol. 12. – #2. – pp. 42-45. – eng.; abs: eng., rus.
In two regions of
Georgia (Racha, Svaneti), the percentage of arsenic in soils of the area
adjoining the arsenic-containing landfills have been studied using the TCLP
(toxicity characteristic leaching procedure) and WET (waste extraction test)
methods/standards. Their forms, valence, solubility, and range were identified.
As a result of the study, the soils are found to contain liquid forms of
arsenate, namely sodium arsenates being noted for high toxicity level and
range. For the soils distanced from the landfills by 10, 200, 500 the total arsenic
contained in them was calculated. The toxicity level is found to decrease with
the distance from the source of contamination and correspondingly equals 12.5,
7.0, 4.0 and 1.5 g/kg in percentage terms. Tab. 3, Ref. 5.
Auth.
b14.4.1.4. Morphological peculiarities of fungal fruit bodies against adverse
conditions.
/M.Kutsia/. Bulletin of Akaki Tsereteli State University. – 2014. – #2(4). – pp. 10-17. – geo.; abs.: geo., eng.
The article presents a general overview of
disease-causing fungi. Special attention is paid to fungal diseases of agricultural crops in
Georgia and their
ability to adapt to adverse conditions. The research data about the anatomical and morphological peculiarities of fungal fruit bodies are presented. Fig. 2, Ref. 3.
Auth.
b14.4.1.5. Asymmetric, combined soil-processing agricultural machine. /A. Samadalashvili, T.
Modebadze/. Bulletin of Akaki Tsereteli State University. – 2014. – #2(4). – pp. 24-32. – geo.;abs.: geo., eng.
Treatment
(milling) of soil around fruit plants and dosed (spot) fertilizing is possible
by means of asymmetric,
combined soil-processing agricultural machine.
The machine encompasses ploughing mill, mineral fertilizer storage tanker,
fertilizer scattering rolls, which are switched on and off by means of clutching
blade, and a gear, which is activated through the tractor-power drive shaft.
The machine can be aggregated symmetrically as well and can be applied for
surface treatment of soil, to bring in fertilizers and for scattered sowing of
grass seeds (instead of fertilizer) after complete tillage of the soil with
ordinary ploughs. Fig. 2, Ref. 2.
Auth.
b4.2. Animal
and dairy science
b14.4.2.1. General characteristics of sheep-breeding in Georgia. /M.Tsintsadze/. Metsniereba da Tskhovreba. –
2014. – #2(10). – pp.102-105. – geo.; abs.: geo., eng., rus.
The paper discusses
sheep-breeding as the oldest field of farming. The article intensively covers
contemporary trends of its development and current situation in this field.
Thoroughly are discussed what kind of sheep breeds exist nowadays in Georgia,
their structure, exterior as well as productive indexes. Also concerns about
current structure of the sheep breeding are discussed in the paper. The authors
state the importance of revival of this field and raising the number of sheep
heads in Georgia, which shall contribute to its productivity and would further
develop the market economy in the country. Ref.1
Auth.
b4.4. Agricultural
biotechnologies
b14.4.4.1. Transformation
of biologically active stilbenoids from grapevine to red wine, food supplement
and beverage. /M. Bezhuashvili, P.Vashakidze, N.
Vepkhishvili, L. Elanidze/. Annals of Agrarian Science. – 2014. – vol. 12. –
#4. – pp. 63-70. – eng.; abs: eng., rus.
Cis- and
trans-piceid stilbenoids have been identified and determined in juice and skin
of the red-grape vine varieties growing in Georgia. The experiment used
different grape varieties, such as Saperavi, Cabernet Sauvignon, Otskhanuri
Sapere, Aleksandrouli, Mujuretuli, Shavkapito, Tavkveri, Aladasturi, Dzelshavi,
Ojaleshi. The substance isolated by means of preparations was identified with
acid hydrolysis, thin-layer and high-effective liquid chromatography and
UV-spectroscopy. It was found that the grape juice contains more trans-piceid,
while the grape skin contains more cis-piceid. It was for the first time,
trans-resveratrol was identified in the shoots of Saperavi grape (Vitis vinifera L.). Based on the gained
data, the transformation of the grape stilbenoids in the red wine identified by
us was fixed. We have developed the technologies to produce biologically active
products containing stilbenoids by using the grapes. Tab. 6, Fig. 3, Ref. 27.
Auth.
b14.5.2.1. Evolution of modeling of innovation
processes. /Z. Gasitashvili, S. Khutsishvili, J. Gagloshvili/.
Transactions of
Technical University of Georgia. – 2014. – #4(494). – pp. 55-64. – geo.; res.:
geo., eng., rus.
The effective
innovation process organization problems in modern enterprises are considered.
The definitions of innovation and innovation process, along with its meaning
and forms are given. The innovation process modeling evolution periods are
described, particularly five models are presented: starting from easy
"linear" model to complicated nonlinear net and interactive models.
The main features of such models, their pros and cons are analyzed; also the
general peculiarities and development directions for non-linear models are
presented. Fig. 8,
Ref. 3.
Auth.
b14.5.2.2. Macro and micro factors operating on the improvement of
the competitiveness of air carriers. /Y. Sukhitashvili, N. Dumbadze, M. Sukhitashvili,
B. Davitadze/. Air Transport. – 2014. – #1(9). – pp. 42-53.
– rus.; abs.: geo., rus., eng.
Due the world global economic crisis and acute
competition air carriers pay more attention to the reduction of costs and
improvement quality of services, meeting thus population needs for movement. It
is very important nowadays for air companies to take into account an optimal
balance between tariffs and quality. In this case, the air carrier will offer
to the customer quality services together with the acceptable price, which, in
general, will increase its competitiveness on the air market. Ref. 6.
Auth.
b14.5.2.3. Analysis of risk factors influencing an investment
process. /M.
Lomsadze-Kuchava/. Modern Issues of Medicine and
Management. – 2014. – #1. – pp. 117-124. –
geo.; abs.: geo. eng. rus.
This article
discusses risk factors acting on an investment process. The concept of risk and
methods reducing the impact of risk are given. Differences by types of
investment risks are considered. The article refers to the process of return,
as the difference between the receivables and payables. The paper describes the
features of an investment decision, which becomes relevant when taking into
account the risk factors. When evaluating prospective investment results,
different methods, such as Net Present Value, Discount Rate, Divestment, are
applied. Tab. 1, Fig. 1,
Ref. 7
Auth.
b14.5.2.4. Modelling of managerial decision-making in an energy
company. /N.
Giorgishvili/. Modern Issues of Medicine and Management. –
2014. – #1. – pp. 125-133. – geo.; abs.: geo. eng. rus.
The models of
decision-making, their varieties and application issues are considered in this
work. Opportunities of managerial decision- making at different limitations are
defined. Theoretical and practical approaches of application of models are
studied. Tab. 1, Fig. 2,
Ref. 9.
Auth.
b14.5.2.5. Leadership
development characteristics under conditions of global economy. /G. Amkoladze, A. Gabrichidze, M. Giorgobiani, M.
Zedgenidze, N. Kharadze/. Modern Issues of Medicine and
Management. – 2014. – #1. – pp. 141-145. – geo.; abs.: geo. eng. rus.
The issues related
to the selection of a leader of a high emotional intellectual level to manage
the situations resulting from changes of of internal and external factors
effecting the global economy, market, and a company are considered in this
work. Ref. 5.
Auth.
It is known
that the success and competitiveness of the enterprises and firms is
conditioned by their innovative activities. With this point of view the article
analyzes the problem of introduction of new techniques in our mining and
geological enterprises. It is stated that in spite of some positive trends, the
innovative activities of said enterprises are still on a low level. It is
conditioned by both the specific peculiarities of their activities, as well as
by some subjective and objective factors. Certain measures to be taken to
activate such innovative activities in the field are set out on a basis of
analysis.
Ref. 11.
Auth.
b14.5.2.7. Support to small and medium business. /D. Silagadze/. Agrarian-economic
Science and Technologies. – 2014. – #3 (24). – pp. 6-11. – geo.; abs.: geo., eng.
The necessity of development of small and medium
business, which is the basis of modern market infrastructure of any developed
country, is considered. The share of small business in the total volume of production
and services makes 60-80%. The situation of agriculture in the business sector
of Georgia is considered based on the data of the National Statistics Service.
It is underlined that the country became the largest consumer of foreign
products. According to a research made on 194 countries, Georgia ranks the
last. Measures taken and to be taken by the State in the current year are
discussed. The activities for supporting the development of small and medium
business and the active role of the State in the process of their
implementation are considered.
Auth.
b14.5.2.8. Agrarian risks and insurance. /N.
Damenia/. Agrarian-economic Science and Technologies. – 2015. – #1 (26). – pp. 41-45. – geo.; abs.: geo., eng.
Georgia is an
agricultural
country. Out of 52
types of soil met in the
world, 49 are found in
Georgia, which, however, does not mean much for banks; agriculture is considered as a high-risk segment and,
therefore, agriculture makes only 1.9% of total lending. The biggest puzzle for agriculture
is agro-insurance. As regards lending, most of banks avoid issuing credits due
to the fact that agriculture is considered as a high-risk segment. International
statistics and examples demonstrate that the State can greatly contribute to the
development of the agricultural sector insurance. It is also possible to
effectively increase the interest of the people by subsidies and encourage them
to benefit from this type of insurance.
Auth.
b14.5.2.9. Quality management and ISO 9000: as a new
business model. /D. Chakhvashvili, O. Tomaradze/. Automated
Control Systems. – 2014. – #1(17). – pp. 111-114. – eng.; abs.: geo.,
eng., rus.
The universality of
standards ISO 9000 is that they do not offer absolute
measurable quality criteria for individual types of products and services (for
example, the required technical characteristics of the products). This would be
impossible because the quality is the ability of products or services to meet
people's needs, but the needs are diverse. Standards ISO 9000 reflect the
methodology of the quality system’s functioning, which must, in turn, provide
for high quality of products and services, ensuring thus high degree of
customer satisfaction. Fig. 1, Ref. 4.
Auth.
b14.5.2.10.
Development technological process of
credit risk assessment. /E. Turkia, Zv. Arkhoshashvili, T. Pkhakadze/.
Automated Control Systems. – 2014. – #1(17). – pp. 115-120. – eng.; abs.: geo., eng., rus.
In
the article issues of technological development and improvement of the banking
credit system are discussed. For the assessment of credit risk, the attention
is focused on the analysis and decision support of the loan disbursement
process. From this perspective, in the represented article formalizing and
analytical methods (methods of questioning and portfolio, models of credit
scoring and classification tree) of researching creditworthiness of the
borrower and automating mechanisms of these methods are suggested. As the
practical example there are represented business-processes diagram of loan disbursement,
decision tree model and credit scoring algorithm for research of loan
disbursement. Fig.
3, Ref. 4.
Auth
b14.5.2.11.
The standards and goals to improve
operational risks management in organizations. /E. Turkia, N. Morozi, T. Kachlishvili/.
Automated Control Systems. – 2014. – #1(17). – pp. 121-124. – eng.; abs.: geo.,
eng., rus.
Operational
risk management in organizations is one of the high priorities and sensitive matters. Operational risk management
prevents material, non-material and vital damage to the organization. In order
to adequately and timely address such critical issues, maximal automation of
data analysis, evaluation, centralized monitoring, data collection of internal
weaknesses and external threats to the organization, appropriate implementation
methods and analytical tools are required. The article deals with above
mentioned problems of operational risk management in organizations. It proposes
goals and standards for the carrying out implementation of automated data
processing. Fig.1, Ref. 4.
Auth.
b14.5.2.12.
Information
support of exchange activity. /M. Tevdoradze, M. Saltkhutsishvili, M.
Gedevanishvili,N. Lolashvili/. Automated Control
Systems. – 2014. – #1(17). – pp. 125-130. – eng.; abs.:
geo., eng., rus.
Activity of a modern
exchange is characterized by rich information flows. For
proper work of any type of market it needs a powerful information
infrastructure. Many other organizations are included in information support of
exchange. These organizations execute highly complex data processing protocols.
In this article there are discussed different questions: components and
segments of information infrastructure of markets; used documents; types of
information. There are characterized functions of information service of
exchanges and the functions that perform various types of organizations that in
the field of information support the activities of the exchange. There are
considered channels and methods of information transmission in the exchange. Tab. 1, Ref. 2.
Auth.
b14.5.2.13. Modeling of processes of office-work in the
distributed organizational-administrative systems of management. /T. Sukhiashvili, G. Maniev,
I. Shurgaia/. Automated Control Systems. – 2014. – #1(17).
– pp. 131-136.
– eng.; abs.: geo., eng., rus.
Automation
of management by organizational management systems demands creation of the
distributed, multilevel systems. For the analysis and design of similar systems
is used UML technology and different CASE of means developed on its basis. In a
type of existing problems in management of organizational management systems,
modeling of processes of office-work by the specified technology demands
specific approach for creation of adequate models and elimination of those
shortcomings which are shown upon functioning of similar systems. The given
approach gives the chance to develop model patterns for organizational
management systems which are necessary for development of similar computer systems. Fig. 2, Ref. 4,
Auth.
b14.5.2.14. Management of supermarket business processes.
/G.
Janelidze, N. Gogilashvili/. Automated Control Systems. – 2014. –
#1(17). – pp. 137-140.
– eng.; abs.: geo., eng., rus.
Activity of a modern commercial organization
exhibits the unification of the inter-related projects and processes. Several
projects that are realized simultaneously are built in structure of existing
business processes. Thereby, planning of business processes including the
requirements of realized projects and external and internal influences of the
environment is of key importance. The article presents the organization and
management of the supermarket's main business processes, taking into account
the achievement of ultimate goals depending on changing parameters of external and internal environment. Such
approach to the organization and management of business processes will increase
competitiveness of a supermarket. Fig. 1, Ref. 4.
Auth.
b14.5.2.15. Role and significance of SNA (System of National Accounts) in economy. /sh. Metreveli/.
Caucasus International
University Herald. – 2014. – #7. – pp. 89-92. – geo.; abs.: geo. eng. rus.
System of National
Accounts (SNA) is an internationally agreed standard set of recommendations for
the calculation of indicators of economic activity in accordance with clear
rules of accounting at the macro level, based on the principles of economic
theory. This modern information system is used actually in all countries of the
world to describe and analyze the development of the market economy at the
macro level. Indicators and classifications of the system reflect the structure
of the market economy, its institutions and functioning mechanism. In order to
clear out what happens in the economy and to identify the most important
results of the economic process some way is needed to organize information
about economic entities themselves as well as the various operations they
carry, their assets and liabilities. This arrangement is carried out within the
framework of the SNA using special rules and procedures. Nowadays experimental
evaluations of sectorial accounts take place in the national accounts of
Georgia. Besides the sectorial distribution, it is important to obtain reliable
data sources. The main source of indicators displayed in the accounts is
regular quarterly survey on household income and expenditure, as well as data
of the Ministry of Finance and the National Bank of Georgia. In December 2014
methodological explanations are planned to be published on the official website
of the National Statistics Office of Georgia which will reflect in detail the
principles of data calculation and application for the formation of sectorial
accounts. Ref. 6.
Auth.
b14.5.2.16. Motivation paradigm in
comparative management. /A. Katukia/. Caucasus International University Herald. – 2014. – #7. – pp.
97-101. – geo.; abs.: geo. eng. rus.
The
work deals with motivation as the most basic function of management, because by
development of competition the role and significance of motivation is getting
on a higher step. The article begins with preindustrial theories about
motivation and the author shows its genesis and how motivation arose as a
phenomenon and developed as scientific issue; the author mentions reasons of
its development as an object of scientific study. The author also analyzes and
criticizes some theories and describes modern studies and researches. At the
end of the article the situation in Georgia is discussed and the author’s
research is presented. Ref. 10.
Auth.
b14.5.2.17. Possibilities of using Gantt
chart in audit management process. /T. Kikvadze, I.
Parseghashvili/. Business-Engineering. – 2014. – #4. – pp. 55-57. – geo.; abs.: geo., eng.
The article
discusses the advantages of using Gantt chart in the process of planning different
resources in audit management process. Necessary conditions for successful
solution of this task are to reduce the audit process for which are necessary
to calculate the time parameters and define needed human resources for current
operations’ desired effect with the minimum amount of financial costs. The
article provides a detailed analysis of the Gantt chart making stages and
variations of distribution of resources included in the planned chart
implementation process. Fig. 2, Tab. 2, Ref. 4.
Auth.
b14.5.2.18. Marketing research of
Georgian wine export. /T. Bidzinashvili, T. Abuashvili, T.
Tsereteli/. Business-Engineering. – 2014. – #4. – pp. 187-189. - geo; abs: geo, eng.
After Russia’s
embargo restrictions on the export of Georgian wine and its growth has been
fixed only since 2011. In 2013, Georgian wine returned to the Russian market
with noise, but that year the wine was successful not only on this market. In
2014, 15.4 million bottles of Georgian wine Georgia were sent for sale to 19
countries that is 243% higher as compared with the same period of the previous
year. In general, it should be noted that an increase in wine exports, in
addition to opening new markets, was due to the expansion of production in the
country. The appearance of new industrial possibilities is important against
the background that, in addition to Russian market, Georgia has to master the
Belarusian export quotas; the mastering of the EU market is associated with
difficulties of compliance with European standards and regulations. Hopefully,
Georgia’s Deep and Comprehensive Trade Agreement will open new prospects for
Georgian wines on the EU market. Ref. 5.
Auth.
b14.5.2.19. Genesis, problems and
perspectives of Georgian antimonopoly activity.
/S. Pavliashvili, L. Jangulashvili/. Metsniereba da Tskhovreba. – 2014. – #2(10). –
pp. 12-20. – geo.; abs.: geo., eng., rus.
The work deals with the prehistory of antimonopoly activity in
Georgia as well as the stages of the functioning of Antimonopoly Service. It shows
that effective Antimonopoly policy depends not on how "strict" or
"weak" are the rights of this service but on how accurately is
established the legal and institutional base, how the political view of the
authorities is expressed as well as the professionalism of the employees of the
service. There is a brief summary of the new competition law in this work. It
has been concluded that it should be developed the new program of free and fair
competition which lets the government to bring legislation and institutions
closer to the best international practices. There are the recommendations to
promote free and fair competition. Ref. 4.
Auth.
b14.5.2.20. Tendencies and perspectives
of the international and regional tourism development. /G. Nadirashvili, D. Jangulashvili/. Metsniereba da Tskhovreba. –
2014. – #2(10). – pp. 20-30. – geo.; abs.: geo., eng., rus.
The work explores the tendencies and
perspectives of the international and regional tourism development based on the
analyses of the financial earnings and on the number of entering
tourists in the world and according the macro region. The above-mentioned gives
a broad picture how effectively the tourist resources of the countries have
been used and what the particular geographical destinations in 1990-2004 and
2000-2010 years were achieved, as well as the perspectives for 2020 years. Tab.
5, Ref. 10.
Auth.
b14.5.2.21. Modern individual’s requirements to quality. /I. Adeishvili/. Metsniereba da Tskhovreba. – 2014. – #2(10). – pp. 50-52. – geo.; abs.: geo., eng., rus.
The study describes the human’s requirements to quality.
The study discusses five levels of quality according to the Maslow theory. The quality problems are given in competitive
circumstances. It also talks about the quality of philosophy stages. The author
refers to the National Food Agency’s activities within Ministry of Agriculture
and expresses several opinions regarding improvement of a quality. Ref. 5.
Auth.
b14.5.2.22. Georgian hazelnuts in the
world market. /A.
Zedginidze/. Metsniereba da Tskhovreba. –
2014. – #2(10). – pp. 70-74. – geo.; abs.:
geo., eng., rus.
The work reviews the economic significance of Georgian hazelnuts, the
present status of their production and demand for them in the world market.
The world statistics associated with hazelnut spread, production and marketing
in Georgia and on the world markets for the last years are presented. Tab. 1, Ref. 4.
Auth.
b 14.5.2.23. The principles of market infrastructure
formation on the drainage territories of Kolkheti Lowland. /R.
Beraia/. Science and Technologies. – 2014. – #2(716). – pp. 30-32. – geo.; abs.:
geo., eng., rus.
To establish a
market infrastructure on Kolkheti Lowland, it is necessary that associations of
farms be formed on its drainage territories; this would ensure compensation for
the costs of land-reclamation organizations incurred during performance of the
first-, second-, as well as third-order drainage works; it is also promising for
forming branchless commercial banks (mainly joint-stock). Ref. 4.
Auth.
b14.5.3.1. M-Learning in education - problems and perspective. /M.
Gegechkori, V. Bakhtadze, T.
Lominadze, M.
Tevdoradze, T. Kaishauri/. Proceedings of the A.
Eliashvili Institute of Control Systems. – 2014. – #18. – pp. 213-215. – geo.;
abs.: geo., eng., rus.
The essence of
Mobile Learning
(M-Learning)
- modern educational technology is explained in the article. The characteristic
of M-Learning, also overview of its main features and factors that determine
the increasing demand for mobile learning is given. The possibilities of
involving and use of M-Learning in the process of teaching and learning in
educational institutions as well problems and perspectives of mobile learning
is shown. Several advantages and restrictions of this type of learning are
considered. The list of categories of mobile learning also the short
definitions of these categories is given. Ref. 7.
Auth.
b14.5.3.2. Engineering education in Europe:
preparation for professional engineering standards – CDIO
initiative. /O.
Zumburidze, G. Dzidziguri, T. Lominadze, N. Zhizhilashvili/. - Automated
Control Systems. – 2014. – #1(17). – pp. 7-10. – geo.; abs.: geo., eng., rus.
Engineering
education is one of the priorities of the European educational system. There
are developed number of standards and initiatives that have been successfully
implemented in the educational process of leading European universities in
order to issue competitive professional engineers of high quality. The paper
represents the results of the researched conducted within the frame of the
project ENGITEC ("Modernizing higher engineering education in Georgia,
Ukraine and Uzbekistan to meet the technology challenge",
530244-TEMPUS-1-2012-1-SE-TEMPUS-JPCR), funded by the European Commission under
the TEMPUS grant competition. Ref. 4.
Auth.
b14.5.3.3. Analyses of engineering educational
curricula in advanced European universities: best practices from UK (University
of Leeds), Sweden (Kungliga Tekniska Hogskolan) and Italy (Politecnico Di
Torino). /O.
Zumburidze, G. Dzidziguri, T. Lominadze, N. Zhizhilashvili/. Automated
Control Systems. – 2014. – #1(17). – pp. 11-16.
– geo.; abs.: geo., eng., rus.
Within the frame of
the project ENGITEC ("Modernizing higher engineering education in Georgia,
Ukraine and Uzbekistan to meet the technology challenge",
530244-TEMPUS-1-2012-1-SETEMPUS-JPCR), funded by European Commission grant
competition TEMPUS, there was conducted researches of Engineering educational
programs in leading European engineering universities. The paper presents the
results of this research on the bases of the Mechanical Engineering program.
Fig. 2, Ref. 4.
Auth.
b14.5.3.4. Modern education methods for built-in control system
study. /N.
Mchedlishvili, I. Mosashvili, I. Davitashvili/. Business-Engineering.
– 2014. – #4. – pp. 40-42. – geo.; abs.: geo., eng.
The control system
using the Matlab/Simulink and the FPGA board has been studied. The library was built
and design used by the standard Simulink DSP Builder with discrete integrators,
PID controller, PMW generator and A/D controller and represents a FPGA
implementation. “Case study” method has used to demonstrate the control system
with built-in Matlab / Simulink environment. Fig. 4 Ref. 4
Auth.
b14.5.4.1. Application of biometric
technologies in the electoral processes. /A.
Prangishvili, L. Imnaishvili, M. Bedineishvili, N. Kirkitadze, Z.
Matsaberidze/. Proceedings of the A. Eliashvili Institute of Control Systems. –
2014. – #18. – pp. 25-30. – geo.; abs.: geo., eng., rus.
The
paper presents the advantages and problems of using biometrics in
electoral/election systems. Perspective
protocol of biometric election system is proposed in the work. Results are
analyzed by using a biometric election system.Fig. 3, Ref. 4.
Auth.
b14.5.4.2. Main trends of
contemptotary human resources management. /G. Dzidziguri, M.
Nonikashvili/. Automated Control Systems. – 2014. – #1(17).
– pp. 46-51.
– eng.; abs.: geo., eng., rus.
By the Communiqué of
the Conference of European Ministers Responsible for Higher Education, Leuven
and Louvain-la-Neuve, 28-29 April 2009 the higher education institutions have
been asked to pay particular attention to improving the teaching quality of
their study programmes at all levels. For this purpose the work provides to
identify higher education institutions’ personal qualification and competencies
and their development ways. In particular, it reviews the Behaviour Engineering
Model (BEM) developed by Thomas Gilbert and shows how to use opportunities of
this Model. The Model provides us with a way of systemically identifying
barriers to individual and organizational performance. Crucial elements for a
successful functioning of any organization are job analyses and competency
design of positions. Hence, these two aspects are very important in human
resources management processes. Objective matching of an employee with his/her
job tasks can only be based on a job analysis assessment results. Also is given
concrete actions by author’s version to solve the raised problems. Tab. 1, Ref.
5.
Auth.
b14.5.4.3.
Test
reliability for professional selection process. /M. Nonikashvili/. Automated
Control Systems. – 2014. – #1(17). – pp. 141-144.
– eng.; abs.: geo., eng., rus.
Selection and distribution
of professional staff in the workplace, selection of
candidates for targeted training assumes concrete expression in modern
conditions. Properly diagnose to an individual ability contributes the
selection of a suitable profession of each person’s abilities and propensities.
An objective assessment of the tests can be achieved through a well-designed
and flexible system. It is essential to measure the test reliability of during
a professional selection testing. In this work is given reliability assessment
methods and provides recommendations related to this issue. Ref. 4.
Auth.
b14.5.4.4. The problem of measuring
intelligence in modern education. /J. Nikuradze, V. Meladze, V.
Kvintradze/. Automated Control Systems. – 2014. – #1(17).
– pp. 160-163.
– eng.; abs.: geo., eng., rus.
Measurement
of mental abilities became relevant in the first half of the 19th century. The
first study in this area belongs to Galton. Galton is considered the founder of
the empirical approach to intelligence. Today according to I.V. Useltsova
technique has the advantage of “Ravens Progressive Matrices” proposed by L.
Perouzom and J. Raven. Ref. 3.
Auth.
b14.5.4.5. Intelligence and its some models. /J. Nikuradze, V.Kvintradze, V. Meladze/. Automated
Control Systems. – 2014. – #1(17). – pp. 164-167.
– eng.; abs.: geo., eng., rus.
The paper
deals with
the issues related to intelligence. In spite that the problem has been studied
for a long time there is still no universal definition of intelligence. Several
views (models) of several authors on the essence of intelligence are given in
the article. Irrespective of many differences, these models have many common
features, which are presented in the article. Ref. 4.
Auth.
b14.5.4.6. The social-geographical research of quality of
population life in the regions of Georgia with the
development of new and alternative
research methods. /N. Gavardashvili, A. Gavardashvili/. Science and Technologies. – 2014. – #2(716). – pp. 54-60. – geo.; abs.: geo., eng., rus.
With
the aim of defining quality of life in the regions of Georgia (Sighnaghi,
Dusheti, Gori Districs, Cities Rustavi, Batumi) the sociological survey was
carried out during May 1-21, 2014. 300 respondents participated in the survey.
The respondents were chosen by random selection. The respondents assessed the
criteria defining the quality of life with scores from 1 (the lowest) to 5 (the
highest). With the aim of defining quality of life (its qualitative and
quantitative meanings area changing from year to year) the mathematical model
containing the following eight components was developed. They are: life
security, environmental problems, healthcare quality, education system efficiency, gender status, economic state of population, socioeconomic state of the country, status of a person in the society. Fig. 1,
Tab. 1, Ref. 6.
Auth.
b14.5.5.1. “Right to die” in dramatic section of dimensions. /M. Ugrekhelidze, E. Gotsiridze/. Caucasus International University Herald. –
2014. – #1. – pp. 36-52. – geo.; abs.:
geo. eng., rus.
Is the request of euthanasia
a natural right “reasonably alleged by a human being?” Right
to euthanasia has as much “chance” to exist, as the other fundamental human
rights do. It emanates directly from “human dignity” and core principle that
the human being must always be the end, not the means. It is as natural,
inborn, inherent and “reasonably alleged by a human being,” as the other
Fundamental Rights and is based on the idea of fundamental justice. Ref. 11.
Auth.
b14.5.5.2. Rights and values -
guarantees and the reality.
/M. Tsatsanashvili/. Caucasus International University Herald. – 2014. – #7. – pp.
53-59. – geo.; abs.: geo. eng. rus.
The article is devoted
to the philosophical and legal understanding of real guarantees for human
rights protections that introduces a new model of dialogue between the State
and society. Shown is the importance of the main value of this idea - logical
axioms of dignity and freedom to create real guarantees of rights protection.
Analyzed is the correlation value of the rights and obligations in the
formation of the legal system, which is a tool for implementing the rights and
the guarantee of state obligations. Substantiated is the importance of ideology
and psychology in the practical sphere of right protection guarantees - in
legislation and the realization process of the law. On the basis of the
displacement methods from the abstract to the concrete and legal modeling reasons
for the decline of the effectiveness of instruments of human rights protection
in the early 21st century are given. Formulated is a model of
overcoming the crisis and achieving consent in this field. The advantage of
this new model is the self-organization of the legal system on such principles
as: 1. The right is not only the supreme value, the dignity and freedom should
also be reflected in rights; 2. Not only the State and the law are rights
protection guarantees, an ongoing dialogue on the establishment of
correlation systems of rights and obligations between society, the State and
the individual should not be disregarded as well. Ref. 6.
Auth.
b14.5.5.3. The object of entrapment – clarity upon the basic issue.
/P. Guruli/. Caucasus International
University Herald. – 2014. – #7. – pp. 60-66. – geo.; abs.: geo. eng. rus.
The issue of entrapment attracted the attention
of scholars as early as in the 19th century. Despite
almost two centuries of research, controversies around it are still alive. Some scholars support the idea of
complete criminalization of this conduct, while others advocate for its partial
legalization. Besides writers relatively rarely concentrate on the object of
entrapment and
substantial number of the views expressed upon the matter needs further
sophistication. Since
the object of a criminal offence is valuable idea, the protection
of which underlies the criminalization of the conduct, even the slightest
misunderstanding with respect to it may result in distortion of the legal
practice. Therefore, we need to bring an utmost clarity to the issue of the
object of entrapment. The different historical backgrounds led to considerable
distinctions between approaches developed in the civil law countries and common
law countries. A
comparative analysis of these divergent concepts might significantly complement
our knowledge on the matter. The objective of this essay is to
develop a scientific approach useful as a practical commendation in legal life;
to bring clarity upon the basic issue. Ref. 28.
Auth.
b14.5.5.4. Traditional and contemporary
evaluation of engagement institute in legal and civil terms. /N.
Rosefashvili, N. Ivanelashvili/. Caucasus
International University Herald. – 2014. – #7. – pp. 75-79. – geo.; abs.: geo. eng. rus.
Mankind has acquired
lots of traditions during the century-old historical development; some of them
being still kept. One of the most important and viable traditions is marriage,
while engagement is an exceptionally interesting part of it. Exactly
traditional and contemporary legal aspects of the engagement institute are the
main object of our review. Engagement was and is a pre-marriage agreement that
is made between woman and man and comes to an end with marriage. Because of its
importance, the engagement custom gradually found itself in legal regulation
sphere. In some modern states (for instance, Turkey, Germany) different aspects
regarding engagement are represented in legislation. In Georgia, the engagement
institute is more traditional and less legal. Some aspects regarding engagement
need to be perfected in Georgian legislation. Ref. 10.
Auth.
b14.5.5.5. Legal
status of unwed mother with illegal children - general overview. /L. Chiglashvili/. Caucasus International University Herald. – 2014. – #7. – pp.
80-84. – geo.; abs.: geo. eng. rus.
The article refers to survey and analysis of problematic issues
regarding the legal status of unwed mothers. Specifically, the topic for review covers the cases of
women, who delivered babies out of wedlock and undertook a hard burden of
single motherhood. Such women require certain privileges and support on the
part of the government. Although, international law has greatly affected the
formation of Georgian legislation and the mechanism of protecting women’s
rights, most of international norms are still partially implemented in Georgia.
The main purpose of the article is to settle legal regulation of social and
moral issues of single mothers in Georgia in the fastest and most efficient way
on the legislative base of European countries. Ref. 18.
Auth.
b14.5.5.6. Aspects of civil protection of honor, as a form of privacy life manifestation. /M. Bichia/. Metsniereba da Tskhovreba. – 2014. – #2(10). – pp.126-133. – geo.; abs.: geo., eng.,
rus.
The study showed that sociological and legal content of
honor plays an important role in determining the ontological nature
of honor. In addition, the honor and dignity are different categories,
particularly in the civil law sense. However, the honor and dignity in the
legal point of view are characterized by the rights of requirements that are
similar to all legal persons, as a human. Ethical and legal aspects of dignity
and honor, also other important issues relating to subject of discussion of
this article are considered in detail. Ref. 26.
Auth.
b14.5.5.7. The oath as the confirmation
in accordance to the Book of Law by Vakhtang VI.
/M. Kopaliani/. Metsniereba da
Tskhovreba. – 2014. – #2(10).
– pp.133-138. – geo.; abs.: geo., eng., rus
Determination of the
rights and functions of public officials of state organizations, gathering of
the ancient Georgian legislation sources and foreign sources are connected to
the name of Vakhtang IV in Georgia, which is depicted in the Book of Law
written by him. Vakhtang IV was called “the creator of laws” like Roman Emperor
Justinian. In the Book of Law, along with the many issues, the talk goes about
list of different evidences, and namely about the role and purpose of the oath in
our country, subject of oath, about the people making the oath, legal
relationships generated from the obligation and based on oath. Ref. 6.
Auth.
b14.5.5.8. Death penalty in Georgia and
Former Eastern Bloc Countries. /G. Asatiani/. Metsniereba da Tskhovreba. – 2014. – #2(10). – pp.142-147. – geo.; abs.: geo., eng.,
rus.
The article reviews death penalty as a type
of punishment that had been used in Georgia from the ancient times till the end
of 20th century. It contains a brief description of legislation in
both feudal and soviet era, namely, the crimes for which death penalty as the
capital punishment was used in different historic periods of time. The article
also speaks about the way that the Georgian state and the law have passed
concerning such an important issue as a refusal of death penalty as the capital
punishment. Along with the Georgian example, it touches the experience on the
use and subsequently on the abolition of death penalty in the countries of
former “socialist block”. There are also research results conducted by
different organizations in different periods of time about the attitude of the
society towards the death penalty. The article views international legislation,
particularly international conventions and agreements that regulated and still
regulate the possibility of use of death penalty in the civilized world.
Namely, it is applied to crimes and cases that were committed for which
international legislation allowed death penalty as a possibility of use of a
punishment. It also talks about the modern world’s views, arguments often
presented by the supporters and opponents of death penalty abolition,
principles of humanism and state competence on using the capital punishment. In
conclusion, the author stresses his own opinion on the problematic issues in
the article. Ref. 5.
Auth.
b14.5.5.9. Social and material-technical
guarantees of judges’ independence. /K. Koberidze/. Metsniereba da Tskhovreba. – 2014. – #2(10). – pp.148-151. – geo.; abs.: geo., eng.,
rus.
The article reviews inferences made by
Consultative Council of European Judges and recommendations by Committee of
Ministers of Council of Europe about social and material-technical guarantees
of independence and the rules of financing courts in some of the European
countries. Moreover, in this regard, the existing condition in Georgia, recent
judicial reforms and legislative amendments reinforcing the establishment of
fair justice are also considered. Ref. 7.
Auth.
b14.5.5.10. Intersection
of human rights and international investment law: some brief observation. /G.
Khatidze/. Law and the World. – 2015. – #1. – pp. 6-20. – eng.; abs.:
geo., eng.,
The
ultimate goal of IIAs, as different from the rationale of human rights, is to
promote and protect investment flows in capital-importing states.
Notwithstanding those two different areas of international law, intersection of
international investment law and human rights, as evidenced by some recent
investment cases where investment tribunals had to engage with human rights
issues in investment arbitration, is obvious; furthermore, characterized with
growing trends. Considering a growing process of globalization and
interdependence of public and private actors, as well as a power and an
influence of foreign direct investment makers, it becomes obvious that the IIAs
should be converted from one pillar
into double pillar mechanisms wherein
those investment agreements and treaties should seriously consider various human
rights issues. Without that approach, intersection of human rights and
investment issues is concerned with substantive as well as procedural
difficulties. Ref. 60.
Auth.
b14.5.5.11. European
Court of Human Rights’ advisory opinion:
pros and cons. /I. Kelenjeridze/. Law and the World. –
2015. – #1. – pp. 21-30. – geo.; abs.: geo., eng.
This
study explores Legal Aspects of Advisory Opinion which is one of the functions
of the European Court of Human Rights. The study describes positive as well as
those problematic issues of Advisory Opinion which have been outlined in
Protocol No.16 to the Convention on the Protection of Human Rights and
Fundamental Freedoms. The aforementioned topic has not yet been explored from a
legitimate perspective. The function of Advisory Opinion, as proposed by the
European Court of Human Rights, is to provide a legal guideline since a
political body may not properly decide a legal issue. Provision of an Advisory
Opinion to the highest national jurisdictions relating to pending cases, as a
novelty introduced by Protocol No.16, may itself limit the independence of and
cause the impact on national courts. Apart from that, the European Court of
Human Rights may itself be impacted by its Advisory Opinion as a decision of
national courts could be appealed to the European Court of Human Rights.
Ratification of Protocol No.16, therefore, reduces the level of independence of
national jurisdictions. This study aims to analyze those risks within the
scientific level in context of legal measurement. Ref. 22.
Auth.
b14.5.5.12. New considerations on Sino-European relations from the perspective of the global balance of power; the
mirage of the silk road. /D. Popescu/. Law and the World. – 2015. – #1. – pp. 31-56. – eng..; abs.: eng.
The world today is a mess - there is no doubt about
it. But probably this is also how the contemporaries of other historical times
saw their present. We could rather say that the international order is
difficult to predict at the beginning of a century which is already dominated
by very confusing moves and combinations. Using the author’s own means of
research and observation (field research, the perception of reality from the
perspective of the study of history, and a compared dimension), this article
wishes to shed some light on a part of the role played by the European Union in
the international policy under the circumstances of the fast transformations
suffered by the global economic and security environment. The strategic
relation with China is worth discussing at several levels (depending on the
various categories of interests); our considerations about the course of the
strategic partnership between the two powers and about the current evolutions
of the international scene try to provide only some necessary benchmarks for an
overall understanding of this diplomatic closeness. The United States and
Russia are global phenomena with complex, eventful trajectories and a direct
impact on modern universal history. Having emerged on the international arena
approximately at the same time, the evolution of the European Union and China
(the name Zhōngguó means the Middle Kingdom) is not reflected in the
adoption or appropriation of the features of the old dualist model generated by
the two ideologically opposing groups, the West and the East. They both try
specific governing and extension formulas: the first chooses the road of the
European integration and thus stands out in the classical landscape of
intergovernmental cooperation and transnational dialogue between the states and
the second counts on the advantages of its physical architecture which
generates prosperity, to make its presence felt on the global scene. Last but
not least, the article wishes to bring forward, within a certain contextual
framework, those essential elements of civilisation which provide an easier
understanding of the surrounding political and economic realities, advancing
new reflection leads. Ref. 104.
Auth.
b14.5.5.13. Hong Kong, China - 1997 (What is the way to Abkhazia?!). /J. Gakhokidze, S. Midelashvili/. Law and the
World. – 2015. – #1. – pp. 67-75. – geo.; abs.: geo., eng.
Despite
of twenty-year efforts of Georgian Government, International Community and
Friendly Countries of Georgia, the situation in the conflict resolution is not
getting better. Russian-Georgian War in 2008 turned out to be fatal for Georgia
the disastrous results of which radically changed the political reality of the
region. The results of war encroached the national interests of Georgia,
including the prospects for conflict resolution in the first place. 20% of
Georgian territory is occupied. After the war, we completely lost the control
on the Kodori gorge and Akhalgori region. While the International Community and
even the Russian Federation have repeatedly recognized Georgia in its borders,
Russia, neglecting the fundamental principles of International Law (in
particular, the territorial integrity) recognized Abkhazia and so-called South
Ossetia as Independent States. Unfortunately, after the war, Abkhazia and so-called
South Ossetia were considered towards Georgia as separated regions. Under such
circumstances, it became necessary to search for new ways of conflict
resolution based only upon real politics. Real politics is non-alternative and
the only right way to peacefully sett le the conflicts. The use of war and
violence to accomplish this is nonsense and nothing more. Apparently, based
upon the new political realities, a different strategy is necessary for both
Georgian Government and International Community to take the conflicts out of
deadlock. Hong Kong is a very interesting phenomenon for us because its return
to the Mother Country on the first day of July 1997 was truly a unique event
and the current reality. Therefore we consider it is important to analyze historical
as well as political-legal and economic aspects of the solution of the conflict
like Hong Kong and draw possible parallels, search for similarities and
differences between Georgia and its separated regions. Ref. 6.
Auth.
This article is a
pioneering scientific work at the intersection of natural and human sciences,
which aim is to ensure sustainable peace and prevent global economic,
political, social and legal disorder under the aegis of the Bill of Human
Rights. The proposed
theory offers a new mechanism to overcome existing disorders and to
prevent further disorders, pushing mankind to move from the closed circular position on the position of spiral
development. The paper serves as a fruitful
source of new ideas for researchers, professionals and successful students
working in the area of physics, mathematics, biology, philosophy, anthropology, sociology, economics, and
jurisprudence or connected areas. Ref. 5
Auth.
b14.5.5.15. Progressive method of taxing on income. /E. Shubitidze/. Law
and the World. – 2015. – #1. – pp. 89-109. – geo.; abs.: geo., eng.
Progressive
method of taxing personal income is one of the most effective ways of
distributing financial resources among taxpayers. This article aims at
emphasizing the advantages of progressive taxation compared to proportional
method. Though, herewith we highlight the risks to be considered when acquiring
the progressive taxation method. The essay suggests discussing alternative
principles to justify the personal income tax, which have been formulated
recently and tend to acquire rising attention among analysts and tax law
scholars. The essay aims to measure the progressive method of personal income
taxation in legal perspective, by setting aside economic factors. Doing so, we
may doubt the essay will fail to reflect the objective reality, still it offers
alternative legal point of view and strengthens the ground for legal dispute
within tax law as interdisciplinary study. Facts and reasoning lead to the
following statements: taking into account the inequality measures in Georgia,
given the GINI coefficient, resource redistribution is by all means the task of
leading priority, to achieve diminishing social inequality and to guarantee
equal opportunities for self-realization and promotion of democracy, etc. Ref.
15
Auth.
b14.5.5.16. Function of judiciary power in the enforcement process. /Z. Chkonia/. Justice and Law. – 2013. – #3(38). – pp. 122-127. –
geo.; abs. eng.
As a result of
analyzing the opinions of founders of the theory of division of power and those
of the thinkers referred to in this paper, we can conclude that the enforcement
function should not be included within the competence of the judicial power,
because performing such function will violate the balance that should be protected
pursuant to the principle of the division of power. This is why the procedural
(and not the agency-level) control of court is necessary not only over the
enforcement of the judgment delivered by the court itself, but also during the
enforcement proceedings in general, which from its side serves the goal of
protecting the lawfulness of this process and effective performance of
enforcement, and thus securing the protection of rights of both a creditor and
a debtor in the process. Ref. 20.
Auth.
b14.5.5.17. Evolution of civil enforcement law in Georgia. /Z. Chkonia/. Justice and Law. – 2014. – #2(41). – pp. 122-132. – geo.; abs.: eng.
The following can be
concluded based on a historical-legal analysis of the development of the enforcement
proceedings in Georgia: Study of the Georgian law of the feudal era enables us
to conclude that there were effective mechanisms of enforcing the court
judgments and other judicial acts, which of course represented significant
safeguards for protecting the parties of enforcement. There used to be a
refined and effective system of legal proceedings in the
kingdoms-principalities of Georgia, which was gradually replaced since joining
Russia in 1801 by the clearly demonstrated reactive legal proceedings, which
was based on the inequality among nobility ranks. Consequently, instead of the
refined enforcement system, which existed before this, we ended up with a
completely ineffective system of enforcement and legal proceedings in general.
In regards to the development of enforcement proceedings and the civil law
proceedings in general, we should say that it was a progress to implement the
judiciary reform in 1864 and consequently to establish the procedural
legislation as a separate field after these reforms. However, we should also
point out that despite the reform, in fact, the enforcement proceedings still
remained to be ineffective. The civil law proceedings and, consequently, the
system of enforcement proceedings in fact did not change in Georgia during
1918-1921. As for the Soviet period, the enforcement proceedings were less
effective in Georgia. Besides, we should point out that procedural rights of
the parties were neglected during legal proceedings, in general, at the
legislative level. Based
on the historical-legal analysis of the enforcement law of Georgia I consider
that the administrative independence of enforcement agencies should be ensured
as a necessary way towards creation of the effective enforcement proceedings,
under the procedural and not administrative control by the judiciary power.
Ref. 6.
Auth.
b14.5.5.18. Development
of judicial organization and civil procedure in Georgia. (historical-legal
analysis). /Z.
Chkonia/. Justice and Law. – 2014.
– #3(42).
– pp. 81-101.
– geo.; abs.: eng.
The following
conclusions can be drawn after studying the development of civil procedure and
judicial organization in Georgia: there had been a well-organized system of
civil proceedings and judicial organization in Georgia since ancient times,
which was replaced after joining to Russia in the beginning of the 19th
century by the legal proceedings, where the key principles of the procedure
(discretion, adversary process, openness, etc.) were substantially neglected, although
these principles were formally recognized at full length by the Statutes of
Civil Proceedings adopted in the Russian Empire in 1864; they were incompletely
implemented in practice, especially in the Caucasus, where the judiciary reform
was implemented with limited scope. After the Soviet annexation, a judicial
system was established in Georgia, although it significantly depended on the
executive power and its political will. The Soviet legislation did not
recognize the separation of state power into several branches. Consequently,
the judiciary body was not considered to be a ‘power’ at all during the Soviet
period. The prosecutor’s office had a function to oversight the judiciary,
which substantially limited its independence, and thus, ruled out the existence
of a fair trial. The inquisitorial nature of the civil courts, prosecutor’s
involvement and its unlimited roles in fact neglected the directional,
adversarial and other recognized principles of civil procedure. Ref. 4.
Auth.
The recommendations
for government agencies to improve the relationship with the parties which are
collaboratively working on addressing challenges posed to the state and are
directly responsible for them, as well as on mechanisms to improve the
management of these structures are given. Ref. 3.
Auth.
b14.5.6.2. Working out of a model of an
effective management of organizational system of the region's sustainable
development. /A. Prangishvili, M. Macharadze, Z.
Gasitashvili, M. Kiknadze/. Proceedings of the A. Eliashvili Institute of Control
Systems. – 2014. – #18. – pp. 19-24. – geo.; abs.: geo., eng., rus.
Regional economics
considerably determines the regional development. Regional development is
characterized by factors of such development. Therefore, in order to determine
the problems of management of regional development, degree of impact of factors
(indicators) of regional development on the criteria of regional development
should be studied. Criteria of regional development are many, so we have
inconceivably large range of scenarios in simulated experiment. The work tries
to develop the sub-range of factors with high magnitude (high degree of impact)
from the range of factors of regional development. This sub-range will be the
basis for studying economics of regional development and it is very actual
problem. Simulation of social-political situations is effectively used for
studying these problems. The work considers the tasks of modeling and studying
economical sustainability on the basis of control impact and different types of
experiments. Tab. 1, Fig. 2, Ref. 3.
Auth.
b14.5.6.3. Prospects of federalism in Ukraine.
/G. Goradze/. Caucasus International University Herald. – 2014. – #7. – pp.
67-73. – geo.; abs.: geo. eng. rus.
The article aims at analyzing the possible federalization
of Ukraine, which has caught an eye recently and has become the topic of
international discussion. Ukraine is a unitary country with one
autonomic unit – the Autonomous Republic of Crimea that has the special chapter
in the constitution, where its purviews are defined. Ukrainian federalization
is compared to Belgium and sometimes even to Canada by some politicians and
scientists, so the optimal model for Ukraine is bipolar federalism. Belgian
federalism is deeply discussed in the article stating that Belgian model cannot
be an example for Ukraine according to several authors. The article has
skeptical view about the bipolar and ethnical federalism, as disintegrated
processes are generally strong in these federalisms. Other than that the article
also includes the disadvantages of any type of federalization of Ukraine. For
instance, the bureaucratization, the delay in decisions, the problem of
controlling local political elite, budget crisis, additional expenses, closing
of economy and dependence of particular regions on Russian economy. At the end
the article also states that the best option for Ukraine is the decentralized
unitary state. The optimization of public entities and employees should be done
to minimize the negative elements of bureaucracy in governing the country. Ref.
24.
Auth.
Modern computer
systems, as compared with their predecessors, have to operate in a
territorially and temporally distributed network environment. Furthermore, they
must adapt quickly to requirements and changes in the government. This approach
to the creation of a system requires detailed agreement of joint actions, not
only regarding the judicial matters, but also referring to the relations with
higher authorities. The article provides guidance for developers of computer
systems with the goal to improve the interactions between these branches of
government. Fig. 1,
Ref. 4.
Auth.